Changes in maternal and fetal nicotine distribution after maternal administration of monoclonal nicotine-specific antibody to rats

International Immunopharmacology

Volumn 6, Issue 11, 2006, Pages 1665-1672

  Keyler, D E ^b,c   LeSage, M G ^a,c   Dufek, M B ^c   Pentel, P R ^a,c  

^a UNIVERSITY OF MINNESOTA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c MINNEAPOLIS MEDICAL RESEARCH FOUNDATION   (United States)

Author keywords

Distribution; Fetal; Immunization; Monoclonal antibody; Nicotine

Indexed keywords

MATERNAL ANTIBODY; MONOCLONAL ANTIBODY; NIC311 ANTIBODY; NICOTINE; UNCLASSIFIED DRUG;

ADOLESCENT; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG MECHANISM; FEMALE; FETUS; IMMUNIZATION; NONHUMAN; PASSIVE IMMUNIZATION; PREGNANCY; PRIORITY JOURNAL; RAT; SMOKING; TOBACCO DEPENDENCE;

ANIMALS; ANTIBODIES, MONOCLONAL; BRAIN; FEMALE; IMMUNIZATION, PASSIVE; MATERNAL-FETAL EXCHANGE; MICE; NICOTINE; PREGNANCY; RATS; RATS, SPRAGUE-DAWLEY;

EID: 33748430001     PISSN: 15675769     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.intimp.2006.06.013     Document Type: Article

References (32)

1. USDHHS. The health consequences of smoking. A report of the surgeon general (2004), U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, National Center for Chronic Disease Prevention and Health Promotion, Office on Smoking and Health, Atlanta
2. Milberger S., Biederman J., Faraone S.V., and Jones J. Further evidence of an association between maternal smoking during pregnancy and attention deficit hyperactivity disorder: findings from a high-risk sample of siblings. J Clin Child Psychol 27 (1998) 352-358
3. Wakschlag L.S., Pickett K.E., and Leventhal B.L. The association between maternal cigarette smoking and psychiatric diseases or criminal outcome in the offspring. Reprod Toxicol 14 (2000) 579-580
4. Niaura R., Bock B., Lloyd E.E., Brown R., Lipsitt L.P., and Buka S. Maternal transmission of nicotine dependence: psychiatric, neurocognitive and prenatal factors. Am J Addict 10 (2001) 16-29
5. Slotkin T.A., Saleh J.L., McCook E.C., and Seidler F.J. Impaired cardiac function during postnatal hypoxia in rats exposed to nicotine prenatally: implications for perinatal morbidity and mortality, and for sudden infant death syndrome. Teratology 55 (1997) 177-184
6. Xu Z., Seidler F.J., Ali S.F., Slikker Jr. W., and Slotkin T.A. Fetal and adolescent nicotine administration: effects on CNS serotonergic systems. Brain Res 914 (2001) 166-178
7. Fewell J.E., Smith F.G., and Ng V.K. Threshold levels of maternal nicotine impairing protective responses of newborn rats to intermittent hypoxia. J Appl Physiol 90 (2001) 1968-1976
8. Levin E.D., Wilkerson A., Jones J.P., Christopher N.C., and Briggs S.J. Prenatal nicotine effects on memory in rats: pharmacological and behavioral challenges. Brain Res Dev Brain Res 97 (1996) 207-215
9. USDHHS. The health consequences of smoking: nicotine addiction, a report of the Surgeon General (1988), U.S. Department of Health and Human Services, Centers for Disease Control and Prevention, Office on Smoking and Health, Atlanta
10. Pentel P.R., and Malin D.H. Vaccines for nicotine dependence; targeting the drug instead of the brain. Respiration 69 (2002) 193-197
11. Pentel P.R., Malin D.H., Ennifar S., Heida Y., Keyler D.E., Lake J.R., et al. Attenuation of nicotine effects in rats by a nicotine conjugate vaccine. Pharmacol Biochem Behav 65 (2000) 191-198
12. LeSage M.G., Keyler D.E., Hieda Y., Collins G., Burroughs D., Le C., et al. Effects of a nicotine conjugate vaccine on the acquisition and maintenance of nicotine self-administration in rats. Psychopharmacology (Berl) 184 (2006) 409-416
13. Hatsukami D.K., Rennard S., Jorenby D., Fiore M., Koopmeiners J., de Vos A., et al. Safety and immunogenicity of a nicotine conjugate vaccine in current smokers. Clin Pharmacol Ther 78 (2005) 456-467
14. Keyler D.E., Shoeman D., LeSage M.G., Calvin A.D., and Pentel P.R. Maternal vaccination against nicotine reduces nicotine distribution to fetal brain in rats. J Pharmacol Exp Ther 305 (2003) 587-592
15. Keyler D.E., Dufek M.B., Calvin A.D., Bramwell T.J., LeSage M.G., Raphael D.E., et al. Reduced nicotine distribution from mother to fetal brain in rats vaccinated against nicotine: time course and influence of nicotine dosing regimen. Biochem Pharmacol 69 (2005) 1385-1395
16. Simister N.E., and Story C.M. Human placental Fc receptors and the transmission of antibodies from mother to fetus. J Reprod Immunol 37 (1997) 1-23
17. Malin D.H., Alvarado C.L., Woodhouse K.S., Karp H., Urdiales H., Lay D., et al. Passive immunization against nicotine attenuates nicotine discrimination. Life Sci 70 (2002) 2793-2798
18. Malin D.H., Lake J.R., Lin A., Saldana M., Balch L., Irvine M.L., et al. Passive immunization against nicotine prevents nicotine alleviation of nicotine abstinence syndrome. Pharmacol Biochem Behav 68 (2001) 87-92
19. Carrera M.R., Ashley J.A., Hoffman T.Z., Isomura S., Wirsching P., Koob G.F., et al. Investigations using immunization to attenuate the psychoactive effects of nicotine. Bioorg Med Chem 12 (2004) 563-570
20. Keyler D.E., Roiko S.A., Benlhabib E., LeSage M.G., St. Peter J.V., Stewart S., et al. Monoclonal nicotine-specific antibodies reduce nicotine distribution to brain in rats: dose- and affinity-response relationships. Drug Metab Dispos 33 (2005) 1056-1061
21. LeSage M.G., Keyler D.E., Collins G., and Pentel P.R. Effects of continuous nicotine infusion on nicotine self-administration in rats: relationship between continuously infused and self-administered nicotine doses and serum concentrations. Psychopharmacology (Berl) 170 (2003) 278-286
22. Jacob P., Wilson M., and Benowitz N.L. Improved gas chromatographic method for the determination of nicotine and cotinine in biologic fluids. J Chromatogr 222 (1981) 61-70
23. Hieda Y., Keyler D.E., VanDeVoort J.T., Niedbala R.S., Raphael D.E., Ross C.A., et al. Immunization of rats reduces nicotine distribution to brain. Psychopharmacology 143 (1999) 150-157
24. Pentel P.R., and Keyler D.E. Effects of high dose alpha-1-acid glycoprotein on desipramine toxicity in rats. J Pharmacol Exp Ther 246 (1988) 1061-1066
25. Hieda Y., Keyler D.E., Ennifar S., Fattom A., and Pentel P.R. Vaccination against nicotine during continued nicotine administration in rats: immunogenicity of the vaccine and effects on nicotine distribution to brain. Int J Immunopharmacol 22 (2000) 809-819
26. Pentel P.R., Dufek M.B., Roiko S., Lesage M.G., and Keyler D.E. Differential effects of passive immunization with nicotine-specific antibodies on the acute and chronic distribution of nicotine to brain in rats. J Pharmacol Exp Ther 317 (2006) 660-666
27. Henningfield J.E., Miyasato K., and Jasinski D.R. Abuse liability and pharmacodynamic characteristics of intravenous and inhaled nicotine. J Pharmacol Exp Ther 234 (1985) 1-12
28. Zevin S., Schaner M.E., and Giacomini K.M. Nicotine transport in a human choriocarcinoma cell line (JAR). J Pharm Sci 87 (1998) 702-706
29. Nekhayeva I.A., Nanovskaya T.N., Pentel P.R., Keyler D.E., Hankins G.D., and Ahmed M.S. Effects of nicotine-specific antibodies, Nic311 and Nic-IgG, on the transfer of nicotine across the human placenta. Biochem Pharmacol 70 (2005) 1664-1672
30. Pastrakuljic A., Schwartz R., Simone C., Derewlany L.O., Knie B., and Koren G. Transplacental transfer and biotransformation studies of nicotine in the human placental cotyledon perfused in vitro. Life Sci 63 (1998) 2333-2342
31. Windsor R., Oncken C., Henningfield J., Hartmann K., and Edwards N. Behavioral and pharmacological treatment methods for pregnant smokers: issues for clinical practice. J Am Med Women's Assoc 55 (2000) 304-310
32. Briggs G.G., Freeman R.K., and Yaffe S.J. Drugs in pregnancy and lactation. 6th ed. (2002), Lippincott Williams & Wilkins, Philadelphia