-
1
-
-
18744366334
-
Hox regulation of normal and leukemic hematopoietic stem cells
-
Abramovich, C., and R. K. Humphries. 2005. Hox regulation of normal and leukemic hematopoietic stem cells. Curr. Opin. Hematol. 12:210-216.
-
(2005)
Curr. Opin. Hematol.
, vol.12
, pp. 210-216
-
-
Abramovich, C.1
Humphries, R.K.2
-
2
-
-
3142781225
-
Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
-
Arkin, M. R., and J. A. Wells. 2004. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat. Rev. Drug Discov. 3:301-317.
-
(2004)
Nat. Rev. Drug Discov.
, vol.3
, pp. 301-317
-
-
Arkin, M.R.1
Wells, J.A.2
-
3
-
-
0027204066
-
The E2A gene product contains two separable and functionally distinct transcription activation domains
-
Aronheim, A., R. Shiran, A. Rosen, and M. D. Walker. 1993. The E2A gene product contains two separable and functionally distinct transcription activation domains. Proc. Natl. Acad. Sci. USA 90:8063-8067.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 8063-8067
-
-
Aronheim, A.1
Shiran, R.2
Rosen, A.3
Walker, M.D.4
-
4
-
-
0027992622
-
E2a proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements
-
Bain, G., E. C. Robanus Maandag, D. J. Izon, D. Amsen, A. M. Kruisbeek, B. C. Weintraub, I. Krop, M. S. Schlissel, A. J. Feeney, M. van Roon, M. van der Valk, H. P. J. te Riele, A. Berns, and C. Murre. 1994. E2a proteins are required for proper B cell development and initiation of immunoglobulin gene rearrangements. Cell 79:885-892.
-
(1994)
Cell
, vol.79
, pp. 885-892
-
-
Bain, G.1
Robanus Maandag, E.C.2
Izon, D.J.3
Amsen, D.4
Kruisbeek, A.M.5
Weintraub, B.C.6
Krop, I.7
Schlissel, M.S.8
Feeney, A.J.9
Van Roon, M.10
Van Der Valk, M.11
Te Riele, H.P.J.12
Berns, A.13
Murre, C.14
-
5
-
-
11244308073
-
E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells
-
Bayly, R., L. Chuen, R. A. Currie, B. D. Hyndman, R. Casselman, G. A. Blobel, and D. P. LeBrun. 2004. E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells. J. Biol. Chem. 279:55362-55371.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 55362-55371
-
-
Bayly, R.1
Chuen, L.2
Currie, R.A.3
Hyndman, B.D.4
Casselman, R.5
Blobel, G.A.6
LeBrun, D.P.7
-
6
-
-
0033860086
-
Role for homodimerization in growth deregulation by E2a fusion proteins
-
Bayly, R., and D. P. LeBrun. 2000. Role for homodimerization in growth deregulation by E2a fusion proteins. Mol. Cell. Biol. 20:5789-5796.
-
(2000)
Mol. Cell. Biol.
, vol.20
, pp. 5789-5796
-
-
Bayly, R.1
LeBrun, D.P.2
-
7
-
-
12144252423
-
High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia
-
Bijl, J., M. Sauvageau, A. Thompson, and G. Sauvageau. 2005. High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia. Genes Dev. 19:224-233.
-
(2005)
Genes Dev.
, vol.19
, pp. 224-233
-
-
Bijl, J.1
Sauvageau, M.2
Thompson, A.3
Sauvageau, G.4
-
8
-
-
0037462721
-
Regulation of E2A activities by histone acetyltransferases in B lymphocyte development
-
Bradney, C., M. Hjelmeland, Y. Komatsu, M. Yoshida, T. P. Yao, and Y. Zhuang. 2003. Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J. Biol. Chem. 278:2370-2376.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 2370-2376
-
-
Bradney, C.1
Hjelmeland, M.2
Komatsu, Y.3
Yoshida, M.4
Yao, T.P.5
Zhuang, Y.6
-
9
-
-
0037180374
-
Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB
-
Campbell, K. M., and K. J. Lumb. 2002. Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB. Biochemistry 41:13956-13964.
-
(2002)
Biochemistry
, vol.41
, pp. 13956-13964
-
-
Campbell, K.M.1
Lumb, K.J.2
-
10
-
-
0021354188
-
Pre-B cell leukemia associated with chromosome translocation 1:19
-
Carroll, A. J., W. M. Crist, R. T. Parmley, M. Roper, M. D. Cooper, and W. H. Finley. 1984. Pre-B cell leukemia associated with chromosome translocation 1:19. Blood 63:721.
-
(1984)
Blood
, vol.63
, pp. 721
-
-
Carroll, A.J.1
Crist, W.M.2
Parmley, R.T.3
Roper, M.4
Cooper, M.D.5
Finley, W.H.6
-
11
-
-
0028947525
-
Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins
-
Chang, C. P., W. F. Shen, S. Rozenfeld, H. J. Lawrence, C. Largman, and M. L. Cleary. 1995. Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins. Genes Dev. 9:663-674.
-
(1995)
Genes Dev.
, vol.9
, pp. 663-674
-
-
Chang, C.P.1
Shen, W.F.2
Rozenfeld, S.3
Lawrence, H.J.4
Largman, C.5
Cleary, M.L.6
-
12
-
-
0027184079
-
Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice
-
Dedera, D. A., E. K. Waller, D. P. LeBrun, A. Sen-Majumdar, M. E. Stevens, G. S. Barsh, and M. L. Cleary. 1993. Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice. Cell 74:833-843.
-
(1993)
Cell
, vol.74
, pp. 833-843
-
-
Dedera, D.A.1
Waller, E.K.2
LeBrun, D.P.3
Sen-Majumdar, A.4
Stevens, M.E.5
Barsh, G.S.6
Cleary, M.L.7
-
13
-
-
0029825698
-
Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation
-
Eckner, R., T. P. Yao, E. Oldread, and D. M. Livingston. 1996. Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev. 10:2478-2490.
-
(1996)
Genes Dev.
, vol.10
, pp. 2478-2490
-
-
Eckner, R.1
Yao, T.P.2
Oldread, E.3
Livingston, D.M.4
-
14
-
-
0035102477
-
MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein
-
Ernst, P., J. Wang, M. Huang, R. H. Goodman, and S. J. Korsmeyer. 2001. MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol. Cell. Biol. 21:2249-2258.
-
(2001)
Mol. Cell. Biol.
, vol.21
, pp. 2249-2258
-
-
Ernst, P.1
Wang, J.2
Huang, M.3
Goodman, R.H.4
Korsmeyer, S.J.5
-
15
-
-
0034234237
-
CBP/p300 in cell growth, transformation, and development
-
Goodman, R. H., and S. Smolik. 2000. CBP/p300 in cell growth, transformation, and development. Genes Dev. 14:1553-1577.
-
(2000)
Genes Dev.
, vol.14
, pp. 1553-1577
-
-
Goodman, R.H.1
Smolik, S.2
-
16
-
-
0037044756
-
Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain
-
Goto, N. K., T. Zor, M. Martinez-Yamout, H. J. Dyson, and P. E. Wright. 2002. Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain. J. Biol. Chem. 277:43168-43174.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 43168-43174
-
-
Goto, N.K.1
Zor, T.2
Martinez-Yamout, M.3
Dyson, H.J.4
Wright, P.E.5
-
17
-
-
0030986236
-
A signature motif in transcriptional co-activators mediates binding to nuclear receptors
-
Heery, D. M., E. Kalkhoven, S. Hoare, and M. G. Parker. 1997. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387:733-736.
-
(1997)
Nature
, vol.387
, pp. 733-736
-
-
Heery, D.M.1
Kalkhoven, E.2
Hoare, S.3
Parker, M.G.4
-
18
-
-
0025034673
-
Two distinct transcription factors that bind the immunoglobulin enhancer microES/kappa 2 motif
-
Henthorn, P., M. Kiledjian, and T. Kadesch. 1990. Two distinct transcription factors that bind the immunoglobulin enhancer microES/kappa 2 motif. Science 247:467-470.
-
(1990)
Science
, vol.247
, pp. 467-470
-
-
Henthorn, P.1
Kiledjian, M.2
Kadesch, T.3
-
19
-
-
0027434620
-
E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice
-
Kamps, M. P., and D. Baltimore. 1993. E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice. Mol. Cell. Biol. 13:351-357.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 351-357
-
-
Kamps, M.P.1
Baltimore, D.2
-
20
-
-
0025137176
-
A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL
-
Kamps, M. P., C. Murre, X. H. Sun, and D. Baltimore. 1990. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 60:547-555.
-
(1990)
Cell
, vol.60
, pp. 547-555
-
-
Kamps, M.P.1
Murre, C.2
Sun, X.H.3
Baltimore, D.4
-
21
-
-
0028099632
-
Oncoprotein E2A-Pbx1 immortalizes a myeloid progenitor in primary marrow cultures without abrogating its factor-dependence
-
Kamps, M. P., and D. D. Wright. 1994. Oncoprotein E2A-Pbx1 immortalizes a myeloid progenitor in primary marrow cultures without abrogating its factor-dependence. Oncogene 9:3159-3166.
-
(1994)
Oncogene
, vol.9
, pp. 3159-3166
-
-
Kamps, M.P.1
Wright, D.D.2
-
22
-
-
0030054255
-
DNA-binding by oncoprotein E2a-Pbx1 is important for blocking differentiation but dispensable for fibroblast transformation
-
Kamps, M. P., D. D. Wright, and Q. Lu. 1996. DNA-binding by oncoprotein E2a-Pbx1 is important for blocking differentiation but dispensable for fibroblast transformation. Oncogene 12:19-30.
-
(1996)
Oncogene
, vol.12
, pp. 19-30
-
-
Kamps, M.P.1
Wright, D.D.2
Lu, Q.3
-
23
-
-
0037126308
-
A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis
-
Kasper, L. H., F. Boussouar, P. A. Ney, C. W. Jackson, J. Rehg, J. M. van Deursen, and P. K. Brindle. 2002. A transcription-factor-binding surface of coactivator p300 is required for haematopoiesis. Nature 419:738-743.
-
(2002)
Nature
, vol.419
, pp. 738-743
-
-
Kasper, L.H.1
Boussouar, F.2
Ney, P.A.3
Jackson, C.W.4
Rehg, J.5
Van Deursen, J.M.6
Brindle, P.K.7
-
24
-
-
3142660508
-
E2a basic helix-loop-helix transcription factors in human leukemia
-
LeBrun, D. P. 2003. E2a basic helix-loop-helix transcription factors in human leukemia. Front. Biosci. 8:S206-S222.
-
(2003)
Front. Biosci.
, vol.8
-
-
LeBrun, D.P.1
-
25
-
-
0028303736
-
Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias
-
LeBrun, D. P., and M. L. Cleary. 1994. Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias. Oncogene 9:1641-1647.
-
(1994)
Oncogene
, vol.9
, pp. 1641-1647
-
-
LeBrun, D.P.1
Cleary, M.L.2
-
26
-
-
0029054140
-
Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes
-
Lu, Q., P. S. Knoepfler, J. Scheele, D. D. Wright, and M. P. Kamps. 1995. Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. Mol. Cell. Biol. 15:3786-3795.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 3786-3795
-
-
Lu, Q.1
Knoepfler, P.S.2
Scheele, J.3
Wright, D.D.4
Kamps, M.P.5
-
27
-
-
0028231938
-
Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation
-
Lu, Q., D. D. Wright, and M. P. Kamps. 1994. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. Mol. Cell. Biol. 14:3938-3948.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 3938-3948
-
-
Lu, Q.1
Wright, D.D.2
Kamps, M.P.3
-
28
-
-
0029655318
-
The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells
-
Massari, M. E., P. A. Jennings, and C. Murre. 1996. The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells. Mol. Cell. Biol. 16:121-129.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 121-129
-
-
Massari, M.E.1
Jennings, P.A.2
Murre, C.3
-
29
-
-
0028089760
-
Transformation properties of the E2a-Pbx1 chimeric oncoprotein: Fusion with E2a is essential, but the Pbx1 homeodomain is dispensable
-
Monica, K., D. P. LeBrun, D. A. Dedera, R. B. Brown, and M. L. Cleary. 1994. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable. Mol. Cell. Biol. 14:8304-8314.
-
(1994)
Mol. Cell. Biol.
, vol.14
, pp. 8304-8314
-
-
Monica, K.1
LeBrun, D.P.2
Dedera, D.A.3
Brown, R.B.4
Cleary, M.L.5
-
30
-
-
0025064238
-
Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor
-
Nourse, J., J. D. Mellentin, N. Galili, J. Wilkinson, E. Stanbridge, S. D. Smith, and M. L. Cleary. 1990. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 60:535-545.
-
(1990)
Cell
, vol.60
, pp. 535-545
-
-
Nourse, J.1
Mellentin, J.D.2
Galili, N.3
Wilkinson, J.4
Stanbridge, E.5
Smith, S.D.6
Cleary, M.L.7
-
31
-
-
0029008293
-
Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif
-
Phelan, M. L., I. Rambaldi, and M. S. Featherstone. 1995. Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif. Mol. Cell. Biol. 15:3989-3997.
-
(1995)
Mol. Cell. Biol.
, vol.15
, pp. 3989-3997
-
-
Phelan, M.L.1
Rambaldi, I.2
Featherstone, M.S.3
-
32
-
-
13244295627
-
The LxxLL motif: A multi-functional binding sequence in transcriptional regulation
-
Plevin, M. J., M. M. Mills, and M. Ikura. 2005. The LxxLL motif: a multi-functional binding sequence in transcriptional regulation. Trends Biochem. Sci. 30:66-69.
-
(2005)
Trends Biochem. Sci.
, vol.30
, pp. 66-69
-
-
Plevin, M.J.1
Mills, M.M.2
Ikura, M.3
-
33
-
-
0031943003
-
p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene
-
Qiu, Y., A. Sharma, and R. Stein. 1998. p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol. Cell. Biol. 18:2957-2964.
-
(1998)
Mol. Cell. Biol.
, vol.18
, pp. 2957-2964
-
-
Qiu, Y.1
Sharma, A.2
Stein, R.3
-
34
-
-
0027472051
-
A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells
-
Quong, M. W., M. E. Massari, R. Zwart, and C. Murre. 1993. A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells. Mol. Cell. Biol. 13:792-800.
-
(1993)
Mol. Cell. Biol.
, vol.13
, pp. 792-800
-
-
Quong, M.W.1
Massari, M.E.2
Zwart, R.3
Murre, C.4
-
36
-
-
0344936739
-
Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: A model for activator: Coactivator interactions
-
Radhakrishnan, I., G. C. Perez-Alvarado, D. Parker, H. J. Dyson, M. R. Montminy, and P. E. Wright. 1997. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator: coactivator interactions. Cell 91:741-752.
-
(1997)
Cell
, vol.91
, pp. 741-752
-
-
Radhakrishnan, I.1
Perez-Alvarado, G.C.2
Parker, D.3
Dyson, H.J.4
Montminy, M.R.5
Wright, P.E.6
-
37
-
-
0031045835
-
Molecular mechanisms of myogenic coactivation by p300: Direct interaction with the activation domain of MyoD and with the MADS box of MEF2C
-
Sartorelli, V., J. Huang, Y. Hamamori, and L. Kedes. 1997. Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol. Cell. Biol. 17:1010-1026.
-
(1997)
Mol. Cell. Biol.
, vol.17
, pp. 1010-1026
-
-
Sartorelli, V.1
Huang, J.2
Hamamori, Y.3
Kedes, L.4
-
38
-
-
0032796188
-
The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells
-
Thorsteinsdottir, U., J. Krosl, E. Kroon, A. Haman, T. Hoang, and G. Sauvageau. 1999. The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells. Mol. Cell. Biol. 19:6355-6366.
-
(1999)
Mol. Cell. Biol.
, vol.19
, pp. 6355-6366
-
-
Thorsteinsdottir, U.1
Krosl, J.2
Kroon, E.3
Haman, A.4
Hoang, T.5
Sauvageau, G.6
-
39
-
-
0027176915
-
Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia
-
van Dijk, M. A., P. M. Voorhoeve, and C. Murre. 1993. Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia. Proc. Natl. Acad. Sci. USA 90:6061-6065.
-
(1993)
Proc. Natl. Acad. Sci. USA
, vol.90
, pp. 6061-6065
-
-
Van Dijk, M.A.1
Voorhoeve, P.M.2
Murre, C.3
-
40
-
-
4344669438
-
E protein silencing by the leukemogenic AML1-ETO fusion protein
-
Zhang, J., M. Kalkum, S. Yamamura, B. T. Chait, and R. G. Roeder. 2004. E protein silencing by the leukemogenic AML1-ETO fusion protein. Science 305:1286-1289.
-
(2004)
Science
, vol.305
, pp. 1286-1289
-
-
Zhang, J.1
Kalkum, M.2
Yamamura, S.3
Chait, B.T.4
Roeder, R.G.5
-
41
-
-
0028148938
-
The helix-loop-helix gene E2A is required for B cell formation
-
Zhuang, Y., P. Soriano, and H. Weintraub. 1994. The helix-loop-helix gene E2A is required for B cell formation. Cell 79:875-884.
-
(1994)
Cell
, vol.79
, pp. 875-884
-
-
Zhuang, Y.1
Soriano, P.2
Weintraub, H.3
-
42
-
-
1542358794
-
Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb
-
Zor, T., R. N. De Guzman, H. J. Dyson, and P. E. Wright. 2004. Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb. J. Mol. Biol. 337:521-534.
-
(2004)
J. Mol. Biol.
, vol.337
, pp. 521-534
-
-
Zor, T.1
De Guzman, R.N.2
Dyson, H.J.3
Wright, P.E.4
|