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Volumn 20, Issue 1, 2000, Pages 31-37

Neuropathological heterogeneity in Alzheimer's disease: A study of 80 cases using principal components analysis

Author keywords

Alzheimer's disease; Analysis; Apolipoprotein E; Neurodegeneration; Neurofibrillary tangles; Principal components; Senile plaques

Indexed keywords

APOLIPOPROTEIN E;

EID: 0034111406     PISSN: 09196544     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1789.2000.00284.x     Document Type: Article
Times cited : (51)

References (34)
  • 1
    • 0026753914 scopus 로고
    • Principal components analysis of Alzheimer's disease based on neuropathological data: A study of 79 patients
    • Armstrong RA, Myers D. Principal components analysis of Alzheimer's disease based on neuropathological data: A study of 79 patients. Neurosci Res Communs 1992; 11: 1-9.
    • (1992) Neurosci Res Communs , vol.11 , pp. 1-9
    • Armstrong, R.A.1    Myers, D.2
  • 2
    • 0028358134 scopus 로고
    • The identification of pathological subtypes of Alzheimer's disease using cluster analysis
    • Armstrong RA, Wood L. The identification of pathological subtypes of Alzheimer's disease using cluster analysis. Acta Neuropathol 1994; 88: 60-66.
    • (1994) Acta Neuropathol , vol.88 , pp. 60-66
    • Armstrong, R.A.1    Wood, L.2
  • 3
    • 0028597867 scopus 로고
    • Diagnostic confirmation, severity and subtypes of Alzheimer's disease
    • Forstl H, Fischer P. Diagnostic confirmation, severity and subtypes of Alzheimer's disease. Eur Arch Psy Clin Neurosci 1994; 244: 252-260.
    • (1994) Eur Arch Psy Clin Neurosci , vol.244 , pp. 252-260
    • Forstl, H.1    Fischer, P.2
  • 4
    • 0026458377 scopus 로고
    • Mapping of neurofibrillary degeneration in Alzheimer's disease: Evaluation of heterogeneity using the quantification of abnormal tau proteins
    • Vermersch P, Frigand B, Delacourte A. Mapping of neurofibrillary degeneration in Alzheimer's disease: Evaluation of heterogeneity using the quantification of abnormal tau proteins. Acta Neuropathol 1992; 85: 48-54.
    • (1992) Acta Neuropathol , vol.85 , pp. 48-54
    • Vermersch, P.1    Frigand, B.2    Delacourte, A.3
  • 5
    • 0027104773 scopus 로고
    • Heterogeneity in senile dementia of the Alzheimer type: Individual differences, progressive deterioration or clinical subtypes?
    • Ritchie K, Touchon J. Heterogeneity in senile dementia of the Alzheimer type: Individual differences, progressive deterioration or clinical subtypes? J Clin Epidemiol 1992; 45: 1391-1398.
    • (1992) J Clin Epidemiol , vol.45 , pp. 1391-1398
    • Ritchie, K.1    Touchon, J.2
  • 6
    • 0026088977 scopus 로고
    • Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease
    • Goate R, Chartier-Harlin MC, Mullan M et al. Segregation of a missense mutation in the amyloid precursor protein gene with familial Alzheimer's disease. Nature (London) 1991; 349: 704-706.
    • (1991) Nature (London) , vol.349 , pp. 704-706
    • Goate, R.1    Chartier-Harlin, M.C.2    Mullan, M.3
  • 7
    • 0027194791 scopus 로고
    • Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late-onset families
    • Corder EH, Saunders AM, Strittmatter WJ et al. Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late-onset families. Science 1992; 261: 921-923.
    • (1992) Science , vol.261 , pp. 921-923
    • Corder, E.H.1    Saunders, A.M.2    Strittmatter, W.J.3
  • 8
    • 0029004341 scopus 로고
    • Cloning of a gene bearing missense mutations in early onset familial Alzheimer's disease
    • Sherrington R, Rogaev EI, Liang Y et al. Cloning of a gene bearing missense mutations in early onset familial Alzheimer's disease. Nature 1993; 375: 754-760.
    • (1993) Nature , vol.375 , pp. 754-760
    • Sherrington, R.1    Rogaev, E.I.2    Liang, Y.3
  • 9
    • 0029087026 scopus 로고
    • Candidate gene for the chromosome 1 familial Alzheimer's disease locus
    • Levy-Lahad E, Wasco W, Poorkaj P et al. Candidate gene for the chromosome 1 familial Alzheimer's disease locus. Science 1995; 269: 973-977.
    • (1995) Science , vol.269 , pp. 973-977
    • Levy-Lahad, E.1    Wasco, W.2    Poorkaj, P.3
  • 10
    • 12044254746 scopus 로고
    • Binding of human apolipoprotein E to synthetic amyloid-β-peptide: Isoform specific effects and implications for late-onset Alzheimer's disease
    • Strittmatter WJ, Weisgraber KH, Huang DY et al. Binding of human apolipoprotein E to synthetic amyloid-β-peptide: isoform specific effects and implications for late-onset Alzheimer's disease. Proc Natl Acad Sci USA 1993; 90: 8098-8102.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 8098-8102
    • Strittmatter, W.J.1    Weisgraber, K.H.2    Huang, D.Y.3
  • 11
    • 0027936599 scopus 로고
    • Apolipoprotein E allele ε4 is linked to increased deposition of the amyloid β-peptide (Aβ) in cases with or without Alzheimer's disease
    • Berr C, Hauw JJ, Delaere P et al. Apolipoprotein E allele ε4 is linked to increased deposition of the amyloid β-peptide (Aβ) in cases with or without Alzheimer's disease. Neurosci Lett 1994; 178: 221-224.
    • (1994) Neurosci Lett , vol.178 , pp. 221-224
    • Berr, C.1    Hauw, J.J.2    Delaere, P.3
  • 12
    • 0028828649 scopus 로고
    • Regional variation in the distribution of apolipoprotein E and Aβ in Alzheimer's disease
    • Gearing M, Schneider JA, Robins RS et al. Regional variation in the distribution of apolipoprotein E and Aβ in Alzheimer's disease. J Neuropathol Exp Neurol 1995; 54: 833-841.
    • (1995) J Neuropathol Exp Neurol , vol.54 , pp. 833-841
    • Gearing, M.1    Schneider, J.A.2    Robins, R.S.3
  • 13
    • 0028899724 scopus 로고
    • Quantitative analysis of senile plaques in Alzheimer's disease: Observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down's syndrome)
    • Hyman BT, West HL, Rebeck GW et al. Quantitative analysis of senile plaques in Alzheimer's disease: Observation of log-normal size distribution and molecular epidemiology of differences associated with apolipoprotein E genotype and trisomy 21 (Down's syndrome). Proc Natl Acad Sci USA 1995; 92: 3586-3590.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 3586-3590
    • Hyman, B.T.1    West, H.L.2    Rebeck, G.W.3
  • 14
    • 0030009670 scopus 로고    scopus 로고
    • Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease
    • Beffert U, Poirier J. Apolipoprotein E, plaques, tangles and cholinergic dysfunction in Alzheimer's disease. Ann NY Acad Sci 1996; 777: 166-174.
    • (1996) Ann NY Acad Sci , vol.777 , pp. 166-174
    • Beffert, U.1    Poirier, J.2
  • 15
    • 0028841027 scopus 로고
    • Apolipoprotein E, dementia and cortical deposition of β-amyloid protein
    • Polvikoski T, Sulkava R, Hatha M et al. Apolipoprotein E, dementia and cortical deposition of β-amyloid protein. New Engl J Med 1995; 333: 1242-1247.
    • (1995) New Engl J Med , vol.333 , pp. 1242-1247
    • Polvikoski, T.1    Sulkava, R.2    Hatha, M.3
  • 16
    • 0028951080 scopus 로고
    • Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer's disease: Implications for disease pathogenesis
    • Richey PL, Siedlak SL, Smith MA, Perry G. Apolipoprotein E interaction with the neurofibrillary tangles and senile plaques in Alzheimer's disease: Implications for disease pathogenesis. Biochem Biophys Res Commun 1995; 208: 657-663.
    • (1995) Biochem Biophys Res Commun , vol.208 , pp. 657-663
    • Richey, P.L.1    Siedlak, S.L.2    Smith, M.A.3    Perry, G.4
  • 17
    • 0028787064 scopus 로고
    • Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease
    • Nagy Z, Esiri MM, Jobst KA et al. Influence of the apolipoprotein E genotype on amyloid deposition and neurofibrillary tangle formation in Alzheimer's disease. Neurosci 1995; 69: 757-761.
    • (1995) Neurosci , vol.69 , pp. 757-761
    • Nagy, Z.1    Esiri, M.M.2    Jobst, K.A.3
  • 18
    • 6744224822 scopus 로고
    • Alzheimer's disease and Parkinson's disease: Clinical and pathological associations
    • Reisberg B (ed.) London: MacMillan
    • Boller F. Alzheimer's disease and Parkinson's disease: clinical and pathological associations. In: Reisberg B (ed.) Alzheimer's Disease. The Standard Reference. London: MacMillan, 1983; 295-302.
    • (1983) Alzheimer's Disease. The Standard Reference , pp. 295-302
    • Boller, F.1
  • 19
    • 0022572209 scopus 로고
    • A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study
    • Brun A, Englund E. A white matter disorder in dementia of the Alzheimer type: A pathoanatomical study. Ann Neurol 1986; 19: 253-262.
    • (1986) Ann Neurol , vol.19 , pp. 253-262
    • Brun, A.1    Englund, E.2
  • 20
    • 0345512210 scopus 로고
    • Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer's disease
    • Pearson RCA, Esiri MM, Hiorns RW et al. Anatomical correlates of the distribution of the pathological changes in the neocortex in Alzheimer's disease. Proc Natl Acad Sci USA 1985; 82: 4531-4534.
    • (1985) Proc Natl Acad Sci USA , vol.82 , pp. 4531-4534
    • Pearson, R.C.A.1    Esiri, M.M.2    Hiorns, R.W.3
  • 21
    • 0026475167 scopus 로고
    • The human entorhinal cortex: Normal morphology and lamina-specific pathology in various diseases
    • Braak H, Braak E. The human entorhinal cortex: Normal morphology and lamina-specific pathology in various diseases. Neurosci Res 1992; 15: 6-31.
    • (1992) Neurosci Res , vol.15 , pp. 6-31
    • Braak, H.1    Braak, E.2
  • 22
    • 0025879025 scopus 로고
    • Alzheimer's disease: Size class frequency distributions of senile plaques: Do they indicate when a brain tissue was affected?
    • Armstrong RA, Myers D, Smith CUM. Alzheimer's disease: Size class frequency distributions of senile plaques: Do they indicate when a brain tissue was affected? Neurosci Lett 1991; 127: 223-226.
    • (1991) Neurosci Lett , vol.127 , pp. 223-226
    • Armstrong, R.A.1    Myers, D.2    Smith, C.U.M.3
  • 23
    • 0027511389 scopus 로고
    • The role of cortical connectivity in Alzheimer's disease pathogenesis: A review and model system
    • De Lacoste M, White CL III. The role of cortical connectivity in Alzheimer's disease pathogenesis: A review and model system. Neurobiol Aging 1993; 14: 1-16.
    • (1993) Neurobiol Aging , vol.14 , pp. 1-16
    • De Lacoste, M.1    White III, C.L.2
  • 24
    • 0025172064 scopus 로고
    • Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease
    • Vogt BA, Van Hoesen GW, Vogt LJ. Laminar distribution of neuron degeneration in posterior cingulate cortex in Alzheimer's disease. Acta Neuropathol 1990; 80: 581-589.
    • (1990) Acta Neuropathol , vol.80 , pp. 581-589
    • Vogt, B.A.1    Van Hoesen, G.W.2    Vogt, L.J.3
  • 25
    • 0026665034 scopus 로고
    • Heterogeneity in Alzheimer's disease: Progression rate segregated by distinct neuropsychological and cerebral metabolic profiles
    • Mann UM, Mohr E, Gearing M, Chase TM. Heterogeneity in Alzheimer's disease: Progression rate segregated by distinct neuropsychological and cerebral metabolic profiles. J Neurol Neurosurg Psychiatr 1992; 55: 956-959.
    • (1992) J Neurol Neurosurg Psychiatr , vol.55 , pp. 956-959
    • Mann, U.M.1    Mohr, E.2    Gearing, M.3    Chase, T.M.4
  • 26
    • 0025908356 scopus 로고
    • The consortium to establish a registry for Alzheimer's disease (CERAD). II. Standardisation of the neuropathologic assessment of Alzheimer's disease
    • Mirra SS, Heyman A, McKeel D et al. The consortium to establish a registry for Alzheimer's disease (CERAD). II. Standardisation of the neuropathologic assessment of Alzheimer's disease. Neurol 1991; 41: 479-486.
    • (1991) Neurol , vol.41 , pp. 479-486
    • Mirra, S.S.1    Heyman, A.2    McKeel, D.3
  • 28
    • 0000039882 scopus 로고
    • Relationships between morphological types of plaque in Alzheimer's disease as revealed in silver and immunostained preparations
    • Armstrong RA. Relationships between morphological types of plaque in Alzheimer's disease as revealed in silver and immunostained preparations. Neurodegen 1993; 2: 259-266.
    • (1993) Neurodegen , vol.2 , pp. 259-266
    • Armstrong, R.A.1
  • 29
    • 0026572346 scopus 로고
    • Alzheimer's disease: Identical phenotype of familial and non-familial cases
    • Haupt M, Kurz A, Pollman S, Romero B. Alzheimer's disease: Identical phenotype of familial and non-familial cases. J Neurol 1992; 239: 248-250.
    • (1992) J Neurol , vol.239 , pp. 248-250
    • Haupt, M.1    Kurz, A.2    Pollman, S.3    Romero, B.4
  • 30
    • 0027438964 scopus 로고
    • Comparison of the severity of neuropathologic changes in familial and sporadic Alzheimer's disease
    • Nochlin D, Van belle G, Bird TD, Sumi SM. Comparison of the severity of neuropathologic changes in familial and sporadic Alzheimer's disease. Alz Dis Assoc Dis 1993; 7: 212-222.
    • (1993) Alz Dis Assoc Dis , vol.7 , pp. 212-222
    • Nochlin, D.1    Van Belle, G.2    Bird, T.D.3    Sumi, S.M.4
  • 31
    • 0022204961 scopus 로고
    • Clinical subtypes of dementia of the Alzheimer type
    • Chui HC, Teng EL, Henderson VW, Moy AC. Clinical subtypes of dementia of the Alzheimer type. Neurol 1985; 35: 1544-1550.
    • (1985) Neurol , vol.35 , pp. 1544-1550
    • Chui, H.C.1    Teng, E.L.2    Henderson, V.W.3    Moy, A.C.4
  • 32
    • 0030050286 scopus 로고    scopus 로고
    • Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease
    • Gomez-Isla T, West HL, Rebeck GW et al. Clinical and pathological correlates of apolipoprotein E ε4 in Alzheimer's disease. Anns Neurol 1996; 39: 62-70.
    • (1996) Anns Neurol , vol.39 , pp. 62-70
    • Gomez-Isla, T.1    West, H.L.2    Rebeck, G.W.3
  • 33
    • 0028946291 scopus 로고
    • Apolipoprotein E genotype, Alzheimer pathologies and related gene expression in the aged population
    • Oyama F, Shimada H, Oyama R, Ihara Y. Apolipoprotein E genotype, Alzheimer pathologies and related gene expression in the aged population. Mole Brain Res 1995; 29: 92-98.
    • (1995) Mole Brain Res , vol.29 , pp. 92-98
    • Oyama, F.1    Shimada, H.2    Oyama, R.3    Ihara, Y.4
  • 34
    • 0029886171 scopus 로고    scopus 로고
    • SPECT and MRI analysis in Alzheimer's disease: Relation to apolipoprotein E epsilon-4 allele
    • Lehtovirta M, Soininen H, Laakso MP et al. SPECT and MRI analysis in Alzheimer's disease: relation to apolipoprotein E epsilon-4 allele. J Neurol Neurosurg Psychiatr 1996; 60: 644-649.
    • (1996) J Neurol Neurosurg Psychiatr , vol.60 , pp. 644-649
    • Lehtovirta, M.1    Soininen, H.2    Laakso, M.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.