Pulmonary distribution, regulation, and functional role of Trk receptors in a murine model of asthma

Journal of Allergy and Clinical Immunology

Volumn 118, Issue 3, 2006, Pages 597-605

  Nassenstein, Christina ^a   Dawbarn, David ^b   Pollock, Kenneth ^c   Allen, Shelley Jane ^b   Erpenbeck, Veit Johannes ^a   Spies, Emma ^a   Krug, Norbert ^a   Braun, Armin ^a  

^a FRAUNHOFER INSTITUTE FOR TOXICOLOGY AND EXPERIMENTAL MEDICINE   (Germany)

^b UNIVERSITY OF BRISTOL   (United Kingdom)

^c RENEURON LTD   (United Kingdom)

Author keywords

airway hyperreactivity; airway inflammation; capsaicin; reflex bronchospasm; Sensory nerves

Indexed keywords

ALLERGEN; CYTOKINE; INTERLEUKIN 13; INTERLEUKIN 4; INTERLEUKIN 5; METHACHOLINE; OVALBUMIN; REN 1826; TYROSINE KINASE RECEPTOR; UNCLASSIFIED DRUG;

AEROSOL; ALLERGIC ASTHMA; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRONCHUS OBSTRUCTION; CONTROLLED STUDY; CYTOKINE PRODUCTION; DOWN REGULATION; DRUG EFFECT; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; FEMALE; FLUORESCENCE MICROSCOPY; IMMUNOHISTOCHEMISTRY; IMMUNOREACTIVITY; LUNG FUNCTION; LUNG PARENCHYMA; MOUSE; MOUSE STRAIN; NONHUMAN; PLETHYSMOGRAPHY; PRIORITY JOURNAL; PROTEIN EXPRESSION; QUANTITATIVE ANALYSIS; RESPIRATORY EPITHELIUM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENSORY NERVE; SMOOTH MUSCLE FIBER; STATISTICAL DISTRIBUTION;

ALLERGENS; ANIMALS; ASTHMA; DISEASE MODELS, ANIMAL; FEMALE; GENE EXPRESSION REGULATION; LUNG; MICE; MICE, INBRED BALB C; RECEPTOR PROTEIN-TYROSINE KINASES; RECEPTOR, TRKA; RECEPTOR, TRKB; RECEPTOR, TRKC; RNA, MESSENGER;

EID: 33748072400     PISSN: 00916749     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jaci.2006.04.052     Document Type: Article

References (38)

1. National Institutes of Health. Global initiative for asthma. Natl Heart Lung Blood Inst Publ (1995) Publication no. 95-3659
2. Braun A., Appel E., Baruch R., Herz U., Botchkarev V., Paus R., et al. Role of nerve growth factor in a mouse model of allergic airway inflammation and asthma. Eur J Immunol 28 (1998) 3240-3251
3. Braun A., Lommatzsch M., Neuhaus-Steinmetz U., Quarcoo D., Glaab T., McGregor G.P., et al. Brain-derived neurotrophic factor (BDNF) contributes to neuronal dysfunction in a model of allergic airway inflammation. Br J Pharmacol 141 (2004) 431-440
4. Braun A., Quarcoo D., Schulte-Herbruggen O., Lommatzsch M., Hoyle G., and Renz H. Nerve growth factor induces airway hyperresponsiveness in mice. Int Arch Allergy Immunol 124 (2001) 205-207
5. Path G., Braun A., Meents N., Kerzel S., Quarcoo D., Raap U., et al. Augmentation of allergic early-phase reaction by nerve growth factor. Am J Respir Crit Care Med 166 (2002) 818-826
6. Nassenstein C., Braun A., Erpenbeck V.J., Lommatzsch M., Schmidt S., Krug N., et al. The neurotrophins nerve growth factor, brain-derived neurotrophic factor, neurotrophin-3, and neurotrophin-4 are survival and activation factors for eosinophils in patients with allergic bronchial asthma. J Exp Med 198 (2003) 455-467
7. Goedert M., Stoeckel K., and Otten U. Biological importance of the retrograde axonal transport of nerve growth factor in sensory neurons. Proc Natl Acad Sci U S A 78 (1981) 5895-5898
8. Bibel M., Hoppe E., and Barde Y.A. Biochemical and functional interactions between the neurotrophin receptors trk and p75NTR. EMBO J 18 (1999) 616-622
9. Esposito D., Patel P., Stephens R.M., Perez P., Chao M.V., Kaplan D.R., et al. The cytoplasmic and transmembrane domains of the p75 and Trk A receptors regulate high affinity binding to nerve growth factor. J Biol Chem 276 (2001) 32687-32695
10. Lee K.F., Davies A.M., and Jaenisch R. p75-deficient embryonic dorsal root sensory and neonatal sympathetic neurons display a decreased sensitivity to NGF. Development 120 (1994) 1027-1033
11. Caroleo M.C., Costa N., Bracci-Laudiero L., and Aloe L. Human monocyte/macrophages activate by exposure to LPS overexpress NGF and NGF receptors. J Neuroimmunol 113 (2001) 193-201
12. Dechant G. Molecular interactions between neurotrophin receptors. Cell Tissue Res 305 (2001) 229-238
13. Huang E.J., and Reichardt L.F. Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci 24 (2001) 677-736
14. Kerzel S., Path G., Nockher W.A., Quarcoo D., Raap U., Groneberg D.A., et al. Pan-neurotrophin receptor p75 contributes to neuronal hyperreactivity and airway inflammation in a murine model of experimental asthma. Am J Respir Cell Mol Biol 28 (2003) 170-178
15. Ricci A., Felici L., Mariotta S., Mannino F., Schmid G., Terzano C., et al. Neurotrophin and neurotrophin receptor protein expression in the human lung. Am J Respir Cell Mol Biol 30 (2004) 12-19
16. Szallasi A., and Blumberg P.M. Vanilloid (capsaicin) receptors and mechanisms. Pharmacol Rev 51 (1999) 159-212
17. Suh Y.G., and Oh U. Activation and activators of TRPV1 and their pharmaceutical implication. Curr Pharm Des 11 (2005) 2687-2698
18. Shu X., and Mendell L.M. Nerve growth factor acutely sensitizes the response of adult rat sensory neurons to capsaicin. Neurosci Lett 274 (1999) 159-162
19. Bonnington J.K., and McNaughton P.A. Signalling pathways involved in the sensitisation of mouse nociceptive neurones by nerve growth factor. J Physiol 551 suppl (2003) S433-S446
20. Zhang Y.H., and Nicol G.D. NGF-mediated sensitization of the excitability of rat sensory neurons is prevented by a blocking antibody to the p75 neurotrophin receptor. Neurosci Lett 366 (2004) 187-192
21. Saria A., Theodorsson-Norheim E., Gamse R., and Lundberg J.M. Release of substance P- and substance K-like immunoreactivities from the isolated perfused guinea-pig lung. Eur J Pharmacol 106 (1984) 207-208
22. Joos G.F., Germonpre P.R., and Pauwels R.A. Role of tachykinins in asthma. Allergy 55 (2000) 321-337
23. Szolcsanyi J., and Bartho L. Capsaicin-sensitive non-cholinergic excitatory innervation of the guinea-pig tracheobronchial smooth muscle. Neurosci Lett 34 (1982) 247-251
24. Mazzone S.B., and Canning B.J. Synergistic interactions between airway afferent nerve subtypes mediating reflex bronchospasm in guinea pigs. Am J Physiol Regul Integr Comp Physiol 283 (2002) R86-R98
25. Fuller R.W., Dixon C.M., and Barnes P.J. Bronchoconstrictor response to inhaled capsaicin in humans. J Appl Physiol 58 (1985) 1080-1084
26. Lindsay R.M., and Harmar A.J. Nerve growth factor regulates expression of neuropeptide genes in adult sensory neurons. Nature 337 (1989) 362-364
27. Hunter D.D., Myers A.C., and Undem B.J. Nerve growth factor-induced phenotypic switch in guinea pig airway sensory neurons. Am J Respir Crit Care Med 161 (2000) 1985-1990
28. Fischer A., McGregor G.P., Saria A., Philippin B., and Kummer W. Induction of tachykinin gene and peptide expression in guinea pig nodose primary afferent neurons by allergic airway inflammation. J Clin Invest 98 (1996) 2284-2291
29. Barnes P.J. Asthma as an axon reflex. Lancet 1 (1986) 242-245
30. Lundberg J.M., Martling C.R., and Saria A. Substance P and capsaicin-induced contraction of human bronchi. Acta Physiol Scand 119 (1983) 49-53
31. de Vries A., Dessing M.C., Engels F., Henricks P.A., and Nijkamp F.P. Nerve growth factor induces a neurokinin-1 receptor-mediated airway hyperresponsiveness in guinea pigs. Am J Respir Crit Care Med 159 (1999) 1541-1544
32. Barnes P.J. Neural mechanisms in asthma. Br Med Bull 48 (1992) 149-168
33. Hahn H.L. Role of the parasympathetic nervous system and of cholinergic mechanisms in bronchial hyperreactivity. Bull Eur Physiopathol Respir 22 suppl 7 (1986) 112-142
34. Bachar O., Adner M., Uddman R., and Cardell L.O. Nerve growth factor enhances cholinergic innervation and contractile response to electric field stimulation in a murine in vitro model of chronic asthma. Clin Exp Allergy 34 (2004) 1137-1145
35. Nassenstein C., Kerzel S., and Braun A. Neurotrophins and neurotrophin receptors in allergic asthma. Prog Brain Res 146 (2004) 347-367
36. Malm-Erjefalt M., Persson C.G., and Erjefalt J.S. Degranulation status of airway tissue eosinophils in mouse models of allergic airway inflammation. Am J Respir Cell Mol Biol 24 (2001) 352-359
37. Quarcoo D., Schulte-Herbruggen O., Lommatzsch M., Schierhorn K., Hoyle G.W., Renz H., et al. Nerve growth factor induces increased airway inflammation via a neuropeptide-dependent mechanism in a transgenic animal model of allergic airway inflammation. Clin Exp Allergy 34 (2004) 1146-1151
38. Barnes P.J. Neurogenic inflammation in the airways. Respir Physiol 125 (2001) 145-154