Human topoisomerase I forms double cleavage complexes on natural DNA

Biochemical and Biophysical Research Communications

Volumn 349, Issue 1, 2006, Pages 178-185

  Søe, Kent ^a   Hartung, Sabine ^a   Grosse, Frank ^a  

^a FRITZ LIPMANN INSTITUTE   (Germany)

Author keywords

Camptothecin; Double cleavage complex; Plasmid DNA; Protein protein interaction; Topoisomerase I; Topoisomerase I damage response

Indexed keywords

CAMPTOTHECIN; DIMER; DNA; DNA TOPOISOMERASE; MONOMER; NUCLEOTIDE; OLIGONUCLEOTIDE; PLASMID DNA; RECOMBINANT ENZYME;

ARTICLE; CATALYSIS; CHROMATIN; CONTROLLED STUDY; COVALENT BOND; DNA CLEAVAGE; DNA DAMAGE; DNA PROTEIN COMPLEX; DNA REPLICATION; DNA TRANSCRIPTION; DOUBLE CLEAVAGE COMPLEX; ENZYME SUBSTRATE COMPLEX; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MOLECULAR DYNAMICS; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; STRESS;

CAMPTOTHECIN; CATALYSIS; CHROMATIN; DIMERIZATION; DNA; DNA TOPOISOMERASES, TYPE I; ENZYME INHIBITORS; HELA CELLS; HUMANS; NUCLEIC ACID CONFORMATION; OLIGONUCLEOTIDES; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS;

EID: 33748308869     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.08.027     Document Type: Article

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