Using a tritiated compound to elucidate its preclinical metabolic and excretory pathways in vivo: Exploring tritium exchange risk

Drug Metabolism and Disposition

Volumn 34, Issue 9, 2006, Pages 1615-1623

  Shaffer, Christopher L ^a,c   Gunduz, Mithat ^a,c   Thornburgh, Bruce A ^b   Fate, Gwendolyn D ^b  

^a PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

^b Department of Metabolism and Pharmacokinetics ^*

^c PFIZER INC   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

1 AZABICYCLO[2.2.2]OCT 3 YLFURO[2,3 C]PYRIDINE 5 CARBOXAMIDE; AMIDE; NICOTINIC AGENT; TRITIUM; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ARTICLE; BIOTRANSFORMATION; CONTROLLED STUDY; DOG; EXCRETION; FREEZE DRYING; IN VIVO STUDY; NONHUMAN; PRIORITY JOURNAL; RADIOACTIVITY; RAT;

ANIMALS; BICYCLO COMPOUNDS, HETEROCYCLIC; BIOTRANSFORMATION; DOGS; DRUG EVALUATION, PRECLINICAL; DRUG STABILITY; FECES; ISOTOPE LABELING; MOLECULAR STRUCTURE; QUINUCLIDINES; RATS; RATS, SPRAGUE-DAWLEY; SPECIES SPECIFICITY; TRITIUM;

CANIS FAMILIARIS;

EID: 33747864478     PISSN: 00909556     EISSN: 1521009X     Source Type: Journal    
DOI: 10.1124/dmd.106.010934     Document Type: Article

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