Effects of mutation at the D-JH junction on affinity, specificity, and idiotypy of anti-progesterone antibody DB3

Protein Science

Volumn 15, Issue 9, 2006, Pages 2141-2148

  He, Mingyue ^a   Hamon, Maureen ^a   Liu, Hong ^a   Corper, Adam L ^b   Taussig, Michael J ^a  

^a BABRAHAM INSTITUTE   (United Kingdom)

^b SCRIPPS RESEARCH INSTITUTE   (United States)

Author keywords

Anti progesterone; Antibody engineering; Idiotype; Single chain antibody fragment; Site directed mutagenesis

Indexed keywords

ANTIGESTAGEN; ARGININE; ETIOCHOLANOLONE; IDIOTYPIC ANTIBODY; IMMUNOGLOBULIN IDIOTYPE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY DB3; PROGESTERONE; TRYPTOPHAN; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; DRUG INHIBITION; ESCHERICHIA COLI; MUTATION; PRIORITY JOURNAL; PROTEIN CONFORMATION; PROTEIN EXPRESSION; PROTEIN PROTEIN INTERACTION; SITE DIRECTED MUTAGENESIS;

AMINO ACID SEQUENCE; ANTIBODIES; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; BINDING SITES, ANTIBODY; ESCHERICHIA COLI; MODELS, CHEMICAL; MOLECULAR SEQUENCE DATA; MUTATION; PROGESTERONE; PROTEIN STRUCTURE, SECONDARY; SENSITIVITY AND SPECIFICITY;

ESCHERICHIA COLI;

EID: 33748158771     PISSN: 09618368     EISSN: 1469896X     Source Type: Journal    
DOI: 10.1110/ps.062236806     Document Type: Article

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