Clinical Benefits of a Metabolic Approach in the Cardiac Rehabilitation of Patients with Coronary Artery Disease

American Journal of Cardiology

Volumn 98, Issue 5 SUPPL. 1, 2006, Pages 25-33

  Belardinelli, Romualdo ^a   Lacalaprice, Francesca ^a   Faccenda, Ernesto ^a   Volpe, Loretta ^a  

^a Struttura di Cardiologia Riabilitativa e Preventiva   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIANGINA PECTORIS AGENT; ASCORBIC ACID; ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; DIPYRIDAMOLE; DOBUTAMINE; METOPROLOL; NITRIC ACID DERIVATIVE; NITRIC OXIDE; TETROFOSMIN TC 99M; TRIMETAZIDINE;

ARTICLE; CORONARY ARTERY DISEASE; DIARRHEA; EXERCISE; HEART REHABILITATION; HUMAN; PATIENT IDENTIFICATION; PERIPHERAL OCCLUSIVE ARTERY DISEASE; PRIORITY JOURNAL; STABLE ANGINA PECTORIS; TREADMILL EXERCISE;

CORONARY CIRCULATION; CORONARY DISEASE; HUMANS; MYOCARDIUM; TREATMENT OUTCOME; TRIMETAZIDINE; VASODILATOR AGENTS; VENTRICULAR FUNCTION, LEFT;

EID: 33747620734     PISSN: 00029149     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.amjcard.2006.07.006     Document Type: Article

References (39)

1. Kantor P.F., Lucien A., Kozak R., and Lopaschuk G.D. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A tiolase. Circ Res 86 (2000) 580-588
2. Belardinelli R., and Purcaro A. Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischaemic cardiomyopathy. Eur Heart J 22 (2001) 2164-2170
3. Brottier L., Barat J.L., Combe C., Boussens B., Bonnet J., and Bricand H. Therapeutic value of a cardioprotective agent in patients with severe ischaemic cardiomyopathy. Eur Heart J 11 (1990) 207-212
4. Fragasso G., Piatti P.M., Monti L., Palloshi A., Setola E., Puccetti P., Calori G., Lopaschuk G.D., and Margonato A. Short- and long-term beneficial effects of trimetazidine in patients with diabetes and ischemic cardiomyopathy. Am Heart J 146 (2003) E18-E25
5. Belardinelli R., Solenghi M., Volpe L., and Purcaro A. Trimetazidine improves endothelial dysfunction in chronic heart failure. an antioxidant effect?. Circulation 104 suppl II (2001) 1612 [abstract]
6. Belardinelli R., Georgiou D., Cianci G., Berman N., Ginzton L., and Purcaro A. Exercise training improves left ventricular diastolic filling in patients with dilated cardiomyopathy. clinical and prognostic implications. Circulation 91 (1995) 2775-2784
7. Belardinelli R., Georgiou D., Ginzton L., Cianci G., and Purcaro A. Effects of moderate exercise training on thallium uptake and contractile response to low-dose dobutamine of dysfunctional myocardium in patients with ischemic cardiomyopathy. Circulation 97 (1998) 553-561
8. Giannuzzi P., Saner H., Björnstad H., Fioretti P., Mendes M., Cohen-Solal A., Dugmore L., Hambrecht R., Hellemans I., McGee H., et al. Secondary prevention through cardiac rehabilitation. position paper of the Working Group on Cardiac Rehabilitation and Exercise Physiology of the European Society of Cardiology. Eur Heart J 24 (2003) 1273-1278
9. Rehabilitation after cardiovascular diseases, with special emphasis on developing countries. report of a WHO Expert Committee. World Health Organ Tech Rep Ser 831 (1993) 1-122
10. Klein W., Jackson G., and Tavazzi L. Efficacy of monotherapy compared with combined antianginal drugs in the treatment of chronic stable angina pectoris. a meta-analysis. Coron Artery Dis 13 (2002) 427-436
11. Szwed H., Sadowski Z., Elikowski W., Koronkiewicz A., Mamcarz A., Orszulak W., Skibinska E., Szymczak K., Swiatek J., and Winter M. Combination treatment in stable effort angina using trimetazidine and metoprolol. results of a randomized, double-blind, multicentre study (TRIMPOL II). Eur Heart J 22 (2001) 2267-2274
12. Sellier P., and Broustet J.P. Assessment of anti-ischemic and antianginal effect at trough plasma concentration and safety of trimetazidine MR 35 mg in patients with stable angina pectoris. a multicenter, double-blind, placebo-controlled study. Am J Cardiovasc Drugs 3 (2003) 361-369
13. Rosano G.M., Vitale C., Sposato B., Mercuro G., and Fini M. Trimetazidine improves left ventricular function in diabetic patients with coronary artery disease. a double-blind placebo-controlled study. Cardiovasc Diabetol 2 (2003) 16-24
14. Vitale C., Wajngaten M., Sposato B., Gebara O., Rossini P., Fini M., Volterrani M., and Rosano G.M. Trimetazidine improves left ventricular function and quality of life in elderly patients with coronary artery disease. Eur Heart J 25 (2004) 1814-1821
15. Maridonneau-Parini K., and Harpey C. Effects of trimetazidine on membrane damage induced by oxygen free radicals in human red cells. Br J Clin Pharmacol 20 (1985) 148-151
16. Wiemer G., Itter G., Malinski T., and Linz W. Decreased nitric oxide availability in normotensive and hypertensive rats with failing hearts after myocardial infarction. Hypertension 38 (2001) 1367-1371
17. Heitzer T., Schlinzig T., Krohn K., Meinertz T., and Munzel T. Endothelial dysfunction, oxidative stress, and risk of cardiovascular events in patients with coronary artery disease. Circulation 104 (2001) 2673-2678
18. Prasad K., Gupta J.B., Kalra J., and Bharadwaj B. Oxygen free radicals in volume overload heart failure. Mol Cell Biochem 111 (1992) 55-59
19. Baumer A.T., Flesch M., Wang X., Shen Q., Feuerstein G.Z., and Bohm M. Antioxidative enzymes in human hearts with idiopathic dilated cardiomyopathy. J Mol Cell Cardiol 32 (2000) 121-130
20. Loscalzo J. Nitric oxide insufficiency, platelet activation, and arterial thrombosis. Circ Res 88 (2001) 756-762
21. 2 from DNA damage. Free Radic Biol Med 30 (2001) 1357-1364
22. Eschwege E., Simon D., and Balkau B. The growing burden of diabetes in the world population. International Diabetes Federation Bulletin 42 (1997) 14-19
23. Garvey W.T., Hardin D., Juhaszova M., and Dominguez J.H. Effects of diabetes on myocardial glucose transport system in rats. implications for diabetic cardiomyopathy. Am J Physiol 264 (1993) H837-H844
24. Paulson D.J., Kopp S.J., Peace D.G., and Tow J.P. Improved postischemic recovery of cardiac pump function in exercised trained diabetic rats. J Appl Physiol 65 (1988) 187-193
25. Malmberg K., Ryden L., Efendic S., Herlitza J., Nicola P., Waldenströma A., Wedela H., and Welin L. Randomized trial of insulin-glucose infusion followed by subcutaneous insulin treatment in diabetic patients with acute myocardial infarction (DIGAMI study). effects on mortality at 1 year. J Am Coll Cardiol 26 (1995) 57-65
26. Beckman J.A., Creager M.A., and Libby P. Diabetes and atherosclerosis. epidemiology, pathophysiology, and management. JAMA 287 (2002) 2570-2581
27. Stanley W.C., Lopaschuk G.D., Hall J.L., and McCormack J.G. Regulation of myocardial carbohydrate metabolism under normal and ischaemic conditions. potential for pharmacologic interventions. Cardiovasc Res 33 (1997) 243-257
28. Belardinelli R., Cianci G., Gigli M., and Perna G.P. Trimetazidine improves left ventricular systolic function in ischemic cardiomyopathy. Circulation 110 suppl II (2004) 3051 [abstract]
29. Bax J.J., Poldermans D., Elhendy A., Boersma E., and Rahimtoola S.H. Sensitivity, specificity, and predictive accuracies of various noninvasive techniques for detecting hibernating myocardium. Curr Probl Cardiol 26 (2001) 141-188
30. Belardinelli R., Georgiou D., and Purcaro A. Low dose dobutamine echocardiography predicts improvement in functional capacity after exercise training in patients with ischemic cardiomyopathy. prognostic implication. J Am Coll Cardiol 31 (1998) 1027-1034
31. Hornig B., Maier V., and Drexler H. Physical training improves endothelial function in patients with chronic heart failure. Circulation 93 (1996) 210-214
32. Hambrecht R., Niebauer J., Fiehn E., Kälberer B., Offnera B., Hauer K., Riede U., Schlierf G., Kübler W., and Schuler G. Physical training in patients with stable chronic heart failure. effects on cardiorespiratory fitness and ultrastructural abnormalities of leg muscles. J Am Coll Cardiol 25 (1995) 1239-1249
33. Radaelli A., Coats A.J., Leuzzi S., Piepoli M., Meyer T.E., Calciati A., Finardi G., Bernardi L., and Sleight P. Physical training enhances sympathetic and parasympathetic control of heart rate and peripheral vessels in chronic heart failure. Clin Sci 91 (1996) 92-94
34. Tyni-Lenne R., Gordon A., Jansson E., Bermann G., and Sylven C. Skeletal muscle endurance training improves peripheral oxidative capacity, exercise tolerance, and health-related quality of life in women with chronic congestive heart failure secondary to either ischemic cardiomyopathy or idiopathic dilated cardiomyopathy. Am J Cardiol 80 (1997) 1025-1029
35. Piña I.L., Apstein C.A., Balady G.J., Belardinelli R., Chaitman B.R., Duscha B.D., Fletcher B.J., Fleg J.L., Myers J.N., Sullivan M.J., American Heart Association Committee on Exercise, Rehabilitation, and and Prevention. Exercise and heart failure. a statement from the American Heart Association Committee on Exercise, Rehabilitation, and Prevention. Circulation 107 (2003) 1210-1225
36. Stehno-Bittel L., Laughlin M.H., and Sturek M. Exercise training depletes sarcoplasmic reticulum Ca in coronary smooth muscle. J Appl Physiol 71 (1991) 1764-1773
37. Laughlin M.H., and McAllister R.M. Exercise training-induced coronary vascular adaptation. J Appl Physiol 73 (1992) 2209-2225
38. Belardinelli R., Belardinelli L., and Shryock J.C. Effects of dipyridamole on coronary collateralization and myocardial perfusion in patients with ischemic cardiomyopathy. Eur Heart J 22 (2001) 1205-1213
39. Frank M.W., Harris K.R., Ahlin K.A., and Klocke F.J. Endothelium-derived relaxing factor (nitric oxide) has a tonic vasodilating action on coronary collaterals vessels. J Am Coll Cardiol 27 (1996) 658-663