Complement Factor H Increases Risk for Atrophic Age-Related Macular Degeneration

Ophthalmology

Volumn 113, Issue 9, 2006, Pages 1504-1507

  Postel, Eric A ^a   Agarwal, Anita ^b   Caldwell, Jennifer ^a   Gallins, Paul ^c   Toth, Cynthia ^a   Schmidt, Silke ^c   Scott, William K ^c   Hauser, Michael A ^c   Haines, Jonathan L ^d   Pericak Vance, Margaret A ^c  

^a DUKE UNIVERSITY EYE CENTER   (United States)

^b VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

^c DUKE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^d VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COMPLEMENT FACTOR H;

AGED; ARTICLE; CASE CONTROL STUDY; CONTROLLED STUDY; FEMALE; GENETIC RISK; GENOTYPE; HUMAN; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RETINA MACULA AGE RELATED DEGENERATION; RISK ASSESSMENT; STANDARD;

AGED; ATROPHY; CASE-CONTROL STUDIES; COMPLEMENT FACTOR H; FEMALE; GENOTYPE; HUMANS; MACULA LUTEA; MACULAR DEGENERATION; MALE; MIDDLE AGED; POLYMORPHISM, SINGLE NUCLEOTIDE; RETROSPECTIVE STUDIES; RISK FACTORS;

EID: 33747873216     PISSN: 01616420     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ophtha.2006.02.049     Document Type: Article

References (23)

1. Tomany S.C., Wang J.J., Van Leeuwen R., et al. Risk factors for incident age-related macular degeneration. Pooled findings from 3 continents. Ophthalmology 111 (2004) 1280-1287
2. Buch H., Nielsen N.V., Vinding T., et al. 14-year incidence, progression, and visual morbidity of age-related maculopathy. The Copenhagen City Eye Study. Ophthalmology 112 (2005) 787-798
3. Haines J.L., Hauser M.A., Schmidt S., et al. Complement factor H variant increases the risk of age-related macular degeneration. Science 308 (2005) 419-421
4. Edwards A.O., Ritter III R., Abel K.J., et al. Complement factor H polymorphism and age-related macular degeneration. Science 308 (2005) 421-424
5. Klein R.J., Zeiss C., Chew E.Y., et al. Complement factor H polymorphism in age-related macular degeneration. Science 308 (2005) 385-389
6. Hageman G.S., Anderson D.H., Johnson L.V., et al. A common haplotype in the complement regulatory gene factor H (HF1/CFH) predisposes individuals to age-related macular degeneration. Proc Natl Acad Sci U S A 102 (2005) 7227-7232
7. Seddon J.M., Gensler G., Milton R.C., et al. Association between C-reactive protein and age-related macular degeneration. JAMA 291 (2004) 704-710
8. Gurne D.H., Tso M.O., Edward D.P., and Ripps H. Antiretinal antibodies in serum of patients with age-related macular degeneration. Ophthalmology 98 (1991) 602-607
9. Killingsworth M.C., Sarks J.P., and Sarks S.H. Macrophages related to Bruch's membrane in age-related macular degeneration. Eye 4 (1990) 613-621
10. Mullins R.F., Russell S.R., Anderson D.H., and Hageman G.S. Drusen associated with aging and age-related macular degeneration contain proteins common to extracellular deposits associated with atherosclerosis, elastosis, amyloidosis, and dense deposit disease. FASEB J 14 (2000) 835-846
11. Klein R., Klein B.E., Knudtson M.D., et al. Systemic markers of inflammation, endothelial dysfunction, and age-related maculopathy. Am J Ophthalmol 140 (2005) 35-4
12. Postel E.A., Agarwal A., Schmidt S., et al. Comparing age-related macular degeneration phenotype in probands from singleton and multiplex families. Am J Ophthalmol 139 (2005) 820-825
13. De La Paz M.A., Pericak-Vance M., Haines J.L., and Seddon J.M. Phenotypic heterogeneity in families with age-related macular degeneration. Am J Ophthalmol 124 (1997) 331-343
14. Age-Related Eye Disease Study Research Group. The Age-Related Eye Disease Study system for classifying age-related macular degeneration from stereoscopic color fundus photographs. the Age-Related Eye Disease Study report number 6. Am J Ophthalmol 132 (2001) 668-681
15. Age-Related Eye Disease Study Research Group. The Age-Related Eye Disease Study (AREDS). design implications. AREDS report no. 1. Control Clin Trials 20 (1999) 573-600
16. Jakobsdottir J., Conley Y.P., Weeks D.E., et al. Susceptibility genes for age-related maculopathy on chromosome 10q26. Am J Hum Genet 77 (2005) 389-407
17. Rivera A., Fisher S.A., Fritsche L.G., et al. Hypothetical LOC387715 is a second major susceptibility gene for age-related macular degeneration, contributing independently of complement factor H to disease risk. Hum Mol Genet 14 (2005) 3227-3236
18. Haines J.L., Schnetz-Boutaud N., Schmidt S., et al. Functional candidate genes in age-related macular degeneration. significant association with VEGF, VLDLR, and LRP6. Invest Ophthalmol Vis Sci 47 (2006) 329-335
19. Age-Related Eye Disease Study Research Group. Risk factors for the incidence of advanced age-related macular degeneration in the Age-Related Eye Disease Study (AREDS). AREDS report no. 19. Ophthalmology 112 (2005) 533-539
20. Wang J.J., Mitchell P., Smith W., et al. Systemic use of anti-inflammatory medications and age-related maculopathy. the Blue Mountains Eye Study. Ophthalmic Epidemiol 10 (2003) 37-48
21. Schachat A.P. New treatments for age-related macular degeneration. Ophthalmology 112 (2005) 531-532
22. Cahill M.T., Mruthyunjaya P., Bowes-Rickman C., and Toth C.A. Recurrence of retinal pigment epithelial changes after macular translocation with 360 degrees peripheral retinectomy for geographic atrophy. Arch Ophthalmol 123 (2005) 935-938
23. Dunaief J.L., Dentchev T., Ying G.S., and Milam A.H. The role of apoptosis in age-related macular degeneration. Arch Ophthalmol 120 (2002) 1435-1442