Central Overexpression of the TRH Precursor Gene Induces Hypertension in Rats: Antisense Reversal

Hypertension

Volumn 30, Issue 3, 1997, Pages 759-766

  Garcia, Silvia I ^a   Porto, Patricia I ^a   Alvarez, Azucena L ^a   Martinez, Veronica N ^a   Shaurli, Daniela ^a   Finkielman, Samuel ^a   Pirola, Carlos J ^a  

^a INSTITUTO DE INVESTIGACIONES MÉDICAS ALFREDO LANARI   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

ANGIOTENSIN; ANTISENSE OLIGONUCLEOTIDE; HORMONE PRECURSOR; MESSENGER RNA; PLASMID VECTOR; PROTIRELIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTERIAL PRESSURE; CONFERENCE PAPER; CONTROLLED STUDY; DIENCEPHALON; GENE OVEREXPRESSION; HEART RATE; HUMAN; HUMAN CELL; HYPERTENSION; HYPOTHALAMUS PERIVENTRICULAR NUCLEUS; IMMUNOHISTOCHEMISTRY; MALE; NONHUMAN; NORTHERN BLOTTING; PLETHYSMOGRAPHY; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; START CODON; SYSTOLIC BLOOD PRESSURE;

ANIMALS; BRAIN; GENE EXPRESSION REGULATION; HUMANS; HYPERTENSION; MALE; OLIGONUCLEOTIDES, ANTISENSE; PROTEIN PRECURSORS; RATS; RATS, WISTAR; THYROTROPIN-RELEASING HORMONE; TRANSFECTION;

EID: 0030761889     PISSN: 0194911X     EISSN: 15244563     Source Type: Journal    
DOI: 10.1161/01.HYP.30.3.759     Document Type: Article

References (36)

1. Bhargava HN, Das S. Evidence for opiate action at the brain receptors for thyrotropin releasing hormone. Brain Res. 1986;368:262-267.
2. Braitman DJ, Auker CR, Carpenter DO. Thyrotropin releasing hormone has multiple actions in cortex. Brain Res. 1980;194:244-248.
3. Brownstein MJ, Palkovits M, Saavedra JM, Bassiri RM, Utiger RD. Thyrotropin releasing hormone in specific nuclei of rat brain. Science. 1974;185:267-269.
4. Sharif NA. Diverse roles of thyrotropin releasing hormone in brain, pituitary and spinal function. Trends Pharmacol Sci. 1985;6:119-122.
5. Brody MJ, Johnson AK. Role of the anteroventral third ventricle (AV3V) region in the fluid and electrolyte balance, arterial blood pressure regulation and hypertension. In: Martini L, Gannong WF, eds. Frontiers in Neuroendocrinology. New York, NY: Raven Press Publishers; 1980:249-292.
6. Brody MJ, Fink GC, Buggy J, Haywood JR, Gordon FJ, Johnson AK. The role of anteroventral third ventricle (AV3V) region in experimental hypertension. Circ Res. 1978;43:12-13.
7. Mow MT, Haywood JR, Johnson AK, Brody MJ. The role of anteroventral third ventricle (AV3V) region in development of neurogenic hypertension. Soc Neurosci Abstr. 1978;4:23.
8. Feuerstein G, Hassen AH, Faden AI. TRH cardiovascular and sympathetic modulation in brain nuclei of the rat. Peptides. 1983;4:617-620.
9. Siren AL, Feuerstein G. Effect of thyrotropin releasing hormone on blood pressure and peripheral blood flow in conscious rats. Fed Proc. 1985;44:721.
10. Ganten D, Hermann K, Bayer C, Unger T, Lang RE. Angiotensin synthesis in the brain and increased turnover in hypertensive rats. Science. 1983;221:869-871.
11. Scheucher A, Alvarez AL, Torres N, Dabsys SM, Finkielman S, Nahmod VE, Pirola CJ. Cholinergic hyperactivity in the lateral septal area of spontaneously hypertensive rats: depressor effect of hemicholinium-3 and pirenzepine. Neuropharmacology. 1991;30:391-395.
12. Pirola CJ, Balda MS, Finkielman S, Nahmod VE. Thyrotropin releasing hormone increases the number of muscarinic receptors in the lateral septal area of the rat brain. Brain Res. 1983;273:387-391.
13. Garcia SI, Dabsys SM, Santajuliana D, Delorenzi A, Finkielman S, Nahmod VE, Pirola CJ. Interaction between thyrotropin releasing hormone and the muscarinic cholinergic system in rat brain. J Endocrinol. 1992;134:215-218.
14. Garcia SI, Dabsys SM, Martinez VN, Delorenzi A, Santajuliana DO, Nahmod VE, Finkielman S, Pirola CJ. Thyrotropin-releasing hormone hyperactivity in the preoptic area of spontaneously hypertensive rats. Hypertension. 1995;26(pt 2):1105-1110.
15. Wagner RW. Gene inhibition using antisense oligodeoxynucleotides. Nature. 1994;372:333-335.
16. Stein CA, Cheng Y. Antisense oligonucleotides as therapeutic agents: is the bullet really magical? Science. 1993;261:1004-1012.
17. Wahlestedt C, Golanov E, Yamamoto S, Yee F, Ericson H, Yoo H, Inturrisi CE, Reis DJ. Antisense oligodeoxynucleotides to NMDA-R1 receptor channel protect cortical neurons from excitotoxicity and reduce focal ischaemic infarction. Nature. 1993;363:260-263.
18. Wielbo D, Sernia C, Gyurko R, Philips MI. Antisense inhibition of hypertension in the spontaneously hypertensive rat. Hypertension. 1995;25:314-319.
19. Gyurko R, Wielbo D, Phillips MI. Antisense inhibition of AT1 receptor mRNA and angiotensinogen mRNA in the brain of spontaneously hypertensive rats reduces hypertension of neurogenic origin. Regul Pept. 1993;49:167-174.
20. Lee SL, Sevarino K, Roos BA, Goodman RH. Characterization and expression of the gene encoding rat thyrotropin-releasing hormone (TRH). Ann N Y Acad Sci. 1989;553:14-28.
21. Redei E, Hilderbrand H, Aird F. Corticotropin release inhibiting factor is encoded within PreProTRH. Endocrinology. 1995;136:1813-1816.
22. Chomczynski P, Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal Biochem. 1987;162:156-159.
23. Danielson PE, Forse-Petter S, Brow MA, Calaretta LL, Douglass J, Milner RJ, Sutcliff JG. A cDNA clone of the rat mRNA encoding cyclophylin. DNA (NY). 1988;7:261-267.
24. Thompson R. A Behavioural Atlas of the Rat Brain. New York, NY: Oxford University Press; 1978.
25. Cockle SM, Aitken A, Beg F, Smyth DG. A novel peptide pyroglutamylprolineamide in rabbit prostate complex, structurally related to TRH. J Biol Chem. 1989;264:7788-7791.
26. Bassiri RM, Utiger RD. The preparation and specificity of antibody to thyrotropin releasing hormone. Endocrinology. 1972;90:3.
27. Delorenzi A, Pedreira M, Romano A, Garcia SI, Pirola CJ, Nahmod VN, Maldonado H. Angiotensin II enhances long-term memory in the crab Chasmagnatus. Brain Res Bull. 1996;41:211-220.
28. Becu D, Libertum C. Comparative maturation of the regulation of prolactin and thyrotropin by serotonin and thyrotropin-releasing hormone in male and female rats. Endocrinol. 1982;110:1879-1884.
29. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951;193:265-275.
30. Sambrook J, Fritsch I, Maniatis T. Molecular Cloning: A Laboratory Manual. 2nd ed. Cold Spring Harbor, NY: Cold Spring Harbor Laboratory; 1989.
31. Zhang R, Lu Z, Zhang X, Zhao H, Diasio RB, Liut T, Jiang Z, Agrawal S. In vivo stability and disposition of a self-stabilized oligodeoxynucleotide phosphorothiate in rats. Clin Chem. 1995;41:836-843.
32. Hallback M, Folkow B. Cardiovascular responses to acute mental stress in spontaneous hypertensive rats. Acta Physiol Scand. 1974;90:684-698.
33. Tsay BL, Lin MT. Effects of intracerebrovascular administration of thyrotropin-releasing hormone on cardiovascular function in the rat. Neuroendocrinology. 1982;35:173-177.
34. Bansinath M, Das S, Bhargava HN. Spontaneously hypertensive rats exhibit supersensitivity to the hypertensive and hyperthermic effects of thyrotropin releasing hormone. Peptides. 1987;8:227-230.
35. Trippodo NC, Frohlich ED. Similarities of genetic (spontaneous) hypertension: man and rat. Circ Res. 1981;48:309-319.
36. Aoki K, Tankawa H, Fujinama T, Miyazaki A, Hashimoto Y. Pathological studies on the endocrine organs of the spontaneously hypertensive rats. Jpn Heart J. 1963;4:426-442.