Modulation of activator protein-1 (AP-1) and MAPK pathway by flavonoids in human prostate cancer PC3 cells

Archives of Pharmacal Research

Volumn 29, Issue 8, 2006, Pages 633-644

  Gopalakrishnan, Avanthika ^a   Xu, Chang Jiang ^a   Nair, Sujit S ^a   Chen, Chi ^a   Hebbar, Vidya ^a   Kong, Ah Ng Tony ^a  

^a RUTGERS UNIVERSITY   (United States)

Author keywords

AP 1; ERK; Flavonoids; JNK; MAPK

Indexed keywords

EID: 33748355855     PISSN: 02536269     EISSN: 02536269     Source Type: Journal    
DOI: 10.1007/BF02968247     Document Type: Article

References (58)

1. Agarwal, C., Singh, R. P., and Agarwal, R., Grape seed extract induces apoptotic death of human prostate carcinoma DU145 cells via caspases activation accompanied by dissipation of mitochondrial membrane potential and cytochrome c release. Carcinogenesis, 23, 1869-1876 (2002).
2. Agarwal, C., Singh, R. P., Tyagi, A. K., Tecklenburg, M., Sclafani, R. A., and Agarwal, R., Silibinin upregulates the expression of cyclin-dependent kinase inhibitors and causes cell cycle arrest and apoptosis in human colon carcinoma HT-29 cells. Oncogene, 22, 8271-8282 (2003).
3. Agarwal, R., Cell signaling and regulators of cell cycle as molecular targets for prostate cancer prevention by dietary agents. Biochem. Pharmacol., 60, 1051-1059 (2000).
4. Agarwal, R., Katiyar, S. K., Lundgren, D. W., and Mukhtar, H., Inhibitory effect of silymarin, an anti-hepatotoxic flavonoid, on 12-O- tetradecanoylphorbol-13-acetate-induced epidermal ornithine decarboxylase activity and mRNA in SENCAR mice. Carcinogenesis, 15, 1099-1103 (1994).
5. Angel, P. and Karin, M., The role of Jun, Fos and the AP-1 complex in cell-proliferation and transformation. Biochim. Biophys. Acta., 1072, 129-157 (1991).
6. Boldt, S., Weidle, U. H., and Kolch, W., The role of MAPK pathways in the action of chemotherapeutic drugs. Carcinogenesis, 23, 1831-1838 (2002).
7. Chan, F. L., Choi, H. L., Chen, Z. Y., Chan, P. S., and Huang, Y., Induction of apoptosis in prostate cancer cell lines by a flavonoid, baicalin. Cancer Lett., 160, 219-228 (2000).
8. Chen, S., Ruan, Q., Bedner, E., Deptala, A., Wang, X., Hsieh, T. C., Traganos, F., and Darzynkiewicz, Z., Effects of the flavonoid baicalin and its metabolite baicalein on androgen receptor expression, cell cycle progression and apoptosis of prostate cancer cell lines. Cell Prolif., 34, 293-304 (2001).
9. Conney, A. H., Lu, Y., Lou, Y., Xie, J., and Huang, M., Inhibitory effect of green and black tea on tumor growth. Proc. Soc. Exp. Biol. Med., 220, 229-233 (1999).
10. Croisy-Delcey, M., Croisy, A., Croisy, A., Mousset, S., Letourneur, M., Bisagni, E., Jacquemin-Sablon, A., and Pierre, J., Genistein analogues: effects on epidermal growth factor receptor tyrosine kinase and on stress-activated pathways. Biomed. Pharmacother., 51, 286-294 (1997).
11. Dong, Z., Lavrovsky, V., and Colburn, N. H., Transformation reversion induced in JB6 RT101 cells by AP-1 inhibitors. Carcinogenesis, 16, 749-756 (1995).
12. Foletta, V. C., Transcription factor AP-1, and the role of Fra-2. Immunol. Cell Biol., 74, 121-133 (1996).
13. Frey, R. S. and Singletary, K.W., Genistein activates p38 mitogen-activated protein kinase, inactivates ERK1/ERK2 and decreases Cdc25C expression in immortalized human mammary epithelial cells. J. Nutr., 133, 226-231 (2003).
14. Frigo, D. E., Duong, B. N., Melnik, L. I., Schief, L. S., Collins-Burow, B. M., Pace, D. K., McLachlan, J. A., and Burow, M. E., Flavonoid phytochemicals regulate activator protein-1 signal transduction pathways in endometrial and kidney stable cell lines. J. Nutr., 132, 1848-1853 (2002).
15. Gabrielska, J., Oszmianski,J., Zylka, R., and Komorowska, M., Antioxidant activity of flavones from Scutellaria baicalensis in lecithin liposomes. Z Naturforsch [C]., 52, 817-823 (1997).
16. Gao, J., Arnold, J. T., and Isaacs, J. T., Conversion from a paracrine to an autocrine mechanism of androgen-stimulated growth during malignant transformation of prostatic epithelial cells. Cancer Res., 61, 5038-5044 (2001).
17. Geller, J., Sionit, L., Partido, C., Li, L., Tan, X., Youngkin, T., Nachtsheim, D., and Hoffman, R. M., Genistein inhibits the growth of human-patient BPH and prostate cancer in histoculture. Prostate, 34, 75-79 (1998).
18. Ghosh, P. M., Malik, S. N., Bedolla, R. G., Wang, Y., Mikhailova, M., Prihoda, T. J., Troyer, D. A., and Kreisberg, J. I., Signal transduction pathways in androgen-dependent and - independent prostate cancer cell proliferation. Endocr. Relat. Cancer., 12, 119-134 (2005).
19. Gonzalgo,M. L. and Isaacs, W. B., Molecular pathways to prostate cancer. J. Urol., 170, 2444-2452 (2003).
20. Greco, K. E. and Kulawiak, L., Prostate cancer prevention: risk reduction through life-style, diet, and chemoprevention. Oncol. Nurs. Forum., 21, 1504-1511 (1994).
21. Hahn, G., Lehmann, H. D., Kurten, M., Uebel, H., and Vogel, G., On the pharmacology and toxicology of silymarin, an antihepatotoxic active principle from Silybum marianum (L.) Gaertn. Arzneimittelforschung, 18, 698-704 (1968).
22. Isaacs, J. T. and Isaacs, W. B., Androgen receptor outwits prostate cancer drugs. Nat. Med., 10, 26-27 (2004)
23. Ishikawa, Y. and Kitamura, M., Anti-apoptotic effect of quercetin: intervention in the JNK- and ERK-mediated apoptotic pathways. Kidney Int., 58, 1078-1087 (2000).
24. Jeong, W. S., Kim, I. W., Hu, R., and Kong, A. N., Modulation of AP-1 by natural chemopreventive compounds in human colon HT-29 cancer cell line. Pharm. Res., 21, 649-660 (2004).
25. Jeong, W. S., Kim, I. W., Hu, R., and Kong, A. N., Modulatory properties of various natural chemopreventive agents on the activation of NF-kappaB signaling pathway. Pharm. Res., 21, 661-670 (2004).
26. Joshi, S. S., Kuszynski, C. A., and Bagchi, D., The cellular and molecular basis of health benefits of grape seed proanthocyanidin extract. Curr. Pharm. Biotechnol., 2, 187-200 (2001).
27. Kaminska, B., Pyrzynska, B., Ciechomska, I., and Wisniewska, M., Modulation of the composition of AP-1 complex and its impact on transcriptional activity. Acta. Neurobiol. Exp (Wars)., 60, 395-402 (2000).
28. Karin, M., The regulation of AP-1 activity by mitogen-activated protein kinases. J. Biol. Chem., 270, 16483-16486 (1995).
29. Karin, M., The regulation of AP-1 activity by mitogen-activated protein kinases. Philos. Trans. R. Soc. Lond. B. Biol. Sci., 351, 127-34 (1996).
30. Karin, M., Liu, Z., and Zandi, E., AP-1 function and regulation. Curr. Opin. Cell Biol., 9, 240-246 (1997).
31. Karin, M., Smeal, T., Binetruy, B., Deng, T., and Chambard, J. C., Control of transcription factors by signal transduction pathways: the beginning of the end. Trends. Biochem. Sci., 17, 418-422 (1992).
32. Katiyar, S. K., Mohan, R. R., Agarwal, R., and Mukhtar, H., Protection against induction of mouse skin papillomas with low and high risk of conversion to malignancy by green tea polyphenols. Carcinogenesis, 18, 497-502 (1997).
33. Kong, A. N., Yu, R., Chen, C., Mandlekar, S., and Primiano, T., Signal transduction events elicited by natural products: role of MAPK and caspase pathways in homeostatic response and induction of apoptosis. Arch. Pharm. Res., 23, 1-16 (2000).
34. Kubo, M., Matsuda, H., Tani, T., Arichi, S., Kimura, Y., and Okuda, H., Studies on Scutellariae radix. XII. Anti-thrombic actions of various flavonoids from Scutellariae radix. Chem. Pharm. Bull (Tokyo)., 33, 2411-2415 (1985).
35. Liao, S., Umekita, Y., Guo, J., Kokontis, J. M., and Hiipakka, R. A., Growth inhibition and regression of human prostate and breast tumors in athymic mice by tea epigallocatechin gallate. Cancer Lett., 96, 239-243 (1995).
36. Litvinov, I. V., De Marzo, A. M., and Isaacs, J. T., Is the Achilles' heel for prostate cancer therapy a gain of function in androgen receptor signaling? J. Clin. Endocrinol. Metab., 88, 2972-2982 (2003).
37. Mallikarjuna, G., Dhanalakshmi, S., Singh, R. P., Agarwal, C., and Agarwal, R., Silibinin protects against photocarcinogenesis via modulation of cell cycle regulators, mitogen-activated protein kinases, and Akt signaling. Cancer Res., 64, 6349-6356 (2004).
38. Messina, M. J., Persky, V., Setchell, K. D., and Barnes, S., Soy intake and cancer risk: a review of the in vitro and in vivo data. Nutr. Cancer., 21, 113-131 (1994).
39. Motoo, Y. and Sawabu, N., Antitumor effects of saikosaponins, baicalin and baicalein on human hepatoma cell lines. Cancer Lett., 86, 91-95 (1994).
40. Nelson, W. G., De Marzo, A. M., and Isaacs, W. B., Prostate cancer. N. Engl. J. Med., 349, 366-381 (2003).
41. Nguyen, T. T., Tran, E., Ong, C. K., Lee, S. K., Do, P. T., Huynh, T. T., Nguyen, T. H., Lee, J. J., Tan, Y., Ong, C. S., and Huynh, H., Kaempferol-induced growth inhibition and apoptosis in A549 lung cancer cells is mediated by activation of MEK-MAPK. J. Cell Physiol ., 197, 110-121 (2003).
42. Nikolic, D. and van Breemen, R. B., New metabolic pathways for flavanones catalyzed by rat liver microsomes. Drug Metab. Dispos., 32, 387-397 (2004).
43. Onozawa, M., Fukuda, K., Ohtani, M., Akaza, H., Sugimura, T., and Wakabayashi, K., Effects of soybean isoflavones on cell growth and apoptosis of the human prostatic cancer cell line LNCaP. Jpn. J. Clin. Oncol ., 28, 360-363 (1998).
44. Paweletz, C. P., Charboneau, L., Bichsel, V. E., Simone, N. L., Chen, T., Gillespie, J. W., Emmert-Buck, M. R., Roth, M. J., Petricoin, Iii Ef, and Liotta, L. A., Reverse phase protein microarrays which capture disease progression show activation of pro-survival pathways at the cancer invasion front. Oncogene, 20, 1981-1989 (2001).
45. Ross, R. K., Pike, M. C., Coetzee, G. A., Reichardt, J. K., Yu, M. C., Feigelson, H., Stanczyk, F. Z., Kolonel, L. N., and Henderson, B. E., Androgen metabolism and prostate cancer: establishing a model of genetic susceptibility. Cancer Res., 58, 4497-4504 (1998).
46. Saleem, M., Adhami, V. M., Siddiqui, I. A., and Mukhtar, H., Tea beverage in chemoprevention of prostate cancer: a minireview. Nutr. Cancer., 47, 13-23 (2003).
47. Seger, R. and Krebs, E. G., The MAPK signaling cascade. Faseb J., 9, 726-735 (1995).
48. Shaulian, E. and Karin, M., AP-1 in cell proliferation and survival. Oncogene, 20, 2390-2400 (2001).
49. Shaulian, E. and Karin, M., AP-1 as a regulator of cell life and death. Nat. Cell Biol., 4, E131-136 (2002)
50. Shi, H., Zhao, B., and Xin, W., Scavenging effects of baicalin on free radicals and its protection on erythrocyte membrane from free radical injury. Biochem. Mol. Biol. Int., 35, 981-994 (1995).
51. Singh, R. P., Tyagi, A. K., Dhanalakshmi, S., Agarwal, R., and Agarwal, C., Grape seed extract inhibits advanced human prostate tumor growth and angiogenesis and upregulates insulin-like growth factor binding protein-3. Int. J. Cancer., 108, 733-740 (2004).
52. Souquet, J. M., Labarbe, B., Le Guerneve, C., Cheynier, V., and Moutounet, M., Phenolic composition of grape stems. J. Agric. Food Chem., 48, 1076-1080 (2000).
53. Uzgare, A. R. and Isaacs, J. T., Enhanced redundancy in Akt and mitogen-activated protein kinase-induced survival of malignant versus normal prostate epithelial cells. Cancer Res., 64, 6190-6199 (2004).
54. Vogt, P. K., The story of Jun. Arch. Biochem. Biophys., 316, 1-4 (1995).
55. Vogt, P. K. and Bos, T. J., Jun: oncogene and transcription factor. Adv. Cancer Res., 55, 1-35 (1990).
56. Wisdom, R., AP-1: one switch for many signals. Exp. Cell Res., 253, 180-185 (1999).
57. Yu, R., Jiao, J. J., Duh, J. L., Tan, T. H., and Kong, A. N., Phenethyl isothiocyanate, a natural chemopreventive agent, activates c-Jun N-terminal kinase 1. Cancer Res., 56, 2954-2959 (1996).
58. Zerbini, L. F., Wang. Y., Cho, J. Y., and Libermann, T. A., Constitutive activation of nuclear factor kappaB p50/p65 and Fra-1 and JunD is essential for deregulated interleukin 6 expression in prostate cancer. Cancer Res., 63, 2206-2215 (2003).