Enhanced anti-tumor activity and alleviated hepatotoxicity of clotrimazole-loaded suppository using poloxamer-propylene glycol gel

International Journal of Pharmaceutics

Volumn 321, Issue 1-2, 2006, Pages 56-61

  Yong, Chul Soon ^a   Xuan, Jing Ji ^a   Paek, Seung Hwan ^a   Oh, Yu Kyoung ^b   Woo, Jong Soo ^a   Lee, Mann Hyung ^c   Kim, Jung Ae ^a   Choi, Han Gon ^a  

^a Yeungnam University   (South Korea)

^b Korea University   (South Korea)

^c Catholic University of Daegu   (South Korea)

Author keywords

Anti tumor activity; Clotrimazole; Hepatotoxicity; Melting point; Poloxamer 188; Suppository

Indexed keywords

CLOTRIMAZOLE; P 188; POLOXAMER; PROPYLENE GLYCOL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTINEOPLASTIC ACTIVITY; ARTICLE; DRUG SOLUBILITY; LIVER TOXICITY; MALE; MELTING POINT; NONHUMAN; PRIORITY JOURNAL; RAT; RECTUM; ROOM TEMPERATURE; SUPPOSITORY; TUMOR;

ANIMALS; ANTINEOPLASTIC AGENTS; CLOTRIMAZOLE; GELS; LIVER; MALE; MICE; MICE, INBRED BALB C; POLOXAMER; PROPYLENE GLYCOL; RATS; RATS, SPRAGUE-DAWLEY; SOLUBILITY; SUPPOSITORIES;

EID: 33747702825     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ijpharm.2006.05.023     Document Type: Article

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