N-acetyllactosamine conjugated to gold nanoparticles inhibits enteropathogenic Escherichia coli colonization of the epithelium in human intestinal biopsy specimens

Infection and Immunity

Volumn 74, Issue 9, 2006, Pages 5419-5421

  Hyland, Romney M ^a   Beck, Paul ^a   Mulvey, George L ^a   Kitov, Pavel I ^b   Armstrong, Glen D ^a  

^a UNIVERSITY OF CALGARY   (Canada)

^b UNIVERSITY OF ALBERTA   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

GLYCOCONJUGATE; GOLD; N ACETYLGLUCOSAMINE; N ACETYLLACTOSAMINE; NANOPARTICLE; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL COLONIZATION; BACTERIOSTASIS; BACTERIUM ADHERENCE; BACTERIUM PILUS; CELL STRAIN CACO 2; COLON; CONTROLLED STUDY; DUODENUM; ENTEROPATHOGENIC ESCHERICHIA COLI; HEP 2 CELL; HUMAN; HUMAN CELL; HUMAN TISSUE; ILEUM; INTESTINE BIOPSY; INTESTINE EPITHELIUM; NONHUMAN; PRIORITY JOURNAL;

ADULT; AGED; AMINO SUGARS; BACTERIAL ADHESION; CELLS, CULTURED; ESCHERICHIA COLI; FEMALE; GOLD; HUMANS; INTESTINAL MUCOSA; INTESTINES; MALE; MIDDLE AGED; NANOSTRUCTURES;

EID: 33748068124     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.00739-06     Document Type: Article

References (22)

1. Ausubel, F. M., R. Brent, R. E. Kingston, D. D. Moore, J. G. Seidman, J. A. Smith, and K. Struhl. 1999. Short protocols in molecular biology, 4th ed. John Wiley & Sons, New York, NY.
2. Barnett Foster, D., D. Philpott, M. Abul-Milh, M. Huesca, P. M. Sherman, and C. A. Lingwood. 1999. Phosphatidylethanolamine recognition promotes enteropathogenic E coli and enterohemorrhagic E. coli host cell attachment. Microb. Pathog. 27:289-301.
3. Bieber, D., S. W. Ramer, C. Y. Wu, W. J. Murray, T. Tube, R. Fernandez, and G. K. Schoolnik 1998. Type IV pili, transient bacterial aggregates, and virulence of enteropathogenic Escherichia coli. Science 280:2114-2118.
4. Campellone, K. G., and J. M. Leong. 2003, Tails of two Tirs: actin pedestal formation by enteropathogenic E. coli and enterohemorrhagic E. coli O157: H7. Curr. Opin. Microbiol. 6:82-90.
5. Cleary, J., L. C. Lai, R. K. Shaw, A. Straatman-Iwanowska, M. S. Doonenberg, G. Frankel, and S. Knutton. 2004. Enteropathogenic Escherichia coli (EPEC) adhesion to intestinal epithelial cells: role of bundle-forming pili (BFP), EspA filaments and intimin. Microbiology 150:527-538.
6. Delahay, R. M., G. Frankel, and S. Knutton. 2001. Intimate interactions of enteropathogenic Escherichia coli at the host cell surface. Curr. Opin. Infect. Dis. 14:559-565.
7. Donnenberg, M. S., J. A. Giron, J. P. Nataro, and J. B. Kaper. 1992. A plasmid-encoded type IV fimbrial gene of enteropathogenic Escherichia coli associated with localized adherence. Mol. Microbiol. 6:3427-3437.
8. Donnenberg, M. S., and J. B. Kaper. 1992. Enteropathogenic Escherichia coli. Infect. Immun. 60:3953-3961.
9. Donnenberg, M. S., and T. S. Whittam. 2001. Pathogenesis and evolution of virulence in enteropathogenic and enterohemorrhagic Escherichia coli. J. Clin. Investig. 107:539-548.
10. Giron, J. A., A. S. Ho, and G. K. Schoolnik. 1993. Characterization of fimbriae produced by enteropathogenic Escherichia coli. J. Bacteriol. 175: 7391-7403.
11. Giron, J. A., A. G. Torres, E. Freer, and J. B. Kaper. 2002. The flagella of enteropathogenic Escherichia coli mediate adherence to epithelial cells. Mol. Microbiol. 44:361-379.
12. Hicks, S., G. Frankel, J. B. Kaper, G. Dougan, and A. D. Phillips. 1998. Role of intimin and bundle-forming pili in enteropathogenic Escherichia coli adhesion to pediatric intestinal tissue in vitro. Infect. Immun. 66:1570-1578.
13. Hyland, R., T. P. Griener, G. L. Mulvey, P. I. Kitov, O. P. Srivastava, P. Marcato, and G. D. Armstrong. 2005. Basis for N-acetyllactosamine-mediated inhibition of enteropathogenic Escherichia coli localized adherence. J. Med. Microbiol. 55:669-675.
14. Kenny, B. 2002. Mechanism of action of EPEC type III effector molecules. Int. J. Med. Microbiol. 291:469-477.
15. Knutton, S., I. Rosenshine, M. J, Pallen, I. Nisan, B. C. Neves, C Bain, C. Wolff, G. Dougan, and G. Frankel. 1998, A novel EspA-associated surface organelle of enteropathogenic Escherichia coli involved in protein translocation into epithelial cells. EMBO J. 17:2166-2176.
16. Leverton, L. Q., and J. B. Kaper. 2005. Temporal expression of enteropathogenic Escherichia coli virulence genes in an in vitro model of infection. Infect. Immun. 73:1034-1043.
17. Nataro, J. P., and J. B. Kaper. 1998. Diarrheagenic Escherichia coli. Clin. Microbiol. Rev. 11:142-201.
18. Phillips, A. D., and G. Frankel. 2000. Intimin-mediated tissue specificity in enteropathogenic Escherichia coli interaction with human intestinal organ cultures. J. Infect. Dis. 181:1496-1500.
19. Sinclair, J. F., and A. D. O'Brien. 2002. Cell surface-localized nucleolin is a eukaryotic receptor for the adhesin intimin-gamma of enterohemorrhagic Escherichia coli O157:H7. J. Biol. Chem. 277:2876-2885.
20. Vanmaele, R. P., M. C. Finlayson, and G. O. Armstrong. 1995. Effect of enteropathogenic Escherichia coli on adherent properties of Chinese hamster ovary cells. Infect. Immun. 63:191-198.
21. Vanmaele, R. P., L. D. Heerze, and G. D. Armstrong. 1999. Role of lactosyl glycan sequences in inhibiting enteropathogenic Escherichia coli attachment. Infect. Immun. 67:3302-3307.
22. Wu, V., B. Lau, S. Smith, K. Troyan, and D. E. Barnett Foster. 2004. Enteropathogenic Escherichia coli infection triggers host phospholipid metabolism perturbations. Infect. Immun. 72:6764-6772.