Neuropathological changes in ten cases of neuronal intermediate filament inclusion disease (NIFID): A study using α-internexin immunohistochemistry and principal components analysis (PCA)

Journal of Neural Transmission

Volumn 113, Issue 9, 2006, Pages 1207-1215

  Armstrong, R A ^a   Kerty, E ^b   Skullerud, K ^b   Cairns, N J ^c  

^a ASTON UNIVERSITY   (United Kingdom)

^b UNIVERSITY OF OSLO   (Norway)

^c WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Lesion density; Neurofilament intermediate filament inclusion disease (NIFID); Neuronal inclusions (NI); Principal components analysis (PCA); Swollen achromatic neurons (SN)

Indexed keywords

ALPHA INTERNEXIN;

ADULT; ARTICLE; CELL DENSITY; CELL LOSS; CELL POPULATION; CLINICAL ARTICLE; DISEASE ASSOCIATION; FEMALE; FRONTAL LOBE; GLIA CELL; HUMAN; HUMAN TISSUE; IMMUNOHISTOCHEMISTRY; MALE; NERVE CELL; NEUROFILAMENT; NEUROLOGIC DISEASE; NEURONAL INTERMEDIATE FILAMENT INCLUSION DISEASE; NEUROPATHOLOGY; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; SUBICULUM;

ADULT; ATROPHY; CELL SURVIVAL; CEREBRAL CORTEX; FEMALE; FRONTAL LOBE; HUMANS; IMMUNOHISTOCHEMISTRY; INCLUSION BODIES; INTERMEDIATE FILAMENT PROTEINS; INTERMEDIATE FILAMENTS; MALE; MIDDLE AGED; NERVOUS SYSTEM DISEASES; NEUROGLIA; ORGAN SIZE; PRINCIPAL COMPONENT ANALYSIS;

EID: 33747893766     PISSN: 03009564     EISSN: 14351463     Source Type: Journal    
DOI: 10.1007/s00702-005-0387-0     Document Type: Article

References (22)

1. RA Armstrong 1996 Correlations between the morphology of diffuse and primitive β-amyloid (Aβ) deposits and the frequency of associated cells in Down's syndrome Neuropathol Appl Neurobiol 22 527 530
2. RA Armstrong NJ Cairns PL Lantos 1999 Quantification of pathological lesions in the frontal and temporal lobe of ten patients diagnosed with Pick's disease Acta Neuropathol 97 456 462
3. RA Armstrong NJ Cairns PL Lantos 2000a A quantitative study of the pathological lesions in the neocortex and hippocampus of 12 patients with corticobasal degeneration Exp Neurol 163 348 356
4. RA Armstrong D Nochlin TD Bird 2000b Neuropathological heterogeneity in Alzheimer's disease: a study of 80 cases using principal components analysis Neuropathol 20 31 37
5. RA Armstrong PL Lantos NJ Cairns 2000c Laminar distribution of ballooned neurons and tau positive neurons with inclusions in patients with corticobasal degeneration Neurosci Res Commun 27 85 93
6. EH Bigio AM Lipton CL White DW Dickson A Hirano 2003 Frontotemporal dementia and motor neurone degeneration with neurofilament inclusion bodies: additional evidence for overlap between FTD and ALS Neuropathol Appl Neurobiol 29 239 253
7. BF Boeve AE Lang I Litvan 2003 Corticobasal degeneration and its relationship to progressive supranuclear palsy and frontotemporal dementia Ann Neurol 54 Suppl S15 S19
8. M Broe JR Hodges E Schofield CE Shepherd JJ Kril GM Halliday 2003 Staging disease severity in pathologically confirmed cases of frontotemporal dementia Neurology 60 1005 1011
9. NJ Cairns RH Perry E Jaros D Burn IG [tmp] McKeith JS Lowe J Holton MN Rossor K Skullerud C Duyckaerts FF Cruz-Sanchez PL Lantos 2003 Patients with a novel neurofilamentopathy: dementia with neurofilament inclusions Neurosci Lett 341 177 180
10. NJ Cairns V Zhukareva K Uryu B Zhang E Bigio IRA Mackenzie M Gearing C Duyckaerts H Yokoo Y Nakazato E Jaros RH Perry VMY Lee JQ Trojanowski 2004a α-Internexin is present in the pathological inclusions of neuronal intermediate filament inclusion disease Am J Pathol 164 2153 2161
11. NJ Cairns E Jaros RH Perry RA Armstrong 2004b Temporal lobe pathology of human patients with neurofilament inclusion disease Neurosci Lett 354 245 247
12. NJ Cairns M Grossman SE Arnold DJ Burn E Jaros RH Perry C Duyckaerts B Stankoff B Pillon K Skullerud FF Cruz-Sanchez EH Bigio IRA Mackenzie M Gearing JL Juncos JD Glass H Yokoo Y Nakazato S Mosaheb JR Thorpe K Uryu VM-Y Lee JQ Trojanowski 2004c Clinical and neuropathologic variation in neuronal intermediate filament inclusion disease (NIFID) Neurology 63 1376 1384
13. GY Ching RKH Liein 1998 Roles of head and tail domains in alpha-internexin's self-assembly and coassembly with the neurofilament triplet proteins J Cell Sci 111 321 333
14. GY Ching CL Chien R Flores RKH Liein 1999 Overexpression of alpha-internexin causes abnormal neurofilamentous accumulations and motor coordination deficits in transgenic mice J Neurosci 19 2974 2986
15. KA Josephs JL Holton MN Rossor H Braendgaard T Ozawa NC Fox RC Petersen GS Pearl M Ganguly P Rosa H Laursen JE Parisi G Waldemar NP Quinn DW Dickson T Revesz 2003 Neurofilament inclusion body disease: a new proteinopathy? Brain 126 2291 2303
16. A Kertesz T Kawaria E Rogaeva P St George-Hyslop P Poorkaj TD Bird DG Munoz 2000 Familial frontotemporal dementia with ubiquitin-positive, tau-negative inclusions Neurology 54 818 827
17. C Kersaitis GM Halliday JJ Kril 2004 Regional and cellular pathology in frontotemporal dementia: relationship to stage of disease in cases with and without Pick bodies Acta Neuropathol 108 515 523
18. PN Leigh A Dodson M Swash JP Brion BH Anderton 1989 Cytoskeletal abnormalities in motor neuron disease: an immunohistochemical study Brain 112 521 535
19. IRA [tmp] MacKenzie LP Hudson 1995 Achromatic neurons in the cortex of progressive supranuclear palsy Acta Neuropathol 90 615 619
20. D Neary JS Snowden DMA Mann B Northern PJ Goulding N [tmp] MacDermott 1990 Frontal lobe dementia and motor neuron disease J Neurol Neurosurg Psychiatry 53 23 32
21. D Neary JS Snowden L Gustafson U Passant D Stuss S Black M Freedman A Kertesz PH Robert M Albert K Boone BL Miller J Cummings DF Benson 1998 Frontotemporal lobar degeneration: a consensus on clinical diagnostic criteria Neurology 51 1546 1554
22. K Okamoto S Hirai T Yamazaki XY Sun Y Nagazato 1991 New ubiquitin-positive intraneuronal inclusions in the extra-motor cortices in patients with amyotrophic lateral sclerosis Neurosci Lett 129 233 236