Mechanical stress reduces podocyte proliferation in vitro

Kidney International

Volumn 61, Issue 1, 2002, Pages 40-50

  Petermann, Arndt T ^a   Hiromura, Keiju ^a   Blonski, Mary ^a   Pippin, Jeffrey ^a   Monkawa, Toshi ^a   Durvasula, Raghu ^a   Couser, William G ^a   Shankland, Stuart J ^a  

^a UNIVERSITY OF WASHINGTON SCHOOL OF MEDICINE   (United States)

Author keywords

Capillary glomerular hypertension; Cell cycle; Cyclin dependent kinase; Kidney; p21; Stretch; Visceral glomerular epithelial cell podocyre

Indexed keywords

CELL PROTEIN; CYCLIN A; CYCLIN B1; CYCLIN D1; CYCLIN DEPENDENT KINASE INHIBITOR; DNA; MESSENGER RNA; PROTAMINE KINASE; PROTEIN P21; PROTEIN P27; PROTEIN P57; REGULATOR PROTEIN; RIBONUCLEASE; THYMIDINE; TRITIUM;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL COUNT; CELL CYCLE; CELL GROWTH; CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; CORRELATION FUNCTION; DISEASE ASSOCIATION; DNA SYNTHESIS; ENZYME ACTIVITY; FLUORESCENCE ACTIVATED CELL SORTING; HYPERTENSION; IN VITRO STUDY; MECHANICAL STRESS; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REGULATORY MECHANISM; STAINING; STRETCHING; TIME; VACUUM; WESTERN BLOTTING;

EID: 0036149007     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1523-1755.2002.00102.x     Document Type: Article

References (41)

1. Roles of the podocyte in glomerular function
2. Glomerular epithelial cells (chapt 31)
3. A role for podocytes to counteract capilary wall distention
4. Progression of glomerular diseases: Is the podocyte the culprit?
5. Nephron adaptation to renal injury or ablation
6. Modelling the effects of vascular stress in mesangial cells
7. Mechanical stress mechanisms and the cell: An endothelial paradigm
8. Continuous stretch-relaxation in culture alters rat mesangial cell morphology, growth characteristics, and metabolic activity
9. Cyclic stretching force selectively up-regulates transforming growth factor-beta isoforms in cultured rat mesangial cells
10. Regulation of extracellular matrix by mechanical stress in rat glomerular mesangial cells
11. Mesangial cell signaling cascades in response to mechanical strain and glucose
12. G1 events and regulation of cell proliferation
13. Cell cycle proteins and the kidney: Role in proliferation, growth and apoptosis
14. Principles of CDK regulation
15. Cyclin-dependent kinases: Engines, clocks, and microprocessors
16. Progressive renal failure-inability of podocytes to replicate and the consequences for development of glomerulosclerosis
17. How does glomerular epithelial cell injury contribute to progressive glomerular damage?
18. Complement (C5b-9) induces glomerular epithelial cell DNA synthesis but not proliferation in vitro
19. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocyte cell lines
20. Kip1
21. Direct in vivo inhibition of the nuclear cell cycle cascade in experimental mesangial proliferative glomerulonephritis with roscovitine, a novel cyclin-dependent kinase antagonist
22. Cyclin kinase inhibitors are increased during experimental membranous nephropathy: Potential role in limiting glomerular epithelial cell proliferation in vivo
23. Intraglomerular pressure and mesangial stretching stimulate extracellular matrix formation in the rat
24. CDK inhibitors: Positive and negative regulators of G 1-phase progression
25. A frequent pathway to glomerulosclerosis: Deterioration of tuft architecture-podocyte damage-segmental sclerosis
26. Podocyte number predicts long-term urinary albumin excretion in Pima Indians with type II diabetes and microalbuminuria
27. Regulation of podocyte structure during the development of nephrotic syndrome
28. Mechanical strain induces growth of vascular smooth muscle cells via autocrine action of PDGF
29. Physiological cyclic stretch causes cell cycle arrest in cultured vascular smooth muscle cells
30. Cell cycle proteins and renal disease: Role in proliferation, hypertrophy and apoptosis
31. Mitosis and the presence of binucleate cells among glomerular podocytes in diseased human kidneys
32. Podocytes respond to mechanical stress in vitro
33. Renal epithelial cell hyperplasia and hypertrophy
34. Isolation of a human cyclin cDNA: Evidence for cyclin mRNA and protein regulation in cell cycle and for interaction with p34cdc2
35. Involvement of p21 in the PKC-induced regulation of the G2/M cell cycle transition
36. Cellular mechanisms of tubule hypertrophy and hyperplasia in renal injury
37. The cyclin kinase inhibitor p21Cip1/WAF1 limits visceral glomerular epithelial cell proliferation in experimental glomerulonephritis
38. Kip1 safeguards against inflammatory injury
39. Differential expression of CDK-inhibitors in human glomerular disease: Role in podocyte proliferation and differentiation
40. Laminar shear stress inhibits vascular endothelial cell proliferation by inducing cyclin-dependent kinase inhibitor p21(Sdi1/Cip1/Waf1)