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Volumn 26, Issue 17, 2006, Pages 6442-6452

Critical role for a single leucine residue in leukemia induction by E2A-PBX1

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACID; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN; CYCLIC AMP RESPONSIVE ELEMENT BINDING PROTEIN BINDING PROTEIN; GENE PRODUCT; HOX PROTEIN; LEUCINE; PROTEIN SUBUNIT; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR E12; TRANSCRIPTION FACTOR E2A; TRANSCRIPTION FACTOR E47; TRANSCRIPTION FACTOR PBX1; UNCLASSIFIED DRUG;

EID: 33747770261     PISSN: 02707306     EISSN: None     Source Type: Journal    
DOI: 10.1128/MCB.02025-05     Document Type: Article
Times cited : (24)

References (42)
  • 1
    • 18744366334 scopus 로고    scopus 로고
    • Hox regulation of normal and leukemic hematopoietic stem cells
    • Abramovich, C., and R. K. Humphries. 2005. Hox regulation of normal and leukemic hematopoietic stem cells. Curr. Opin. Hematol. 12:210-216.
    • (2005) Curr. Opin. Hematol. , vol.12 , pp. 210-216
    • Abramovich, C.1    Humphries, R.K.2
  • 2
    • 3142781225 scopus 로고    scopus 로고
    • Small-molecule inhibitors of protein-protein interactions: Progressing towards the dream
    • Arkin, M. R., and J. A. Wells. 2004. Small-molecule inhibitors of protein-protein interactions: progressing towards the dream. Nat. Rev. Drug Discov. 3:301-317.
    • (2004) Nat. Rev. Drug Discov. , vol.3 , pp. 301-317
    • Arkin, M.R.1    Wells, J.A.2
  • 3
    • 0027204066 scopus 로고
    • The E2A gene product contains two separable and functionally distinct transcription activation domains
    • Aronheim, A., R. Shiran, A. Rosen, and M. D. Walker. 1993. The E2A gene product contains two separable and functionally distinct transcription activation domains. Proc. Natl. Acad. Sci. USA 90:8063-8067.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 8063-8067
    • Aronheim, A.1    Shiran, R.2    Rosen, A.3    Walker, M.D.4
  • 5
    • 11244308073 scopus 로고    scopus 로고
    • E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells
    • Bayly, R., L. Chuen, R. A. Currie, B. D. Hyndman, R. Casselman, G. A. Blobel, and D. P. LeBrun. 2004. E2A-PBX1 interacts directly with the KIX domain of CBP/p300 in the induction of proliferation in primary hematopoietic cells. J. Biol. Chem. 279:55362-55371.
    • (2004) J. Biol. Chem. , vol.279 , pp. 55362-55371
    • Bayly, R.1    Chuen, L.2    Currie, R.A.3    Hyndman, B.D.4    Casselman, R.5    Blobel, G.A.6    LeBrun, D.P.7
  • 6
    • 0033860086 scopus 로고    scopus 로고
    • Role for homodimerization in growth deregulation by E2a fusion proteins
    • Bayly, R., and D. P. LeBrun. 2000. Role for homodimerization in growth deregulation by E2a fusion proteins. Mol. Cell. Biol. 20:5789-5796.
    • (2000) Mol. Cell. Biol. , vol.20 , pp. 5789-5796
    • Bayly, R.1    LeBrun, D.P.2
  • 7
    • 12144252423 scopus 로고    scopus 로고
    • High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia
    • Bijl, J., M. Sauvageau, A. Thompson, and G. Sauvageau. 2005. High incidence of proviral integrations in the Hoxa locus in a new model of E2a-PBX1-induced B-cell leukemia. Genes Dev. 19:224-233.
    • (2005) Genes Dev. , vol.19 , pp. 224-233
    • Bijl, J.1    Sauvageau, M.2    Thompson, A.3    Sauvageau, G.4
  • 8
    • 0037462721 scopus 로고    scopus 로고
    • Regulation of E2A activities by histone acetyltransferases in B lymphocyte development
    • Bradney, C., M. Hjelmeland, Y. Komatsu, M. Yoshida, T. P. Yao, and Y. Zhuang. 2003. Regulation of E2A activities by histone acetyltransferases in B lymphocyte development. J. Biol. Chem. 278:2370-2376.
    • (2003) J. Biol. Chem. , vol.278 , pp. 2370-2376
    • Bradney, C.1    Hjelmeland, M.2    Komatsu, Y.3    Yoshida, M.4    Yao, T.P.5    Zhuang, Y.6
  • 9
    • 0037180374 scopus 로고    scopus 로고
    • Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB
    • Campbell, K. M., and K. J. Lumb. 2002. Structurally distinct modes of recognition of the KIX domain of CBP by Jun and CREB. Biochemistry 41:13956-13964.
    • (2002) Biochemistry , vol.41 , pp. 13956-13964
    • Campbell, K.M.1    Lumb, K.J.2
  • 11
    • 0028947525 scopus 로고
    • Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins
    • Chang, C. P., W. F. Shen, S. Rozenfeld, H. J. Lawrence, C. Largman, and M. L. Cleary. 1995. Pbx proteins display hexapeptide-dependent cooperative DNA binding with a subset of Hox proteins. Genes Dev. 9:663-674.
    • (1995) Genes Dev. , vol.9 , pp. 663-674
    • Chang, C.P.1    Shen, W.F.2    Rozenfeld, S.3    Lawrence, H.J.4    Largman, C.5    Cleary, M.L.6
  • 12
    • 0027184079 scopus 로고
    • Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice
    • Dedera, D. A., E. K. Waller, D. P. LeBrun, A. Sen-Majumdar, M. E. Stevens, G. S. Barsh, and M. L. Cleary. 1993. Chimeric homeobox gene E2A-PBX1 induces proliferation, apoptosis, and malignant lymphomas in transgenic mice. Cell 74:833-843.
    • (1993) Cell , vol.74 , pp. 833-843
    • Dedera, D.A.1    Waller, E.K.2    LeBrun, D.P.3    Sen-Majumdar, A.4    Stevens, M.E.5    Barsh, G.S.6    Cleary, M.L.7
  • 13
    • 0029825698 scopus 로고    scopus 로고
    • Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation
    • Eckner, R., T. P. Yao, E. Oldread, and D. M. Livingston. 1996. Interaction and functional collaboration of p300/CBP and bHLH proteins in muscle and B-cell differentiation. Genes Dev. 10:2478-2490.
    • (1996) Genes Dev. , vol.10 , pp. 2478-2490
    • Eckner, R.1    Yao, T.P.2    Oldread, E.3    Livingston, D.M.4
  • 14
    • 0035102477 scopus 로고    scopus 로고
    • MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein
    • Ernst, P., J. Wang, M. Huang, R. H. Goodman, and S. J. Korsmeyer. 2001. MLL and CREB bind cooperatively to the nuclear coactivator CREB-binding protein. Mol. Cell. Biol. 21:2249-2258.
    • (2001) Mol. Cell. Biol. , vol.21 , pp. 2249-2258
    • Ernst, P.1    Wang, J.2    Huang, M.3    Goodman, R.H.4    Korsmeyer, S.J.5
  • 15
    • 0034234237 scopus 로고    scopus 로고
    • CBP/p300 in cell growth, transformation, and development
    • Goodman, R. H., and S. Smolik. 2000. CBP/p300 in cell growth, transformation, and development. Genes Dev. 14:1553-1577.
    • (2000) Genes Dev. , vol.14 , pp. 1553-1577
    • Goodman, R.H.1    Smolik, S.2
  • 16
    • 0037044756 scopus 로고    scopus 로고
    • Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain
    • Goto, N. K., T. Zor, M. Martinez-Yamout, H. J. Dyson, and P. E. Wright. 2002. Cooperativity in transcription factor binding to the coactivator CREB-binding protein (CBP). The mixed lineage leukemia protein (MLL) activation domain binds to an allosteric site on the KIX domain. J. Biol. Chem. 277:43168-43174.
    • (2002) J. Biol. Chem. , vol.277 , pp. 43168-43174
    • Goto, N.K.1    Zor, T.2    Martinez-Yamout, M.3    Dyson, H.J.4    Wright, P.E.5
  • 17
    • 0030986236 scopus 로고    scopus 로고
    • A signature motif in transcriptional co-activators mediates binding to nuclear receptors
    • Heery, D. M., E. Kalkhoven, S. Hoare, and M. G. Parker. 1997. A signature motif in transcriptional co-activators mediates binding to nuclear receptors. Nature 387:733-736.
    • (1997) Nature , vol.387 , pp. 733-736
    • Heery, D.M.1    Kalkhoven, E.2    Hoare, S.3    Parker, M.G.4
  • 18
    • 0025034673 scopus 로고
    • Two distinct transcription factors that bind the immunoglobulin enhancer microES/kappa 2 motif
    • Henthorn, P., M. Kiledjian, and T. Kadesch. 1990. Two distinct transcription factors that bind the immunoglobulin enhancer microES/kappa 2 motif. Science 247:467-470.
    • (1990) Science , vol.247 , pp. 467-470
    • Henthorn, P.1    Kiledjian, M.2    Kadesch, T.3
  • 19
    • 0027434620 scopus 로고
    • E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice
    • Kamps, M. P., and D. Baltimore. 1993. E2A-Pbx1, the t(1;19) translocation protein of human pre-B-cell acute lymphocytic leukemia, causes acute myeloid leukemia in mice. Mol. Cell. Biol. 13:351-357.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 351-357
    • Kamps, M.P.1    Baltimore, D.2
  • 20
    • 0025137176 scopus 로고
    • A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL
    • Kamps, M. P., C. Murre, X. H. Sun, and D. Baltimore. 1990. A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell 60:547-555.
    • (1990) Cell , vol.60 , pp. 547-555
    • Kamps, M.P.1    Murre, C.2    Sun, X.H.3    Baltimore, D.4
  • 21
    • 0028099632 scopus 로고
    • Oncoprotein E2A-Pbx1 immortalizes a myeloid progenitor in primary marrow cultures without abrogating its factor-dependence
    • Kamps, M. P., and D. D. Wright. 1994. Oncoprotein E2A-Pbx1 immortalizes a myeloid progenitor in primary marrow cultures without abrogating its factor-dependence. Oncogene 9:3159-3166.
    • (1994) Oncogene , vol.9 , pp. 3159-3166
    • Kamps, M.P.1    Wright, D.D.2
  • 22
    • 0030054255 scopus 로고    scopus 로고
    • DNA-binding by oncoprotein E2a-Pbx1 is important for blocking differentiation but dispensable for fibroblast transformation
    • Kamps, M. P., D. D. Wright, and Q. Lu. 1996. DNA-binding by oncoprotein E2a-Pbx1 is important for blocking differentiation but dispensable for fibroblast transformation. Oncogene 12:19-30.
    • (1996) Oncogene , vol.12 , pp. 19-30
    • Kamps, M.P.1    Wright, D.D.2    Lu, Q.3
  • 24
    • 3142660508 scopus 로고    scopus 로고
    • E2a basic helix-loop-helix transcription factors in human leukemia
    • LeBrun, D. P. 2003. E2a basic helix-loop-helix transcription factors in human leukemia. Front. Biosci. 8:S206-S222.
    • (2003) Front. Biosci. , vol.8
    • LeBrun, D.P.1
  • 25
    • 0028303736 scopus 로고
    • Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias
    • LeBrun, D. P., and M. L. Cleary. 1994. Fusion with E2A alters the transcriptional properties of the homeodomain protein PBX1 in t(1;19) leukemias. Oncogene 9:1641-1647.
    • (1994) Oncogene , vol.9 , pp. 1641-1647
    • LeBrun, D.P.1    Cleary, M.L.2
  • 26
    • 0029054140 scopus 로고
    • Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes
    • Lu, Q., P. S. Knoepfler, J. Scheele, D. D. Wright, and M. P. Kamps. 1995. Both Pbx1 and E2A-Pbx1 bind the DNA motif ATCAATCAA cooperatively with the products of multiple murine Hox genes, some of which are themselves oncogenes. Mol. Cell. Biol. 15:3786-3795.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3786-3795
    • Lu, Q.1    Knoepfler, P.S.2    Scheele, J.3    Wright, D.D.4    Kamps, M.P.5
  • 27
    • 0028231938 scopus 로고
    • Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation
    • Lu, Q., D. D. Wright, and M. P. Kamps. 1994. Fusion with E2A converts the Pbx1 homeodomain protein into a constitutive transcriptional activator in human leukemias carrying the t(1;19) translocation. Mol. Cell. Biol. 14:3938-3948.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 3938-3948
    • Lu, Q.1    Wright, D.D.2    Kamps, M.P.3
  • 28
    • 0029655318 scopus 로고    scopus 로고
    • The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells
    • Massari, M. E., P. A. Jennings, and C. Murre. 1996. The AD1 transactivation domain of E2A contains a highly conserved helix which is required for its activity in both Saccharomyces cerevisiae and mammalian cells. Mol. Cell. Biol. 16:121-129.
    • (1996) Mol. Cell. Biol. , vol.16 , pp. 121-129
    • Massari, M.E.1    Jennings, P.A.2    Murre, C.3
  • 29
    • 0028089760 scopus 로고
    • Transformation properties of the E2a-Pbx1 chimeric oncoprotein: Fusion with E2a is essential, but the Pbx1 homeodomain is dispensable
    • Monica, K., D. P. LeBrun, D. A. Dedera, R. B. Brown, and M. L. Cleary. 1994. Transformation properties of the E2a-Pbx1 chimeric oncoprotein: fusion with E2a is essential, but the Pbx1 homeodomain is dispensable. Mol. Cell. Biol. 14:8304-8314.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 8304-8314
    • Monica, K.1    LeBrun, D.P.2    Dedera, D.A.3    Brown, R.B.4    Cleary, M.L.5
  • 30
    • 0025064238 scopus 로고
    • Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor
    • Nourse, J., J. D. Mellentin, N. Galili, J. Wilkinson, E. Stanbridge, S. D. Smith, and M. L. Cleary. 1990. Chromosomal translocation t(1;19) results in synthesis of a homeobox fusion mRNA that codes for a potential chimeric transcription factor. Cell 60:535-545.
    • (1990) Cell , vol.60 , pp. 535-545
    • Nourse, J.1    Mellentin, J.D.2    Galili, N.3    Wilkinson, J.4    Stanbridge, E.5    Smith, S.D.6    Cleary, M.L.7
  • 31
    • 0029008293 scopus 로고
    • Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif
    • Phelan, M. L., I. Rambaldi, and M. S. Featherstone. 1995. Cooperative interactions between HOX and PBX proteins mediated by a conserved peptide motif. Mol. Cell. Biol. 15:3989-3997.
    • (1995) Mol. Cell. Biol. , vol.15 , pp. 3989-3997
    • Phelan, M.L.1    Rambaldi, I.2    Featherstone, M.S.3
  • 32
    • 13244295627 scopus 로고    scopus 로고
    • The LxxLL motif: A multi-functional binding sequence in transcriptional regulation
    • Plevin, M. J., M. M. Mills, and M. Ikura. 2005. The LxxLL motif: a multi-functional binding sequence in transcriptional regulation. Trends Biochem. Sci. 30:66-69.
    • (2005) Trends Biochem. Sci. , vol.30 , pp. 66-69
    • Plevin, M.J.1    Mills, M.M.2    Ikura, M.3
  • 33
    • 0031943003 scopus 로고    scopus 로고
    • p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene
    • Qiu, Y., A. Sharma, and R. Stein. 1998. p300 mediates transcriptional stimulation by the basic helix-loop-helix activators of the insulin gene. Mol. Cell. Biol. 18:2957-2964.
    • (1998) Mol. Cell. Biol. , vol.18 , pp. 2957-2964
    • Qiu, Y.1    Sharma, A.2    Stein, R.3
  • 34
    • 0027472051 scopus 로고
    • A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells
    • Quong, M. W., M. E. Massari, R. Zwart, and C. Murre. 1993. A new transcriptional-activation motif restricted to a class of helix-loop-helix proteins is functionally conserved in both yeast and mammalian cells. Mol. Cell. Biol. 13:792-800.
    • (1993) Mol. Cell. Biol. , vol.13 , pp. 792-800
    • Quong, M.W.1    Massari, M.E.2    Zwart, R.3    Murre, C.4
  • 35
    • 0036217915 scopus 로고    scopus 로고
    • E protein function in lymphocyte development
    • Quong, M. W., W. J. Romanow, and C. Murre. 2002. E protein function in lymphocyte development. Annu. Rev. Immunol. 20:301-322.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 301-322
    • Quong, M.W.1    Romanow, W.J.2    Murre, C.3
  • 36
    • 0344936739 scopus 로고    scopus 로고
    • Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: A model for activator: Coactivator interactions
    • Radhakrishnan, I., G. C. Perez-Alvarado, D. Parker, H. J. Dyson, M. R. Montminy, and P. E. Wright. 1997. Solution structure of the KIX domain of CBP bound to the transactivation domain of CREB: a model for activator: coactivator interactions. Cell 91:741-752.
    • (1997) Cell , vol.91 , pp. 741-752
    • Radhakrishnan, I.1    Perez-Alvarado, G.C.2    Parker, D.3    Dyson, H.J.4    Montminy, M.R.5    Wright, P.E.6
  • 37
    • 0031045835 scopus 로고    scopus 로고
    • Molecular mechanisms of myogenic coactivation by p300: Direct interaction with the activation domain of MyoD and with the MADS box of MEF2C
    • Sartorelli, V., J. Huang, Y. Hamamori, and L. Kedes. 1997. Molecular mechanisms of myogenic coactivation by p300: direct interaction with the activation domain of MyoD and with the MADS box of MEF2C. Mol. Cell. Biol. 17:1010-1026.
    • (1997) Mol. Cell. Biol. , vol.17 , pp. 1010-1026
    • Sartorelli, V.1    Huang, J.2    Hamamori, Y.3    Kedes, L.4
  • 38
    • 0032796188 scopus 로고    scopus 로고
    • The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells
    • Thorsteinsdottir, U., J. Krosl, E. Kroon, A. Haman, T. Hoang, and G. Sauvageau. 1999. The oncoprotein E2A-Pbx1a collaborates with Hoxa9 to acutely transform primary bone marrow cells. Mol. Cell. Biol. 19:6355-6366.
    • (1999) Mol. Cell. Biol. , vol.19 , pp. 6355-6366
    • Thorsteinsdottir, U.1    Krosl, J.2    Kroon, E.3    Haman, A.4    Hoang, T.5    Sauvageau, G.6
  • 39
    • 0027176915 scopus 로고
    • Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia
    • van Dijk, M. A., P. M. Voorhoeve, and C. Murre. 1993. Pbx1 is converted into a transcriptional activator upon acquiring the N-terminal region of E2A in pre-B-cell acute lymphoblastoid leukemia. Proc. Natl. Acad. Sci. USA 90:6061-6065.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 6061-6065
    • Van Dijk, M.A.1    Voorhoeve, P.M.2    Murre, C.3
  • 40
    • 4344669438 scopus 로고    scopus 로고
    • E protein silencing by the leukemogenic AML1-ETO fusion protein
    • Zhang, J., M. Kalkum, S. Yamamura, B. T. Chait, and R. G. Roeder. 2004. E protein silencing by the leukemogenic AML1-ETO fusion protein. Science 305:1286-1289.
    • (2004) Science , vol.305 , pp. 1286-1289
    • Zhang, J.1    Kalkum, M.2    Yamamura, S.3    Chait, B.T.4    Roeder, R.G.5
  • 41
    • 0028148938 scopus 로고
    • The helix-loop-helix gene E2A is required for B cell formation
    • Zhuang, Y., P. Soriano, and H. Weintraub. 1994. The helix-loop-helix gene E2A is required for B cell formation. Cell 79:875-884.
    • (1994) Cell , vol.79 , pp. 875-884
    • Zhuang, Y.1    Soriano, P.2    Weintraub, H.3
  • 42
    • 1542358794 scopus 로고    scopus 로고
    • Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb
    • Zor, T., R. N. De Guzman, H. J. Dyson, and P. E. Wright. 2004. Solution structure of the KIX domain of CBP bound to the transactivation domain of c-Myb. J. Mol. Biol. 337:521-534.
    • (2004) J. Mol. Biol. , vol.337 , pp. 521-534
    • Zor, T.1    De Guzman, R.N.2    Dyson, H.J.3    Wright, P.E.4


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