Phenothiazine and carbazole-related compounds inhibit mitotic kinesin Eg5 and trigger apoptosis in transformed culture cells

Toxicology Letters

Volumn 166, Issue 1, 2006, Pages 44-52

  Okumura, Hiromi ^a   Nakazawa, Junko ^b   Tsuganezawa, Keiko ^a   Usui, Takeo ^b   Osada, Hiroyuki ^b   Matsumoto, Takehisa ^a   Tanaka, Akiko ^a,c   Yokoyama, Shigeyuki ^a,c  

^a RIKEN YOKOHAMA INSTITUTE   (Japan)

^b RIKEN   (Japan)

^c UNIVERSITY OF TOKYO   (Japan)

Author keywords

Apoptosis; Eg5; Mitotic arrest; Phenothiazine

Indexed keywords

ADENOSINE TRIPHOSPHATASE; BETA TUBULIN; CARBAZOLE DERIVATIVE; GAMMA TUBULIN; KINESIN; PHENOTHIAZINE; PROPRANOLOL DERIVATIVE;

APOPTOSIS; ARTICLE; CELL CULTURE; CELL DEATH; CELL LINE; CONTROLLED STUDY; ENZYME ACTIVITY; HELA CELL; HUMAN; HUMAN CELL; IC 50; INCUBATION TIME; MICROTUBULE; MITOSIS; MITOSIS INHIBITION; NICK END LABELING; PRIORITY JOURNAL; SPINDLE CELL;

ANIMALS; ANTIMITOTIC AGENTS; APOPTOSIS; CARBAZOLES; CELL CYCLE; CELL LINE, TRANSFORMED; CELL LINE, TUMOR; CELL SURVIVAL; HUMANS; KINESIN; MOLECULAR STRUCTURE; PHENOTHIAZINES; RATS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 33747755812     PISSN: 03784274     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.toxlet.2006.05.011     Document Type: Article

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