Effects of trimetazidine on the contractile response of chronically dysfunctional myocardium to low-dose dobutamine in ischaemic cardiomyopathy

European Heart Journal

Volumn 22, Issue 23, 2001, Pages 2164-2170

  Belardinelli, Romualdo ^a,b   Purcaro, A ^a  

^a Department of Cardiology GM Lancisi ^*  (Italy)

^b Ospedale Monospecialistico Cardiologico GM Lancisi   (Italy)

Author keywords

Contractility; Dobutamine stress echocardiography; Dysfunctional myocardium; Trimetazidine

Indexed keywords

DOBUTAMINE; TRIMETAZIDINE;

ADULT; ARTICLE; CARDIOMYOPATHY; CLINICAL ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; CORONARY ARTERY DISEASE; DRUG EFFECT; FEMALE; HEART EJECTION FRACTION; HEART LEFT VENTRICLE FAILURE; HEART LEFT VENTRICLE FUNCTION; HEART MUSCLE CONTRACTILITY; HEART MUSCLE OXYGEN CONSUMPTION; HUMAN; ISCHEMIC HEART DISEASE; MALE; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; STRESS ECHOCARDIOGRAPHY;

ANALYSIS OF VARIANCE; CARDIOMYOPATHIES; DOUBLE-BLIND METHOD; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL CONTRACTION; MYOCARDIAL ISCHEMIA; TRIMETAZIDINE; VASODILATOR AGENTS; VENTRICULAR DYSFUNCTION, LEFT;

EID: 0035208524     PISSN: 0195668X     EISSN: None     Source Type: Journal    
DOI: 10.1053/euhj.2001.2653     Document Type: Article

References (15)

1. Chronic effects of trimetazidine on ergometric parameters in effort angina
2. Comparison of trimetazidine with nifedipine in effort angina: A double-blind, crossover study
3. Trimetazidine: A new concept in the treatment of angina. Comparison with propranolol in patients with stable angina
4. The antianginal drug trimetazidine shifts cardiac energy metabolism from fatty acid oxidation to glucose oxidation by inhibiting mitochondrial long-chain 3-ketoacyl coenzyme A thiolase
5. Internal pH, Na+ and Ca++ regulation by trimetazidine during cardiac cell acidosis
6. Anti-ischemic effects of trimetazidine: 31P-NMR spectroscopy in the isolated rat heart
7. Effects of trimetazidine on ischemic left ventricular dysfunction in patients with coronary artery disease
8. Recommendations for quantitation of the left ventricle by two-dimensional echocardiography: American society of echocardiography committee on standards, subcommittee on quantitation of two-dimensional echocardiograms
9. Low-dose dobutamine echocardiography predicts improvement in functional capacity after exercise training in patients with ischemic cardiomyopathy: Prognostic implication
10. Improvement of long-term preservation of isolated arrested rat heart: Beneficial effect of the antiischemic agent trimetazidine
11. Mechanisms of chronic regional postischemic dysfunction in humans
12. Relation between thallium uptake and contractile response to dobutamine: Implications regarding myocardial viability in patients with chronic coronary artery disease and left ventricular dysfunction
13. Effect of trimetazidine on mitochondrial function and oxidative damage during reperfusion of ischemic hyperthrofied myocardium
14. Increased glycolytic substrate protects against ischemic diastolic dysfunction: 31P-NMR studies in the isolated blood perfused rat heart
15. Therapeutic value of a cardioprotective agent in patients with severe ischaemic cardiomyopathy