Use of silyl ester and enamine protection for an efficient alternate synthesis of (1S,2S,5R,6S)-2-[(2′S)-(2′-amino)propionyl] aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid hydrochloride (LY544344·HCl)

Synthesis

Volumn , Issue 16, 2006, Pages 2659-2664

  Fennell, Jared W ^a   Semo, Michael J ^a   Wirth, David D ^a   Vaid, Radhe K ^a  

^a ELI LILLY AND COMPANY   (United States)

Author keywords

Acylations; Amino acids; Drugs; Process development; Protecting groups

Indexed keywords

AMINES; AMINO ACIDS; DRUG PRODUCTS; ESTERS; SYNTHESIS (CHEMICAL);

ACYLATIONS; PROCESS DEVELOPMENT; PROTECTING GROUPS;

PARAFFINS;

2 [(2'S) (2' AMINO)PROPIONYLAMINOBICYCLO[3.1.0]HEXANE 2,6 DICARBOXYLIC ACID HYDROCHLORIDE; ALANINE DERIVATIVE; ANILIDE; DICARBOXYLIC ACID DERIVATIVE; EGLUMETAD; ENAMINE; N (2 METHOXYCARBONYL 1 METHYLVINYL) ALANINE SODIUM SALT; TALAGLUMETAD; UNCLASSIFIED DRUG;

ACYLATION; ARTICLE; DRUG SYNTHESIS; SILYLATION;

EID: 33748333090     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2006-942487     Document Type: Article

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