Expression of VEGFR-2 on HaCaT cells is regulated by VEGF and plays an active role in mediating VEGF induced effects

Biochemical and Biophysical Research Communications

Volumn 349, Issue 1, 2006, Pages 31-38

  Yang, Xiao Hong ^a   Man, Xiao Yong ^a   Cai, Sui Qing ^a   Yao, Yong Gang ^b   Bu, Zhang Yu ^a   Zheng, Min ^a  

^a ZHEJIANG UNIVERSITY SCHOOL OF MEDICINE   (China)

^b KUNMING INSTITUTE OF ZOOLOGY   (China)

Author keywords

Cell adhesion; Cell migration; Cell proliferation; HaCaT cell; Keratinocyte; p44 42 MAPK; Phosphorylation; PLC ; VEGF; VEGFR 2

Indexed keywords

INTERCELLULAR ADHESION MOLECULE 1; MITOGEN ACTIVATED PROTEIN KINASE; VASCULAR CELL ADHESION MOLECULE 1; VASCULOTROPIN; VASCULOTROPIN RECEPTOR 2;

ARTICLE; AUTOPHOSPHORYLATION; CELL ACTIVITY; CELL ADHESION; CELL MIGRATION; CELL PROLIFERATION; CELL STRAIN HACAT; CELL TYPE; CHEMOTAXIS; EMBRYO DEVELOPMENT; ENDOTHELIUM CELL; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; KERATINOCYTE; MITOGENESIS; PRIORITY JOURNAL; PROTEIN PHOSPHORYLATION; SKIN FIBROBLAST; TARGET CELL;

CELL ADHESION; CELL LINE, TUMOR; CELL MOVEMENT; CELL PROLIFERATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; KERATINOCYTES; NEUROPILIN-1; NEUROPILIN-2; PHOSPHOLIPASE C GAMMA; PHOSPHORYLATION; RNA; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 33748288250     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2006.07.213     Document Type: Article

References (46)

1. Neufeld G., Cohen T., Gengrinovitch S., and Poltorak Z. Vascular endothelial growth factor (VEGF) and its receptors. FASEB J. 13 (1999) 9-22
2. Ferrara N., Gerber H.P., and LeCouter J. The biology of VEGF and its receptors. Nat. Med. 9 (2003) 669-676
3. Olsson A.K., Dimberg A., Kreuger J., and Claesson-Welsh L. VEGF receptor signaling-in control of vascular function. Nat. Rev. Mol. Cell Biol. 7 (2006) 359-371
4. Ferrara N. Role of vascular endothelial growth factor in physiologic and pathologic angiogenesis: therapeutic implications. Semin. Oncol. 29 (2002) 10-14
5. Carmeliet P., and Jain R.K. Angiogenesis in cancer and other diseases. Nature 407 (2000) 249-257
6. M. Murakami, S. Iwai, S. Hiratsuka, M. Yamauchi, K. Nakamura, Y. Iwakura, M. Shibuya, Signaling of vascular endothelial growth factor receptor-1 tyrosine kinase promotes rheumatoid arthritis through activation of monocyte/macrophages, Blood (2006) (Epub ahead of print, doi:10.1182/blood-2006-04-016030).
7. Detmar M., Brown L.F., Claffey K.P., Yeo K.T., Kocher O., Jackman R.W., Berse B., and Dvorak H.F. Overexpression of vascular permeability factor/vascular endothelial growth factor and its receptors in psoriasis. J. Exp. Med. 180 (1994) 1141-1146
8. Tammela T., Enholm B., Alitalo K., and Paavonen K. The biology of vascular endothelial growth factors. Cardiovasc. Res. 65 (2005) 550-563
9. Keck P.J., Hauser S.D., Krivi G., Sanzo K., Warren T., Feder J., and Connolly D.T. Vascular permeability factor, an endothelial cell mitogen related to PDGF. Science 246 (1989) 1309-1312
10. Ng Y.S., Krilleke D., and Shima D.T. VEGF function in vascular pathogenesis. Exp. Cell Res. 312 (2006) 527-537
11. Terman B.I., Dougher-Vermazen M., Carrion M.E., Dimitrov D., Armellino D.C., Gospodarowicz D., and Bohlen P. Identification of the KDR tyrosine kinase as a receptor for vascular endothelial cell growth factor. Biochem. Biophys. Res. Commun. 187 (1992) 1579-1586
12. Millauer B., Wizigmann-Voos S., Schnurch H., Martinez R., Moller N.P., Risau W., and Ullrich A. High affinity VEGF binding and developmental expression suggest Flk-1 as a major regulator of vasculogenesis and angiogenesis. Cell 72 (1993) 835-846
13. Waltenberger J., Claesson-Welsh L., Siegbahn A., Shibuya M., and Heldin C.H. Different signal transduction properties of KDR and Flt1, two receptors for vascular endothelial growth factor. J. Biol. Chem. 269 (1994) 26988-26995
14. Quinn T.P., Peters K.G., De Vries C., Ferrara N., and Williams L.T. Fetal liver kinase 1 is a receptor for vascular endothelial growth factor and is selectively expressed in vascular endothelium. Proc. Natl. Acad. Sci. USA 90 (1993) 7533-7537
15. Kanellis J., Fraser S., Katerelos M., and Power D.A. Vascular endothelial growth factor is a survival factor for renal tubular epithelial cells. Am. J. Physiol. Renal Physiol. 278 (2000) F905-F915
16. Korpelainen E.I., Karkkainen M.J., Tenhunen A., Lakso M., Rauvala H., Vierula M., Parvinen M., and Alitalo K. Overexpression of VEGF in testis and epididymis causes infertility in transgenic mice. evidence for non-endothelial targets for VEGF. J. Cell Biol. 143 (1998) 1705-1712
17. Brown L.F., Yeo K.T., Berse B., Yeo T.K., Senger D.R., Dvorak H.F., and van de Water L. Expression of vascular permeability factor (vascular endothelial growth factor) by epidermal keratinocytes during wound healing. J. Exp. Med. 176 (1992) 1375-1379
18. Kurschat P., Bielenberg D., Rossignol-Tallandier M., Stahl A., and Klagsbrun M. Neuron restrictive silencer factor NRSF/REST is a transcriptional repressor of neuropilin-1 and diminishes the ability of semaphorin 3A to inhibit keratinocyte migration. J. Biol. Chem. 281 (2006) 2721-2729
19. X.Y. Man, X.H. Yang, S.Q. Cai, Y.G. Yao, M. Zheng, Immunolocalization and expression of vascular endothelial growth factor receptors (VEGFRs) and neuropilins (NRPs) on keratinocytes in human epidermis, Mol. Med. (2006), in press.
20. Wilgus T.A., Matthies A.M., Radek K.A., Dovi J.V., Burns A.L., Shankar R., and DiPietro L.A. Novel function for vascular endothelial growth factor receptor-1 on epidermal keratinocytes. Am. J. Pathol. 167 (2005) 1257-1266
21. Kim E.J., Park H.Y., Yaar M., and Gilchrest B.A. Modulation of vascular endothelial growth factor receptors in melanocytes. Exp. Dermatol. 14 (2005) 625-633
22. Lehman T.A., Modali R., Boukamp P., Stanek J., Bennett W.P., Welsh J.A., Metcalf R.A., Stampfer M.R., Fusenig N., Rogan E.M., et al. p53 mutations in human immortalized epithelial cell lines. Carcinogenesis 14 (1993) 833-839
23. Larrivee B., and Karsan A. Isolation and culture of primary endothelial cells. Methods Mol. Biol. 290 (2005) 315-329
24. Weichert H., Blechschmidt I., Schroder S., and Ambrosius H. The MTT-assay as a rapid test for cell proliferation and cell killing: application to human peripheral blood lymphocytes (PBL). Allerg. Immunol. (Leipz) 37 (1991) 139-144
25. Matsumoto K., Matsumoto K., Nakamura T., and Kramer R.H. Hepatocyte growth factor/scatter factor induces tyrosine phosphorylation of focal adhesion kinase (p125FAK) and promotes migration and invasion by oral squamous cell carcinoma cells. J. Biol. Chem. 269 (1994) 31807-31813
26. Zhang K., and Kramer R.H. Laminin 5 deposition promotes keratinocyte motility. Exp. Cell Res. 227 (1996) 309-322
27. Claesson-Welsh L. Signal transduction by vascular endothelial growth factor receptors. Biochem. Soc. Trans. 31 (2003) 20-24
28. Glade-Bender J., Kandel J.J., and Yamashiro D.J. VEGF blocking therapy in the treatment of cancer. Expert Opin. Biol. Ther. 3 (2003) 263-276
29. Ancelin M., Chollet-Martin S., Herve M.A., Legrand C., El Benna J., and Perrot-Applanat M. Vascular endothelial growth factor VEGF189 induces human neutrophil chemotaxis in extravascular tissue via an autocrine amplification mechanism. Lab. Invest. 84 (2004) 502-512
30. Barleon B., Sozzani S., Zhou D., Weich H.A., Mantovani A., and Marme D. Migration of human monocytes in response to vascular endothelial growth factor (VEGF) is mediated via the VEGF receptor flt-1. Blood 87 (1996) 3336-3343
31. Lacal P.M., Ruffini F., Pagani E., and D'Atri S. An autocrine loop directed by the vascular endothelial growth factor promotes invasiveness of human melanoma cells. Int. J. Oncol. 27 (2005) 1625-1632
32. Detmar M., Brown L.F., Berse B., Jackman R.W., Elicker B.M., Dvorak H.F., and Claffey K.P. Hypoxia regulates the expression of vascular permeability factor/vascular endothelial growth factor (VPF/VEGF) and its receptors in human skin. J. Invest. Dermatol. 108 (1997) 263-268
33. Murdaca J., Treins C., Monthouel-Kartmann M.N., Pontier-Bres R., Kumar S., Van Obberghen E., and Giorgetti-Peraldi S. Grb10 prevents Nedd4-mediated vascular endothelial growth factor receptor-2 degradation. J. Biol. Chem. 279 (2004) 26754-26761
34. Herve M.A., Meduri G., Petit F.G., Domet T.S., Lazennec G., Mourah S., and Perrot-Applanat M. Regulation of the vascular endothelial growth factor (VEGF) receptor Flk-1/KDR by estradiol through VEGF in uterus. J. Endocrinol. 188 (2006) 91-99
35. Singh A.J., Meyer R.D., Band H., and Rahimi N. The carboxyl terminus of VEGFR-2 is required for PKC-mediated down-regulation. Mol. Biol. Cell 16 (2005) 2106-2118
36. Takahashi T., Yamaguchi S., Chida K., and Shibuya M. A single autophosphorylation site on KDR/Flk-1 is essential for VEGF-A-dependent activation of PLC-gamma and DNA synthesis in vascular endothelial cells. EMBO J. 20 (2001) 2768-2778
37. Marshall C.J. Specificity of receptor tyrosine kinase signaling: transient versus sustained extracellular signal-regulated kinase activation. Cell 80 (1995) 179-185
38. Hunter T. Protein kinases and phosphatases: the yin and yang of protein phosphorylation and signaling. Cell 80 (1995) 225-236
39. Hill C.S., and Treisman R. Transcriptional regulation by extracellular signals: mechanisms and specificity. Cell 80 (1995) 199-211
40. Cowley S., Paterson H., Kemp P., and Marshall C.J. Activation of MAP kinase is necessary and sufficient for PC12 differentiation and for transformation of NIH 3T3 cells. Cell 77 (1994) 841-852
41. Shen H., Clauss M., Ryan J., Schmidt A.M., Tijburg P., Borden L., Connolly D., Stern D., and Kao J. Characterization of vascular permeability factor/vascular endothelial growth factor receptors on mononuclear phagocytes. Blood 81 (1993) 2767-2773
42. Takahashi T., Ueno H., and Shibuya M. VEGF activates protein kinase C-dependent, but Ras-independent Raf-MEK-MAP kinase pathway for DNA synthesis in primary endothelial cells. Oncogene 18 (1999) 2221-2230
43. Kim I., Moon S.O., Park S.K., Chae S.W., and Koh G.Y. Angiopoietin-1 reduces VEGF-stimulated leukocyte adhesion to endothelial cells by reducing ICAM-1, VCAM-1, and E-selectin expression. Circ. Res. 89 (2001) 477-479
44. Miyamoto K., Khosrof S., Bursell S.E., Moromizato Y., Aiello L.P., Ogura Y., and Adamis A.P. Vascular endothelial growth factor (VEGF)-induced retinal vascular permeability is mediated by intercellular adhesion molecule-1 (ICAM-1). Am. J. Pathol. 156 (2000) 1733-1739
45. Lu M., Perez V.L., Ma N., Miyamoto K., Peng H.B., Liao J.K., and Adamis A.P. VEGF increases retinal vascular ICAM-1 expression in vivo. Invest. Ophthalmol. Vis. Sci. 40 (1999) 1808-1812
46. Goebel S., Huang M., Davis W.C., Jennings M., Siahaan T.J., Alexander J.S., and Kevil C.G. VEGF-A stimulation of leukocyte adhesion to colonic microvascular endothelium: implications for inflammatory bowel disease. Am. J. Physiol. Gastrointest. Liver Physiol. 290 (2006) G648-G654