Effects of exercise training on mortality in patients with coronary heart disease

Coronary Artery Disease

Volumn 17, Issue 3, 2006, Pages 219-225

  Erbs, Sandra ^a   Linke, Axel ^a   Hambrecht, Rainer ^a  

^a UNIVERSITY OF LEIPZIG   (Germany)

Author keywords

Collaterals; Coronary heart disease; Endothelial dysfunction; Endothelial nitric oxide synthase; Endothelial progenitor cells; Exercise training; Mortality

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; ANTILIPEMIC AGENT; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; NITRIC OXIDE;

ANGIOGENESIS; BONE MARROW; CARDIAC PATIENT; CLINICAL TRIAL; COLLATERAL CIRCULATION; CORONARY ARTERY ATHEROSCLEROSIS; CORONARY ARTERY OBSTRUCTION; ENDOTHELIAL DYSFUNCTION; EXERCISE; HEART INFARCTION; HEART MUSCLE PERFUSION; HUMAN; ISCHEMIC HEART DISEASE; META ANALYSIS; MORBIDITY; MORTALITY; PHYSICAL ACTIVITY; PRIORITY JOURNAL; REVIEW; STEM CELL; SURVIVAL; SYMPTOM; SYSTEMATIC REVIEW;

CORONARY CIRCULATION; CORONARY DISEASE; ENDOTHELIUM, VASCULAR; EXERCISE THERAPY; HUMANS; MOTOR ACTIVITY; NITRIC OXIDE; STEM CELLS; VASODILATION;

EID: 33748298748     PISSN: 09546928     EISSN: None     Source Type: Journal    
DOI: 10.1097/00019501-200605000-00003     Document Type: Review

References (42)

1. Thompson PD, Buchner D, Pina IL, Balady GJ, Williams MA, Marcus BH, et al. Exercise and physical activity in the prevention and treatment of atherosclerotic cardiovascular disease: a statement from the Council on Clinical Cardiology (Subcommittee on Exercise, Rehabilitation, and Prevention) and the Council on Nutrition, Physical Activity, and Metabolism (Subcommittee on Physical Activity). Circulation 2003; 107:3109-3116.
2. Jolliffe JA, Rees K, Taylor RS, Thompson D, Oldrige N, Ebrahim S. Exercise-based rehabilitation for coronary heart disease. Cochrane Database Systematic Rev 2001; (1):CD001800. •• In this meta-analysis involving more than 8440 patients from 51 studies, the impact of exercise-based cardiac rehabilitation on mortality was assessed in middle-aged patients with CHD. Total mortality and cardiovascular mortality were found to be reduced by 27% and 31%, respectively, as a result of the exercise training intervention. This was not the result of either a decrease in nonfatal myocardial infarctions or a decline in rates of sudden cardiac death.
3. Chamberlain DA, Fox KAA, Henderson RA, Julian DG, Parker DJ, Pocock SJ. Coronary angioplasty versus medical therapy for angina: The Second Randomised Intervention Treatment of Angina (RITA-2) Trial. Lancet 1997; 350:461-468.
4. Pitt B, Waters D, Brown WV, van Boven J, Schwartz L, Title LM, et al. Aggressive lipid-lowering therapy compared with angioplasty in stable coronary artery disease. N Engl J Med 1999; 341:70-76.
5. Hambrecht R, Wolff A, Gielen S, Linke A, Hofer J, Erbs S, et al. Effect of exercise on coronary endothelial function in patients with coronary artery disease. N Engl J Med 2000; 342:454-460. • This study revealed that 4 weeks of exercise training partially corrects endothelial dysfunction of conduit and resistance vessels in patients with CAD.
6. Ornish D, Scherwitz LW, Billings JH, Gould KL, Merritt TA, Sparler S, et al. Intensive lifestyle changes for reversal of coronary heart disease. JAMA 1998; 280:2001-2007.
7. Haskell WL, Alderman EL, Fair JM, Maron DJ, Mackey SF, Superko R, et al. Effects of intensive multiple risk factor reduction on coronary atherosclerosis and clinical cardiac events in men and women with coronary artery disease. The Stanford Coronary Risk Intervention Project (SCRIP). Circulation 1994; 89:975-990.
8. Schuler G, Hambrecht R, Schlierf G, Niebauer J, Hauer K, Neumann J, et al. Regular physical exercise and low-fat diet. Effects on progression of coronary artery disease. Circulation 1992; 86:1-11.
9. Niebauer J, Hambrecht R, Velich T, Hauer K, Marburger C, Kälberer B, et al. Attenuated progression of coronary artery disease after 6 years of multifactorial risk intervention: role of physical exercise. Circulation 1997; 96:2534-2541.
10. Hambrecht R, Niebauer J, Marburger Ch, Grunze M, Kälberer B, Hauer K, et al. Various intensities of leisure time physical activity in patients with coronary artery disease: effects on cardiorespiratory fitness and progression of coronary atherosclerotic lesions. J Am Coll Cardiol 1993; 22:468-477.
11. Hambrecht R, Walther C, Möbius-Winkler S, Gielen S, Linke A, Conradi K, et al. Percutaneous coronary angioplasty compared with exercise training in patients with stable coronary artery disease: a randomized trail. Circulation 2004; 109:1371-1378.
12. Belardinelli R, Paolini I, Cianci G, Piva R, Georgiou D, Purcaro A. Exercise training intervention after coronary angioplasty: The ETICA Trial. J Am Coll Cardiol 2001; 37:1891-1900.
13. Piepoli MF, Davos C, Francis DP, Coats AJ. Exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH). BMJ 2004; 328:189-195. ••In the exercise training meta-analysis of trials in patients with chronic heart failure (ExTraMATCH), the effects of exercise training on survival in patients with heart failure owing to left ventricular systolic dysfunction were assessed. Data sets from nine trials in which a total number of 801 patients had been randomly assigned to exercise training or control were analyzed. Exercise training significantly reduced mortality in patients with chronic heart failure (hazard ratio 0.65, 95% confidence interval 0.46-0.93, P<0.05). In contrast to the anticipation that exercise training might be harmful in patients with chronic heart failure, these data rather imply a reduction in mortality and morbidity in response to supervised aerobic exercise training in these patients.
14. Schächinger V, Britten MB, Zeiher A. Prognostic impact of coronary vasodilator dysfunction on adverse long-term outcome of coronary heart disease. Circulation 2000; 101:1899-1906. •In this study, endothelial dysfunction of coronary arteries was shown to predict atherosclerotic disease progression and future cardiovascular events in patients with cardiovascular risk factors.
15. Lerman A, Zeiher AM. Endothelial function: cardiac events. Circulation 2005; 111:363-368.
16. Harrison DG. Cellular and molecular mechanisms of endothelial cell dysfunction. J Clin Invest 1997; 100:2153-2157.
17. Hambrecht R, Adams V, Erbs S, Linke A, Kränkel N, Shu Y, et al. Regular physical activity improves endothelial function in patients with coronary artery disease by increasing phosphorylation of endothelial nitric oxide synthase. Circulation 2003; 107:3152-3158.
18. Fleming I, Busse R. Molecular mechanisms involved in the regulation of the endothelial nitric oxide synthase. Am J Physiol Regul Integr Comp Physiol 2003; 284:R1-R12.
19. Dimmeler S, Zeiher AM. Exercise and cardiovascular health: get active to 'AKTivate' your endothelial nitric oxide synthase. Circulation 2003; 107:3118-3120.
20. Tesauro M, Thompson WC, Rogliani P, Qi L, Chaudhary PP, Moss J. Intracellular processing of endothelial nitric oxide synthase isoforms associated with differences in severity of cardiopulmonary diseases: cleavage of proteins with aspartate vs. glutamate at position 298. Proc Natl Acad Sci 2000; 97:2832-2835.
21. Leeson CPM, Hingorani AD, Mullen MJ, Jeerooburkhan N, Kattenhorn M, Cole TJ, et al. Glu298Asp endothelial nitric oxide synthase gene polymorphism interacts with environmental and dietary factors to influence endothelial function. Circ Res 2002; 90:1153-1158.
22. Wassmann S, Wassmann K, Nickenig G. Modulation of oxidant and antioxidant enzyme expression and function in vascular cells. Hypertension 2004; 44:381-386.
23. Adams V, Linke A, Kränkel N, Erbs S, Gielen S, Möbius-Winkler S, et al. Impact of regular physical activity on the NAD(P)H oxidase and angiotensin receptor system in patients with coronary artery disease. Circulation 2005; 111:555-562.
24. Erbs S, Baither Y, Linke A, Adams V, Shu Y, Lenk K, et al. Promoter but not exon 7 polymorphism of endothelial nitric oxide synthase affects training-induced correction of endothelial dysfunction. Arterioscler Thromb Vasc Biol 2003; 23:1814-1819.
25. Lu TM, Ding YA, Charng MJ, Lin SJ. Asymmetrical dimethylarginine: a novel risk factor for coronary artery disease. Clin Cardiol 2003; 26:458-464.
26. Harrison DG, Griendling KK, Landmesser U, Hornig B, Drexler H. Role of oxidative stress in atherosclerosis. Am J Cardiol 2003; 91:7A-11A.
27. Ito A, Tsao PS, Adimoolam S, Kimoto M, Ogawa T, Cooke JP. Novel mechanism for endothelial dysfunction: dysregulation of dimethylarginine dimethylaminohydrolase. Circulation 1999; 99:3092-3095.
28. Spiekermann S, Landmesser U, Dikalov S, Bredt M, Gamez G, Tatge H, et al. Electron spin resonance characterization of vascular xanthine and NAD(P)H oxidase activity in patients with coronary artery disease: relation to endothelium-dependent vasodilation. Circulation 2003; 107:1383-1389.
29. Griendling KK, FitzGerald GA. Oxidative stress and cardiovascular injury. Part I: basic mechanisms and in vivo monitoring of ROS. Circulation 2003; 108:1912-1916.
30. Landmesser U, Dikalov S, Price SR, McCann L, Fukai T, Holland SM, et al. Oxidation of tetrahydrobiopterin leads to uncoupling of endothelial cell nitric oxide synthase in hypertension. J Clin Invest 2003; 111:1201-1209.
31. Landmesser U, Merten R, Spiekermann S, Büttner K, Drexler H, Hornig B. Vascular extracellular superoxide dismutase activity in patients with coronary artery disease. Circulation 2000; 101:2264-2270.
32. Crosby JR, Kaminski WE, Schatteman G, Martin PJ, Raines EW, Seifert RA, Bowen-Pope DF. Endothelial cells of hematopoietic origin make a significant contribution to adult blood vessel formation. Circ Res 2000; 87:728-730.
33. Asahara T, Masuda H, Takahashi T, Kalka C, Pastore C, Silver M, et al. Bone marrow origin of endothelial progenitor cells responsible for postnatal vasculogenesis in physiological and pathological neovascularization. Circ Res 1999; 85:221-228.
34. Vasa M, Fichtlscherer S, Aicher A, Adler K, Urbich C, Martin H, et al. Number and migratory activity of circulating endothelial progenitor cells inversely correlate with risk factors for coronary artery disease. Circ Res 2001; 89:e1-e7.
35. Hill JM, Zalos G, Halcox JPJ, Schenke WH, Waclawiw MA, Quyyumi AA, Finkel T. Circulating endothelial progenitor cells, vascular function, and cardiovascular risk. N Engl J Med 2003; 348:593-600.
36. Schmidt-Lucke C, Rossig L, Fichtlscherer S, Vasa M, Britten M, Kamper U, et al. Reduced number of circulating endothelial progenitor cells predicts future cardiovascular events: proof of concept for the clinical importance of endogenous vascular repair. Circulation 2005; 111:2981-2987.
37. Khakoo AY, Finkel T. Endothelial progenitor cells. Annu Rev Med 2005; 56:79-101.
38. Belardinelli R, Georgiou D, Ginzton L, Cianci G, Purcaro A. Effects of moderate exercise training on thallium uptake and contractile response to low-dose dobutamine of dysfunctional myocardium in patients with ischemic cardiomyopathy. Circulation 1998; 97:553-561.
39. Niebauer J, Hambrecht R, Marburger C, Hauer K, Velich T, von Hodenberg E, et al. Impact of intensive physical exercise and low-fat diet on collateral vessel formation in stable angina pectoris and angiographically confirmed coronary artery disease. Am J Cardiol 1996; 76:771-775.
40. Laufs U, Werner N, Link A, Endres M, Wassmann S, Jürgens K, et al. Physical training increases endothelial progenitor cells, inhibition of neointima formation, and enhances angiogenesis. Circulation 2004; 109:220-226.
41. Adams V, Lenk K, Linke A, Lenz D, Erbs S, Sandri M, et al. Increase of circulating endothelial progenitor cells in patients with coronary artery disease after exercise-induced ischemia. Arterioscler Thromb Vasc Biol 2004; 24:684-690.
42. Sandri M, Adams V, Gielen S, Linke A, Lenk K, Krankel N, et al. Effects of exercise and ischemia on mobilization and functional activation of blood-derived progenitor cells in patients with ischemic syndromes: results of 3 randomized studies. Circulation 2005; 111:3391-3399.