Contact lenses for drug delivery: Achieving sustained release with novel systems

American Journal of Drug Delivery

Volumn 4, Issue 3, 2006, Pages 131-151

  Alvarez Lorenzo, Carmen ^a   Hiratani, Haruyuki ^b   Concheiro, Angel ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

^b MENICON CO LTD   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

CIPROFLOXACIN; CROMOGLYCATE DISODIUM; DEXAMETHASONE SODIUM PHOSPHATE; DICLOFENAC; IDOXURIDINE; INDOMETACIN; KETOROLAC TROMETAMOL; KETOTIFEN FUMARATE; OFLOXACIN; PILOCARPINE; PREDNISOLONE; TIMOLOL; TIMOLOL MALEATE; TOBRAMYCIN;

CONTACT LENS; CORNEA; DRUG BIOAVAILABILITY; DRUG DELIVERY SYSTEM; EYE DISEASE; EYE PAIN; EYE PROTECTION; HEALING; HUMAN; HYDROPHILICITY; HYDROPHOBICITY; NONHUMAN; PRIORITY JOURNAL; REVIEW; SUSTAINED DRUG RELEASE; VISCOSITY;

EID: 33748337150     PISSN: 11759038     EISSN: 11759038     Source Type: Journal    
DOI: 10.2165/00137696-200604030-00002     Document Type: Review

References (147)

1. Reddy IK, Ganesan MG. Ocular therapeutics and drug delivery: an overview. In: Reddy IK, editor. Ocular therapeutics and drug delivery. Lancaster (PA): Technomic Publishing Co., 1999: 3-29
2. Myles ME, Neumann DM, Hill JM. Recent progress in ocular drug delivery for posterior segment disease: emphasis on transscleral iontophoresis. Adv Drug Deliv Rev 2005; 57: 2063-79
3. Plazonnet B. Ophthalmic drug delivery. In: Rathbone MJ, Hadgraft J, Roberts MS, editors. Modified-release drug delivery technology. New York: Marcel Dekker Inc., 2003: 289-313
4. Sander B, van Best J, Johansen S, et al. Fluorescein transport through the blood-aqueous and blood-retinal barriers in diabetic macular edema. Curr Eye Res 2003; 27: 247-52
5. Mainardes RM, Urban MCC, Cinto PO, et al. Colloidal carriers for ophthalmic drug delivery. Curr Drug Targets 2005; 6: 363-71
6. Bejjani R, Benezra D, Cohen H, et al. Nanoparticles for gene delivery to retinal pigment epithelial cells. Mol Vis 2005; 11: 124-32
7. Davies NM. Biopharmaceutical considerations in topical ocular drug delivery. Clin Exp Pharmacol Physiol 2000; 27: 558-62
8. Hughes PM, Olejnik O, Chang-Lin JE, et al. Topical and systemic drug delivery to the posterior segments. Adv Drug Deliv Rev 2005; 57: 2010-32
9. Zhu H, Chauhan A. A mathematical model for ocular tear and solute balance. Curr Eye Res 2005; 30: 841-54
10. Tomlinson A, Khanal S. Assessment of tear film dynamics: quantification approach. Ocul Surf 2005; 3: 81-95
11. Robinson JR. Ocular drug delivery mechanism of corneal drug transport and mucoadhesive delivery systems. STP Pharma Sci 1989; 5: 839-46
12. Singh CP, Shah DO. Surface chemical aspects of ocular drug delivery systems. In: Reddy IK, editor. Ocular therapeutics and drug delivery. Lancaster (PA): Technomic Publishing Co., 1999: 31-49
13. Keister JC, Cooper ER, Missel PJ, et al. Limits on optimizing ocular drug delivery. J Pharm Sci 1991; 80: 50-3
14. Wilson CG. Topical drug delivery in the eye. Exp Eye Res 2004; 78: 737-43
15. Ding SL. Recent developments in ophthalmic drug delivery. Pharm Sci Technol Today 1998; 1: 328-35
16. Kaur IP, Kanwar M. Ocular preparations: the formulation approach. Drug Dev Ind Pharm 2002; 28: 473-93
17. Felt O, Einmahl S, Gurny R, et al. Polymeric systems for ophthalmic drug delivery. In: Dumitriu S, editor. Polymeric biomaterials. New York: Marcel Dekker Inc., 2002: 377-421
18. Davis JL, Gilger BC, Robinson MR. Novel approaches to ocular drug delivery. Curr Opin Mol Ther 2004; 6: 195-205
19. Ludwig A. The use of mucoadhesive polymers in ocular drug delivery. Adv Drug Deliv Rev 2005; 57: 1595-639
20. Aqil M. Advances in ophthalmic drug delivery systems. Phamainfo.net [online]. Available from URL: http://www.pharmainfo.net/exclusive/reviews/ advances_in_ophthalmic_drug_delivery_systems_-_part_ii./ [Accessed 2006 Jul 24]
21. Pandit JC, Nagyova B, Bron AJ, et al. Physical properties of stimulated and unstimulated tears. Exp Eye Res 1999; 68: 247-53
22. Sintzel MB, Bernatchez SF, Tabatabay C, et al. Biomaterials in ophthalmic drug delivery. Eur J Pharm Biopharm 1996; 42: 358-74
23. Vadnere M, Amidon G, Lindenbaum S, et al. Thermodynamic studies on the gel sol transition of some pluronic polyols. Int J Pharm 1984; 22: 207-18
24. Sultana Y, Jha MC, Ali A, et al. A three-way comparative study on the efficacy of twin sol to gel systems and marketed eye drops of pefloxacin mesylate. J Ocul Pharmacol Ther 2004; 20: 363-71
25. Zignani M, Tabatabay C, Gurny R. Topical semisolid drug-delivery: kinetics and tolerance of ophthalmic hydrogels. Adv Drug Deliv Rev 1995; 16: 51-60
26. Schenker HI, Silver LH. Long-term intraocular pressure-lowering efficacy and safety of timolol maleate gel-forming solution 0.5% compared with Timoptic XE 0.5% in a 12-month study. Am J Ophthalmol 2000; 130: 145-50
27. Srividya B, Cardoza RM, Amin PD. Sustained ophthalmic delivery of ofloxacin from a pH triggered in situ gelling system. J Control Release 2001; 73: 205-11
28. Herrero-Vanrell R, Fernandez-Carballido A, Frutos G, et al. Enhancement of the mydriatic response to tropicamide by bioadhesive polymers. J Ocul Pharmacol Ther 2000; 16: 419-28
29. Zimmer A, Kreuter J. Microspheres and nanoparticles used in ocular delivery systems. Adv Drug Deliv Rev 1995; 16: 61-73
30. Calvo P, Vila-Jato JL, Alonso MJ. Comparative in vitro evaluation of several colloidal systems, nanoparticles, nanocapsules, and nanoemulsions as ocular drug carriers. J Pharm Sci 1996; 85: 530-6
31. Gavini E, Chetoni P, Cossu M, et al. PLGA microspheres for the ocular delivery of a peptide drug, vancomycin using emulsification/spray-drying as the preparation method: in vitro/in vivo studies. Eur J Pharm Biopharm 2004; 57: 207-12
32. Ebrahim S, Peyman GA, Lee PJ. Applications of liposomes in ophthalmology. Surv Ophthalmol 2005; 50: 167-82
33. Alonso MJ. Nanomedicines for overcoming biological barriers. Biomed Pharmacother 2004; 58: 168-72
34. Aggarwal D, Kaur IP. Improved pharmacodynamics of timolol maleate from a mucoadhesive niosomal ophthalmic drug delivery system. Int J Pharm 2005; 290: 155-9
35. Willoughby CE, Batterbury M, Kaye SB. Collagen corneal shields. Surv Ophthalmol 2002; 47: 174-82
36. Weyenberg W, Vermeire A, Dhondt MMM, et al. Ocular bioerodible minitablets as strategy for the management of microbial keratitis. Invest Ophthalmol Vis Sci 2004; 45: 3229-33
37. Schwarz S, Nick J. Effectiveness of lubricating daily disposable lenses with different additives. Optician 2006; 231: 22-6
38. Peterson RC, Wolffsohn JS, Nick J, et al. Clinical performance of daily disposable soft contact lenses using sustained release technology. Cont Lens Anterior Eye 2006 Jul; 29 (3): 127-34
39. Munoa-Roiz JL, Aramendia-Salvador E. Historia y desarrollo de las lentes de contacto [online]. Available from URL: http://www.oftalmo.com/publicaciones/ lentes/cap2.htm [Accessed 2006 Jul 24]
40. Witcherle O, Lim D. Hydrophilic gels for biological use. Nature 1960; 185: 117-8
41. McMahon TT, Zadnik K. Twenty-five years of contact lenses. Cornea 2000; 19: 730-40
42. Yamauchi A. Soft contact lenses. In: Osada Y, Kajiwara K, editors. Gels handbook. Vol. 3. San Diego (CA): Academic Press, 2001: 166-79
43. Nicolson PC, Vogt J. Soft contact lens polymers: an evolution. Biomaterials 2001; 22: 3273-83
44. US FDA. Premarket notification (510(k)) guidance document for daily wear contact lenses [online]. Available from URL: http://www.fda.gov/cdrh/ode/conta. html [Accessed 2006 Jul 24]
45. Shah C, Raj S, Foulks GN. The evolution in therapeutic contact lenses. Ophthalmol Clin North Am 2003; 16: 95-101
46. Karlgard CCS, Wong NS, Jones LW, et al. In vitro uptake and release studies of ocular pharmaceutical agents by silicon-containing and p-HEMA hydrogel contact lens materials. Int J Pharm 2003; 257: 141-51
47. Tighe B. Silicone hydrogel materials: how do they work? In: Sweeney DF, editor. Silicone hydrogels. Oxford: Butterworth Heinemann, 2000: 1-27
48. Donshik PC. Extended wear contact lenses. Ophthalmol Clin North Am 2003; 16: 79-83
49. Hiratani H, Nakajima T, Yamamoto K. The state and prospect of contact lenses. Jpn Soc Biomater 2002; 20: 221-7
50. Vision Council of America [online]. Available from URL: http://www.vision-site.org/s_vision/ [Accessed 2006 Jul 24]
51. Steele CF. Fitting and management of therapeutic contact lenses. Hospital Optometrists Information series, 2000 Nov [online]. Available from URL: http://www.assoc-optometrists.org/uploaded_files/pdf/fm-tcl-info1.pdf [Accessed 2006 Jul 24]
52. Lim L, Tan DTH, Chan WK. Therapeutic use of Bausch & Lomb pure vision contact lenses. CLAO J 2001; 27: 179-85
53. Kanpolat A, Ucakhan O. Therapeutic use of Focus Night and Day contact lenses. Cornea 2003; 22: 726-34
54. Mely R. Therapeutic and cosmetic indications of Lotrafilcon: a silicone hydrogel extended-wear lenses. Ophthalmologica 2004; 218: 33-8
55. Silbert JA. Therapeutic uses of silicone hydrogels [online]. Available from URL: http://www.siliconehydrogels.org/editorials/oct_05.asp [Accessed 2006 Jul 24]
56. Krejci L, Brettschneider I, Praus R. Hydrophilic gel contact lenses as a new drug delivery system in ophthalmology and as a therapeutic bandage lenses. Act Univ Carol Med 1975; 21: 387-96
57. Silbert JA. A review of therapeutic agents and contact lens wear. J Am Optom Assoc 1996; 67: 165-72
58. Zegans ME, Becker HI, Budzik J, et al. The role of bacterial biofilms in ocular infections. DNA Cell Biol 2002; 21: 415-20
59. Wong T, Ormonde S, Gamble G, et al. Severe infective keratitis leading to hospital admission in New Zealand. Br J Ophthalmol 2003; 87: 1103-8
60. Galezowski X. Sur la place cornéenne dans l'extraction de la cataracte et sur les moyens de prévenir la suppuration. Bull Mem Soc Fr Ophthalmol 1886; 4: 217-26
61. Sedlacek J. Possibilities of application of eye drugs with the aid of gel-contact lenses. Cesk Oftalmol 1965; 21: 509-12
62. Gasset A, Kaufman HE. Therapeutic uses of hydrophilic contact lenses. Am J Ophthalmol 1970; 69: 252-9
63. Waltman SR, Kaufman HE. Use of hydrophilic contact lenses to increase ocular penetration of topical drugs. Invest Ophthalmol 1970; 9: 250-5
64. Hillman JS. Management of acute glaucoma with pilocarpine-soaked hydrophilic lens. Br J Ophthalmol 1974, 679
65. Ruben M, Watkins R. Pilocarpine dispensation for soft hydrophilic contact-lens. Br J Ophthalmol 1975; 59: 455-8
66. Marmion VJ, Jain MR. Role of soft contact-lenses and delivery of drugs. Trans Ophthalmol Soc U K 1976; 96: 319-21
67. Rubinstein MP, Evans JE. Therapeutic contact lenses and eyedrops: is there a problem? Cont Lens Anterior Eye 1997; 20: 9-11
68. Hull DS, Edelhauser HF, Hyndiuk RA. Ocular penetration of prednisolone and hydrophilic contact-lens. Arch Ophthalmol 1974; 92: 413-6
69. Matoba AY, McCulley JP. The effect of therapeutic soft contact-lenses on antibiotic delivery to the cornea. Ophthalmology 1985; 92: 97-9
70. Jain MR. Drug delivery through soft contact-lenses. Br J Ophthalmol 1988; 72: 150-4
71. Li CC, Chauhan A. Modeling ophthalmic drug delivery by soaked contact lenses. Ind Eng Chem Res 2006; 45: 3718-34
72. Vandorselaer T, Youssfi H, Caspers-Valu LE, et al. Treatment of traumatic corneal abrasion with contact lens associated with topical nonsteroid anti-inflammatory drug (NSAID) and antibiotic: a safe, effective, and comfortable solution. J Fr Ophtalmol 2001; 24: 1025-33
73. Refojo MF, Leong FL, Chan IM, et al. Absorption and release of antibiotics by a hydrophilic implant for scleral buckling. Retina 1983; 3: 45-9
74. Podos SM, Becker B, Asseff CF, et al. Pilocarpine therapy with soft contact lenses. Am J Ophthalmol 1972; 73: 336-41
75. Lesher GA, Gunderson GG. Continuous drug-delivery through the use of disposable contact-lenses. Optom Vis Sci 1993; 70: 1012-8
76. Kaufman HE, Uotila MH, Gasset AR, et al. The medical uses of soft contact lenses. Trans Am Acad Ophthalmol Otolaryngol 1971; 75: 361-73
77. Salz JJ, Reader AL, Schwartz LJ, et al. Treatment of corneal abrasions with soft contact-lenses and topical diclofenac. J Refract Corneal Surg 1994; 10: 640-6
78. Pinilla-Lozano I, Polo-Llorens V, Larrosa-Poves JM, et al. Medium-water-content contact lenses ciprofloxacin saturation: differences between exposure times [in Spanish]. Rev Esp Contact 1998 [online]. Available from URL: http://www.oftalmo.com/sec/98-tomo-2/02.htm [Accessed 2006 Jul 24]
79. Pinilla-Lozano I, Larrosa-Poves JM, Perez-Olivan S, et al. Quinolones intraocular penetration depending on therapeutic contact lens wear [in Spanish]. Rev Esp Contact 1998 [online]. Available from URL: http://www.oftalmo.com/sec/ 98-tomo-2/03.htm [Accessed 2006 Jul 24]
80. Tian X, Iwatsu M, Kanai A. Disposable 1-day Acuvue® contact lenses for the delivery of lomefloxacin to rabbits' eyes. CLAO J 2001; 27: 209-15
81. Tian X, Iwatsu M, Sado K, et al. Studies on the uptake and release of fluoroquinolones by disposable contact lenses. CLAO J 2001; 27: 216-20
82. Hehl EM, Beck R, Luthard K, et al. Improved penetration of aminoglycosides and fluoroquinolones into the aqueous humour of patients by means of Acuvue contact lenses. Eur J Clin Pharmacol 1999; 55: 317-23
83. Momose T, Ito N, Kanai A, et al. Adsorption of levocabastine eye drops by soft contact lenses and its effects in rabbit eyes. CLAO J 1997; 23: 96-9
84. Heyrman TP, McDermott ML, Ubels JL, et al. Drug uptake and release by a hydrogel intraocular-lens and the human crystalline lens. J Cataract Refract Surg 1989; 15: 169-75
85. Chapman JM, Cheeks L, Green K. Drug-interaction with intraocular lenses of different materials. J Cataract Refract Surg 1992; 18: 456-9
86. Weiner AL. Polymeric site-specific pharmacotherapy. In: Domb AJ, editor. Polymeric drug delivery systems for the eye. Chichester: Wiley, 1994: 315-46
87. Krejci L. Therapeutic use of scleral gel contact lenses. Cesk Oftalmol 1971; 27: 104-9
88. Krejci L, Brettschneider I, Praus R. Comparative study of fluorescein release from various types of therapeutic hydrophilic gel contact lenses. Cesk Oftalmol 1971; 27: 285-91
89. Praus R, Brettschneider I, Havranek M, et al. Penetration of radioactive sulphate and glucose from hydrophilic gel contact lenses into the eye of rabbit. Ophthal Res 1974; 6: 291-300
90. 2 transmissible contact lenses on bacterial binding and corneal epithelium: a 1-year clinical trial. Ophthalmology 2002; 109: 27-39
91. Ladage PM, Ren DH, Petroll WM, et al. Effects of eyelid closure and disposable and silicone hydrogel extended contact lens wear on rabbit corneal epithelial proliferation. Invest Ophthalmol Vis Sci 2003; 44: 1843-9
92. Holden BA, Mertz GW. Critical oxygen level to avoid corneal edema for daily and extended wear contact lenses. Invest Ophthamol Vis Sci 1984; 25: 1161-7
93. Wajs G, Meslard JC. Release of therapeutic agents from contact lenses. Crit Rev Ther Drug 1986; 2: 275-89
94. Kim SW, Bae YH, Okano T. Hydrogels: swelling, drug loading, and release. Pharm Res 1992; 9: 283-90
95. Kunzler JF, McGee JA. Contact-lens materials. Chem Ind 1995; 16: 651-5
96. Lloyd AW, Faragher RGA, Denyer SP. Ocular biomaterials and implants. Biomaterials 2001; 22: 769-85
97. Langer R. Polymeric delivery systems for controlled drug release. Chem Eng Commun 1980; 6: 1-48
98. Vairon JP, Yean L, Meslard JC, et al. Immobilisation reversible sur polymers et liberation controlee: application aux lentilles corneennes reservoirs de medicaments. Actual Chim 1992; Sep-Oct: 330-5
99. Gulsen D, Chauhan A. Ophthalmic drug delivery through contact lenses. Invest Ophthalmol Vis Sci 2004; 45: 2342-7
100. Gulsen D, Chauhan A. Dispersion of microemulsion drops in HEMA hydrogel: a potential ophthalmic drug delivery vehicle. Int J Pharm 2005; 292: 95-117
101. Gulsen D, Li CC, Chauhan A. Dispersion of DMPC liposomes in contact lenses for ophthalmic drug delivery. Curr Eye Res 2005; 30: 1071-80
102. Gulsen D, Chauhan A. Effect of water content on transparency, swelling, lidocaine diffusion in p-HEMA gels. J Memb Sci 2006; 269: 35-48
103. Miranda MN, Garcia-Castineiras S. Effects of pH and some common topical ophthalmic medications on the contact lens Permalens. CLAO J 1983; 9: 43-8
104. Uchida R, Sato T, Tanigawa H, et al. Azulene incorporation and release by hydrogel containing methacrylamide propyltrimethylammonium chloride, and its application to soft contact lens. J Control Release 2003; 92: 259-64
105. Sato T, Uchida R, Tanigawa H, et al. Application of polymer gels containing side-chain phosphate groups to drug-delivery contact lenses. J Appl Polym Sci 2005; 98: 731-5
106. Lord MS, Stenzel MH, Simmons A, et al. Lysozyme interaction with poly(HEMA)-based hydrogel. Biomaterials 2006; 27: 1341-5
107. Maeda M, Bartsch RA. Molecular and ionic recognition with imprinted polymers: a brief overview. In: Bartsch RA, Maeda M, editors. Molecular and ionic recognition with imprinted polymers, ACS Symposium Series 703. Washington, DC: American Chemical Society, 1998: 1-8
108. Ramström O, Ansell RJ. Molecular imprinting technology: challenges and prospects for the future. Chirality 1998; 10: 195-209
109. Wulff G, Biffis A. Molecularly imprinting with covalent or stoichiometric non-covalent interactions. In: Sellergren B, editor. Molecularly imprinted polymers. Amsterdam: Elsevier, 2001: 71-111
110. Wulff G. Molecular imprinting in cross-linked materials with the aid of molecular templates: a way towards artificial antibodies. Angew Chem Int Ed Engl 1995; 34: 1812-32
111. Arshady R, Mosbach K. Synthesis of substrate-selective polymers by host-guest polymerization. Makromol Chem 1981; 182: 687-92
112. Sellergren B. The non-covalent approach to molecular imprinting. In: Sellergren B, editor. Molecularly imprinted polymers. Amsterdam: Elsevier, 2001: 113-84
113. Allender CJ, Brain KR, Heard CM. Molecularly imprinted polymers: preparation, biomedical applications and technical challenges. In: King FD, Oxford AW, editors. Progress in medicinal chemistry. Vol. 36. Amsterdam: Elsevier, 1999: 235-91
114. Andersson HS, Karlsson JG, Piletsky SA, et al. Study of the nature of recognition in molecularly imprinted polymers: influence of monomer-template ratio and sample load on retention and selectivity. J Chromatogr A 1999; 848: 39-49
115. Mayes AG, Whitcombe MJ. Synthetic strategies for the generation of molecularly imprinted organic polymers. Adv Drug Deliv Rev 2005; 57: 1742-78
116. Kandimalla VB, Ju HX. Molecular imprinting: a dynamic technique for diverse applications in analytical chemistry. Anal Bioanal Chem 2004; 380: 587-605
117. Hillberg AL, Brain KR, Allender CJ. Molecular imprinted polymer sensors: implications for therapeutics. Adv Drug Deliv Rev 2005; 57: 1875-89
118. Allender CJ, Richardson C, Woodhouse B, et al. Pharmaceutical applications for molecularly imprinted polymers. Int J Pharm 2000; 195: 39-43
119. Byrne ME, Park K, Peppas NA. Molecular imprinting within hydrogels. Adv Drug Deliv Rev 2002; 54: 149-61
120. Alvarez-Lorenzo C, Concheiro A. Molecularly imprinted polymers for drug delivery. J Chromatogr B 2004; 804: 231-45
121. Hilt JZ, Byrne ME. Configurational biomimesis in drug delivery: molecular imprinting of biologically significant molecules. Adv Drug Deliv Rev 2004; 56: 1599-620
122. van Nostrum CF. Molecular imprinting: a new tool for drug innovation. Drug Discov Today 2005; 2: 119-24
123. Cunliffe D, Kirby A, Alexander C. Molecularly imprinted drug delivery systems. Adv Drug Deliv Rev 2005; 57: 1836-53
124. Alvarez-Lorenzo C, Concheiro A. Molecularly imprinted gels and nano- and microparticles: manufacture and applications. In: Arshady R, Kono K, editors. Smart nano and microparticulates. MML Series Vol. 7. London: Kentus Books, 2005: 279-336
125. Alvarez-Lorenzo C, Concheiro A. Molecularly imprinted materials as advanced excipients for drug delivery systems. In: El-Gewely MR, editor. Biotechnology annual review. Vol. 12. Amsterdam: Elsevier, 2006: 225-68
126. Sibrian-Vazquez M, Spivak DA. Improving the strategy and performance of molecularly imprinted polymers using cross-linking functional monomers. J Org Chem 2003; 68: 9604-11
127. Alvarez-Lorenzo C, Hiratani H, Gömez-Amoza JL, et al. Soft contact lenses capable of sustained delivery of timolol. J Pharm Sci 2002; 91: 2182-92
128. Hiratani H, Alvarez-Lorenzo C. Timolol uptake and release by imprinted soft contact lenses made of N,N-diethylacrylamide and methacrylic acid. J Control Release 2002; 83: 223-30
129. Hiratani H, Alvarez-Lorenzo C. Process for production of hydrogel material enhanced in the intake of drugs and permitting sustained release of drugs. Patent WO03090805, November 6, 2003
130. Hiratani H, Alvarez-Lorenzo C. The nature of backbone monomers determines the performance of imprinted soft contact lenses as timolol drug delivery systems. Biomaterials 2003; 25: 1105-13
131. Hiratani H, Fujiwara A, Tamiya Y, et al. Ocular release of timolol from molecularly imprinted soft contact lenses. Biomaterials 2005; 26: 1293-8
132. Hiratani H, Mizutani Y, Alvarez-Lorenzo C. Controlling drug release from imprinted hydrogels by modifying the characteristics of the imprinted cavities. Macromol Biosci 2005; 5: 728-33
133. Ahmed I, Gokhale RD, Shah MV, et al. Physicochemical determinants of drug diffusion across the conjunctiva, sclera, and cornea. J Pharm Sci 1987; 76: 583-6
134. Ahmed I, Francoeur ML, Thombre AG, et al. The kinetics of timolol in the rabbit lens: implications for ocular drug delivery. Pharm Res 1989; 6: 772-8
135. Nelson WL, Fraunfelder FT, Sills JM, et al. Adverse respiratory and cardiovascular events attributed to timolol ophthalmic solution, 1978-1985. Am J Ophthalmol 1986; 102: 606-11
136. Andrzejewska E. Photopolymerization kinetics of multifunctional monomers. Prog Polym Sci 2001; 26: 605-65
137. Sellergren B, Shea KJ. Correlation between solute retention and a theoretical ion-exchange model using imprinted polymers. J Chromatogr A 1993; 654: 17-28
138. Molinelli A, O'Mahony J, Nolan K, et al. Analyzing the mechanisms of selectivity in biomimetic self-assemblies via IR and NMR spectroscopy of prepolymerization solutions and molecular dynamics simulations. Anal Chem 2005; 77: 5196-204
139. McStay D, Al-Obaidi AH, Hoskins R, et al. Raman spectroscopy of molecularly imprinted polymers. J Opt A Pure Appl Opt 2005; 7: S340-5
140. Fish WP, Ferreira J, Sheardy RD, et al. Rational design of an imprinted polymer: maximizing selectivity by optimizing the monomer-template ratio of a cinchonidine MIP, prior to polymerization, using microcalorimetry. J Liq Chromatogr Relat Technol 2005; 28: 1-15
141. O'Mahony J, Molinelli A, Nolan K, et al. Towards the rational development of molecularly imprinted polymers: 1H NMR studies on hydrophobicity and ion-pair interactions as driving forces for selectivity. Biosens Bioelectron 2005; 20: 1884-93
142. Alvarez-Lorenzo C, Yañez F, Barreiro-Iglesias R, et al. Imprinted PHEMA soft contact lenses as norfloxacin delivery systems. J Control Release 2006; 113: 236-44
143. D'Oleo R, Alvarez-Lorenzo C, Sun G. A new approach to design imprinted polymer gels without using a template. Macromolecules 2001; 34: 4965-71
144. Moritani T, Alvarez-Lorenzo C. Conformational imprinting effect on stimuli-sensitive gels made with an imprinter monomer. Macromolecules 2001; 34: 7796-803
145. Sano K, Tokoro T, Imai Y. A new drug delivery system utilizing piggyback contact lenses. Acta Ophthalmol Scand 1996; 74: 243-8
146. Nakada K, Sugiyama A, inventor. Menicon Co., Ltd, assignee. Process for producing controlled drug-release contact lens, and controlled drug-release contact lens thereby produced. US Patent 6,027,745. May 1998
147. Rootman DS, Willoughby RPN, Bindlish R, et al. Continuous-flow contact-lens delivery of gentamicin to rabbit cornea and aqueous-humor. J Ocul Pharmacol 1992; 8: 317-23