RNA interference: A potential revolution in disease therapy

Journal of the College of Physicians and Surgeons Pakistan

Volumn 16, Issue 7, 2006, Pages 491-492

  Waseem, Talat ^a  

^a BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

Gene silencing; Gene therapy; RNAi; siRNA

Indexed keywords

ANTINEOPLASTIC AGENT; ANTIVIRUS AGENT; CARCINOEMBRYONIC ANTIGEN RELATED CELL ADHESION MOLECULE 6; CELL ADHESION MOLECULE; SHORT HAIRPIN RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ALZHEIMER DISEASE; ANTINEOPLASTIC ACTIVITY; ANTIVIRAL ACTIVITY; ARTICLE; AUTOIMMUNE HEPATITIS; BIOTECHNOLOGY; CARCINOGENESIS; DEGENERATIVE DISEASE; DRUG DESIGN; DRUG SPECIFICITY; EXPERIMENTAL NEOPLASM; GENE EXPRESSION REGULATION; GENE SILENCING; GENE THERAPY; HEPATITIS B; HEPATITIS C; HUMAN; HUNTINGTON CHOREA; LETHALITY; NONHUMAN; PANCREAS ADENOCARCINOMA; RNA INTERFERENCE; SEQUENCE ANALYSIS; SPINOCEREBELLAR DEGENERATION; TRANSLATION REGULATION; VIRUS INFECTION;

GENETIC ENGINEERING; HUMANS; NEOPLASMS; RNA INTERFERENCE; VIRUS DISEASES;

EID: 33748416749     PISSN: 1022386X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (10)

1. Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in caenorhabditis elegans. Nature 1998; 391: 806-11.
2. Duxbury MS, Whang EE. RNA interference: a practical approach. J Surg Res 2004; 117: 339-44.
3. Shankar P, Manjunath N, Lieberman J. The prospect of silencing disease using RNA interference. JAMA 2005; 293: 1367-73.
4. Radhakrishnan SK, Layden TJ, Gartel AL. RNA interference as a new strategy against viral hepatitis. Virology 2004; 323: 173-81.
5. Stevenson M. Dissecting HIV-1 through RNA interference. Nat Rev Immunol 2003; 3: 851-8.
6. Duxbury MS, Matros E, Ito H, Zinner MJ, Ashley SW, Whang EE. Systemic siRNA-mediated gene silencing: a new approach to targeted therapy of cancer. Ann Surg 2004; 240: 667-76.
7. Miller VM, Xia H, Marrs GL, Gouvion CM, Lee G, Davidson BL, et al. Allele-specific silencing of dominant disease genes. Proc Natl Acad Sci USA 2003; 100: 7195-200.
8. Xia H, Mao Q, Eliason SL, Harper SQ, Martins IH, Orr HT, et al. RNAi suppresses polyglutamine-induced neurodegeneration in a model of spinocerebellar ataxia. Nat Med 2004; 10: 816-20.
9. Song E, Lee SK, Wang J, Ince N, Ouyang N, Min J, et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 2003; 9: 347-51.
10. Soutschek J, Akinc A, Bramlage B, Charisse K, Constien R, Donoghue M, et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 2004; 432: 173-8.