Conditional deletion of hypothalamic Y2 receptors reverts gonadectomy-induced bone loss in adult mice

Journal of Biological Chemistry

Volumn 281, Issue 33, 2006, Pages 23436-23444

  Allison, Susan J ^a   Baldock, Paul ^a   Sainsbury, Amanda ^a   Enriquez, Ronaldo ^a   Lee, Nicola J ^a   Lin, En Ju Deborah ^a   Klugman, Matthias ^b   During, Matthew ^b   Eisman, John A ^a   Li, Mei ^d   Pan, Lydia C ^d   Herzog, Herbert ^a   Gardiner, Edith M ^c  

^a ST VINCENT S HOSPITAL   (Australia)

^b UNIVERSITY OF AUCKLAND   (New Zealand)

^c UNIVERSITY OF QUEENSLAND   (Australia)

^d PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AMINO ACIDS; DRUG THERAPY; ESTERS; HORMONES; PATIENT TREATMENT; TISSUE; VIRUSES;

GONADECTOMY; OSTEOPOROSIS TREATMENT; SEX HORMONES; SKELETAL MASS;

BONE;

NEUROPEPTIDE Y2 RECEPTOR; SEX HORMONE;

ADIPOSE TISSUE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY FAT; BODY WEIGHT; BONE DEVELOPMENT; CONTROLLED STUDY; FEMALE; GENE DELETION; GERM LINE; GONADECTOMY; HORMONE DEFICIENCY; HYPOGONADISM; HYPOTHALAMUS; MALE; MOUSE; NONHUMAN; OSSIFICATION; OSTEOBLAST; OSTEOLYSIS; OSTEOPOROSIS; OVARIECTOMY; PRIORITY JOURNAL;

ADIPOSE TISSUE; AGING; ANIMALS; BODY WEIGHT; BONE RESORPTION; FEMALE; FEMUR; GENE DELETION; HYPOTHALAMUS; MALE; MICE; MICE, KNOCKOUT; ORCHIECTOMY; RECEPTORS, NEUROPEPTIDE Y; SPINE;

EID: 33747646239     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M604839200     Document Type: Article

References (26)

1. Manolagas, S. C. (2000) Endocr. Rev. 21, 115-137
2. Manolagas, S. C., Kousteni, S., and Jilka, R. L. (2002) Recent Prog. Horm. Res. 57, 385-409
3. Baldock, P. A., Sainsbury, A., Couzens, M., Enriquez, R. F., Thomas, G. P., Gardiner, E. M., and Herzog, H. (2002) J. Clin. Investig. 109, 915-921
4. Sainsbury, A., Schwarzer, C., Couzens, M., and Herzog, H. (2002) Diabetes 51, 3420-3427
5. Naveilhan, P., Svensson, L., Nystrom, S., Ekstrand, A. J., and Ernfors, P. (2002) Peptides 23, 1087-1091
6. Poehlman, E. T., Toth, M. J., and Gardner, A. W. (1995) Ann. Intern. Med. 123, 673-675
7. Godsland, I. F., Manassiev, N. A., Felton, C. V., Proudler, A. J., Crook, D., Whitehead, M. I., and Stevenson, J. C. (2004) Clin. Endocrinol. 60, 541-549
8. Shimizu, H., Ohtani, K., Kato, Y., Tanaka, Y., and Mori, M. (1996) Neurosci. Lett. 204, 81-84
9. Ainslie, D. A., Morris, M. J., Wittert, G., Turnbull, H., Proietto, J., and Thorburn, A. W. (2001) Int. J. Obes. Relat. Metab. Disord. 25, 1680-1688
10. Sainsbury, A., Schwarzer, C., Couzens, M., Fetissov, S., Furtinger, S., Jenkins, A., Cox, H. M., Sperk, G., Hokfelt, T., and Herzog, H. (2002) Proc. Natl. Acad. Sci. U. S. A. 99, 8938-8943
11. Rehman, M. T., Hoyland, J. A., Denton, J., and Freemont, A. J. (1994) J. Clin. Pathol. 47, 529-534
12. Wronski, T. J., Walsh, C. C., and Ignaszewski, L. A. (1986) Bone 7, 119-123
13. Wronski, T. J., Dann, L. M., Scott, K. S., and Cintron, M. (1989) Calcif. Tissue Int. 45, 360-366
14. Baldock, P. A., Morris, H. A., Need, A. G., Moore, R. J., and Durbridge, T. C. (1998) J. Bone Miner. Res. 13, 1451-1457
15. Toth, M. J., Tchernof, A., Sites, C. K., and Poehlman, E. T. (2000) Ann. N. Y. Acad. Sci. 904, 502-506
16. Escobar, C. M., Krajewski, S. J., Sandoval-Guzman, T., Voytko, M. L., and Rance, N. E. (2004) J. Clin. Endocrinol. Metab. 89, 2338-2343
17. Denes, A., Boldogkoi, Z., Uhereczky, G., Hornyak, A., Rusvai, M., Palkovits, M., and Kovacs, K. J. (2005) Neuroscience 134, 947-963
18. Reid, I. R., Ames, R., Evans, M. C., Sharpe, S., Gamble, G., France, J. T., Lim, T. M., and Cundy, T. F. (1992) J. Clin. Endocrinol. Metab. 75, 45-51
19. McCarthy, T. L., and Centrella, M. (2001) Growth Horm. IGF Res. 11, 213-219
20. Inoue, K., Ohgushi, H., Yoshikawa, T., Okumura, M., Sempuku, T., Tamai, S., and Dohi, Y. (1997) J. Bone Miner. Res. 12, 989-994
21. Roholl, P. J., Blauw, E., Zurcher, C., Dormans, J. A., and Theuns, H. M. (1994) J. Bone Miner. Res. 9, 355-366
22. Yudoh, K., Matsuno, H., Nakazawa, F., Katayama, R., and Kimura, T. (2001) J. Bone Miner. Res. 16, 1453-1464
23. Weinstein, R. S., and Manolagas, S. C. (2000) Am. J. Med. 108, 153-164
24. Finkelstein, J. S., Hayes, A., Hunzelman, J. L., Wyland, J. J., Lee, H., and Neer, R. M. (2003) N. Engl. J. Med. 349, 1216-1226
25. Black, D. M., Greenspan, S. L., Ensrud, K. E., Palermo, L., McGowan, J. A., Lang, T. F., Garnero, P., Bouxsein, M. L., Bilezikian, J. P., and Rosen, C. J. (2003) N. Engl. J. Med. 349, 1207-1215
26. Gullberg, B., Johnell, O., and Kanis, J. A. (1997) Osteoporos. Int. 7, 407-413