Mechanisms permitting nephrotic patients to achieve nitrogen equilibrium with a protein-restricted diet

Journal of Clinical Investigation

Volumn 99, Issue 10, 1997, Pages 2479-2487

  Maroni, Bradley J ^a,d   Staffeid, Cathy ^a   Young, Vernon R ^c   Manatunga, Amita ^b   Tom, Karen ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b EMORY UNIVERSITY   (United States)

^c MASSACHUSETTS INSTITUTE OF TECHNOLOGY   (United States)

^d EMORY UNIVERSITY   (United States)

Author keywords

leucine turnover; nephrotic syndrome; nitrogen balance; protein synthesis

Indexed keywords

LEUCINE; NITROGEN; PROTEIN;

ADULT; AGED; AMINO ACID METABOLISM; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CROSSOVER PROCEDURE; DIET THERAPY; DOSE RESPONSE; FEMALE; GLOMERULUS FILTRATION RATE; HIGH RISK PATIENT; HUMAN; HYPERCHOLESTEROLEMIA; KIDNEY FAILURE; MALE; MALNUTRITION; NEPHROTIC SYNDROME; NITROGEN BALANCE; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; PROTEIN METABOLISM; PROTEIN RESTRICTION; PROTEINURIA; UREMIA;

EID: 0030926828     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119432     Document Type: Article

References (44)

1. Farr, L.E. 1938. The assimilation of protein by young children with the nephrotic syndrome. Am. J. Med. Sci. 195:70-83.
2. Blainey, B.J.D. 1954. High protein diets in the treatment of the nephrotic syndrome, Clin. Sci. 13:567-581.
3. Kaysen, G.A., J. Gambertoglio, I. Jimenez, H. Jones, and F.N. Hutchinson. 1986. Effect of dietary protein intake on albumin homeostasis in nephrotic patients. Kidney Int. 29:572-577.
4. Benigni, A., and G. Remuzzi. 1996. Glomerular protein trafficking and progression of renal disease to terminal uremia. Semin, in Nephrol. 16:151-159.
5. Choi, E.-J., R.C. May, J. Bailey, T. Masud, A. Dixon, and B.J. Maroni. 1993. Mechanisms of adaptation to proteinuria in adriamycin nephrosis. Am. J. Physiol, 265:F257-F263.
6. Choi, E.-J., J. Bailey, T. Masud, R.C. May, and B.J. Maroni. 1994. Metabolic responses to nephrosis: the effect of a low-protein diet. Am. J. Physiol. 266:F432-F438.
7. Kaysen, G.A. 1988. Albumin metabolism in the nephrotic syndrome: the effect of dietary protein intake. Am. J. Kidney Dis. 12:461-480.
8. Pedrini, M.T., A.S. Levey, J. Lau, T.C Chalmers, and P.M. Wang. 1996. The effects of dietary protein restriction on the progression of diabetic and nondiabetic renal diseases: a meta-analysis. Ann. Intern. Med. 124:627-632.
9. Kopple, J.D., and J.W. Coburn. 1973. Metabolic studies of low protein diets in uremia: I. Nitrogen and potassium. Medicine (Baltimore). 52:583-595.
10. Masud, T., V.R. Young, T. Chapman, and B.J. Maroni, 1994. Adaptive responses to very low protein diets: the first comparison of keloacids to essential amino acids. Kidney Int. 45:1182-1192.
11. Waiser, M., A.W. Coulter, S. Digne, and F.R. Crantz. 1973. The effect of keto-analogues of essential amino acids in severe chronic uremia. J. Clin. Invest. 52:678-690.
12. Goodship, T.H.J., W.E. Mitch, R.A. Hoerr, D.A. Wagner, T.I. Steinman, and V.R. Young. 1990. Adaptation to low-protein diets in renal failure: leucine turnover and nitrogen balance. J. Am. Soc. Nephrol. 1:66-75.
13. FAO/WHO/UNU. 1985. Energy and protein requirements. In Technical Report Series 724. World Health Organization. Geneva. 206 pp.
14. Jacobson, H.R., and G.E. Striker. 1995. Report on a workshop to develop management recommendations for the prevention of progression in chronic renal disease. Am. J. Kidney Dis. 25:103-106.
15. Frisancho, A.R. 1990. Anthropometric standards for the Assessment of Growth and Nutritional Status. University of Michigan, Ann Arbor, MI. 189 pp.
16. Klahr, S., A.S. Levey, G.J. Beck, A.W. Caggiula, L. Hunsicker, J.W. Kusek, G. Striker, and The Modification of Diet in Renal Disease (MDRD) Study Group. 1994. The effects of dietary protein restriction and blood pressure control on the progression of chronic renal disease. N. Engl. J. Med. 330:877-884.
17. Kopple, J.D., F.J. Monteon, and J.K. Shaib. 1986. Effect of energy intake on nitrogen metabolism in nondialyzed patients with chronic renal failure. Kidney Int. 29:734-742.
18. Maroni, B.J., T. Steinman, and W.E. Milch. 1985. A method for estimating nitrogen intake of patients with chronic renal failure. Kidney Int. 27:58-65.
19. Tom, K., V. Young, R.T. Chapman, T. Masud, L. Akpele, and B.J. Maroni. 1994. Long-term adaptive responses to dietary protein restriction in chronic renal failure. Am. J. Physiol. 4:E668-E677.
20. 2 breath tests. Am. J. Clin. Nutr. 33:2375-2385.
21. 3 infused by gut and vein: effect of feeding. Am. J. Physiol. 257:E426-E438.
22. Abumrad, N.M., D. Rabin, M.P. Diamond, and W.W. Lacy. 1981. Use of a heated superficial hand vein as an alternative site for the measurement of amino acid concentrations and for the study of glucose and alanine kinetics in man. Metab. Clin. Exp. 30:936-940.
23. 13C]leucine. Am. J. Physiol. 238:E473-E479.
24. Horber, F.F., C.M. Horber-Feyder, S. Krayer, W.F. Schwenk, and M.W. Haymond. 1989. Plasma reciprocal pool specific activity predicts that of intracellular free leucine for protein synthesis. Am. J. Physiol. 257:E385-E399.
25. 3]- and [l3C]leucine infused simultaneously by gut and vein. Am. J. Physiol. 251:E111-E117.
26. Nissen, S., and M.W. Haymond. 1986. Changes in leucine kinetics during meal absorption: effects of dietary leucine availability. Am. J. Physiol. 250: E695-E701.
27. Adams, R.F. 1974. Determination of amino acid profiles in biological samples by gas chromatography. J Chromatogr. 95:189-212.
28. Chaves das Neves, H.J., and A.M.P. Vasconcelos. 1987. Capillary gas chromatography of amino acids, including asparagine and glutamine: sensitive gas Chromatographic mass spectrometric and selective ion monitoring gas Chromatographic - mass spectrometric detection of the N.O. (S) -ten butyldimethylsilyl derivatives. J. Chromatogr. 392:249-258.
29. Rocchiccioli, F., J.P. Leroux, and P. Cartier. 1981. Quantitation of 2-ketoacids in biological fluids by as chromatography chemical ionization mass spectrometry of o-trimethylsilyl-quinoxalinol derivatives. Biomed. Mass. Spectrom. 8:160-164.
30. Langenbeck, U., H. Luthe, and G. Schaper. 1985. Ketoacids in tissues and biological fluids: O-t-butyldimethylsilyl quinoxalinols as derivatives for sensitive gas chromatographic/mass spectrometric determination. Biomed. Mass. Spectrom. 12:507-509.
31. Peterson, J.C., S. Adler, J.M. Burkart, T. Greene, L.A. Hebert. L.G. Hunsicker, A.J. King, S. Klahr, S.G. Massry, and J.L. Seifter. 1995. Blood pressure control, proteinuria and the progression of renal disease. Ann. Int. Med. 123:754-762.
32. Ikizler, T.A., J.H. Greene, R.L. Wingard, R.A. Parker, and R.M. Hakim. 1995. Spontaneous dietary protein intake during progression of chronic renal failure. J. Am. Soc. Nephrol. 6:1386-1391.
33. McNurlan, M.A., and P.J. Garlick. 1989. Influence of nutrient intake on protein turnover. Diabetes Metab. Rev. 5:165-189.
34. Pacy, P.J., G.M. Price, D. Halliday, M.R. Quevedo, and D.J. Millward. 1994. Nitrogen homeostasis in man: the diurnal responses of protein synthesis and degradation and amino acid oxidation to diets with increasing protein intakes. Clin. Sci. 86:103-118.
35. Castellino, P., L. Luzi, D.C. Simonson, M. Haymond, and R.A. DeFronzo. 1987. Effect of insulin and plasma amino acid concentrations on leucine metabolism in man. J. Clin. Invest. 80:1784-1793.
36. Tessari, P., S. Inchiostro, G. Biolo, R. Trevisan, G. Fantin, M.C. Marescotti, E. Lori, A. Tiengo, and G. Crepaldi. 1987. Differential effects of hyperinsulinemia and hyperaminoacidemia on leucine-carbon metabolism in vivo. J. Clin. Invest. 79:1062-1069.
37. Reifenstein, E.C., F. Albright, and S.L. Wells. 1945. The accumulation, interpretation, and presentation of data pertaining to metabolic balances, notably those of calcium, phosphorus, and nitrogen. J. Clin. Endocrinol. 5:367-395.
38. Bier, D.M. 1989. Intrinsically difficult problems: the kinetics of body proteins and amino acids in man. Diabetes Metab. Rev. 5:111-132.
39. Kopple, J.D. 1987. Uses and limitations of the balance technique. J. Parenter. Enteral Nutr. 11:79S-85S.
40. Oddoye, A.E., and S. Margen. 1979. Nitrogen balance studies in humans: long-term effect of high nitrogen intake on nitrogen accretion. J. Nutr. 109:363-377.
41. Costa, G. 1960. Hypothetical pathway of nitrogen metabolism. Nature (Lond.). 188:549-552.
42. Fisher, H., M.K. Brush, P. Griminger, and E.R. Sostman. 1967. Nitrogen retention in adult man: a possible factor in protein requirements. Am. J. Clin. Nutr. 20:927-934.
43. Rand, W.M., N.S. Scrimshaw, and V.R. Young. 1981. Conventional ("LONG-TERM") nitrogen balance studies for protein quality evaluation in adults: rationale and limitations. In Protein Quality in Humans: Assessment and In Vitro Estimation. C.E. Bodwell, J.S. Adkins, and D.T. Hopkins, editors. AVI Publishing Co., Inc. Westport. 61-97.
44. Waiser, M., S. Hill, and E.A. Tomalis. 1996. Treatment of nephrotic adults with a supplemented, very low-protein diet. Am. J. Kidney Dis. 28:354-364.