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Volumn 362, Issue 4, 2006, Pages 664-681

Expression of Distinct Classes of Titin Isoforms in Striated and Smooth Muscles by Alternative Splicing, and Their Conserved Interaction with Filamins

Author keywords

differential splicing; filamins; smooth and striated muscle; titin; Z disks and dense bodies

Indexed keywords

ALPHA ACTININ; ALPHA ACTININ 1; ALPHA ACTININ 2; ALPHA ACTININ 3; ANTIBODY; CONNECTIN; FILAMIN; FILAMIN A; FILAMIN C; ISOPROTEIN; MESSENGER RNA; UNCLASSIFIED DRUG;

EID: 33748079591     PISSN: 00222836     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jmb.2006.07.077     Document Type: Article
Times cited : (78)

References (46)
  • 2
    • 1242342244 scopus 로고    scopus 로고
    • The giant protein titin: a major player in myocardial mechanics, signaling, and disease
    • Granzier H.L., and Labeit S. The giant protein titin: a major player in myocardial mechanics, signaling, and disease. Circulat. Res. 94 (2004) 284-295
    • (2004) Circulat. Res. , vol.94 , pp. 284-295
    • Granzier, H.L.1    Labeit, S.2
  • 4
    • 0026730042 scopus 로고
    • Identification and characterization of two huge protein components of the brush border cytoskeleton: evidence for a cellular isoform of titin
    • Eilertsen K.J., and Keller III T.C. Identification and characterization of two huge protein components of the brush border cytoskeleton: evidence for a cellular isoform of titin. J. Cell Biol. 119 (1992) 549-557
    • (1992) J. Cell Biol. , vol.119 , pp. 549-557
    • Eilertsen, K.J.1    Keller III, T.C.2
  • 5
    • 0024440423 scopus 로고
    • Visualization of the polarity of isolated titin molecules: a single globular head on a long thin rod as the M band anchoring domain?
    • Nave R., Furst D.O., and Weber K. Visualization of the polarity of isolated titin molecules: a single globular head on a long thin rod as the M band anchoring domain?. J. Cell Biol. 109 (1989) 2177-2187
    • (1989) J. Cell Biol. , vol.109 , pp. 2177-2187
    • Nave, R.1    Furst, D.O.2    Weber, K.3
  • 6
    • 0027956823 scopus 로고
    • Cellular titin localization in stress fibers and interaction with myosin II filaments in vitro
    • Eilertsen K.J., Kazmierski S.T., and Keller III T.C. Cellular titin localization in stress fibers and interaction with myosin II filaments in vitro. J. Cell Biol. 126 (1994) 1201-1210
    • (1994) J. Cell Biol. , vol.126 , pp. 1201-1210
    • Eilertsen, K.J.1    Kazmierski, S.T.2    Keller III, T.C.3
  • 8
    • 0037033791 scopus 로고    scopus 로고
    • Smitin, a novel smooth muscle titin-like protein, interacts with myosin filaments in vivo and in vitro
    • Kim K., and Keller III T.C. Smitin, a novel smooth muscle titin-like protein, interacts with myosin filaments in vivo and in vitro. J. Cell Biol. 156 (2002) 101-111
    • (2002) J. Cell Biol. , vol.156 , pp. 101-111
    • Kim, K.1    Keller III, T.C.2
  • 10
    • 0022380542 scopus 로고
    • Zeugmatin: a new high molecular weight protein associated with Z lines in adult and early embryonic striated muscle
    • Maher P.A., Cox G.F., and Singer S.J. Zeugmatin: a new high molecular weight protein associated with Z lines in adult and early embryonic striated muscle. J. Cell Biol. 101 (1985) 1871-1883
    • (1985) J. Cell Biol. , vol.101 , pp. 1871-1883
    • Maher, P.A.1    Cox, G.F.2    Singer, S.J.3
  • 12
    • 0033988021 scopus 로고    scopus 로고
    • Targeting of cardiac muscle titin fragments to the Z-bands and dense bodies of living muscle and non-muscle cells
    • Ayoob J.C., Turnacioglu K.K., Mittal B., Sanger J.M., and Sanger J.W. Targeting of cardiac muscle titin fragments to the Z-bands and dense bodies of living muscle and non-muscle cells. Cell. Motil Cytoskel. 45 (2000) 67-82
    • (2000) Cell. Motil Cytoskel. , vol.45 , pp. 67-82
    • Ayoob, J.C.1    Turnacioglu, K.K.2    Mittal, B.3    Sanger, J.M.4    Sanger, J.W.5
  • 13
    • 0032550178 scopus 로고    scopus 로고
    • Human autoantibodies reveal titin as a chromosomal protein
    • Machado C., Sunkel C.E., and Andrew D.J. Human autoantibodies reveal titin as a chromosomal protein. J. Cell Biol. 141 (1998) 321-333
    • (1998) J. Cell Biol. , vol.141 , pp. 321-333
    • Machado, C.1    Sunkel, C.E.2    Andrew, D.J.3
  • 14
    • 0034735537 scopus 로고    scopus 로고
    • D-Titin: a giant protein with dual roles in chromosomes and muscles
    • Machado C., and Andrew D.J. D-Titin: a giant protein with dual roles in chromosomes and muscles. J. Cell Biol. 151 (2000) 639-652
    • (2000) J. Cell Biol. , vol.151 , pp. 639-652
    • Machado, C.1    Andrew, D.J.2
  • 15
    • 32244437071 scopus 로고    scopus 로고
    • Nuclear titin interacts with A- and B-type lamins in vitro and in vivo
    • Zastrow M.S., Flaherty D.B., Benian G.M., and Wilson K.L. Nuclear titin interacts with A- and B-type lamins in vitro and in vivo. J. Cell Sci. 119 (2006) 239-249
    • (2006) J. Cell Sci. , vol.119 , pp. 239-249
    • Zastrow, M.S.1    Flaherty, D.B.2    Benian, G.M.3    Wilson, K.L.4
  • 16
    • 1242281665 scopus 로고    scopus 로고
    • Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium
    • Lahmers S., Wu Y., Call D.R., Labeit S., and Granzier H. Developmental control of titin isoform expression and passive stiffness in fetal and neonatal myocardium. Circulat. Res. 94 (2004) 505-513
    • (2004) Circulat. Res. , vol.94 , pp. 505-513
    • Lahmers, S.1    Wu, Y.2    Call, D.R.3    Labeit, S.4    Granzier, H.5
  • 17
    • 20544438018 scopus 로고    scopus 로고
    • MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination
    • Witt S.H., Granzier H., Witt C.C., and Labeit S. MURF-1 and MURF-2 target a specific subset of myofibrillar proteins redundantly: towards understanding MURF-dependent muscle ubiquitination. J. Mol. Biol. 350 (2005) 713-722
    • (2005) J. Mol. Biol. , vol.350 , pp. 713-722
    • Witt, S.H.1    Granzier, H.2    Witt, C.C.3    Labeit, S.4
  • 18
    • 0035793703 scopus 로고    scopus 로고
    • Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain
    • Centner T., Yano J., Kimura E., McElhinny A.S., Pelin K., Witt C.C., et al. Identification of muscle specific ring finger proteins as potential regulators of the titin kinase domain. J. Mol. Biol. 306 (2001) 717-726
    • (2001) J. Mol. Biol. , vol.306 , pp. 717-726
    • Centner, T.1    Yano, J.2    Kimura, E.3    McElhinny, A.S.4    Pelin, K.5    Witt, C.C.6
  • 19
    • 0035941020 scopus 로고    scopus 로고
    • Identification of ubiquitin ligases required for skeletal muscle atrophy
    • Bodine S.C., Latres E., Baumhueter S., Lai V.K., Nunez L., Clarke B.A., et al. Identification of ubiquitin ligases required for skeletal muscle atrophy. Science 294 (2001) 1704-1708
    • (2001) Science , vol.294 , pp. 1704-1708
    • Bodine, S.C.1    Latres, E.2    Baumhueter, S.3    Lai, V.K.4    Nunez, L.5    Clarke, B.A.6
  • 21
    • 0034749302 scopus 로고    scopus 로고
    • Multiple antibodies to titin immunoreact with AHNAK and localize to the mitotic spindle machinery
    • Wernyj R.P., Ewing C.M., and Isaacs W.B. Multiple antibodies to titin immunoreact with AHNAK and localize to the mitotic spindle machinery. Cell Motil. Cytoskel. 50 (2001) 101-113
    • (2001) Cell Motil. Cytoskel. , vol.50 , pp. 101-113
    • Wernyj, R.P.1    Ewing, C.M.2    Isaacs, W.B.3
  • 22
    • 0035941407 scopus 로고    scopus 로고
    • The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system
    • Bang M.L., Centner T., Fornoff F., Geach A.J., Gotthardt M., McNabb M., et al. The complete gene sequence of titin, expression of an unusual approximately 700-kDa titin isoform, and its interaction with obscurin identify a novel Z-line to I-band linking system. Circulat. Res. 89 (2001) 1065-1072
    • (2001) Circulat. Res. , vol.89 , pp. 1065-1072
    • Bang, M.L.1    Centner, T.2    Fornoff, F.3    Geach, A.J.4    Gotthardt, M.5    McNabb, M.6
  • 23
    • 33748058496 scopus 로고    scopus 로고
    • Nebulin regulates thin filament length, contractility, and z-disk structure in vivo
    • in press. (PMID 16902413)
    • Witt C.C., Burkart C., Labeit D., McNabb M., Wu Y., Granzier H., et al. Nebulin regulates thin filament length, contractility, and z-disk structure in vivo. EMBO J. (2006) in press. (PMID 16902413)
    • (2006) EMBO J.
    • Witt, C.C.1    Burkart, C.2    Labeit, D.3    McNabb, M.4    Wu, Y.5    Granzier, H.6
  • 24
    • 24944550989 scopus 로고    scopus 로고
    • The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins
    • Gontier Y., Taivainen A., Fontao L., Sonnenberg A., van der Flier A., Carpen O., et al. The Z-disc proteins myotilin and FATZ-1 interact with each other and are connected to the sarcolemma via muscle-specific filamins. J. Cell Sci. 118 (2005) 3739-3749
    • (2005) J. Cell Sci. , vol.118 , pp. 3739-3749
    • Gontier, Y.1    Taivainen, A.2    Fontao, L.3    Sonnenberg, A.4    van der Flier, A.5    Carpen, O.6
  • 25
    • 0037148534 scopus 로고    scopus 로고
    • Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits
    • van der Flier A., Kuikman I., Kramer D., Geerts D., Kreft M., Takafuta T., et al. Different splice variants of filamin-B affect myogenesis, subcellular distribution, and determine binding to integrin [beta] subunits. J. Cell Biol. 156 (2002) 361-376
    • (2002) J. Cell Biol. , vol.156 , pp. 361-376
    • van der Flier, A.1    Kuikman, I.2    Kramer, D.3    Geerts, D.4    Kreft, M.5    Takafuta, T.6
  • 26
    • 0021239130 scopus 로고
    • Presence of connectin-like protein in white blood cells and platelets
    • Hashimoto K., Kamitani T., Wada Y., and Tatsumi N. Presence of connectin-like protein in white blood cells and platelets. Tohoku J. Expt. Med. 143 (1984) 59-70
    • (1984) Tohoku J. Expt. Med. , vol.143 , pp. 59-70
    • Hashimoto, K.1    Kamitani, T.2    Wada, Y.3    Tatsumi, N.4
  • 27
    • 0031560933 scopus 로고    scopus 로고
    • The N-terminal Z repeat 5 of connectin/titin binds to the C-terminal region of alpha-actinin
    • Ohtsuka H., Yajima H., Maruyama K., and Kimura S. The N-terminal Z repeat 5 of connectin/titin binds to the C-terminal region of alpha-actinin. Biochem. Biophys. Res. Commun. 235 (1997) 1-3
    • (1997) Biochem. Biophys. Res. Commun. , vol.235 , pp. 1-3
    • Ohtsuka, H.1    Yajima, H.2    Maruyama, K.3    Kimura, S.4
  • 28
    • 0032536770 scopus 로고    scopus 로고
    • Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin
    • (J. Cell Biol. 24)
    • Young P., Ferguson C., Banuelos S., and Gautel M. Molecular structure of the sarcomeric Z-disk: two types of titin interactions lead to an asymmetrical sorting of alpha-actinin. EMBO J. 17 (1998) 1614-1616 (J. Cell Biol. 24)
    • (1998) EMBO J. , vol.17 , pp. 1614-1616
    • Young, P.1    Ferguson, C.2    Banuelos, S.3    Gautel, M.4
  • 29
    • 0031213849 scopus 로고    scopus 로고
    • Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin: implications for the nature of vertebrate Z-discs
    • Sorimachi H., Freiburg A., Kolmerer B., Ishiura S., Stier G., Gregorio C.C., et al. Tissue-specific expression and alpha-actinin binding properties of the Z-disc titin: implications for the nature of vertebrate Z-discs. J. Mol. Biol. 270 (1997) 688-695
    • (1997) J. Mol. Biol. , vol.270 , pp. 688-695
    • Sorimachi, H.1    Freiburg, A.2    Kolmerer, B.3    Ishiura, S.4    Stier, G.5    Gregorio, C.C.6
  • 30
    • 0026582867 scopus 로고
    • Towards a molecular understanding of titin
    • Labeit S., Gautel M., Lakey A., and Trinick J. Towards a molecular understanding of titin. EMBO J. 11 (1992) 1711-1716
    • (1992) EMBO J. , vol.11 , pp. 1711-1716
    • Labeit, S.1    Gautel, M.2    Lakey, A.3    Trinick, J.4
  • 31
    • 0033799038 scopus 로고    scopus 로고
    • Binding of filamin isoforms to myofibrils
    • Chiang W., and Greaser M.L. Binding of filamin isoforms to myofibrils. J. Muscle Res. Cell Motil. 21 (2000) 321-333
    • (2000) J. Muscle Res. Cell Motil. , vol.21 , pp. 321-333
    • Chiang, W.1    Greaser, M.L.2
  • 32
    • 0037423366 scopus 로고    scopus 로고
    • The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin
    • Kontrogianni-Konstantopoulos A., and Bloch R.J. The hydrophilic domain of small ankyrin-1 interacts with the two N-terminal immunoglobulin domains of titin. J. Cell Biol. 278 (2003) 3985-3991
    • (2003) J. Cell Biol. , vol.278 , pp. 3985-3991
    • Kontrogianni-Konstantopoulos, A.1    Bloch, R.J.2
  • 33
    • 0037455559 scopus 로고    scopus 로고
    • Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles
    • Bagnato P., Barone V., Giacomello E., Rossi D., and Sorrentino V. Binding of an ankyrin-1 isoform to obscurin suggests a molecular link between the sarcoplasmic reticulum and myofibrils in striated muscles. J. Cell Biol. 160 (2003) 245-253
    • (2003) J. Cell Biol. , vol.160 , pp. 245-253
    • Bagnato, P.1    Barone, V.2    Giacomello, E.3    Rossi, D.4    Sorrentino, V.5
  • 34
    • 0029836627 scopus 로고    scopus 로고
    • The structure of the sarcomeric M band: localization of defined domains of myomesin, M-protein, and the 250-kD carboxy-terminal region of titin by immunoelectron microscopy
    • Obermann W.M., Gautel M., Steiner F., van der Ven P.F., Weber K., and Furst D.O. The structure of the sarcomeric M band: localization of defined domains of myomesin, M-protein, and the 250-kD carboxy-terminal region of titin by immunoelectron microscopy. J. Cell Biol. 134 (1996) 1441-1453
    • (1996) J. Cell Biol. , vol.134 , pp. 1441-1453
    • Obermann, W.M.1    Gautel, M.2    Steiner, F.3    van der Ven, P.F.4    Weber, K.5    Furst, D.O.6
  • 35
    • 0027246620 scopus 로고
    • Phosphorylation of KSP motifs in the C-terminal region of titin in differentiating myoblasts
    • Gautel M., Leonard K., and Labeit S. Phosphorylation of KSP motifs in the C-terminal region of titin in differentiating myoblasts. EMBO J. 12 (1993) 3827-3834
    • (1993) EMBO J. , vol.12 , pp. 3827-3834
    • Gautel, M.1    Leonard, K.2    Labeit, S.3
  • 36
    • 0029859276 scopus 로고    scopus 로고
    • The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers
    • Gautel M., Goulding D., Bullard B., Weber K., and Furst D.O. The central Z-disk region of titin is assembled from a novel repeat in variable copy numbers. J. Cell Sci. 109 (1996) 2747-2754
    • (1996) J. Cell Sci. , vol.109 , pp. 2747-2754
    • Gautel, M.1    Goulding, D.2    Bullard, B.3    Weber, K.4    Furst, D.O.5
  • 37
    • 0033988046 scopus 로고    scopus 로고
    • Filamin isogene expression during mouse myogenesis
    • Chiang W., Greaser M.L., and Lyons G.E. Filamin isogene expression during mouse myogenesis. Dev. Dynam. 217 (2000) 99-108
    • (2000) Dev. Dynam. , vol.217 , pp. 99-108
    • Chiang, W.1    Greaser, M.L.2    Lyons, G.E.3
  • 38
    • 0029919189 scopus 로고    scopus 로고
    • Genomic organization of M line titin and its tissue-specific expression in two distinct isoforms
    • Kolmerer B., Olivieri N., Witt C.C., Herrmann B.G., and Labeit S. Genomic organization of M line titin and its tissue-specific expression in two distinct isoforms. J. Mol. Biol. 256 (1996) 556-563
    • (1996) J. Mol. Biol. , vol.256 , pp. 556-563
    • Kolmerer, B.1    Olivieri, N.2    Witt, C.C.3    Herrmann, B.G.4    Labeit, S.5
  • 39
    • 0035798418 scopus 로고    scopus 로고
    • Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system
    • Furukawa T., Ono Y., Tsuchiya H., Katayama Y., Bang M.L., Labeit D., et al. Specific interaction of the potassium channel beta-subunit minK with the sarcomeric protein T-cap suggests a T-tubule-myofibril linking system. J. Mol. Biol. 313 (2001) 775-784
    • (2001) J. Mol. Biol. , vol.313 , pp. 775-784
    • Furukawa, T.1    Ono, Y.2    Tsuchiya, H.3    Katayama, Y.4    Bang, M.L.5    Labeit, D.6
  • 40
    • 0037184992 scopus 로고    scopus 로고
    • The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy
    • Knoll R., Hoshijima M., Hoffman H.M., Person V., Lorenzen-Schmidt I., Bang M.L., et al. The cardiac mechanical stretch sensor machinery involves a Z disc complex that is defective in a subset of human dilated cardiomyopathy. Cell 111 (2002) 943-955
    • (2002) Cell , vol.111 , pp. 943-955
    • Knoll, R.1    Hoshijima, M.2    Hoffman, H.M.3    Person, V.4    Lorenzen-Schmidt, I.5    Bang, M.L.6
  • 41
    • 0035833261 scopus 로고    scopus 로고
    • Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly
    • Young P., Ehler E., and Gautel M. Obscurin, a giant sarcomeric Rho guanine nucleotide exchange factor protein involved in sarcomere assembly. J. Cell Biol. 154 (2001) 123-136
    • (2001) J. Cell Biol. , vol.154 , pp. 123-136
    • Young, P.1    Ehler, E.2    Gautel, M.3
  • 42
    • 0037056103 scopus 로고    scopus 로고
    • Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness
    • Wu Y., Bell S.P., Trombitas K., Witt C.C., Labeit S., LeWinter M.M., and Granzier H. Changes in titin isoform expression in pacing-induced cardiac failure give rise to increased passive muscle stiffness. Circulation 106 (2002) 1384-1389
    • (2002) Circulation , vol.106 , pp. 1384-1389
    • Wu, Y.1    Bell, S.P.2    Trombitas, K.3    Witt, C.C.4    Labeit, S.5    LeWinter, M.M.6    Granzier, H.7
  • 43
    • 4143108034 scopus 로고    scopus 로고
    • Dynamics of obscurin localization during differentiation and remodeling of cardiac myocytes: obscurin as an integrator of myofibrillar structure
    • Borisov A.B., Kontrogianni-Konstantopoulos A., Bloch R.J., Westfall M.V., and Russell M.W. Dynamics of obscurin localization during differentiation and remodeling of cardiac myocytes: obscurin as an integrator of myofibrillar structure. J. Histochem. Cytochem. 52 (2004) 1117-1127
    • (2004) J. Histochem. Cytochem. , vol.52 , pp. 1117-1127
    • Borisov, A.B.1    Kontrogianni-Konstantopoulos, A.2    Bloch, R.J.3    Westfall, M.V.4    Russell, M.W.5
  • 45
    • 0028957373 scopus 로고
    • Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments
    • Granzier H.L., and Irving T.C. Passive tension in cardiac muscle: contribution of collagen, titin, microtubules, and intermediate filaments. Biophys. J. 68 (1995) 1027-1044
    • (1995) Biophys. J. , vol.68 , pp. 1027-1044
    • Granzier, H.L.1    Irving, T.C.2
  • 46
    • 0038219368 scopus 로고    scopus 로고
    • Vertical agarose gel electrophoresis and electroblotting of high-molecular-weight proteins
    • Warren C.M., Krzesinski P.R., and Greaser M.L. Vertical agarose gel electrophoresis and electroblotting of high-molecular-weight proteins. Electrophoresis 24 (2003) 1695-1702
    • (2003) Electrophoresis , vol.24 , pp. 1695-1702
    • Warren, C.M.1    Krzesinski, P.R.2    Greaser, M.L.3


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