Regulation of N-acetylaspartate and N-acetylaspartylglutamate biosynthesis by protein kinase activators

Journal of Neurochemistry

Volumn 98, Issue 6, 2006, Pages 2034-2042

  Arun, Peethambaran ^a   Madhavarao, Chikkathur N ^a   Moffett, John R ^a   Namboodiri, M A Aryan ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

Aspartate; Glutamate; Glutamine; N acetylaspartate; N acetylaspartylglutamate; SH SY5Y cells

Indexed keywords

CYCLIC AMP DEPENDENT PROTEIN KINASE; N ACETYLASPARTIC ACID; N ACETYLASPARTYLGLUTAMIC ACID; PROTEIN KINASE; PROTEIN KINASE C;

ARTICLE; BIOSYNTHESIS; CELL DIFFERENTIATION; CELL STIMULATION; CONTROLLED STUDY; HUMAN; HUMAN CELL; ISOTOPE LABELING; NERVE CELL; NEUROBLASTOMA CELL; PRIORITY JOURNAL;

ASPARTIC ACID; BUCLADESINE; CELL LINE, TUMOR; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DIPEPTIDES; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; GLUTAMINE; HUMANS; NEUROBLASTOMA; PROTEIN KINASE C; PROTEIN KINASES; TETRADECANOYLPHORBOL ACETATE; TIME FACTORS;

EID: 33748037039     PISSN: 00223042     EISSN: 14714159     Source Type: Journal    
DOI: 10.1111/j.1471-4159.2006.04068.x     Document Type: Article

References (35)

1. Arun P., Madhavarao C. N., Hershfield J. R., Moffett J. R. and Namboodiri M. A. (2004) SH-SY5Y neuroblastoma cells: a model system for studying biosynthesis of NAAG. Neuroreport 15, 1167-1170.
2. Benuck M. and D'Adamo A. F. Jr (1968) Acetyl transport mechanisms. Metabolism of N-acetyl-L-aspartic acid in the non-nervous tissues of the rat. Biochim. Biophys. Acta 152, 611-618.
3. Berger U. V., Luthi-Carter R., Passani L. A., Elkabes S., Black I., Konradi C. and Coyle J. T. (1999) Glutamate carboxypeptidase II is expressed by astrocytes in the adult rat nervous system. J. Comp. Neurol. 415, 52-64.
4. Buttram J. G., Engler J. A., Grossfeld R. M., Urazaev A. K. and Lieberman E. M. (2002) Glutamine uptake and metabolism to N-acetylaspartylglutamate (NAAG) by crayfish axons and glia. Comp. Biochem. Physiol. B Biochem. Mol. Biol. 133, 209-220.
5. Cangro C. B., Namboodiri M. A., Sklar L. A., Corigliano-Murphy A. and Neale J. H. (1987) Immunohistochemistry and biosynthesis of N- acetylaspartylglutamate in spinal sensory ganglia. J. Neurochem. 49, 1579-1588.
6. Encinas M., Iglesias M., Liu Y., Wang H., Muhaisen A., Cena V., Gallego C. and Comella J. X. (2000) Sequential treatment of SH-SY5Y cells with retinoic acid and brain-derived neurotrophic factor gives rise to fully differentiated, neurotrophic factor-dependent, human neuron-like cells. J. Neurochem. 75, 991-1003.
7. Garrido Sanabria E. R., Wozniak K. M., Slusher B. S. and Keller A. (2003) GCP II (NAALADase) inhibition suppresses mossy fiber-CA3 synaptic transmission by a presynaptic mechanism. J. Neurophysiol. 91, 182-193.
8. Gehl L. M., Saab O. H., Bzdega T., Wroblewska B. and Neale J. H. (2004) Biosynthesis of NAAG by an enzyme-mediated process in rat central nervous system neurons and glia. J. Neurochem. 90, 989-997.
9. Goodall A. R., Turner N. A., Walker J. H., Ball S. G. and Vaughan P. F. (1997) Activation of protein kinase Cα and translocation of the myristoylated alanine-rich C-kinase substrate correlate with phorbol ester-enhanced noradrenaline release from SH-SY5Y human neuroblastoma cells. J. Neurochem. 68, 392-401.
10. Lahdesmaki P. and Timonen M. (1982) Non-coded biosynthesis of N-acetylaspartyl peptides in mouse brain homogenates. J. Liq. Chrom. 5, 989-1002.
11. Lu Z. H., Chakraborty G., Ledeen R. W., Yahya D. and Wu G. (2004) N-Acetylaspartate synthase is bimodally expressed in microsomes and mitochondria of brain. Brain Res. Mol. Brain Res. 122, 71-78.
12. Madhavarao C. N., Chinopoulos C., Chandrasekaran K. and Namboodiri M. A. (2003) Characterization of the N-acetylaspartate biosynthetic enzyme from rat brain. J. Neurochem. 86, 824-835.
13. Mathew R., Arun P., Madhavarao C., Moffett J. and Namboodiri A. (2005) Progress toward acetate supplementation therapy for Canavan disease: glyceryl triacetate administration increases acetate, but not N-acetylaspartate levels in brain. J. Pharmacol. Exp. Ther. 315, 297-303.
14. Miyamoto E., Kakimoto Y. and Sano I. (1966) Identification of N-acetylaspartylglutamic acid in the bovine brain. J. Neurochem. 13, 999-1003.
15. Moffett J. R. (2003) Reductions in N-acetylaspartylglutamate and the 67-kDa form of glutamic acid decarboxylase immunoreactivities in the visual system of albino and pigmented rats after optic nerve transections. J. Comp. Neurol. 458, 221-239.
16. Moffett J. R. and Namboodiri M. A. (1995) Differential distribution of N-acetylaspartylglutamate and N-acetylaspartate immunoreactivities in rat forebrain. J. Neurocytol. 24, 409-433.
17. Moffett J. R., Namboodiri M. A., Cangro C. B. and Neale J. H. (1991) Immunohistochemical localization of N-acetylaspartate in rat brain. Neuroreport 2, 131-134.
18. Moffett J. R., Namboodiri M. A. and Neale J. H. (1993) Enhanced carbodiimide fixation for immunohistochemistry: application to the comparative distributions of N-acetylaspartylglutamate and N-acetylaspartate immunoreactivities in rat brain. J. Histochem. Cytochem. 41, 559-570.
19. Pahlman S., Mamaeva S., Meyerson G., Mattsson M. E., Bjelfman C., Ortoft E. and Hammerling U. (1990) Human neuroblastoma cells in culture: a model for neuronal cell differentiation and function. Acta Physiol. Scand. Suppl. 592, 25-37.
20. Pahlman S., Hoehner J. C., Nanberg E., Hedborg F., Fagerstrom S., Gestblom C., Johansson I., Larsson U., Lavenius E. and Ortoft E. (1995) Differentiation and survival influences of growth factors in human neuroblastoma. Eur. J. Cancer 31A, 453-458.
21. Poschel B., Wroblewska B., Heinemann U. and Manahan-Vaughan D. (2005) The metabotropic glutamate receptor mGluR3 is critically required for hippocampal long-term depression and modulates long-term potentiation in the dentate gyrus of freely moving rats. Cereb. Cortex 15, 1414-1423.
22. Reichelt K. L. and Kvamme E. (1973) Histamine-dependent formation of N-acetyl-aspartyl peptides in mouse brain. J. Neurochem. 21, 849-859.
23. Reichelt K. L., Wedege E. and Kvamme E. (1971) Effects of amines on the level of N-acetyl-aspartate and N-acetyl-aspartyl-glutamate in mouse brain tissue slices. J. Neurochem. 18, 2129-2136.
24. Reichelt K. L., Edminson P. D. and Kvamme E. (1976) The formation of peptido-amines from constituent amino acids and histamine in hypothalamic tissue. J. Neurochem. 26, 811-815.
25. Sanchez S., Jimenez C., Carrera A. C., Diaz-Nido J., Avila J. and Wandosell F. (2004) A cAMP-activated pathway, including PKA and PI3K, regulates neuronal differentiation. Neurochem. Int. 44, 231-242.
26. Tallan H. H. (1957) Studies on the distribution of N-acetyl-L-aspartic acid in brain. J. Biol. Chem. 224, 41-45.
27. Tallan H. H., Moore S. and Stein W. H. (1956) N-Acetyl-L-aspartic acid in brain. J. Biol. Chem. 219, 257-264.
28. Tieman S. B. and Tieman D. G. (1996) N-acetylaspartylglutamate immunoreactivity in human retina. Vision Res. 36, 941-947.
29. Tieman S. B., Cangro C. B. and Neale J. H. (1987) N- acetylaspartylglutamate immunoreactivity in neurons of the cat's visual system. Brain Res. 420, 188-193.
30. Tieman S. B., Moffett J. R. and Irtenkauf S. M. (1991) Effect of eye removal on N-acetylaspartylglutamate immunoreactivity in retinal targets of the cat. Brain Res. 562, 318-322.
31. Truckenmiller M. E., Namboodiri M. A., Brownstein M. J. and Neale J. H. (1985) N-Acetylation of L-aspartate in the nervous system: differential distribution of a specific enzyme. J. Neurochem. 45, 1658-1662.
32. Urazaev A. K., Grossfeld R. M., Fletcher P. L., Speno H., Gafurov B. S., Buttram J. G. and Lieberman E. M. (2001) Synthesis and release of N-acetylaspartylglutamate (NAAG) by crayfish nerve fibers: implications for axon-glia signaling. Neuroscience 106, 237-247.
33. Williamson L. C. and Neale J. H. (1988) Calcium-dependent release of N-acetylaspartylglutamate from retinal neurons upon depolarization. Brain Res. 475, 151-155.
34. Wroblewska B., Santi M. R. and Neale J. H. (1998) N- acetylaspartylglutamate activates cyclic AMP-coupled metabotropic glutamate receptors in cerebellar astrocytes. Glia 24, 172-179.
35. Wroblewska B., Wegorzewska I. N., Bzdega T., Olszewski R. T. and Neale J. H. (2006) Differential negative coupling of type 3 metabotropic glutamate receptor to cyclic GMP levels in neurons and astrocytes. J. Neurochem. 96, 1071-1077.