Actions of ketamine and its isomers on contractility and calcium transients in human myocardium

Anesthesiology

Volumn 90, Issue 5, 1999, Pages 1363-1371

  Kunst, Gudrun ^a   Martin, Eike ^b   Graf, Bernhard M ^b   Hagl, Siegfried ^b   Vahl, Christian F ^b  

^a UNIVERSITY OF HEIDELBERG   (Germany)

^b NONE

Author keywords

Force; Intravenous anesthetics; Stereoisomers

Indexed keywords

KETAMINE;

ADULT; AGED; ARTICLE; CALCIUM CELL LEVEL; CLINICAL ARTICLE; DRUG EFFECT; FEMALE; HEART MUSCLE CONTRACTILE FORCE; HEART MUSCLE CONTRACTILITY; HUMAN; HUMAN TISSUE; INOTROPISM; INTRAVENOUS ANESTHESIA; MALE; MUSCLE ISOMETRIC CONTRACTION; PRIORITY JOURNAL;

ADULT; AGED; ANESTHETICS, DISSOCIATIVE; CALCIUM; FEMALE; HUMANS; KETAMINE; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION; MYOCARDIUM; STEREOISOMERISM;

EID: 0032912971     PISSN: 00033022     EISSN: None     Source Type: Journal    
DOI: 10.1097/00000542-199905000-00021     Document Type: Article

References (27)

1. Urthaler F, Walker AA, James TN: Comparison of the inotropic action of morphine and ketamine studied in canine cardiac muscle. J Thorac Cardiovasc Surg 1976; 72:142-9
2. Rusy BF, Amuzu JK, Bosscher HA, Redon D, Komai H: Negative inotropic effect of ketamine in rabbit ventricular muscle. Anesth Analg 1990; 71:275-8
3. Endou M, Hattori Y, Nakaya H, Gotoh Y, Kanno M: Electrophysiologic mechanisms responsible for inotropic responses to ketamine in guinea pig and rat myocardium. ANESTHESIOLOGY 1992; 76:409-18
4. Kongsayreepong S, Cook DJ, Housmans PR: Mechanism of the direct, negative inotropic effect of ketamine in isolated ferret and frog ventricular myocardium. ANESTHESIOLOGY 1993; 79:313-22
5. Barrigon S, De Miguel B, Tamargo J, Tejerina T: The mechanism of the positive inotropic action of ketamine on isolated atria of the rat. Br J Pharmacol 1982; 76:85-93
6. Riou B, Lecarpentier Y, Viars P: Inotropic effect of ketamine on rat cardiac papillary muscle. ANESTHESIOLOGY 1989; 71:116-25
7. 2+ transients and contraction in rat ventricular myocytes at supraclinical concentrations. ANESTHESIOLOGY 1998; 88: 781-91
8. Baum VC, Tecson ME: Ketamine inhibits transsarcolemmal calcium entry in guinea pig myocardium: Direct evidence by single cell voltage clamp. Anesth Analg 1991; 73:804-7
9. Connelly TJ, Ahem C, Coronado R: Ketamine, at clinical concentrations, does not alter the function of cardiac sarcoplasmic reticulum calcium release channels. Anesth Analg 1995; 81:849-54
10. Lynch C III, Frazer MJ: Depressant effects of volatile anesthetics upon rat and amphibian ventricular myocardium: Insights into anesthetic mechanisms of action. ANESTHESIOLOGY 1989; 70:511-22
11. White PF, Ham J, Way WL, Trevor AJ: Pharmacology of ketamine isomers in surgical patients. ANESTHESIOLOGY 1980; 52:238-9
12. Lundy PM, Lockwood PA, Thompson G, Frew R: Differential effects of ketamine isomers on neuronal and extraneuronal catecholamine uptake mechanisms. ANESTHESIOLOGY 1986; 64:359-63
13. Graf BM, Vicenzi MN, Martin E, Bosnjak ZJ, Stowe DF: Ketamine has stereospecinc effects in the isolated perfused guinea pig heart. ANESTHESIOLOGY 1995; 82:1426-37
14. 2+ current in the guinea pig heart. Anesth Analg 1996; 83:75-80
15. Waxman K, Shoemaker WC, Lippmann M: Cardiovascular effects of anesthetic induction with ketamine. Anesth Analg 1980; 59: 355-8
16. Vahl CF, Bonz A, Hagl C, Hagl S: Reversible desensitisation of the myocardial contractile apparatus for calcium. Eur J Cardiothorac Surg 1994; 8:370-8
17. Mulieri LA, Hasenfuss G, Ittleman F, Blanchard EM, Alpert NR: Protection of human left ventricular myocardium from cutting injury with 2,3-butanedione monoxime. Circ Res 1989; 65:1441-9
18. Vahl CF, Bonz A, Timek T, Hagl S: Intracellular calcium transient of working human myocardium of seven patients transplanted for congestive heart failure. Circ Res 1994; 7:952-8
19. 2+ indicators with greatly improved fluorescence properties. J Biol Chem 1985; 260:3440-50
20. Roe MW, Lemasters JJ, Herman B: Assessment of Fura-2 for measurements of cytosolic free calcium. Cell Calcium 1990; 11:63-73
21. Salt PJ, Barnes PK, Beswick FJ: Inhibition of neuronal and extraneuronal uptake of noradrenaline by ketamine in the isolated perfused rat heart. Br J Anaesth 1979; 51:835-8
22. Idvall J, Ahlgren I, Aronsen KR, Stenberg P: Ketamine infusions: pharmacokinetics and clinical effects. Br J Anaesth 1979; 51:1167-73
23. Gelissen HP, Epema AH, Henning RH, Krijnen HJ, Hennis PJ, den Hertog A: Inotropic effects of propofol, thiopental, midazolam, etomidate, and ketamine on isolated human atrial muscle. ANESTHESIOLOGY 1996; 84:397-403
24. Durieux ME, Nietgen GW. Synergistic inhibition of muscarinic signaling by ketamine stereoisomers and the preservative benzethonium chloride. ANESTHESIOLOGY 1997; 86:1326-33
25. Sprung J, Schuetz SM, Stewart RW, Moravec CS: Effects of ketamine on the contractility of failing and nonfailing human heart muscles in vitro. ANESTHESIOLOGY 1998; 88:1202-10
26. Pagel PS, Kampine JP, Schmeling WT, Warltier DC: Ketamine depresses myocardial contractility as evaluated by the preload recruitable stroke work relationship in chronically instrumented dogs with autonomic nervous system blockade. ANESTHESIOLOGY 1992; 76: 564-72
27. 2+ imaging in single living cells: Theoretical and practical issues. Cell Calcium 1990; 11:157-79