-
1
-
-
0033759545
-
Non-myeloablative stem cell transplants
-
Barrett J., and Childs R. Non-myeloablative stem cell transplants. Br J Haematol 111 (2000) 6-17
-
(2000)
Br J Haematol
, vol.111
, pp. 6-17
-
-
Barrett, J.1
Childs, R.2
-
2
-
-
1542267219
-
Graft-versus-leukemia reactions in allogeneic chimeras
-
Kolb H.J., Schmid C., Barrett A.J., and Schendel D.J. Graft-versus-leukemia reactions in allogeneic chimeras. Blood 103 (2004) 767-776
-
(2004)
Blood
, vol.103
, pp. 767-776
-
-
Kolb, H.J.1
Schmid, C.2
Barrett, A.J.3
Schendel, D.J.4
-
3
-
-
0033168770
-
Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation
-
Ruggeri L., Capanni M., Casucci M., Volpi I., Tosti A., Perruccio K., Urbani E., Negrin R.S., Martelli M.F., and Velardi A. Role of natural killer cell alloreactivity in HLA-mismatched hematopoietic stem cell transplantation. Blood 94 (1999) 333-339
-
(1999)
Blood
, vol.94
, pp. 333-339
-
-
Ruggeri, L.1
Capanni, M.2
Casucci, M.3
Volpi, I.4
Tosti, A.5
Perruccio, K.6
Urbani, E.7
Negrin, R.S.8
Martelli, M.F.9
Velardi, A.10
-
4
-
-
0037443557
-
Elimination of leukemia in the absence of lethal graft-versus-host disease after allogenic bone marrow transplantation
-
Drobyski W.R., Gendelman M., Vodanovic-Jankovic S., and Gorski J. Elimination of leukemia in the absence of lethal graft-versus-host disease after allogenic bone marrow transplantation. J Immunol 170 (2003) 3046-3053
-
(2003)
J Immunol
, vol.170
, pp. 3046-3053
-
-
Drobyski, W.R.1
Gendelman, M.2
Vodanovic-Jankovic, S.3
Gorski, J.4
-
6
-
-
0036107517
-
In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens
-
Dickinson A.M., Wang X.N., Sviland L., Vyth-Dreese F.A., Jackson G.H., Schumacher T.N., Haanen J.B., Mutis T., and Goulmy E. In situ dissection of the graft-versus-host activities of cytotoxic T cells specific for minor histocompatibility antigens. Nat Med 8 (2002) 410-414
-
(2002)
Nat Med
, vol.8
, pp. 410-414
-
-
Dickinson, A.M.1
Wang, X.N.2
Sviland, L.3
Vyth-Dreese, F.A.4
Jackson, G.H.5
Schumacher, T.N.6
Haanen, J.B.7
Mutis, T.8
Goulmy, E.9
-
7
-
-
0037418284
-
Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukaemia
-
Marijt W.A., Heemskerk M.H., Kloosterboer F.M., Goulmy E., Kester M.G., van der Hoorn M.A., van Luxemburg-Heys S.A., Hoogeboom M., Mutis T., Drijfhout J.W., et al. Hematopoiesis-restricted minor histocompatibility antigens HA-1- or HA-2-specific T cells can induce complete remissions of relapsed leukaemia. Proc Natl Acad Sci USA 100 (2003) 2742-2747
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 2742-2747
-
-
Marijt, W.A.1
Heemskerk, M.H.2
Kloosterboer, F.M.3
Goulmy, E.4
Kester, M.G.5
van der Hoorn, M.A.6
van Luxemburg-Heys, S.A.7
Hoogeboom, M.8
Mutis, T.9
Drijfhout, J.W.10
-
8
-
-
11844255367
-
Minor histocompatibility antigen-specific T cells with multiple distinct specificities can be isolated by direct cloning of IFNγ-secreting T cells from patients with relapsed leukemia responding to donor lymphocyte infusion
-
Kloosterboer F.M., van Luxemburg-Heijs S.A., van Soest R.A., van Egmond H.M., Barbui A.M., Strijbosch M.P., Willemze R., and Falkenburg J.H. Minor histocompatibility antigen-specific T cells with multiple distinct specificities can be isolated by direct cloning of IFNγ-secreting T cells from patients with relapsed leukemia responding to donor lymphocyte infusion. Leukemia 19 (2005) 83-90
-
(2005)
Leukemia
, vol.19
, pp. 83-90
-
-
Kloosterboer, F.M.1
van Luxemburg-Heijs, S.A.2
van Soest, R.A.3
van Egmond, H.M.4
Barbui, A.M.5
Strijbosch, M.P.6
Willemze, R.7
Falkenburg, J.H.8
-
9
-
-
0029870222
-
Specific human cellular immunity to bcr-abl oncogene-derived peptides
-
Bocchia M., Korontsvit T., Xu Q., Mackinnon S., Yang S.Y., Sette A., and Scheinberg D.A. Specific human cellular immunity to bcr-abl oncogene-derived peptides. Blood 87 (1996) 3587-3592
-
(1996)
Blood
, vol.87
, pp. 3587-3592
-
-
Bocchia, M.1
Korontsvit, T.2
Xu, Q.3
Mackinnon, S.4
Yang, S.Y.5
Sette, A.6
Scheinberg, D.A.7
-
10
-
-
0032523810
-
Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia
-
Yotnda P., Firat H., Garcia-Pons F., Garcia Z., Gourru G., Vernant J.P., Lemonnier F.A., Leblond V., and Langlade-Demoyen P. Cytotoxic T cell response against the chimeric p210 BCR-ABL protein in patients with chronic myelogenous leukemia. J Clin Invest 101 (1998) 2290-2296
-
(1998)
J Clin Invest
, vol.101
, pp. 2290-2296
-
-
Yotnda, P.1
Firat, H.2
Garcia-Pons, F.3
Garcia, Z.4
Gourru, G.5
Vernant, J.P.6
Lemonnier, F.A.7
Leblond, V.8
Langlade-Demoyen, P.9
-
11
-
-
0033063104
-
Generation of bcr-abl specific cytotoxic T-lymphocytes by using dendritic cells pulsed with bcr-abl (b3a2) peptide: its applicability for donor leukocyte transfusions in marrow grafted CML patients
-
Osman Y., Takahashi M., Zheng Z., Koike T., Toba K., Liu A., Furukawa T., Aoki S., and Aizawa Y. Generation of bcr-abl specific cytotoxic T-lymphocytes by using dendritic cells pulsed with bcr-abl (b3a2) peptide: its applicability for donor leukocyte transfusions in marrow grafted CML patients. Leukemia 13 (1999) 166-174
-
(1999)
Leukemia
, vol.13
, pp. 166-174
-
-
Osman, Y.1
Takahashi, M.2
Zheng, Z.3
Koike, T.4
Toba, K.5
Liu, A.6
Furukawa, T.7
Aoki, S.8
Aizawa, Y.9
-
12
-
-
0035892131
-
Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein
-
Clark R.E., Dodi I.A., Hill S.C., Lill J.R., Aubert G., Macintyre A.R., Rojas J., Bourdon A., Bonner P.L., Wang L., et al. Direct evidence that leukemic cells present HLA-associated immunogenic peptides derived from the BCR-ABL b3a2 fusion protein. Blood 98 (2001) 2887-2893
-
(2001)
Blood
, vol.98
, pp. 2887-2893
-
-
Clark, R.E.1
Dodi, I.A.2
Hill, S.C.3
Lill, J.R.4
Aubert, G.5
Macintyre, A.R.6
Rojas, J.7
Bourdon, A.8
Bonner, P.L.9
Wang, L.10
-
13
-
-
1842526868
-
BCR-ABL-specific T cells can be detected in healthy donors and in chronic myeloid leukemia patients following allogeneic stem cell transplantation
-
Butt N.M., Wang L., Abu-Eisha H.M., Christmas S.E., and Clark R.E. BCR-ABL-specific T cells can be detected in healthy donors and in chronic myeloid leukemia patients following allogeneic stem cell transplantation. Blood 103 (2004) 3245
-
(2004)
Blood
, vol.103
, pp. 3245
-
-
Butt, N.M.1
Wang, L.2
Abu-Eisha, H.M.3
Christmas, S.E.4
Clark, R.E.5
-
14
-
-
2042470794
-
T cell recognition of bcr/abl in healthy donors and in patients with chronic myeloid leukaemia
-
Westermann J., Schlimper C., Richter G., Mohm J., Dorken B., and Pezzutto A. T cell recognition of bcr/abl in healthy donors and in patients with chronic myeloid leukaemia. Br J Haematol 125 (2004) 213-216
-
(2004)
Br J Haematol
, vol.125
, pp. 213-216
-
-
Westermann, J.1
Schlimper, C.2
Richter, G.3
Mohm, J.4
Dorken, B.5
Pezzutto, A.6
-
16
-
-
4644310651
-
Proteosomal degradation of BCR/ABL protein can generate an HLA-A*0301-restricted peptide, but high-avidity T cells recognizing this leukemia-specific antigen were not demonstrated
-
The authors show that, in contrast to Clark et al. [12], BCR-ABL peptide could not be detected from the surface of HLA-A*0301-transduced K562 cells. In addition, high-avidity BCR-ABL-specific T cells could not be isolated from antigen-primed healthy donors or CML patients in remission following DLI. The binding of BCR-ABL-specific T cells to the tetramer complexes was completely abrogated by anti-CD8 antibodies, which questions the T-cell epitope specific binding of these tetramer-positive cells.
-
Posthuma E.F., van Bergen C.A., Kester M.G., de Paus R.A., van Veelen P.A., de Ru A.H., Drijfhout J.W., Lurvink E.G., Willemze R., and Falkenburg J.H. Proteosomal degradation of BCR/ABL protein can generate an HLA-A*0301-restricted peptide, but high-avidity T cells recognizing this leukemia-specific antigen were not demonstrated. Haematologica 89 (2004) 1062-1071. The authors show that, in contrast to Clark et al. [12], BCR-ABL peptide could not be detected from the surface of HLA-A*0301-transduced K562 cells. In addition, high-avidity BCR-ABL-specific T cells could not be isolated from antigen-primed healthy donors or CML patients in remission following DLI. The binding of BCR-ABL-specific T cells to the tetramer complexes was completely abrogated by anti-CD8 antibodies, which questions the T-cell epitope specific binding of these tetramer-positive cells.
-
(2004)
Haematologica
, vol.89
, pp. 1062-1071
-
-
Posthuma, E.F.1
van Bergen, C.A.2
Kester, M.G.3
de Paus, R.A.4
van Veelen, P.A.5
de Ru, A.H.6
Drijfhout, J.W.7
Lurvink, E.G.8
Willemze, R.9
Falkenburg, J.H.10
-
17
-
-
27144520232
-
Synthetic peptide analogs derived from bcr/abl fusion proteins and the induction of heteroclitic human T-cell responses
-
Pinilla-Ibarz J., Korontsvit T., Zakhaleva V., Roberts W., and Scheinberg D.A. Synthetic peptide analogs derived from bcr/abl fusion proteins and the induction of heteroclitic human T-cell responses. Haematologica 90 (2005) 1324-1332
-
(2005)
Haematologica
, vol.90
, pp. 1324-1332
-
-
Pinilla-Ibarz, J.1
Korontsvit, T.2
Zakhaleva, V.3
Roberts, W.4
Scheinberg, D.A.5
-
18
-
-
0037097736
-
Induction of granulocytic differentiation by 2 pathways
-
Zhang P., Nelson E., Radomska H.S., Iwasaki-Arai J., Akashi K., Friedman A.D., and Tenen D.G. Induction of granulocytic differentiation by 2 pathways. Blood 99 (2002) 4406-4412
-
(2002)
Blood
, vol.99
, pp. 4406-4412
-
-
Zhang, P.1
Nelson, E.2
Radomska, H.S.3
Iwasaki-Arai, J.4
Akashi, K.5
Friedman, A.D.6
Tenen, D.G.7
-
19
-
-
33644845212
-
Neutrophil granule proteins as targets of leukemia-specific immune responses
-
This is a complete review on the nature and biology of proteinase 3 and neutrophil elastase as leukemia-specific immune responses.
-
Barrett J., and Rezvani K. Neutrophil granule proteins as targets of leukemia-specific immune responses. Curr Opin Hematol 13 (2006) 15-20. This is a complete review on the nature and biology of proteinase 3 and neutrophil elastase as leukemia-specific immune responses.
-
(2006)
Curr Opin Hematol
, vol.13
, pp. 15-20
-
-
Barrett, J.1
Rezvani, K.2
-
20
-
-
0024817730
-
Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells
-
Bories D., Raynal M.C., Solomon D.H., Darzynkiewicz Z., and Cayre Y.E. Down-regulation of a serine protease, myeloblastin, causes growth arrest and differentiation of promyelocytic leukemia cells. Cell 59 (1989) 959-968
-
(1989)
Cell
, vol.59
, pp. 959-968
-
-
Bories, D.1
Raynal, M.C.2
Solomon, D.H.3
Darzynkiewicz, Z.4
Cayre, Y.E.5
-
21
-
-
0029838112
-
Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells
-
Molldrem J., Dermime S., Parker K., Jiang Y.Z., Mavroudis D., Hensel N., Fukushima P., and Barrett A.J. Targeted T-cell therapy for human leukemia: cytotoxic T lymphocytes specific for a peptide derived from proteinase 3 preferentially lyse human myeloid leukemia cells. Blood 88 (1996) 2450-2457
-
(1996)
Blood
, vol.88
, pp. 2450-2457
-
-
Molldrem, J.1
Dermime, S.2
Parker, K.3
Jiang, Y.Z.4
Mavroudis, D.5
Hensel, N.6
Fukushima, P.7
Barrett, A.J.8
-
22
-
-
0030841573
-
Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units
-
Molldrem J.J., Clave E., Jiang Y.Z., Mavroudis D., Raptis A., Hensel N., Agarwala V., and Barrett A.J. Cytotoxic T lymphocytes specific for a nonpolymorphic proteinase 3 peptide preferentially inhibit chronic myeloid leukemia colony-forming units. Blood 90 (1997) 2529-2534
-
(1997)
Blood
, vol.90
, pp. 2529-2534
-
-
Molldrem, J.J.1
Clave, E.2
Jiang, Y.Z.3
Mavroudis, D.4
Raptis, A.5
Hensel, N.6
Agarwala, V.7
Barrett, A.J.8
-
23
-
-
0033152972
-
A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia
-
Molldrem J.J., Lee P.P., Wang C., Champlin R.E., and Davis M.M. A PR1-human leukocyte antigen-A2 tetramer can be used to isolate low-frequency cytotoxic T lymphocytes from healthy donors that selectively lyse chronic myelogenous leukemia. Cancer Res 59 (1999) 2675-2681
-
(1999)
Cancer Res
, vol.59
, pp. 2675-2681
-
-
Molldrem, J.J.1
Lee, P.P.2
Wang, C.3
Champlin, R.E.4
Davis, M.M.5
-
24
-
-
0033826799
-
Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia
-
Molldrem J.J., Lee P.P., Wang C., Felio K., Kantarjian H.M., Champlin R.E., and Davis M.M. Evidence that specific T lymphocytes may participate in the elimination of chronic myelogenous leukemia. Nat Med 6 (2000) 1018-1023
-
(2000)
Nat Med
, vol.6
, pp. 1018-1023
-
-
Molldrem, J.J.1
Lee, P.P.2
Wang, C.3
Felio, K.4
Kantarjian, H.M.5
Champlin, R.E.6
Davis, M.M.7
-
25
-
-
0037370364
-
Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells
-
Molldrem J.J., Lee P.P., Kant S., Wieder E., Jiang W., Lu S., Wang C., and Davis M.M. Chronic myelogenous leukemia shapes host immunity by selective deletion of high-avidity leukemia-specific T cells. J Clin Invest 111 (2003) 639-647
-
(2003)
J Clin Invest
, vol.111
, pp. 639-647
-
-
Molldrem, J.J.1
Lee, P.P.2
Kant, S.3
Wieder, E.4
Jiang, W.5
Lu, S.6
Wang, C.7
Davis, M.M.8
-
26
-
-
20444378186
-
Ex vivo characterization of multiepitopic tumor-specific CD8 T cells in patients with chronic myeloid leukemia: implications for vaccine development and adoptive cellular immunotherapy
-
CML patients develop natural immunity to several leukemia-associated antigens. WT1, hTERT, PR1 and extrajunction BCR-specific T cells were detected in 60 to 85% of patients. These CTLs were shown to be quiescent unless appropriately stimulated. In addition, PR1, hTERT and BCR74 peptides, but not WT1 peptide, were detected from the surface of patient leukemia cells and by mass spectrometry analysis.
-
Gannage M., Abel M., Michallet A.S., Delluc S., Lambert M., Giraudier S., Kratzer R., Niedermann G., Saveanu L., Guilhot F., et al. Ex vivo characterization of multiepitopic tumor-specific CD8 T cells in patients with chronic myeloid leukemia: implications for vaccine development and adoptive cellular immunotherapy. J Immunol 174 (2005) 8210-8218. CML patients develop natural immunity to several leukemia-associated antigens. WT1, hTERT, PR1 and extrajunction BCR-specific T cells were detected in 60 to 85% of patients. These CTLs were shown to be quiescent unless appropriately stimulated. In addition, PR1, hTERT and BCR74 peptides, but not WT1 peptide, were detected from the surface of patient leukemia cells and by mass spectrometry analysis.
-
(2005)
J Immunol
, vol.174
, pp. 8210-8218
-
-
Gannage, M.1
Abel, M.2
Michallet, A.S.3
Delluc, S.4
Lambert, M.5
Giraudier, S.6
Kratzer, R.7
Niedermann, G.8
Saveanu, L.9
Guilhot, F.10
-
27
-
-
0032522925
-
Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells
-
Inoue K., Tamaki H., Ogawa H., Oka Y., Soma T., Tatekawa T., Oji Y., Tsuboi A., Kim E.H., Kawakami M., et al. Wilms' tumor gene (WT1) competes with differentiation-inducing signal in hematopoietic progenitor cells. Blood 91 (1998) 2969-2976
-
(1998)
Blood
, vol.91
, pp. 2969-2976
-
-
Inoue, K.1
Tamaki, H.2
Ogawa, H.3
Oka, Y.4
Soma, T.5
Tatekawa, T.6
Oji, Y.7
Tsuboi, A.8
Kim, E.H.9
Kawakami, M.10
-
28
-
-
0037111734
-
Two distinct HLA-A0201-presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL
-
Bellantuono I., Gao L., Parry S., Marley S., Dazzi F., Apperley J., Goldman J.M., and Stauss H.J. Two distinct HLA-A0201-presented epitopes of the Wilms tumor antigen 1 can function as targets for leukemia-reactive CTL. Blood 100 (2002) 3835-3837
-
(2002)
Blood
, vol.100
, pp. 3835-3837
-
-
Bellantuono, I.1
Gao, L.2
Parry, S.3
Marley, S.4
Dazzi, F.5
Apperley, J.6
Goldman, J.M.7
Stauss, H.J.8
-
29
-
-
0035577861
-
Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals
-
Vonderheide R.H., Schultze J.L., Anderson K.S., Maecker B., Butler M.O., Xia Z., Kuroda M.J., von Bergwelt-Baildon M.S., Bedor M.M., Hoar K.M., et al. Equivalent induction of telomerase-specific cytotoxic T lymphocytes from tumor-bearing patients and healthy individuals. Cancer Res 61 (2001) 8366-8370
-
(2001)
Cancer Res
, vol.61
, pp. 8366-8370
-
-
Vonderheide, R.H.1
Schultze, J.L.2
Anderson, K.S.3
Maecker, B.4
Butler, M.O.5
Xia, Z.6
Kuroda, M.J.7
von Bergwelt-Baildon, M.S.8
Bedor, M.M.9
Hoar, K.M.10
-
30
-
-
0035881885
-
Spontaneous cytotoxic T-cell responses against survivin-derived MHC class I-restricted T-cell epitopes in situ as well as ex vivo in cancer patients
-
Andersen M.H., Pedersen L.O., Capeller B., Brocker E.B., Becker J.C., and thor Straten P. Spontaneous cytotoxic T-cell responses against survivin-derived MHC class I-restricted T-cell epitopes in situ as well as ex vivo in cancer patients. Cancer Res 61 (2001) 5964-5968
-
(2001)
Cancer Res
, vol.61
, pp. 5964-5968
-
-
Andersen, M.H.1
Pedersen, L.O.2
Capeller, B.3
Brocker, E.B.4
Becker, J.C.5
thor Straten, P.6
-
31
-
-
0037818503
-
Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells
-
Schmidt S.M., Schag K., Muller M.R., Weck M.M., Appel S., Kanz L., Grunebach F., and Brossart P. Survivin is a shared tumor-associated antigen expressed in a broad variety of malignancies and recognized by specific cytotoxic T cells. Blood 102 (2003) 571-576
-
(2003)
Blood
, vol.102
, pp. 571-576
-
-
Schmidt, S.M.1
Schag, K.2
Muller, M.R.3
Weck, M.M.4
Appel, S.5
Kanz, L.6
Grunebach, F.7
Brossart, P.8
-
32
-
-
0031671357
-
Polymorphism in CD33 and CD34 genes: a source of minor histocompatibility antigens on haemopoietic progenitor cells?
-
Raptis A., Clave E., Mavroudis D., Molldrem J., Van Rhee F., and Barrett A.J. Polymorphism in CD33 and CD34 genes: a source of minor histocompatibility antigens on haemopoietic progenitor cells?. Br J Haematol 102 (1998) 1354-1358
-
(1998)
Br J Haematol
, vol.102
, pp. 1354-1358
-
-
Raptis, A.1
Clave, E.2
Mavroudis, D.3
Molldrem, J.4
Van Rhee, F.5
Barrett, A.J.6
-
33
-
-
0037305594
-
Allorestricted cytotoxic T cells specific for human CD45 show potent antileukemic activity
-
Amrolia P.J., Reid S.D., Gao L., Schultheis B., Dotti G., Brenner M.K., Melo J.V., Goldman J.M., and Stauss H.J. Allorestricted cytotoxic T cells specific for human CD45 show potent antileukemic activity. Blood 101 (2003) 1007-1014
-
(2003)
Blood
, vol.101
, pp. 1007-1014
-
-
Amrolia, P.J.1
Reid, S.D.2
Gao, L.3
Schultheis, B.4
Dotti, G.5
Brenner, M.K.6
Melo, J.V.7
Goldman, J.M.8
Stauss, H.J.9
-
34
-
-
0037105370
-
CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia
-
Scheibenbogen C., Letsch A., Thiel E., Schmittel A., Mailaender V., Baerwolf S., Nagorsen D., and Keilholz U. CD8 T-cell responses to Wilms tumor gene product WT1 and proteinase 3 in patients with acute myeloid leukemia. Blood 100 (2002) 2132-2137
-
(2002)
Blood
, vol.100
, pp. 2132-2137
-
-
Scheibenbogen, C.1
Letsch, A.2
Thiel, E.3
Schmittel, A.4
Mailaender, V.5
Baerwolf, S.6
Nagorsen, D.7
Keilholz, U.8
-
35
-
-
0141889279
-
+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation
-
+ T cells exist in healthy individuals and in patients with chronic myelogenous leukemia before and after stem cell transplantation. Blood 102 (2003) 2892-2900
-
(2003)
Blood
, vol.102
, pp. 2892-2900
-
-
Rezvani, K.1
Grube, M.2
Brenchley, J.M.3
Sconocchia, G.4
Fujiwara, H.5
Price, D.A.6
Gostick, E.7
Yamada, K.8
Melenhorst, J.9
Childs, R.10
-
36
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29344436442
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T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization
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Rezvani K., Brenchley J.M., Price D.A., Kilical Y., Gostick E., Sewell A.K., Li J., Mielke S., Douek D.C., and Barrett A.J. T-cell responses directed against multiple HLA-A*0201-restricted epitopes derived from Wilms' tumor 1 protein in patients with leukemia and healthy donors: identification, quantification, and characterization. Clin Cancer Res 11 (2005) 8799-8807
-
(2005)
Clin Cancer Res
, vol.11
, pp. 8799-8807
-
-
Rezvani, K.1
Brenchley, J.M.2
Price, D.A.3
Kilical, Y.4
Gostick, E.5
Sewell, A.K.6
Li, J.7
Mielke, S.8
Douek, D.C.9
Barrett, A.J.10
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37
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0034161533
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Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses
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Pinilla-Ibarz J., Cathcart K., Korontsvit T., Soignet S., Bocchia M., Caggiano J., Lai L., Jimenez J., Kolitz J., and Scheinberg D.A. Vaccination of patients with chronic myelogenous leukemia with bcr-abl oncogene breakpoint fusion peptides generates specific immune responses. Blood 95 (2000) 1781-1787
-
(2000)
Blood
, vol.95
, pp. 1781-1787
-
-
Pinilla-Ibarz, J.1
Cathcart, K.2
Korontsvit, T.3
Soignet, S.4
Bocchia, M.5
Caggiano, J.6
Lai, L.7
Jimenez, J.8
Kolitz, J.9
Scheinberg, D.A.10
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38
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1642500316
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A multivalent bcr-abl fusion peptide vaccination trial in patients with chronic myeloid leukemia
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Cathcart K., Pinilla-Ibarz J., Korontsvit T., Schwartz J., Zakhaleva V., Papadopoulos E.B., and Scheinberg D.A. A multivalent bcr-abl fusion peptide vaccination trial in patients with chronic myeloid leukemia. Blood 103 (2004) 1037-1042
-
(2004)
Blood
, vol.103
, pp. 1037-1042
-
-
Cathcart, K.1
Pinilla-Ibarz, J.2
Korontsvit, T.3
Schwartz, J.4
Zakhaleva, V.5
Papadopoulos, E.B.6
Scheinberg, D.A.7
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39
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13844312036
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Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial
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This paper shows the potential additive effect of molecular-targeted therapies and immunotherapy in CML patients. The vaccination with BCR-ABL peptides appeared to further improve patient clinical responses following imatinib or interferon-α treatments.
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Bocchia M., Gentili S., Abruzzese E., Fanelli A., Iuliano F., Tabilio A., Amabile M., Forconi F., Gozzetti A., Raspadori D., et al. Effect of a p210 multipeptide vaccine associated with imatinib or interferon in patients with chronic myeloid leukaemia and persistent residual disease: a multicentre observational trial. Lancet 365 (2005) 657-662. This paper shows the potential additive effect of molecular-targeted therapies and immunotherapy in CML patients. The vaccination with BCR-ABL peptides appeared to further improve patient clinical responses following imatinib or interferon-α treatments.
-
(2005)
Lancet
, vol.365
, pp. 657-662
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-
Bocchia, M.1
Gentili, S.2
Abruzzese, E.3
Fanelli, A.4
Iuliano, F.5
Tabilio, A.6
Amabile, M.7
Forconi, F.8
Gozzetti, A.9
Raspadori, D.10
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40
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29844437061
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Vaccination with the PR1 leukemia-associated antigen can induce complete remission in patients with myeloid leukemia
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(Abstract 259). Preliminary results of PR1-peptide vaccination of leukemia patients presented at the American Society of Hematology meeting available in abstract form.
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Qazilbash M.H., Wieder E., Rios R., Sijie L., Kant S., Giralt S., Estey E.H., Thall P., de Lima M., Couriel D., et al. Vaccination with the PR1 leukemia-associated antigen can induce complete remission in patients with myeloid leukemia. Blood 104 (2004) (Abstract 259). Preliminary results of PR1-peptide vaccination of leukemia patients presented at the American Society of Hematology meeting available in abstract form.
-
(2004)
Blood
, vol.104
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Qazilbash, M.H.1
Wieder, E.2
Rios, R.3
Sijie, L.4
Kant, S.5
Giralt, S.6
Estey, E.H.7
Thall, P.8
de Lima, M.9
Couriel, D.10
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41
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4644289323
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Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression
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These are the first reported clinical results of WT1 peptide vaccination in leukemia patients. AML, MDS but also breast and lung cancer patients were vaccinated with the HLA-A*2402-restricted native or altered WT1 peptide ligand and Montanide ISA51 adjuvant every two weeks. Although the authors ascribe alterations in percentage of blasts to clinical responses, all patients were in remission before vaccination. Therefore, it was not possible to link clinical response to measured immune responses.
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Oka Y., Tsuboi A., Taguchi T., Osaki T., Kyo T., Nakajima H., Elisseeva O.A., Oji Y., Kawakami M., Ikegame K., et al. Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression. Proc Natl Acad Sci USA 101 (2004) 13885-13890. These are the first reported clinical results of WT1 peptide vaccination in leukemia patients. AML, MDS but also breast and lung cancer patients were vaccinated with the HLA-A*2402-restricted native or altered WT1 peptide ligand and Montanide ISA51 adjuvant every two weeks. Although the authors ascribe alterations in percentage of blasts to clinical responses, all patients were in remission before vaccination. Therefore, it was not possible to link clinical response to measured immune responses.
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(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 13885-13890
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Oka, Y.1
Tsuboi, A.2
Taguchi, T.3
Osaki, T.4
Kyo, T.5
Nakajima, H.6
Elisseeva, O.A.7
Oji, Y.8
Kawakami, M.9
Ikegame, K.10
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42
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0742324477
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Complete remission in a patient with recurrent acute myeloid leukemia induced by vaccination with WT1 peptide in the absence of hematological or renal toxicity
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Mailander V., Scheibenbogen C., Thiel E., Letsch A., Blau I.W., and Keilholz U. Complete remission in a patient with recurrent acute myeloid leukemia induced by vaccination with WT1 peptide in the absence of hematological or renal toxicity. Leukemia 18 (2004) 165-166
-
(2004)
Leukemia
, vol.18
, pp. 165-166
-
-
Mailander, V.1
Scheibenbogen, C.2
Thiel, E.3
Letsch, A.4
Blau, I.W.5
Keilholz, U.6
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43
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3242690518
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Immunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase
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Parkhurst M.R., Riley J.P., Igarashi T., Li Y., Robbins P.F., and Rosenberg S.A. Immunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase. Clin Cancer Res 10 (2004) 4688-4698
-
(2004)
Clin Cancer Res
, vol.10
, pp. 4688-4698
-
-
Parkhurst, M.R.1
Riley, J.P.2
Igarashi, T.3
Li, Y.4
Robbins, P.F.5
Rosenberg, S.A.6
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44
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20444448873
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Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia
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This paper reports the results of HSP70 peptide complex vaccine trial in CML patients that had not yet achieved a major cytogenetic response after six months of imatinib mesylate treatment. Following eight weekly intradermal injections of 50 μg autologous purified HSP70 peptide complex, nine out of sixteen patients assessed had an increased frequency of CML-specific interferon-γ-producing T cells and NK cells in the peripheral blood and these immunological responses were, in most cases, correlated with clinical responses. However, patients continued to receive imatinib mesylate and, thus, it is not clear whether HSP70 peptide complex has contributed to the overall clinical responses.
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Li Z., Qiao Y., Liu B., Laska E.J., Chakravarthi P., Kulko J.M., Bona R.D., Fang M., Hegde U., Moyo V., et al. Combination of imatinib mesylate with autologous leukocyte-derived heat shock protein and chronic myelogenous leukemia. Clin Cancer Res 11 (2005) 4460-4468. This paper reports the results of HSP70 peptide complex vaccine trial in CML patients that had not yet achieved a major cytogenetic response after six months of imatinib mesylate treatment. Following eight weekly intradermal injections of 50 μg autologous purified HSP70 peptide complex, nine out of sixteen patients assessed had an increased frequency of CML-specific interferon-γ-producing T cells and NK cells in the peripheral blood and these immunological responses were, in most cases, correlated with clinical responses. However, patients continued to receive imatinib mesylate and, thus, it is not clear whether HSP70 peptide complex has contributed to the overall clinical responses.
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(2005)
Clin Cancer Res
, vol.11
, pp. 4460-4468
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Li, Z.1
Qiao, Y.2
Liu, B.3
Laska, E.J.4
Chakravarthi, P.5
Kulko, J.M.6
Bona, R.D.7
Fang, M.8
Hegde, U.9
Moyo, V.10
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45
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14644390867
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+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909
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This article presents the first human trial of CpG oligodeoxynucleotide 7909 combined with Melan-A peptide and incomplete Freund's adjuvant vaccination. Eight melanoma patients received four monthly vaccinations and showed no major side effects. The vaccination induced a rapid activation of effector memory Melan-A T cells, which were estimated to be at least one order of magnitude higher than reported in the previous vaccine trials. These CTLs specifically recognized and killed melanoma tumor cells. The observed immune responses were not correlated with clinical responses, but the authors notified that the follow-up time was probably too short (∼7 months).
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+ T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909. J Clin Invest 115 (2005) 739-746. This article presents the first human trial of CpG oligodeoxynucleotide 7909 combined with Melan-A peptide and incomplete Freund's adjuvant vaccination. Eight melanoma patients received four monthly vaccinations and showed no major side effects. The vaccination induced a rapid activation of effector memory Melan-A T cells, which were estimated to be at least one order of magnitude higher than reported in the previous vaccine trials. These CTLs specifically recognized and killed melanoma tumor cells. The observed immune responses were not correlated with clinical responses, but the authors notified that the follow-up time was probably too short (∼7 months).
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(2005)
J Clin Invest
, vol.115
, pp. 739-746
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Speiser, D.E.1
Lienard, D.2
Rufer, N.3
Rubio-Godoy, V.4
Rimoldi, D.5
Lejeune, F.6
Krieg, A.M.7
Cerottini, J.C.8
Romero, P.9
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46
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0038153907
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Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma
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Phan G.Q., Yang J.C., Sherry R.M., Hwu P., Topalian S.L., Schwartzentruber D.J., Restifo N.P., Haworth L.R., Seipp C.A., Freezer L.J., et al. Cancer regression and autoimmunity induced by cytotoxic T lymphocyte-associated antigen 4 blockade in patients with metastatic melanoma. Proc Natl Acad Sci USA 100 (2003) 8372-8377
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 8372-8377
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Phan, G.Q.1
Yang, J.C.2
Sherry, R.M.3
Hwu, P.4
Topalian, S.L.5
Schwartzentruber, D.J.6
Restifo, N.P.7
Haworth, L.R.8
Seipp, C.A.9
Freezer, L.J.10
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47
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24944459890
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Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
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The authors reported the clinical results of 56 patients with progressive stage IV melanoma who received two modified gp100-melanoma-associated peptide in conjunction with human anti-CTLA-4 antibody. There was a strong correlation between the clinical responses and the induction of autoimmunity in patients.
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Attia P., Phan G.Q., Maker A.V., Robinson M.R., Quezado M.M., Yang J.C., Sherry R.M., Topalian S.L., Kammula U.S., Royal R.E., et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol 23 (2005) 6043-6053. The authors reported the clinical results of 56 patients with progressive stage IV melanoma who received two modified gp100-melanoma-associated peptide in conjunction with human anti-CTLA-4 antibody. There was a strong correlation between the clinical responses and the induction of autoimmunity in patients.
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(2005)
J Clin Oncol
, vol.23
, pp. 6043-6053
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Attia, P.1
Phan, G.Q.2
Maker, A.V.3
Robinson, M.R.4
Quezado, M.M.5
Yang, J.C.6
Sherry, R.M.7
Topalian, S.L.8
Kammula, U.S.9
Royal, R.E.10
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48
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28244492012
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Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade
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- effector T cells.
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- effector T cells.
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(2005)
J Immunol
, vol.175
, pp. 7746-7754
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Maker, A.V.1
Attia, P.2
Rosenberg, S.A.3
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49
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30144444279
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Enhancement of vaccine-mediated antitumor immunity in cancer patients after depletion of regulatory T cells
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389 was infused before and omitted during the T cell priming phase.
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389 was infused before and omitted during the T cell priming phase.
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(2005)
J Clin Invest
, vol.115
, pp. 3623-3633
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Dannull, J.1
Su, Z.2
Rizzieri, D.3
Yang, B.K.4
Coleman, D.5
Yancey, D.6
Zhang, A.7
Dahm, P.8
Chao, N.9
Gilboa, E.10
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