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Volumn 18, Issue 5, 2006, Pages 599-604

Immunotherapeutic peptide vaccination with leukemia-associated antigens

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; BCR ABL PROTEIN; FREUND ADJUVANT; GRANULOCYTE MACROPHAGE COLONY STIMULATING FACTOR; IMATINIB; LEUKEMIA ANTIGEN; PEPTIDE B2A2; PEPTIDE B3A2; PEPTIDE DERIVATIVE; QS 21; UNCLASSIFIED DRUG; VACCINE; VALYLLEUCYLGLUTAMINYLGLUTAMYLLEUCYLASPARAGINYLVALYLTHREONYLVALINE; WILM TUMOR ANTIGEN;

EID: 33748155666     PISSN: 09527915     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.coi.2006.07.005     Document Type: Review
Times cited : (26)

References (49)
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    • Induction of WT1 (Wilms' tumor gene)-specific cytotoxic T lymphocytes by WT1 peptide vaccine and the resultant cancer regression
    • These are the first reported clinical results of WT1 peptide vaccination in leukemia patients. AML, MDS but also breast and lung cancer patients were vaccinated with the HLA-A*2402-restricted native or altered WT1 peptide ligand and Montanide ISA51 adjuvant every two weeks. Although the authors ascribe alterations in percentage of blasts to clinical responses, all patients were in remission before vaccination. Therefore, it was not possible to link clinical response to measured immune responses.
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    • Immunization of patients with the hTERT:540-548 peptide induces peptide-reactive T lymphocytes that do not recognize tumors endogenously expressing telomerase
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    • This paper reports the results of HSP70 peptide complex vaccine trial in CML patients that had not yet achieved a major cytogenetic response after six months of imatinib mesylate treatment. Following eight weekly intradermal injections of 50 μg autologous purified HSP70 peptide complex, nine out of sixteen patients assessed had an increased frequency of CML-specific interferon-γ-producing T cells and NK cells in the peripheral blood and these immunological responses were, in most cases, correlated with clinical responses. However, patients continued to receive imatinib mesylate and, thus, it is not clear whether HSP70 peptide complex has contributed to the overall clinical responses.
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    • Li, Z.1    Qiao, Y.2    Liu, B.3    Laska, E.J.4    Chakravarthi, P.5    Kulko, J.M.6    Bona, R.D.7    Fang, M.8    Hegde, U.9    Moyo, V.10
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    • 14644390867 scopus 로고    scopus 로고
    • + T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909
    • This article presents the first human trial of CpG oligodeoxynucleotide 7909 combined with Melan-A peptide and incomplete Freund's adjuvant vaccination. Eight melanoma patients received four monthly vaccinations and showed no major side effects. The vaccination induced a rapid activation of effector memory Melan-A T cells, which were estimated to be at least one order of magnitude higher than reported in the previous vaccine trials. These CTLs specifically recognized and killed melanoma tumor cells. The observed immune responses were not correlated with clinical responses, but the authors notified that the follow-up time was probably too short (∼7 months).
    • + T cell responses to vaccination with peptide, IFA, and CpG oligodeoxynucleotide 7909. J Clin Invest 115 (2005) 739-746. This article presents the first human trial of CpG oligodeoxynucleotide 7909 combined with Melan-A peptide and incomplete Freund's adjuvant vaccination. Eight melanoma patients received four monthly vaccinations and showed no major side effects. The vaccination induced a rapid activation of effector memory Melan-A T cells, which were estimated to be at least one order of magnitude higher than reported in the previous vaccine trials. These CTLs specifically recognized and killed melanoma tumor cells. The observed immune responses were not correlated with clinical responses, but the authors notified that the follow-up time was probably too short (∼7 months).
    • (2005) J Clin Invest , vol.115 , pp. 739-746
    • Speiser, D.E.1    Lienard, D.2    Rufer, N.3    Rubio-Godoy, V.4    Rimoldi, D.5    Lejeune, F.6    Krieg, A.M.7    Cerottini, J.C.8    Romero, P.9
  • 47
    • 24944459890 scopus 로고    scopus 로고
    • Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4
    • The authors reported the clinical results of 56 patients with progressive stage IV melanoma who received two modified gp100-melanoma-associated peptide in conjunction with human anti-CTLA-4 antibody. There was a strong correlation between the clinical responses and the induction of autoimmunity in patients.
    • Attia P., Phan G.Q., Maker A.V., Robinson M.R., Quezado M.M., Yang J.C., Sherry R.M., Topalian S.L., Kammula U.S., Royal R.E., et al. Autoimmunity correlates with tumor regression in patients with metastatic melanoma treated with anti-cytotoxic T-lymphocyte antigen-4. J Clin Oncol 23 (2005) 6043-6053. The authors reported the clinical results of 56 patients with progressive stage IV melanoma who received two modified gp100-melanoma-associated peptide in conjunction with human anti-CTLA-4 antibody. There was a strong correlation between the clinical responses and the induction of autoimmunity in patients.
    • (2005) J Clin Oncol , vol.23 , pp. 6043-6053
    • Attia, P.1    Phan, G.Q.2    Maker, A.V.3    Robinson, M.R.4    Quezado, M.M.5    Yang, J.C.6    Sherry, R.M.7    Topalian, S.L.8    Kammula, U.S.9    Royal, R.E.10
  • 48
    • 28244492012 scopus 로고    scopus 로고
    • Analysis of the cellular mechanism of antitumor responses and autoimmunity in patients treated with CTLA-4 blockade
    • - effector T cells.
    • - effector T cells.
    • (2005) J Immunol , vol.175 , pp. 7746-7754
    • Maker, A.V.1    Attia, P.2    Rosenberg, S.A.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.