Central thyrotropin-releasing hormone infusion opposes cardiovascular and metabolic suppression during caloric restriction

Neuroendocrinology

Volumn 83, Issue 2, 2006, Pages 69-76

  Knight, W David ^a   Swoap, Steven J ^b   Parsons, Almetra D ^a   Overton, J Michael ^a  

^a FLORIDA STATE UNIVERSITY   (United States)

^b WILLIAMS COLLEGE   (United States)

Author keywords

Energy balance; Hypophysis; Hypothalamus; Leptin; Thermogenesis; Thyroid

Indexed keywords

PROTIRELIN; SODIUM CHLORIDE; THYROXINE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD PRESSURE MEASUREMENT; BRADYCARDIA; CALORIC RESTRICTION; CANNULA; CARDIOVASCULAR SYSTEM; CONTROLLED STUDY; ENERGY EXPENDITURE; FOOD INTAKE; HEART RATE; HOMEOSTASIS; HORMONE ACTION; HYPOTHALAMUS; MALE; METABOLIC RATE; NONHUMAN; PRIORITY JOURNAL; RAT; STATISTICAL SIGNIFICANCE; TELEMETRY; THERMOGENESIS;

ANALYSIS OF VARIANCE; ANIMALS; BLOOD PRESSURE; BODY WEIGHT; CALORIC RESTRICTION; CARDIOVASCULAR SYSTEM; DRUG ADMINISTRATION ROUTES; DRUG ADMINISTRATION SCHEDULE; EATING; ENERGY METABOLISM; HEART RATE; INJECTIONS, INTRAVENTRICULAR; MALE; MOTOR ACTIVITY; RADIOIMMUNOASSAY; RATS; RATS, SPRAGUE-DAWLEY; THYROTROPIN-RELEASING HORMONE;

EID: 33747779782     PISSN: 00283835     EISSN: None     Source Type: Journal    
DOI: 10.1159/000094004     Document Type: Article

References (52)

1. Fekete C, Legradi G, Mihaly E, Huang QH, Tatro JB, Rand WM, Emerson CH, Lechan RM: Alpha-melanocyte-stimulating hormone is contained in nerve terminals innervating thyrotropin-releasing hormone-synthesizing neurons in the hypothalamic paraventricular nucleus and prevents fasting-induced suppression of prothyrotropin-releasing hormone gene expression. J Neurosci 2000;20:1550-1558.
2. Fekete C, Singru PS, Sanchez E, Sarkar S, Christoffolete MA, Riberio RS, Rand WM, Emerson CH, Bianco AC, Lechan RM: Differential effects of central leptin, insulin or glucose administration during fasting on the hypothalamic-pituitary-thyroid (HPT) axis and feeding-related neurons in the arcuate nucleus. Endocrinology 2006;147:520-529.
3. Harris M, Aschkenasi C, Elias CF, Chandrankunnel A, Nillni EA, Bjoorbaek C, Elmquist JK, Flier JS, Hollenberg AN: Transcriptional regulation of the thyrotropin-releasing hormone gene by leptin and melanocortin signaling. J Clin Invest 2001;107:111-120.
4. Blake NG, Eckland DJ, Foster OJ, Lightman SL: Inhibition of hypothalamic thyrotropin-releasing hormone messenger ribonucleic acid during food deprivation. Endocrinology 1991;129:2714-2718.
5. Silva JE: The thermogenic effect of thyroid hormone and its clinical implications. Ann Intern Med 2003;139:205-213.
6. Sahu A: Minireview: a hypothalamic role in energy balance with special emphasis on leptin. Endocrinology 2004;145:2613-2620.
7. Nillni EA, Vaslet C, Harris M, Hollenberg A, Bjorbak C, Flier JS: Leptin regulates prothyrotropin-releasing hormone biosynthesis. Evidence for direct and indirect pathways. J Biol Chem 2000;275:36124-36133.
8. Perello M, Stuart RC, Nillni EA: The role of intra-cerebroventricular administration of leptin in the stimulation of prothyrotropin releasing hormone (proTRH) neurons in the hypothalamic paraventricular nucleus. Endocrinology, in press.
9. Sanchez VC, Goldstein J, Stuart RC, Hovanesian V, Huo L, Munzberg H, Friedman TC, Bjorbaek C, Nillni EA: Regulation of hypothalamic prohormone convertases 1 and 2 and effects on processing of prothyrotropin-releasing hormone. J Clin Invest 2004;114:357-369.
10. Guo F, Bakal K, Minokoshi Y, Hollenberg AN: Leptin signaling targets the thyrotropin-releasing hormone gene promoter in vivo. Endocrinology 2004;145:2221-2227.
11. Legradi G, Emerson CH, Ahima RS, Flier JS, Lechan RM: Leptin prevents fasting-induced suppression of prothyrotropin-releasing hormone messenger ribonucleic acid in neurons of the hypothalamic paraventricular nucleus. Endocrinology 1997;138:2569-2576.
12. Garcia SI, Porto PI, Alvarez AL, Martinez VN, Shaurli D, Finkielman S, Pirola CJ: Central overexpression of the TRH precursor gene induces hypertension in rats: antisense reversal. Hypertension 1997;30:759-766.
13. Garcia SI, Porto PI, Dieuzeide G, Landa MS, Kirszner T, Plotquin Y, Gonzalez C, Pirola CJ: Thyrotropin-releasing hormone receptor (TRHR) gene is associated with essential hypertension. Hypertension 2001;38:683-687.
14. Nurminen ML, Paakkari I: Role of peripheral and central catecholaminergic and cholinergic mechanisms in the cardiovascular effects of thyrotropin-releasing hormone. Neuropeptides 1991;20:247-253.
15. Yan J, Chen H, Liao W, Lu S: Cardiovascular effects of thyrotropin-releasing hormone in normotensive and hypotensive rats: role of rostral ventrolateral medulla. Circ Shock 1992;37:253-261.
16. Garcia SI, Landa MS, Porto PI, Alvarez AL, Schuman M, Finkielman S, Pirola CJ: Thyrotropin-releasing hormone decreases leptin and mediates the leptin-induced pressor effect. Hypertension 2002;39:491-495.
17. Shintani M, Tamura Y, Monden M, Shiomi H: Thyrotropin-releasing hormone induced thermogenesis in Syrian hamsters: site of action and receptor subtype. Brain Res 2005;1039:22-29.
18. Shiomi H, Tamura Y: Pharmacological aspects of mammalian hibernation: central thermoregulation factors in hibernation cycle. Nippon Yakurigaku Zasshi 2000;116:304-312.
19. Williams TD, Chambers JB, May OL, Henderson RP, Rashotte ME, Overton JM: Concurrent reductions in blood pressure and metabolic rate during fasting in the unrestrained SHR. Am J Physiol Regul Integr Comp Physiol 2000;278:R255-R262.
20. Steward CA, Horan TL, Schuhler S, Bennett GW, Ebling FJ: Central administration of thyrotropin releasing hormone (TRH) and related peptides inhibits feeding behavior in the Siberian hamster. Neuroreport 2003;14:687-691.
21. Suzuki T, Kohno H, Sakurada T, Tadano T, Kisara K: Intracranial injection of thyrotropin releasing hormone (TRH) suppresses starvation-induced feeding and drinking in rats. Pharmacol Biochem Behav 1982;17:249-253.
22. Garcia SI, Alvarez AL, Porto PI, Garfunkel VM, Finkielman S, Pirola CJ: Antisense inhibition of thyrotropin-releasing hormone reduces arterial blood pressure in spontaneously hypertensive rats. Hypertension 2001;37:365-370.
23. Ushijima I, Yamada K, Noda Y, Furukawa T: Progressive augmentation of locomotor activity in mice by long-term treatment with thyrotropin releasing hormone. Arch Int Pharmacodyn Ther 1984;270:29-37.
24. Sharp T, Bennett GW, Marsden CA, Tulloch IF: A comparison of the locomotor effects induced by centrally injected TRH and TRH analogues. Regul Pept 1984;9:305-315.
25. Miyamoto M, Narumi S, Nagai Y, Shima T, Nagawa Y: Thyrotropin-releasing hormone: hyperactivity and mesolimbic dopamine system in rats. Jpn J Pharmacol 1979;29:335-347.
26. Kahaly GJ, Dillmann WH: Thyroid hormone action in the heart. Endocr Rev 2005;26:704-728.
27. Bunag RD, Mattila J: Selective suppression of pressor and sympathetic responses to centrally infused TRH in hypothyroid rats. J Cardiovasc Pharmacol 1988;12:51-57.
28. Garcia SI, Dabsys SM, Martinez VN, Delorenzi A, Santajuliana D, Nahmod VE, Finkielman S, Pirola CJ: Thyrotropin-releasing hormone hyperactivity in the preoptic area of spontaneously hypertensive rats. Hypertension 1995;26:1105-1110.
29. Mattila J, Bunag RD: Pressor and sympathetic responses to dorsal raphe nucleus infusions of TRH in rats. Am J Physiol 1990;258:R1464-R1471.
30. Paakkari I, Nurminen ML, Siren AL: Cardioventilator effects of TRH in anaesthetized rats: role of the brain stem. Eur J Pharmacol 1986;122:131-134.
31. Sharif NA: Quantitative autoradiography of TRH receptors in discrete brain regions of different mammalian species. Ann NY Acad Sci 1989;553:147-175.
32. O'Dowd BF, Lee DK, Huang W, Nguyen T, Cheng R, Liu Y, Wang B, Gershengorn MC, George SR: TRH-R2 exhibits similar binding and acute signaling but distinct regulation and anatomic distribution compared with TRH-R1. Mol Endocrinol 2000;14:183-193.
33. Helke CJ, Phillips ET: Thyrotropin-releasing hormone receptor activation in the spinal cord increases blood pressure and sympathetic tone to the vasculature and the adrenals. J Pharmacol Exp Ther 1988;245:41-46.
34. Jedrusiak J, Brus R, Kostrzewa RM, Slowinski Z: Dopaminergic neuronal systems modulate the central cardiovascular effects of TRH in rats. Pol J Pharmacol 1995;47:43-52.
35. Nurminen ML, Paakkari I, Seppala T: Serotonergic involvement in the cardiovascular stimulation by thyrotropin-releasing hormone (TRH) in anesthetized rats. Neurosci Lett 1991;127:147-149.
36. Yuan PQ, Yang H: Hypothyroidism increases Fos immunoreactivity in cholinergic neurons of brain medullary dorsal vagal complex in rats. Am J Physiol Endocrinol Metab 2005;289:E892-E899.
37. Mattila J, Bunag RD: Sympathomimetic pressor responses to thyrotropin-releasing hormone in rats. Am J Physiol 1986;251:H86-H92.
38. Palkovits M, Mezey E, Eskay RL, Brownstein MJ: Innervation of the nucleus of the solitary tract and the dorsal vagal nucleus by thyrotropin-releasing hormone-containing raphe neurons. Brain Res 1986;373:246-251.
39. Williams TD, Chambers JB, Gagnon SP, Roberts LM, Henderson RP, Overton JM: Cardiovascular and metabolic responses to fasting and thermoneutrality in Ay mice. Physiol Behav 2003;78:615-623.
40. Gehrmann J, Hammer PE, Maguire CT, Wakimoto H, Triedman JK, Berul CI: Phenotypic screening for heart rate variability in the mouse. Am J Physiol Heart Circ Physiol 2000;279:H733.
41. Janssen BJ, Leenders PJ, Smits JF: Short-term and long-term blood pressure and heart rate variability in the mouse. Am J Physiol Regul Integr Comp Physiol 2000;278:R215.
42. Cone RD: Anatomy and regulation of the central melanocortin system. Nat Neurosci 2005;8:571-578.
43. Morton GJ, Schwartz MW: The NPY/AgRP neuron and energy homeostasis. Int J Obes Relat Metab Disord 2001;25(suppl 5):S56-S62.
44. Elmquist JK, Coppari R, Balthasar N, Ichinose M, Lowell BB: Identifying hypothalamic pathways controlling food intake, body weight, and glucose homeostasis. J Comp Neurol 2005;493:63-71.
45. Sarkar S, Legradi G, Lechan RM: Intracerebroventricular administration of alpha-melanocyte stimulating hormone increases phosphorylation of CREB in TRH- and CRH-producing neurons of the hypothalamic paraventricular nucleus. Brain Res 2002;945:50-59.
46. Lechan RM, Fekete C: Role of melanocortin signaling in the regulation of the hypothalamic-pituitary-thyroid (HPT) axis. Peptides 2006;27:310-325.
47. Fekete C, Kelly J, Mihaly E, Sarkar S, Rand WM, Legradi G, Emerson CH, Lechan RM: Neuropeptide Y has a central inhibitory action on the hypothalamic-pituitary-thyroid axis. Endocrinology 2001;142:2606-2613.
48. Sarkar S, Lechan RM: Central administration of neuropeptide Y reduces alpha-melanocyte-stimulating hormone-induced cyclic adenosine 5′-monophosphate response element binding protein (CREB) phosphorylation in pro-thyrotropin-releasing hormone neurons and increases CREB phosphorylation in corticotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 2003;144:281-291.
49. Legradi G, Lechan RM: Agouti-related protein containing nerve terminals innervate thyrotropin-releasing hormone neurons in the hypothalamic paraventricular nucleus. Endocrinology 1999;140:3643-3652.
50. Swoap SJ: Altered leptin signaling is sufficient, but not required, for hypotension associated with caloric restriction. Am J Physiol Heart Circ Physiol 2001;281:H2473-H2479.
51. Overton JM, Williams TD, Chambers JB, Rashotte ME: Cardiovascular and metabolic responses to fasting and thermoneutrality are conserved in obese Zucker rats. Am J Physiol Regul Integr Comp Physiol 2001;280:R1007-R1015.
52. Duclos M, Timofeeva E, Michel C, Richard D: Corticosterone-dependent metabolic and neuroendocrine abnormalities in obese Zucker rats in relation to feeding. Am J Physiol Endocrinol Metab 2005;288:E254-E266.