D-Titin: A giant protein with dual roles in chromosomes and muscles

Journal of Cell Biology

Volumn 151, Issue 3, 2000, Pages 639-651

  Machado, Cristina ^a   Andrew, Deborah J ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Chromosome condensation; Drosophila melanogaster; Myoblast fusion; Sarcomere; Titin

Indexed keywords

ANIMAL TISSUE; ARTICLE; CELL FUSION; CHROMOSOME CONDENSATION; CHROMOSOME STRUCTURE; DROSOPHILA MELANOGASTER; EMBRYO; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SARCOMERE; SISTER CHROMATID;

ANIMALS; CELL FUSION; CHROMATIDS; CHROMOSOMAL PROTEINS, NON-HISTONE; CHROMOSOME BREAKAGE; CHROMOSOME SEGREGATION; CHROMOSOMES; DROSOPHILA MELANOGASTER; DROSOPHILA PROTEINS; EMBRYO, NONMAMMALIAN; INSECT PROTEINS; MITOSIS; MOLECULAR WEIGHT; MUSCLE PROTEINS; MUSCLES; MUTATION; PHENOTYPE; PROTEIN KINASES; SARCOMERES;

ANIMALIA; DROSOPHILA MELANOGASTER; MELANOGASTER; VERTEBRATA;

EID: 0034735537     PISSN: 00219525     EISSN: None     Source Type: Journal    
DOI: 10.1083/jcb.151.3.639     Document Type: Article

References (60)

1. Basic local alignment search tool
2. Both synchronous and asynchronous muscle isoforms of projectin (the Drosophila bent locus product) contain functional kinase domains
3. Targeting of cardiac muscle titin fragments to the Z-bands and dense bodies of living muscle and non-muscle cells
4. Twitchin and related giant Ig super family members of C. elegans and other invertebrates
5. Sequence of an unusually large protein implicated in regulation of myosin activity in C. elegans
6. Sister chromatid cohesion in mitosis
7. Drosophila SNS, a member of the immunoglobulin superfamily that is essential for myoblast fusion
8. The metaphase scaffold is helically folded: Sister chromatids have predominantly opposite helical handedness
9. Chromosomes are highly elastic and can be stretched
10. Genetic analysis of myoblast fusion: Blown fuse is required for progression beyond the prefusion complex
11. Drosophila myoblast city encodes a conserved protein that is essential for myoblast fusion, dorsal closure and cytoskeleton organization
12. Drosophila projectin: Relatedness to titin and twitchin and correlation with lethal(4)102 CDa and bent-dominant mutants
13. Metaphase chromosome structure. Involvement of topoisomerase II
14. Genes controlling essential cell-cycle functions in Drosophila melanogaster
15. Mutations affecting cell division in Drosophila
16. Looking at Drosophila mitotic chromosomes
17. Muscle assembly: A titanic achievement
18. Requirements of Kettin, a giant muscle protein highly conserved in overall structure in evolution, for normal muscle function, viability and flight activity of Drosophila
19. From clone to mutant gene
20. SMC-mediated chromosome mehanics: A conserved scheme from bacteria to vertebrates?
21. Elasticity measurements show the existence of thin rigid cores inside mitotic chromosomes
22. Elasticity and structure of eukaryote chromosomes studied by micromanipulation and micropipette aspiration
23. Molecular cloning and tissue-specific expression of the mutator2 gene (mu2) in Drosophila melanogaster
24. Dosage-dependent modifiers of Polycomb and Antennapedia mutations in Drosophila
25. Cytoplasmic myosin from Drosophila melanogaster
26. Sequence and expression of the kettin gene in Drosophila melanogaster and Caenorhabditis elegans
27. Mitotic chromosome condensation
28. Titins, giant proteins in charge of muscle ultrastructure and elasticity
29. Kettin, a large modular protein in the Z-disc of insect muscles
30. Actin-titin interaction in cardiac myofibrils: Probing a physiological role
31. Distinct morphogenetic funcitons of similar small GTPases: Drosophila Drac1 is involved in axonal outgrowth and myoblast fusion
32. Human autoantibodies reveal titin as a chromosomal protein
33. Zeugmatin: A new high molecular weight protein associated with Z lines in adult and early embryonic striated muscle
34. A view of interphase chromosome
35. Cryo-electron microscopy of vitrified chromosomes in situ
36. Identification and intracellular localization of the unc-22 gene product of Caenorhabditis elegans
37. A catalogue of splice junction sequences
38. Splicing signals in Drosophila: Intron size, information content and consensus sequences
39. Looking at polytene chromosomes
40. The structure of histone-depleted chromosomes
41. Fusion from myoblasts to myotubes is dependent on the rolling stone gene (rost) of Drosophila
42. Homeotic genes regulate the spatial expression of putative growth factors in the visceral mesoderm of Drosophila embryos
43. Mutations in a novel gene, myoblast city, provide evidence in support of the founder cell hypothesis for Drosophila muscle development
44. A direct approach to the structure of eukaryote chromosomes
45. The genetics of the Dras3-Roughened-ecdysoneless chromosomal region (62B3-4 to 62D3-4) in Drosophila melanogaster: Analysis of recessive lethal mutations
46. BCM Search Launcher - An integrated interface to molecular biology data base search and analysis services available on the World Wide Web
47. Structural maintenance of chromosomes (SMC) proteins: Conserved molecular properties for multiple biological functions
48. Involvement of histone H1 in the organization of the nucleosome and of the salt-dependent superstructure of chromatin
49. Titin: A molecular control freak
50. Actin removal from cardiac myocytes shows that near Z line titin attaches to actin while under tension
51. Interaction between titin and thin filaments in intact cardiac muscle
52. Partial characterization of zeugmatin indicates that it is part of the Z-band region of titin
53. An N-terminal fragment of titin coupled to green fluorescent protein localizes to the Z-bands in living muscle cells: Overexpression leads to myofibril disassembly
54. Zeugmatin is part of the Z-band targeting region of titin
55. Mapping a mutator, mu2, which increases the frequency of terminal deletions in Drosophila melanogaster
56. Untangling the role of DNA topoisomerase II in mitotic chromosome structure and function
57. Mutants with altered muscle structure in Caenorhabditis elegans