Anticonvulsant effect of the calcineurin inhibitor ascomycin on seizures induced by picrotoxin microperfusion in the rat hippocampus

Pharmacology Biochemistry and Behavior

Volumn 84, Issue 3, 2006, Pages 511-516

  Vázquez López, Araceli ^a   Sierra Paredes, Germán ^a   Sierra Marcuño, Germán ^a  

^a UNIVERSITY OF SANTIAGO DE COMPOSTELA   (Spain)

Author keywords

Ascomycin; Calcineurin; Hippocampus; Microdialysis; Picrotoxin; Seizures

Indexed keywords

ASCOMYCIN; CALCINEURIN; CALCINEURIN INHIBITOR; PICROTOXIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTICONVULSANT ACTIVITY; ARTICLE; BEHAVIOR CHANGE; BIOCHEMISTRY; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DISEASE DURATION; DOSE RESPONSE; EEG ABNORMALITY; ENZYME ACTIVITY; HIPPOCAMPUS; IN VIVO STUDY; LOW DRUG DOSE; MALE; MICRODIALYSIS; MOLECULAR PROBE; NONHUMAN; PERFUSION; PRIORITY JOURNAL; RAT; SEIZURE; STATISTICAL SIGNIFICANCE;

ANIMALS; ANTICONVULSANTS; CALCINEURIN; CONVULSANTS; EPILEPSY; HIPPOCAMPUS; IMMUNOSUPPRESSIVE AGENTS; MALE; PERFUSION; PHOSPHORYLATION; PICROTOXIN; RATS; RATS, SPRAGUE-DAWLEY; TACROLIMUS;

ANIMALIA;

EID: 33747878492     PISSN: 00913057     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.pbb.2006.06.015     Document Type: Article

References (41)

1. Aguilar-Veiga E., Sierra-Paredes G., Galán-Valiente J., Soto-Otero R., Méndez-Alvarez E., and Sierra-Marcuño G. Correlation between ethosuximide brain levels measured by high performance liquid chromatography and its antiepileptic potential. Res Commun Chem Pathol Pharmacol 71 (1991) 351-364
2. A receptor function in rat cerebellar granule cells in culture. Neuroscience 84 (1998) 529-535
3. Beattie E.C., Carroll R.C., Yu X., Morishita W., Yasuda H., von Zastrow M., et al. Regulation of AMPA receptor endocytosis by a signaling mechanism shared with LTD. Nat Neurosci 3 (2000) 1291-1300
4. Carafoli E. Intracellular calcium homeostasis. Annu Rev Biochem 56 (1987) 395-433
5. Chen Q.X., and Wong R.K.S. Suppression of GABAA receptor responses by NMDA application in hippocampal neurons acutely isolated from the adult guinea-pig. J Physiol (Lond) 482 (1995) 353-362
6. Choi D.W. Calcium-mediated neurotoxicity: relationship to specific channel types and role in ischemic damage. Trends Neurosci 11 (1988) 465-467
7. 2+ transduction pathway causes spontaneous recurrent epileptiform discharges in hippocampal neurons in culture. Proc Natl Acad Sci U S A 95 (1998) 14482-14487
8. DeLorenzo R.J., Sun D.A., and Deshpande L.S. Cellular mechanisms underlying acquired epilepsy: the calcium hypothesis of the induction and maintenance of epilepsy. Pharmacol Ther 105 (2005) 229-266
9. Dingledine R., McBain C.J., and McNamara J.O. Excitatory amino acids in epilepsy. Trends Pharmacol Sci 11 (1990) 334-338
10. Groth R.D., Dunbar R.L., and Mermelstein P.G. Calcineurin regulation of neuronal plasticity. Biochem Biophys Res Commun 311 (2003) 1159-1171
11. Huang R., and Dillon G.H. Maintenance of recombinant type A γ-aminobutyric acid receptor function: role of tyrosine phosphatases and calcineurin. J Pharmacol Exp Ther 286 (1998) 243-255
12. Klee C.B., Ren H., and Wang X. Regulation of the calmodulin-stimulated protein phosphatase, calcineurin. J Biol Chem 273 (1998) 13367-13370
13. Kurz J.E., Sheets D., Travis-Parsons J., Rana A., DeLorenzo R.J., and Churn S.B. A significant increase in both basal and maximal calcineurin activity in the rat pilocarpine model of status epilepticus. J Neurochem 78 (2001) 304-315
14. Lieberman D.N., and Mody I. Regulation of NMDA channel function by endogenous Ca(2+)-dependent phosphatase. Nature 369 (1994) 235-239
15. Lin J.W., Ju W., Foster K., Lee S.H., Ahmadian G., Wyszynski M., et al. Distinct molecular mechanisms and divergent endocytotic pathways of AMPA receptor internalization. Nat Neurosci 3 (2000) 1282-1290
16. Lu Y.M., Mansuy I.M., Kandel E.R., and Roder J. Calcineurin-mediated LTD of GABAergic inhibition underlies the increased excitability of CA1 neurons associated with LTP. Neuron 26 (2000) 197-205
17. A receptor channels. Annu Rev Neurosci 17 (1994) 569-602
18. Meadows R.P., Nettesheim D.G., Xu R.X., Olejniczak E.T., Petros A.M., Holzman T.F., et al. Three-dimensional structure of the FK506 binding protein/ascomycin complex in solution by heteronuclear three- and four-dimensional NMR. Biochemistry 32 3 (1993) 754-765
19. 2+ homeostasis. Annu Rev Biochem 56 (1991) 395-433
20. Misonou H., Mohapatra D.P., Park E.W., Leung V., Zhen D., Misonou K., et al. Regulation of ion channel localization and phosphorylation by neuronal activity. Nat Neurosci 7 (2004) 711-718
21. Moia L., Matsui H., de Barrose G.A.M., Tomizawa K., Miyamoto K., Kuwata Y., et al. Immunosupressants and calcineurin inhibitors cyclosporin A and FK506, reversibly inhibit epileptogenesis in amigdaloid kindled rat. Brain Res 648 (1994) 337-341
22. Montoro R.J., Diaz-Nido J., Avila J., and Lopez-Barneo J. N-metyl-D-aspartate stimulates the dephosphorylation of the microtubule-associated protein 2 and potentiates excitatory synaptic pathways in the rat hippocampus. Neuroscience 54 (1993) 859-871
23. Pal S., Sombati S., Limbrick D.D., and DeLorenzo R.J. In vitro status epilepticus causes sustained elevation of intracellular calcium levels in hippocampal neurons. Brain Res 851 (1999) 20-31
24. Pallen C.J., and Wang J.H. A multifunctional calmodulin-stimulated phosphatase. Arch Biochem Biophys 237 (1985) 281-291
25. 2+ ATPase. J Neurochem 68 (1997) 1124-1134
26. 2+ ATPase. Brain Res 834 (1999) 32-41
27. 2+ uptake. J Neurochem 74 (2000) 1209-1218
28. Paxinos G., and Watson C. The rat brain in stereotaxic coordinates (1997), Academic Press, London
29. Rice A.C., and De-Lorenzo R.J. NMDA receptor activation during status epilepticus is required for the development of epilepsy. Brain Res 782 (1998) 240-247
30. Riedel G. If phosphatases go up, memory goes down. Cell Mol Life Sci 55 (1999) 549-553
31. Rzigalinski B.A., Weber J.T., Willoughby K.A., and Ellis E.F. Intracellular free calcium dynamics in stretch-injured astrocytes. J Neurochem 70 (1998) 2377-2385
32. Sanchez R.M., Dai W., Levada R.E., Lippman J.L., and Jensen E. AMPA/Kainate receptor mediated downregulation of GABAergic synaptic transmission by calcineurin after seizures in the developing rat brain. J Neurosci 25 (2005) 3442-3451
33. Scharfman H.E. Epilepsy as an example of neural plasticity. Neuroscientist 8 2 (2002) 154-173
34. Sharkey J., Jones P.A., McCarter J.F., and Kelly J.S. Calcineurin inhibitors as neuroprotectants: focus of tacrolimus and ciclosporin. CNS Drugs 13 (2000) 1-13
35. Shi J., Townsend M., and Constantine-Paton M. Activity-dependent induction of tonic calcineurin activity mediates a rapid developmental downregulation of NMDA receptor currents. Neuron 28 (2000) 103-114
36. Sierra-Paredes G., and Sierra-Marcuño G. Microperfusion of picrotoxin in the hippocampus of freely moving rats through microdialysis probes: a new method of inducing partial and secondary generalized seizures. J Neurosci Methods 67 (1996) 113-120
37. Solá C., Tusell J.M., and Serratosa J. Decreased expression of calmodulin kinase II and calcineurin messenger RNAs in the mouse hippocampus after kainic acid-induced seizures. J Neurochem 70 4 (1998) 1600-1608
38. Springer J.E., Azbill R.D., Nottingham S.A., and Kennedy S.E. Calcineurin-mediated BAD dephosphorylation activates the caspase-3 apoptotic cascade in traumatic spinal cord injury. J Neurosci 20 (2000) 7246-7251
39. Suzuki K., Omura S., Ohashi Y., Kawai M., Iwata Y., Tani K., et al. FK506 facilitates chemical kindling induced by pentylenetetrazole in rats. Epilepsy Res 46 (2001) 279-282
40. Tong G., Shepherd D., and Jahr C.E. Synaptic desensitization of NMDA receptors by calcineurin. Science 267 (1995) 1510-1512
41. Vázquez-López A., Sierra-Paredes G., and Sierra-Marcuño G. Role of cAMP-dependent protein kinase on acute picrotoxin-induced seizures. Neurochem Res 30 (2005) 613-618