In vitro selection of RNA aptamers that block CCL1 chemokine function

Biochemical and Biophysical Research Communications

Volumn 349, Issue 1, 2006, Pages 270-276

  Marro, Martin L ^a   Daniels, Dion A ^a   Andrew, David P ^a   Chapman, Trevor D ^a   Gearing, Katy L ^a  

^a GLAXOSMITHKLINE   (United Kingdom)

Author keywords

Aptamer; CCL1; CCR8; Chemokine; Chemotaxis; GAGs; I 309; Inflammation; SELEX; TCA 3

Indexed keywords

APTAMER; CCL1 CHEMOKINE; CHEMOATTRACTANT; CHEMOKINE; CHEMOKINE RECEPTOR CCR8; HEPARIN; LIGAND; NUCLEASE; RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; BINDING AFFINITY; CELL TYPE; CHEMOTAXIS; CONTROLLED STUDY; CYTOKINE RELEASE; HUMAN; IN VITRO STUDY; INFLAMMATION; LYMPHOCYTE ACTIVATION; MONOCYTE; MOUSE; NONHUMAN; PRIORITY JOURNAL; TH2 CELL;

ANIMALS; BASE SEQUENCE; BIOCHEMISTRY; CHEMOKINES; CHEMOKINES, CC; CHEMOTACTIC FACTORS; DOSE-RESPONSE RELATIONSHIP, DRUG; HUMANS; INFLAMMATION; LIGANDS; MICE; MOLECULAR SEQUENCE DATA; NUCLEIC ACID CONFORMATION; RNA;

EID: 33748428777     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.08.029     Document Type: Article

References (28)

1. Johnson Z., Power C.A., Weiss C., Rintelen F., Ji H., Ruckle T., Camps M., Wells T.N., Schwarz M.K., Proudfoot A.E., and Rommel C. Chemokine inhibition-why, when, where, which and how?. Biochem. Soc. Trans. 32 (2004) 366-377
2. Luster A.D. Chemokines-chemotactic cytokines that mediate inflammation. N. Engl. J. Med. 338 (1998) 436-445
3. Rollins B.J. Chemokines. Blood 90 (1997) 909-928
4. Miller M.D., Wilson S.D., Dorf M.E., Seuanez H.N., O'Brien S.J., and Krangel M.S. Sequence and chromosomal location of the I-309 gene. Relationship to genes encoding a family of inflammatory cytokines. J. Immunol. 145 (1990) 2737-2744
5. Miller M.D., Hata S., De Waal M.R., and Krangel M.S. A novel polypeptide secreted by activated human T lymphocytes. J. Immunol. 143 (1989) 2907-2916
6. Miller M.D., and Krangel M.S. The human cytokine I-309 is a monocyte chemoattractant. Proc. Natl. Acad. Sci. USA 89 (1992) 2950-2954
7. D'Ambrosio D., Iellem A., Bonecchi R., Mazzeo D., Sozzani S., Mantovani A., and Sinigaglia F. Selective up-regulation of chemokine receptors CCR4 and CCR8 upon activation of polarized human type 2 Th cells. J. Immunol. 161 (1998) 5111-5115
8. Harpel P.C., and Haque N.S. Chemokine receptor-8: potential role in atherogenesis. Isr. Med. Assoc. J. 4 (2002) 1025-1027
9. Haque N.S., Fallon J.T., Pan J.J., Taubman M.B., and Harpel P.C. Chemokine receptor-8 (CCR8) mediates human vascular smooth muscle cell chemotaxis and metalloproteinase-2 secretion. Blood 103 (2004) 1296-1304
10. Schaerli P., Ebert L., Willimann K., Blaser A., Roos R.S., Loetscher P., and Moser B. A skin-selective homing mechanism for human immune surveillance T cells. J. Exp. Med. 199 (2004) 1265-1275
11. Gombert M., Dieu-Nosjean M.C., Winterberg F., Bunemann E., Kubitza R.C., Da Cunha L., Haahtela A., Lehtimaki S., Muller A., Rieker J., Meller S., Pivarcsi A., Koreck A., Fridman W.H., Zentgraf H.W., Pavenstadt H., Amara A., Caux C., Kemeny L., Alenius H., Lauerma A., Ruzicka T., Zlotnik A., and Homey B. CCL1-CCR8 interactions: an axis mediating the recruitment of T cells and Langerhans-type dendritic cells to sites of atopic skin inflammation. J. Immunol. 174 (2005) 5082-5091
12. Chung C.D., Kuo F., Kumer J., Motani A.S., Lawrence C.E., Henderson Jr. W.R., and Venkataraman C. CCR8 is not essential for the development of inflammation in a mouse model of allergic airway disease. J. Immunol. 170 (2003) 581-587
13. Bishop B., and Lloyd C.M. CC chemokine ligand 1 promotes recruitment of eosinophils but not Th2 cells during the development of allergic airways disease. J. Immunol. 170 (2003) 4810-4817
14. Chensue S.W., Lukacs N.W., Yang T.Y., Shang X., Frait K.A., Kunkel S.L., Kung T., Wiekowski M.T., Hedrick J.A., Cook D.N., Zingoni A., Narula S.K., Zlotnik A., Barrat F.J., O'Garra A., Napolitano M., and Lira S.A. Aberrant in vivo T helper type 2 cell response and impaired eosinophil recruitment in CC chemokine receptor 8 knockout mice. J. Exp. Med. 193 (2001) 573-584
15. Goya I., Villares R., Zaballos A., Gutierrez J., Kremer L., Gonzalo J.A., Varona R., Carramolino L., Serrano A., Pallares P., Criado L.M., Kolbeck R., Torres M., Coyle A.J., Gutierrez-Ramos J.C., Martinez A., and Marquez G. Absence of CCR8 does not impair the response to ovalbumin-induced allergic airway disease. J. Immunol. 170 (2003) 2138-2146
16. Tuerk C., and Gold L. Systematic evolution of ligands by exponential enrichment: RNA ligands to bacteriophage T4 DNA polymerase. Science 249 (1990) 505-510
17. Fitzwater T., and Polisky B. A SELEX primer. Methods Enzymol. 267 (1996) 275-301
18. Brody E.N., and Gold L. Aptamers as therapeutic and diagnostic agents. J. Biotechnol. 74 (2000) 5-13
19. Famulok M., Mayer G., and Blind M. Nucleic acid aptamers-from selection in vitro to applications in vivo. Acc. Chem. Res. 33 (2000) 591-599
20. Rhodes A., Smithers N., Chapman T., Parsons S., and Rees S. The generation and characterisation of antagonist RNA aptamers to MCP-1. FEBS Lett. 506 (2001) 85-90
21. Marro M.L., Daniels D.A., McNamee A., Andrew D.P., Chapman T.D., Jiang M.S., Wu Z., Smith J.L., Patel K.K., and Gearing K.L. Identification of potent and selective RNA antagonists of the IFN-gamma-inducible CXCL10 chemokine. Biochemistry 44 (2005) 8449-8460
22. Rhodes A., Deakin A., Spaull J., Coomber B., Aitken A., Life P., and Rees S. The generation and characterization of antagonist RNA aptamers to human oncostatin M. J. Biol. Chem. 275 (2000) 28555-28561
23. Burgstaller P., Jenne A., and Blind M. Aptamers and aptazymes: accelerating small molecule drug discovery. Curr. Opin. Drug Discov. Devel. 5 (2002) 690-700
24. Daniels D.A., Sohal A.K., Rees S., and Grisshammer R. Generation of RNA aptamers to the G-protein-coupled receptor for neurotensin, NTS-1. Anal. Biochem. 305 (2002) 214-226
25. Zuker M. Mfold web server for nucleic acid folding and hybridization prediction. Nucleic Acids Res. 31 (2003) 3406-3415
26. Andrew D.P., Ruffing N., Kim C.H., Miao W., Heath H., Li Y., Murphy K., Campbell J.J., Butcher E.C., and Wu L. C-C chemokine receptor 4 expression defines a major subset of circulating nonintestinal memory T cells of both Th1 and Th2 potential 1. J. Immunol. 166 (2001) 103-111
27. Proudfoot A.E., Handel T.M., Johnson Z., Lau E.K., LiWang P., Clark-Lewis I., Borlat F., Wells T.N., and Kosco-Vilbois M.H. Glycosaminoglycan binding and oligomerization are essential for the in vivo activity of certain chemokines. Proc. Natl. Acad. Sci. USA 100 (2003) 1885-1890
28. Proudfoot A.E., Power C.A., Rommel C., and Wells T.N. Strategies for chemokine antagonists as therapeutics. Semin. Immunol. 15 (2003) 57-65