Quantitative trait loci analysis of mice administered the methionine-choline deficient dietary model of experimental steatohepatitis

Liver International

Volumn 26, Issue 8, 2006, Pages 1000-1005

  Rangnekar, Amol S ^a   Lammert, Frank ^b   Igolnikov, Alexander ^a   Green, Richard M ^a,c  

^a NORTHWESTERN UNIVERSITY   (United States)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c NONE   (United States)

Author keywords

MCD; NASH; QTL; Steatohepatitis

Indexed keywords

ALANINE AMINOTRANSFERASE; CHOLINE; METHIONINE; TRIACYLGLYCEROL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; AMINO ACID DEFICIENCY; ANALYSIS OF VARIANCE; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHROMOSOME 15; CHROMOSOME 2; CHROMOSOME IDENTIFICATION; CHROMOSOME MAP; COMPUTER ANALYSIS; CONTROLLED STUDY; CORRELATION COEFFICIENT; DISEASE PREDISPOSITION; EXPERIMENTAL MODEL; FEMALE; GENE LOCATION; GENE LOCUS; GENETIC SUSCEPTIBILITY; LINEAR REGRESSION ANALYSIS; LIVER FIBROSIS; LIVER WEIGHT; MOUSE; MOUSE STRAIN; MULTIFACTORIAL INHERITANCE; NONALCOHOLIC FATTY LIVER; NONHUMAN; NUTRITIONAL DEFICIENCY; PHENOTYPE; QUANTITATIVE TRAIT LOCUS MAPPING; SPECTROPHOTOMETRY; STRAIN DIFFERENCE; TISSUE LEVEL; WEIGHT REDUCTION;

ANIMALS; CHOLINE DEFICIENCY; DISEASE MODELS, ANIMAL; FATTY LIVER; FEMALE; HEPATITIS; METHIONINE; MICE; MICE, INBRED AKR; MICE, INBRED BALB C; MICE, INBRED C3H; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, INBRED STRAINS; QUANTITATIVE TRAIT LOCI;

EID: 33748325951     PISSN: 14783223     EISSN: 14783231     Source Type: Journal    
DOI: 10.1111/j.1478-3231.2006.01314.x     Document Type: Article

References (22)

1. Angulo P. Nonalcoholic fatty liver disease. N Engl J Med 2002; 346: 1221-3.
2. Caldwell S H, Oelsner D H, Iezzoni J C, Hespenheide E E, Battle E H, Driscoll C J. Cryptogenic cirrhosis: Clinical characterization and risk factors for underlying disease. Hepatology 1999; 29: 664-9.
3. Chitturi S, Farrell G C. Etiopathogenesis of nonalcoholic steatohepatitis. Semin Liver Dis 2001; 21: 27-41.
4. Struben V M D, Hespenheide E E, Calwell S H. Nonalcoholic steatohepatitis and cryptogenic cirrhosis within kindreds. Am J Med 2000; 108: 9-13.
5. Willner I R, Waters B, Patil S R, Reuben A, Morelli J, Riely C A. Ninety patients with nonalcoholic steatohepatitis: Insulin resistance, family tendency, and severity of disease. Am J Gastroenterol 2001; 96: 2957-61.
6. Browning J D, Kumar K S, Saboorian M H, Thiele D L. Ethnic differences in the prevalence of cryptogenic cirrhosis. Am J Gastroenterol 2004; 99: 292-8.
7. Browning J D, Szczepaniak L S, Dobbins R, et al. Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. Hepatology 2004; 40: 1387-95.
8. Almind K, Kulkarni R N, Lannon S M, Kahn C R. Identification of interactive loci linked to insulin and leptin in mice with genetic insulin resistance. Diabetes 2003; 52: 1535-43.
9. Borm M E, He J, Kelsall B, Pena A S, Strober W, Bouma G. A major quantitative trait locus on mouse chromosome 3 is involved in disease susceptibility in different colitis models. Gastroenterology 2005; 128: 74-85.
10. Hillebrandt S, Goos C, Matern S, Lammert F. Genome-wide analysis of hepatic fibrosis in inbred mice identifies the susceptibility locus Hfib1 on chromosome 15. Gastroenterology 2002; 123: 2041-51.
11. Ishimori N, Li R, Kelmenson P M, et al. Quantitative trait loci analysis for plasma HDL-cholesterol concentrations and atherosclerosis susceptibility between inbred mouse strains C57BL/6J and 129S1/svimj. Arterioscler Thromb Vasc Biol 2004; 24: 161-6.
12. Wittenburg H, Lyons M A, Paigen B, Carey M C. Mapping cholesterol gallstone susceptibility (Lith) genes in inbred mice. Dig Liver Dis 2003; 35(Suppl. 3): S2-7.
13. Hillebrandt S, Wasmuthh H E, Weiskirchen R, et al. Complement factor 5 is a quantitative trait gene that modifies liver fibrogenesis in mice and humans. Nat Genet 2005; 37: 835-43.
14. Grupe A, Germer S, Usuka J, et al. In silico mapping of complex disease-related traits in mice. Science 2001; 292: 1915-8.
15. Pletcher M T, Mcclurg P, Batalov S, et al. Use of a dense single nucleotide polymorphism map for in silico mapping in the mouse. PLoS Biol 2004; 2(12): E393: Epub 2004 November 9.
16. Marshall K E, Godden E L, Yang F, Burgers S, Buck K J, Sikela J M. In silico discovery of gene-coding variants in murine quantitative trait loci using strain-specific genome sequence databases. Genome Biol 2002; 3: Research0078.1-9.
17. Smith J D, James D, Dansky H M, Wittkowski K M, Moore K J, Breslow J L. In silico quantitative trait locus map for atherosclerosis susceptibility in apolipoprotein E-deficient mice. Arterioscler Thromb Vasc Biol 2003; 23: 117-22.
18. Chesler E J, Mogil J S, Williams R W. SNP haplotype mapping with inbred strains [online]. Department of Psychology, University of Illinois at Urbana-Champaign. http://www.nervenet.org/xlfiles/SNP/ CheslerSNPMapper.xls [2004].
19. Chesler E J, Rodriguez-Zas S L, Mogil J S. In silico mapping of mouse quantitative trait loci. Science 2001; 294: 2423.
20. Koppe S, Sahai A, Malladi P, Whitington P, Green R. Pentoxifylline attenuates steatohepatitis induced by the methionine choline deficient diet. J Hepatol 2004; 41: 592-8.
21. Sundaram S, Whitington P F, Green R M. Steatohepatitis develops rapidly in transgenic mice overexpressing Abcb11 and fed a methionine-choline-deficient diet. Am J Physiol Gastrointest Liver Physiol 2004; 288: G1321-7.
22. Igolnikov A, Green R. Mice heterozygous for the Mdr2 gene demonstrate decreased PEMT activity and diminished steatohepatitis on the MCD diet. J Hepatol 2006; 44: 586-92.