What is an adequate dose of oral vitamin B12 in older people with poor vitamin B12 status?

Nutrition Reviews

Volumn 64, Issue 8, 2006, Pages 373-378

  Park, Sohyun ^a   Johnson, Mary Ann ^a  

^a UNIVERSITY OF GEORGIA   (United States)

Author keywords

Elderly; Vitamin B12

Indexed keywords

CYANOCOBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHYLMALONIC ACID;

ATROPHIC GASTRITIS; BACTERIAL METABOLISM; CLINICAL TRIAL; CYANOCOBALAMIN DEFICIENCY; DIFFERENTIAL DIAGNOSIS; DIGESTION; DOSE RESPONSE; FISH; GASTRECTOMY; HEALTH STATUS; HUMAN; ILEUM DISEASE; KIDNEY FUNCTION; MALABSORPTION; MEAT; PERNICIOUS ANEMIA; POULTRY; PREVALENCE; PROTEIN INTAKE; RISK FACTOR; SHORT SURVEY; VITAMIN SUPPLEMENTATION;

AGED; AGING; DIGESTION; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INTESTINAL ABSORPTION; MALE; TREATMENT OUTCOME; VITAMIN B 12; VITAMIN B 12 DEFICIENCY; VITAMIN B COMPLEX;

EID: 33747871470     PISSN: 00296643     EISSN: 00296643     Source Type: Journal    
DOI: 10.1301/nr.2006.aug.373-378     Document Type: Short Survey

References (43)

1. 12, Pantothenic Acid, Biotin, and Choline. Washington, DC: National Academies Press; 1998. Available at: http://www.nap.edu/openbook/0309065542/ html/. Accessed July 12, 2006.
2. 12 deficiency in the elderly. Ann Rev Nutr. 1999;19:357-377.
3. 12, demyelination, remyelination and repair in multiple sclerosis. J Neurol Sci. 2005;233:93-97.
4. Wolters M, Ströhle A, Hahn A. Cobalamin: a critical vitamin in the elderly. Prev Med. 2004;39:1256-1266.
5. Reynish W, Andrieu S, Nourhashemi F, Vellas B. Nutritional factors and Alzheimer's disease. J Gerontol A Biol Sci Med Sci. 2001;56:M675-M680.
6. Lewis MS, Miller LS, Johnson MA, Dolce EB, Allen RH, Stabler SP. Elevated methylmalonic acid is related to cognitive impairment in older adults enrolled in an elderly nutrition program. J Nutr Elderly. 2005;24:47-65.
7. Del Parigi A, Panza F, Capurso C, Solfrizzi V. Nutritional factors, cognitive decline, and dementia. Brain Res Bull. 2006;69:1-19.
8. 12 deficiency and depression in physically disabled older women: epidemiologic evidence from the Women's Health and Aging Study. Am J Psychiatry. 2000;157:715-721.
9. 12, and folate in elderly women. Am J Clin Nutr. 1999;69:564-571.
10. Gok U, Halifeoglu I, Canatan C, Yildiz M, Gursu MF, Gur B. Comparative analysis of serum homocysteine, folic acid levels in patients with noise-induced hearing. Auris Nasus Larynx. 2004;31:19-22.
11. 12 deficiency in patients with chronic tinnitus and noise-induced hearing loss. Am J Otolaryngol. 1993;2:94-99.
12. Ames BN, Wakimoto P. Are vitamin and mineral deficiencies a major cancer risk? Nat Rev Cancer. 2002;2:694-704.
13. Morris MS, Jacques PF, Selhub J. Relation between homocysteine and B-vitamin status indicators and bone mineral density in older Americans. Bone. 2005;37:234-242.
14. 12 status relate to bone turnover markers, broadband ultrasound attenuation, and fractures in healthy elderly people. J Bone Miner Res. 2005;20:921-929.
15. Dhonukshe-Rutten RAM, van Dusseldorp M, Schneede J, de Groot LCPGM, van Staveren WA. Low bone mineral density and bone mineral content are associated with low cobalamin status in adolescents. Eur J Nutr. 2005;44:341-347.
16. Herrmann M, Widmann T, Herrmann W. Homocysteine: a newly recognized risk factor for osteoporosis. Clin Chem Lab Med. 2005;43:1111-1117.
17. Martin DC, Francis J, Protetch J, Huff FJ. Time dependency of cognitive recovery with cobalamin replacement: report of a pilot study. J Am Geriatr Soc. 1992;40:168-172.
18. Seshadri S, Beiser A, Selhub J, et al. Plasma homocysteine as a risk factor for dementia and Alzheimer's disease. N Engl J Med. 2002;346:476-483.
19. Jacques PF, Bostom AG, Wilson PW, Rich S, Rosenberg IH, Selhub J. Determinants of plasma total homocysteine concentration in the Framingham Offspring cohort. Am J Clin Nutr. 2001;73:613-621.
20. Selhub J. Homocysteine metabolism. Annu Rev Nutr. 1999;19:217-246.
21. Allen RH, Stabler SP, Savage DG, Lindenbaum J. Elevation of 2-methylcitric acid I and II in the serum, urine and cerebrospinal fluid of patients with cobalamin deficiency. Metabolism. 1993;42:978-988.
22. 12 deficiency and determination of holotranscobalamin in populations at risk. Clin Chem Lab Med. 2003;41:1478-1488.
23. Carmel R. Current concepts in cobalamin deficiency. Annu Rev Med. 2000;51:357-375.
24. Lindenbaum J, Healton EB, Savage DG, et al. Neuropsychiatric disorders caused by cobalamin deficiency in the absence of anemia or macrocytosis. N Engl J Med. 1988;318:1720-1728.
25. 12. In: Bowman BA, Russell RM, eds. Present Knowledge in Nutrition, 8th ed. Washington, DC: ILSI Press; 2001; 230-240.
26. Moelby L, Rasmussen K, Jensen MK, Pedersen KO. The relationship between clinically confirmed cobalamin deficiency and serum methylmalonic acid. J Intern Med. 1990;228:373-378.
27. Lindenbaum J, Rosenberg IH, Wilson PW, Stabler SP, Allen RH. Prevalence of cobalamin deficiency in the Framingham elderly population. Am J Clin Nutr. 1994;60:2-11.
28. Pennypacker LC, Allen RH, Kelly JP, et al. High prevalence of cobalamin deficiency in elderly out-patients. J Am Geriatr Soc. 1992;40:1197-1204.
29. Rasmussen K, Moller J, Lyngbak M, Pedersen AM, Dybkjer L. Age-and gender-specific reference intervals for total homocysteine and methylmalonic acid in plasma before and after vitamin supplementation. Clin Chem. 1996;42:630-636.
30. Stabler SP, Allen RH, Savage DG, Lindenbaum J. Clinical spectrum and diagnosis of cobalamin deficiency. Blood. 1990;76:871-881.
31. 12 deficiency and the elderly: current dilemmas. Am J Clin Nutr. 1997;66:741-749.
32. Pfeiffer CM, Caudill SP, Gunter EW, Osterloh J, Sampson EJ. Biochemical indicators of B vitamin status in the US population after folic acid fortification: results from the National Health and Nutrition Examination Survey 1999-2000. Am J Clin Nutr. 2005;82:442-450.
33. 12 deficiency. Arch Intern Med. 2001;161:1534-1541.
34. 12 deficiency in Elders using Title IIIc Nutrition Services. Am J Clin Nutr. 2003;77:211-220.
35. Garcia A, Paris-Pombo A, Evans L, Day A, Freedman M. Is low-dose oral cobalamin enough to normalize cobalamin function in older people? J Am Geriatr Soc. 2002;50:1401-1404.
36. Rajan S, Wallace JI, Beresford SA, Brodkin KI, Allen RA, Stabler SP. Screening for cobalamin deficiency in geriatric outpatients: prevalence and influence of synthetic cobalamin intake. J Am Geriatr Soc. 2002;50:624-630.
37. US Department of Health and Human Services, US Department of Agriculture. Dietary Guidelines for Americans 2005. Available at: http://www.health.gov/ dietaryguidelines/dga2005/document/pdf/DGA2005.pdf. Accessed July 12, 2006.
38. Stabler SP, Allen RH, Fried LP, et al. Racial differences in prevalence of cobalamin and folate deficiencies in disabled elderly women. Am J Clin Nutr. 1999;70:911-919.
39. Kuzminski AM, Del Giacco EJ, Allen RH, Stabler SP, Lindenbaum J. Effective treatment of cobalamin deficiency with oral cobalamin. Blood. 1998;92:1191-1198.
40. 12 deficiency. Arch Intern Med. 2005;165:1167-1172.
41. 12: United States, 1988-1994. National Center for Health Statistics. Vital Health Stat. 1998;11:1-78.
42. Rajan S, Wallace JI, Brodkin KI, Beresford SA, Allen RA, Stabler SP. Response of elevated methylmalonic acid to three dose levels of oral cobalamin in older adults. J Am Geriatr Soc. 2002;50:1789-1795.
43. 12 concentrations. J Am Geriatr Soc. 2002;50:146-151.