Adsorption of levocabastine eye drops by soft contact lenses and its effects in rabbit eyes

CLAO Journal

Volumn 23, Issue 2, 1997, Pages 96-99

  Momose, Takayuki ^a   Ito, Nobuko ^a   Kanai, Atsushi ^a   Watanabe, Yasuo ^b   Shibata, Minoru ^c  

^a JUNTENDO UNIVERSITY   (Japan)

^b Seed Co Ltd   (Japan)

^c Janssen Pharmaceutical KK   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIALLERGIC AGENT; ANTIHISTAMINIC AGENT; LEVOCABASTINE;

ALLERGIC CONJUNCTIVITIS; ANIMAL EXPERIMENT; ARTICLE; CONTROLLED STUDY; DRUG ABSORPTION; EYE INFLAMMATION; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; NONHUMAN; PAPILLARY CONJUNCTIVITIS; RABBIT; SOFT CONTACT LENS; TOPICAL DRUG ADMINISTRATION; WATER CONTENT;

ADSORPTION; ANIMALS; BENZALKONIUM COMPOUNDS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CONTACT LENSES, HYDROPHILIC; CORNEA; DRUG EVALUATION; FOLLOW-UP STUDIES; HISTAMINE H1 ANTAGONISTS; OPHTHALMIC SOLUTIONS; PIPERIDINES; PRESERVATIVES, PHARMACEUTICAL; RABBITS;

EID: 0030938099     PISSN: 07338902     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (5)

1. Dechant KL, Goa KL et al: Levocabastine, a review of its pharmacological properties and therapeutic potential as a topical antihistamine in allergic rhinitis and conjunctivitis. Drugs 1991,41:202-224.
2. 1-antihistaminic compound levocabastine. Arzneim. Forsch. 1993;43(II):1331-1337.
3. Draize JH: Dermal toxicity. Appraisal of the Safety of Chemicals in Foods, Drugs and Cosmetics, Assoc. of Food and Drug Officials of the United States, Texas, 1959, pp 48-52.
4. Cauteren HV, Coussement W, Lampo A, et al: Single-dose study with levocabastine hydrochloride and repeated dose toxicity studies with its ophthalmic and nasal suspensions Clinical Report 1994;28(12):109-131.
5. Nakamura M, Yamashita T, Nishida T, et al: Effect of benzalkonium chloride on the rabbit corneal epithelium. Journal of Japan Contact Lens Society 1993;35:238-241.