Phosphorylation of ErbB4 on Tyr1056 is critical for inhibition of colony formation by prostate tumor cell lines

Biochemical and Biophysical Research Communications

Volumn 349, Issue 1, 2006, Pages 372-382

  Gallo, Richard M ^a   Bryant, Ianthe ^a   Fry, Rachael ^a   Williams, Eric E ^a   Riese II, David J ^a  

^a PURDUE UNIVERSITY   (United States)

Author keywords

ErbB4; Isoforms; Prostate cancer; Signal transduction; Tumor suppressor; Tyrosine phosphorylation sites

Indexed keywords

CYSTEINE; EPIDERMAL GROWTH FACTOR RECEPTOR 4; GLUTAMINE; MUTANT PROTEIN; PHENYLALANINE; PHOSPHOPEPTIDE; TYROSINE;

AMINO ACID SUBSTITUTION; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; COLONY FORMATION; CONTROLLED STUDY; ENZYME ACTIVITY; HUMAN; HUMAN CELL; MUTATION; PEPTIDE MAPPING; PRIORITY JOURNAL; PROSTATE CANCER; PROTEIN FUNCTION; PROTEIN PHOSPHORYLATION; SIGNAL TRANSDUCTION;

ALTERNATIVE SPLICING; CELL LINE, TUMOR; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; GLUTAMIC ACID; HUMANS; MALE; PHOSPHORYLATION; PROSTATIC NEOPLASMS; RECEPTOR, EPIDERMAL GROWTH FACTOR; SIGNAL TRANSDUCTION; TYROSINE;

EID: 33748316606     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.08.055     Document Type: Article

References (29)

1. Yarden Y., and Sliwkowski M.X. Untangling the ErbB signalling network. Nat. Rev. Mol. Cell Biol. 2 (2001) 127-137
2. Kumar R., and Vadlamudi R.K. The EGF family of growth factors. J. Clin. Ligand Assay 23 (2000) 233-238
3. Carpenter G. ErbB-4: mechanism of action and biology. Exp. Cell Res. 284 (2003) 66-77
4. Ni C.Y., Murphy M.P., Golde T.E., and Carpenter G. γ-Secretase cleavage and nuclear localization of ErbB-4 receptor tyrosine kinase. Science 294 (2001) 2179-2181
5. Junttila T.T., Sundvall M., Lundin M., Lundin J., Tanner M., Harkonen P., Joensuu H., Isola J., and Elenius K. Cleavable ErbB4 isoform in estrogen receptor-regulated growth of breast cancer cells. Cancer Res. 65 (2005) 1384-1393
6. Williams C.C., Allison J.G., Vidal G.A., Burow M.E., Beckman B.S., Marrero L., and Jones F.E. The ERBB4/HER4 receptor tyrosine kinase regulates gene expression by functioning as a STAT5A nuclear chaperone. J. Cell Biol. 167 (2004) 469-478
7. Omerovic J., Puggioni E.M., Napoletano S., Visco V., Fraioli R., Frati L., Gulino A., and Alimandi M. Ligand-regulated association of ErbB-4 to the transcriptional co-activator YAP65 controls transcription at the nuclear level. Exp. Cell Res. 294 (2004) 469-479
8. Komuro A., Nagai M., Navin N.E., and Sudol M. WW domain-containing protein YAP associates with ErbB-4 and acts as a co-transcriptional activator for the carboxyl-terminal fragment of ErbB-4 that translocates to the nucleus. J. Biol. Chem. 278 (2003) 33334-33341
9. Kainulainen V., Sundvall M., Maatta J.A., Santiestevan E., Klagsbrun M., and Elenius K. A natural ErbB4 isoform that does not activate phosphoinositide 3-kinase mediates proliferation but not survival or chemotaxis. J. Biol. Chem. 275 (2000) 8641-8649
10. Salomon D.S., Brandt R., Ciardiello F., and Normanno N. Epidermal growth factor-related peptides and their receptors in human malignancies. Crit. Rev. Oncol. Hematol. 19 (1995) 183-232
11. Robinson D., He F., Pretlow T., and Kung H.J. A tyrosine kinase profile of prostate carcinoma. Proc. Natl. Acad. Sci. USA 93 (1996) 5958-5962
12. Grasso A.W., Wen D., Miller C.M., Rhim J.S., Pretlow T.G., and Kung H.J. ErbB kinases and NDF signaling in human prostate cancer cells. Oncogene 15 (1997) 2705-2716
13. Lyne J.C., Melhem M.F., Finley G.G., Wen D., Liu N., Deng D.H., and Salup R. Tissue expression of neu differentiation factor/heregulin and its receptor complex in prostate cancer and its biologic effects on prostate cancer cells in vitro. Cancer J. Sci. Am. 3 (1997) 21-30
14. Memon A.A., Sorensen B.S., Melgard P., Fokdal L., Thykjaer T., and Nexo E. Expression of HER3, HER4 and their ligand heregulin-4 is associated with better survival in bladder cancer patients. Br. J. Cancer 91 (2004) 2034-2041
15. Penington D.J., Bryant I., and Riese II D.J. Constitutively active ErbB4 and ErbB2 mutants exhibit distinct biological activities. Cell Growth Differ. 13 (2002) 247-256
16. Williams E.E., Trout L.J., Gallo R.M., Pitfield S.E., Bryant I., Penington D.J., and Riese D.J. A constitutively active ErbB4 mutant inhibits drug-resistant colony formation by the DU-145 and PC-3 human prostate tumor cell lines. Cancer Lett. 192 (2003) 67-74
17. S.E. Pitfield, I. Bryant, D.J. Penington, G. Park, D.J. Riese 2nd, Phosphorylation of ErbB4 on tyrosine 1056 is critical for ErbB4 coupling to inhibition of colony formation by human mammary cell lines, Oncol. Res. (2006) in press.
18. Vidal G.A., Clark D.E., Marrero L., and Jones F.E. A constitutively active ERBB4/HER4 allele with enhanced transcriptional coactivation and cell-killing activities. Oncogene (2006) in press
19. Riese II D.J., and DiMaio D. An intact PDGF signaling pathway is required for efficient growth transformation of mouse C127 cells by the bovine papillomavirus E5 protein. Oncogene 10 (1995) 1431-1439
20. Leptak C., Ramon y Cajal S., Kulke R., Horwitz B.H., Riese II D.J., Dotto G.P., and DiMaio D. Tumorigenic transformation of murine keratinocytes by the E5 genes of bovine papillomavirus type 1 and human papillomavirus type 16. J. Virol. 65 (1991) 7078-7083
21. Riese II D.J., van Raaij T.M., Plowman G.D., Andrews G.C., and Stern D.F. The cellular response to neuregulins is governed by complex interactions of the erbB receptor family. Mol. Cell Biol. 15 (1995) 5770-5776
22. Keshvara L.M., Isaacson C.C., Yankee T.M., Sarac R., Harrison M.L., and Geahlen R.L. Syk- and Lyn-dependent phosphorylation of Syk on multiple tyrosines following B cell activation includes a site that negatively regulates signaling. J. Immunol. 161 (1998) 5276-5283
23. West M.H.P., Wu R.S., and Bonner W.M. Polyacrylamide gel electrophoresis of small peptides. Electrophoresis 5 (1984) 133-138
24. Carraway III K.L., and Cantley L.C. A neu acquaintance for erbB3 and erbB4: a role for receptor heterodimerization in growth signaling. Cell 78 (1994) 5-8
25. Luo J., Sobkiw C.L., Logsdon N.M., Watt J.M., Signoretti S., O'Connell F., Shin E., Shim Y., Pao L., Neel B.G., Depinho R.A., Loda M., and Cantley L.C. Modulation of epithelial neoplasia and lymphoid hyperplasia in PTEN+/- mice by the p85 regulatory subunits of phosphoinositide 3-kinase. Proc. Natl. Acad. Sci. USA 102 (2005) 10238-10243
26. Hamburger A.W., and Yoo J.Y. Phosphatidylinositol 3-kinase mediates heregulin-induced growth inhibition in human epithelial cells. Anticancer Res. 17 (1997) 2197-2200
27. Puricelli L., Proiettii C.J., Labriola L., Salatino M., Balana M.E., Aguirre Ghiso J., Lupu R., Pignataro O.P., Charreau E.H., Bal de Kier Joffe E., and Elizalde P.V. Heregulin inhibits proliferation via ERKs and phosphatidyl-inositol 3-kinase activation but regulates urokinase plasminogen activator independently of these pathways in metastatic mammary tumor cells. Int. J. Cancer 100 (2002) 642-653
28. Vidal G.A., Naresh A., Marrero L., and Jones F.E. Presenilin-dependent γ-secretase processing regulates multiple ERBB4/HER4 activities. J. Biol. Chem. 280 (2005) 19777-19783
29. Naresh A., Long W., Vidal G.A., Wimley W.C., Marrero L., Sartor C.I., Tovey S., Cooke T.G., Bartlett J.M., and Jones F.E. The ERBB4/HER4 intracellular domain 4ICD is a BH3-only protein promoting apoptosis of breast cancer cells. Cancer Res. 66 (2006) 6412-6420