메뉴 건너뛰기




Volumn 7, Issue 8, 2006, Pages 709-720

Transmitted multidrug resistant HIV-1: New and investigational therapeutic approaches

Author keywords

Investigational antiretroviral agents; Multidrug resistant HIV 1; Therapeatic approach; Transmission

Indexed keywords

1 BENZOYL 4 [(4,7 DIMETHOXY 1H PYRROLO[2,3 C]PYRIDIN 3 YL)OXOACETYL]PIPERAZINE; 3 O (3,3 DIMETHYLSUCCINYL)BETULIC ACID; AMD 070; ANTIVIRUS AGENT; APLAVIROC; AVX 754; BEVIRIMAT; CD4 IMMUNOGLOBULIN G2; DARUNAVIR; DELAVIRDINE; DEXELVUCITABINE; DIDANOSINE; EFAVIRENZ; ENFUVIRTIDE; ETRAVIRINE; INDINAVIR; INTEGRASE INHIBITOR; JTK 303; MARAVIROC; MK 0518; NEVIRAPINE; PLACEBO; RITONAVIR; SAQUINAVIR; TENOFOVIR; TIPRANAVIR; TNX 355; UNCLASSIFIED DRUG; UNINDEXED DRUG; VICRIVIROC; ZALCITABINE; ZIDOVUDINE;

EID: 33747617818     PISSN: 14724472     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (12)

References (99)
  • 1
    • 33747614720 scopus 로고    scopus 로고
    • UNAIDS/WHO AIDS Epidemic update: UNAIDS, Geneva, Switzerland
    • UNAIDS/WHO AIDS Epidemic update: UNAIDS, Geneva, Switzerland (2005). http.//www.unaids.org/epi/2OO5/doc/report_pdf.asp
    • (2005)
  • 5
    • 0029967721 scopus 로고    scopus 로고
    • HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time
    • Perelson AS, Neumann AU, Markowitz M, Leonard JM, Ho DD: HIV-1 dynamics in vivo: Virion clearance rate, infected cell life-span, and viral generation time. Science (1996) 271(5255):1582-1586.
    • (1996) Science , vol.271 , Issue.5255 , pp. 1582-1586
    • Perelson, A.S.1    Neumann, A.U.2    Markowitz, M.3    Leonard, J.M.4    Ho, D.D.5
  • 6
    • 0037385686 scopus 로고    scopus 로고
    • A novel antiviral Intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo
    • Markowitz M, Louie M, Hurley A, Sun E, Di Mascio M, Perelson AS, Ho DD: A novel antiviral Intervention results in more accurate assessment of human immunodeficiency virus type 1 replication dynamics and T-cell decay in vivo. J Virol (2003) 77(8):5037-5038.
    • (2003) J Virol , vol.77 , Issue.8 , pp. 5037-5038
    • Markowitz, M.1    Louie, M.2    Hurley, A.3    Sun, E.4    Di Mascio, M.5    Perelson, A.S.6    Ho, D.D.7
  • 7
    • 0028952146 scopus 로고
    • HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy
    • Coffin JM: HIV population dynamics in vivo: Implications for genetic variation, pathogenesis, and therapy. Science (1995) 287(5197):483-489.
    • (1995) Science , vol.287 , Issue.5197 , pp. 483-489
    • Coffin, J.M.1
  • 9
    • 0033391009 scopus 로고    scopus 로고
    • Sociodemographic and psychological variables influencing adherence to antiretroviral therapy
    • Gordillo V, del Amo J, Soriano V, Gonzalez-Lahoz J: Sociodemographic and psychological variables influencing adherence to antiretroviral therapy. AIDS (1999) 13(13):1763-1769.
    • (1999) AIDS , vol.13 , Issue.13 , pp. 1763-1769
    • Gordillo, V.1    del Amo, J.2    Soriano, V.3    Gonzalez-Lahoz, J.4
  • 10
    • 0029757751 scopus 로고    scopus 로고
    • Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme
    • Back NK, Nijhuis M, Keulen W, Boucher CA, Oude Essink BO, van Kuilenburg AB, van Gennip AH, Berkhout B: Reduced replication of 3TC-resistant HIV-1 variants in primary cells due to a processivity defect of the reverse transcriptase enzyme. EMBO J (1996) 15(15):4040-4049.
    • (1996) EMBO J , vol.15 , Issue.15 , pp. 4040-4049
    • Back, N.K.1    Nijhuis, M.2    Keulen, W.3    Boucher, C.A.4    Oude Essink, B.O.5    van Kuilenburg, A.B.6    van Gennip, A.H.7    Berkhout, B.8
  • 11
    • 0030926277 scopus 로고    scopus 로고
    • Broad spectrum of in vivo fitness of human immunodeficiency virus type 1 subpopulations differing at reverse transcriptase codons 41 215
    • Goudsmit J, de Ronde A, de Rooij E, de Boer R: Broad spectrum of in vivo fitness of human immunodeficiency virus type 1 subpopulations differing at reverse transcriptase codons 41 and 215. J Virol (1997) 71(8):4479-4484.
    • (1997) J Virol , vol.71 , Issue.8 , pp. 4479-4484
    • Goudsmit, J.1    de Ronde, A.2    de Rooij, E.3    de Boer, R.4
  • 12
    • 0031846317 scopus 로고    scopus 로고
    • Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: Phenotypic analysis of protesse and gag coevolution in protease inhibitor-treated patients
    • Mammano F, Petit C, Clavel F: Resistance-associated loss of viral fitness in human immunodeficiency virus type 1: Phenotypic analysis of protesse and gag coevolution in protease inhibitor-treated patients. J Virol (1998) 72(9):7632-7637.
    • (1998) J Virol , vol.72 , Issue.9 , pp. 7632-7637
    • Mammano, F.1    Petit, C.2    Clavel, F.3
  • 13
    • 0032928065 scopus 로고    scopus 로고
    • Replicative fitness of protease Inhibitor-resistant mutants of human immunodeficiency virus type 1
    • Martinez-Picado J, Savera AV, Sutton L, D'Aquila RT: Replicative fitness of protease Inhibitor-resistant mutants of human immunodeficiency virus type 1. J Virol (1999) 73(5):3744-3752.
    • (1999) J Virol , vol.3 , Issue.5 , pp. 3744-3752
    • Martinez-Picado, J.1    Savera, A.V.2    Sutton, L.3    D'Aquila, R.T.4
  • 14
    • 0034867418 scopus 로고    scopus 로고
    • Replicative fitness in vivo of HIV-1 variants with multiple drug resistance-associated mutations
    • Devereux HL, Emery VC, Johnson MA, Loveday C: Replicative fitness in vivo of HIV-1 variants with multiple drug resistance-associated mutations. J Med Virol (2001) 65(2):218-224.
    • (2001) J Med Virol , vol.65 , Issue.2 , pp. 218-224
    • Devereux, H.L.1    Emery, V.C.2    Johnson, M.A.3    Loveday, C.4
  • 16
    • 0032804864 scopus 로고    scopus 로고
    • Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy
    • Nijhuis M, Schuurman R, de Jong D, Erickson J, Gustchina E, Albert J, Schipper P, Gulnik S, Boucher CA: Increased fitness of drug resistant HIV-1 protease as a result of acquisition of compensatory mutations during suboptimal therapy. AIDS (1999) 13(17):2349-2359.
    • (1999) AIDS , vol.13 , Issue.17 , pp. 2349-2359
    • Nijhuis, M.1    Schuurman, R.2    de Jong, D.3    Erickson, J.4    Gustchina, E.5    Albert, J.6    Schipper, P.7    Gulnik, S.8    Boucher, C.A.9
  • 17
    • 0038082378 scopus 로고    scopus 로고
    • Infectivity and replication capacity of drug-resistant human immunodeficiency virus type 1 variants isolated during primary infection
    • Simon V, Padte N, Murray D, Vanderhoeven J, Wrin T, Parkin N, Di Mascio M, Markowitz M: Infectivity and replication capacity of drug-resistant human immunodeficiency virus type 1 variants isolated during primary infection. J Virol (2003) 77(14):7736-7745.
    • (2003) J Virol , vol.77 , Issue.14 , pp. 7736-7745
    • Simon, V.1    Padte, N.2    Murray, D.3    Vanderhoeven, J.4    Wrin, T.5    Parkin, N.6    Di Mascio, M.7    Markowitz, M.8
  • 18
    • 0030769354 scopus 로고    scopus 로고
    • Drug resistance during Indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites
    • Zhang YM, Imamichi H, Imamichi T, Lane HC, Falloon J, Vasudevachari MB, Salzman NP: Drug resistance during Indinavir therapy is caused by mutations in the protease gene and in its Gag substrate cleavage sites. J Virol (1997) 71(9):6662-6670.
    • (1997) J Virol , vol.71 , Issue.9 , pp. 6662-6670
    • Zhang, Y.M.1    Imamichi, H.2    Imamichi, T.3    Lane, H.C.4    Falloon, J.5    Vasudevachari, M.B.6    Salzman, N.P.7
  • 24
    • 0033385403 scopus 로고    scopus 로고
    • Rapid decline in detectability of HIV-1 drug resistance mutations after stopping therapy
    • Devereux HL, Youle M, Johnson MA, Loveday C: Rapid decline in detectability of HIV-1 drug resistance mutations after stopping therapy. AIDS (1999) 13(18):F123-F127.
    • (1999) AIDS , vol.13 , Issue.18
    • Devereux, H.L.1    Youle, M.2    Johnson, M.A.3    Loveday, C.4
  • 26
    • 0030953711 scopus 로고    scopus 로고
    • Transmission of human immunodeficiency virus type 1 resistant to nevirapine and zidovudine. Sydney Primary HIV Infection Study Group
    • Imrie A, Beveridge A, Genn W, Vizzard J, Cooper DA: Transmission of human immunodeficiency virus type 1 resistant to nevirapine and zidovudine. Sydney Primary HIV Infection Study Group. J Infect Dis (1997) 175(6):1502-1506.
    • (1997) J Infect Dis , vol.175 , Issue.6 , pp. 1502-1506
    • Imrie, A.1    Beveridge, A.2    Genn, W.3    Vizzard, J.4    Cooper, D.A.5
  • 28
    • 0142179899 scopus 로고    scopus 로고
    • Selective transmission of multidrug resistant HIV to a newborn related to poor maternal adherence
    • Desai N, Mathur M: Selective transmission of multidrug resistant HIV to a newborn related to poor maternal adherence. Sex Transm Infect (2003) 79(5):419-421.
    • (2003) Sex Transm Infect , vol.79 , Issue.5 , pp. 419-421
    • Desai, N.1    Mathur, M.2
  • 34
    • 0034785773 scopus 로고    scopus 로고
    • Predicting the unpredictable: Transmission of drug-resistant HIV
    • Blower SM, Aschenbach AN, Gershengorn HB, Kahn JO: Predicting the unpredictable: Transmission of drug-resistant HIV. Nat Med (2001) 7(9):1016-1020.
    • (2001) Nat Med , vol.7 , Issue.9 , pp. 1016-1020
    • Blower, S.M.1    Aschenbach, A.N.2    Gershengorn, H.B.3    Kahn, J.O.4
  • 35
    • 0037443126 scopus 로고    scopus 로고
    • Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population
    • Leigh Brown AJ, Frost SD, Mathews WC, Dawson K, Hellmann NS, Daar ES, Richman DD, Little SJ: Transmission fitness of drug-resistant human immunodeficiency virus and the prevalence of resistance in the antiretroviral-treated population. J Infect Dfs (2003) 187(4):683-686.
    • (2003) J Infect Dfs , vol.187 , Issue.4 , pp. 683-686
    • Leigh Brown, A.J.1    Frost, S.D.2    Mathews, W.C.3    Dawson, K.4    Hellmann, N.S.5    Daar, E.S.6    Richman, D.D.7    Little, S.J.8
  • 36
    • 0035104646 scopus 로고    scopus 로고
    • Individual contributions of mutant protease and reverse transcriptase to viral infectivity, replication, and protein maturation of antiretroviral drug-resistant human immunodeficiency virus type 1
    • Bleiber G, Munoz M, Ciuffi A, Meylan P, Telenti A: Individual contributions of mutant protease and reverse transcriptase to viral infectivity, replication, and protein maturation of antiretroviral drug-resistant human immunodeficiency virus type 1. J Virol (2001) 76(7):3291-300.
    • (2001) J Virol , vol.76 , Issue.7 , pp. 3291-3300
    • Bleiber, G.1    Munoz, M.2    Ciuffi, A.3    Meylan, P.4    Telenti, A.5
  • 37
    • 33747592740 scopus 로고    scopus 로고
    • US Department of Health and Human Services - AIDSinfo, Rockville, MD, USA
    • AIDSinfo clinical guidelines. US Department of Health and Human Services - AIDSinfo, Rockville, MD, USA (2005). http://www.aidsinfo.nih.gov/Guidelines/
    • (2005) AIDSinfo Clinical Guidelines
  • 38
    • 27144549662 scopus 로고    scopus 로고
    • Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection
    • Deeks SG, Hoh R, Neilands TB, Liegier T, Aweeka F, Petropoulos CJ, Grant RM, Martin JN: Interruption of treatment with individual therapeutic drug classes in adults with multidrug-resistant HIV-1 infection. J Infect Dis (2005) 192(9):1537-1544.
    • (2005) J Infect Dis , vol.192 , Issue.9 , pp. 1537-1544
    • Deeks, S.G.1    Hoh, R.2    Neilands, T.B.3    Liegier, T.4    Aweeka, F.5    Petropoulos, C.J.6    Grant, R.M.7    Martin, J.N.8
  • 41
    • 28044454891 scopus 로고    scopus 로고
    • Drugs used in the treatment of HIV infection
    • US Food and Drug Administration Food and Drug Administration, Rockville, MA, USA
    • US Food and Drug Administration: Drugs used in the treatment of HIV infection. Food and Drug Administration, Rockville, MA, USA (2005). http://www.fda.gov/oashi/aids/virals.html
    • (2005)
  • 44
    • 20544435888 scopus 로고    scopus 로고
    • A treatment staging proposal derived from a post-hoc analysis of the 48 week results from the TORO studies
    • Abs TuPeB4483
    • Montaner J, Chung J, Guimaraes D, DeMasi R, Gafoor Z, Salgo M: A treatment staging proposal derived from a post-hoc analysis of the 48 week results from the TORO studies. International AIDS Conference (2004) 15:Abs TuPeB4483.
    • (2004) International AIDS Conference , vol.15
    • Montaner, J.1    Chung, J.2    Guimaraes, D.3    DeMasi, R.4    Gafoor, Z.5    Salgo, M.6
  • 49
    • 33747602935 scopus 로고    scopus 로고
    • Tolerability and anti HiV-1 activity of SPD764 in 10 days monotherapy in treatment naive patients
    • Abs
    • Cahn P, Van Leeuwen R, Sawyer J, Shiveley L: Tolerability and anti HiV-1 activity of SPD764 in 10 days monotherapy in treatment naive patients. ICAAC (2003) 4:Abs H-869.
    • (2003) ICAAC , vol.4
    • Cahn, P.1    Van Leeuwen, R.2    Sawyer, J.3    Shiveley, L.4
  • 57
    • 19544386471 scopus 로고    scopus 로고
    • TMC114, a novel human immunodeficiency virus type 1 protease, inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates
    • De Meyer S, Azijn H, Surleraux D, Jochmans D, Tahri A, Pauwels R, Wgerinck P, de Bethune MP: TMC114, a novel human immunodeficiency virus type 1 protease, inhibitor active against protease inhibitor-resistant viruses, including a broad range of clinical isolates. Antimicrob Agents Chemother (2005) 49(6):2314-2321.
    • (2005) Antimicrob Agents Chemother , vol.49 , Issue.6 , pp. 2314-2321
    • De Meyer, S.1    Azijn, H.2    Surleraux, D.3    Jochmans, D.4    Tahri, A.5    Pauwels, R.6    Wgerinck, P.7    de Bethune, M.P.8
  • 58
    • 20644450806 scopus 로고    scopus 로고
    • TMC114/ritonavir substitution for protease inhibitor(s) in a non-suppressive andretroviral regimen: A 14-day proof-of-principle trial
    • Arasteh K, Clumeck N, Pozniak A, Lazzarin A, De Meyer S, Muller H, Peelers M, Rinehart A, Lefebvre E: TMC114/ritonavir substitution for protease inhibitor(s) in a non-suppressive andretroviral regimen: A 14-day proof-of-principle trial. AIDS (2005) 19(9):943-947.
    • (2005) AIDS , vol.19 , Issue.9 , pp. 943-947
    • Arasteh, K.1    Clumeck, N.2    Pozniak, A.3    Lazzarin, A.4    De Meyer, S.5    Muller, H.6    Peelers, M.7    Rinehart, A.8    Lefebvre, E.9
  • 59
    • 33750314199 scopus 로고    scopus 로고
    • TMCI 14/r superior to standard of care in 3-class-experienced patients: 24-Wks primary analysis of the Power 2 study (C202)
    • Abs
    • Wilkin T, Haubrich R, Steinhart CR: TMCI 14/r superior to standard of care in 3-class-experienced patients: 24-Wks primary analysis of the Power 2 study (C202). ICAAC (2005) 45:Abs H-413.
    • (2005) ICAAC , vol.45
    • Wilkin, T.1    Haubrich, R.2    Steinhart, C.R.3
  • 66
    • 0035717630 scopus 로고    scopus 로고
    • Combination of protease inhibitors far the treatment of HIV-1-infected patients: A review of pharmacolkinetics and clinical experience
    • van Heeswijk RP, Veldkamp A, Mulder JW, Meenhorst PL, Lange JM, Beijnen JH, Hoetelmans, RM: Combination of protease inhibitors far the treatment of HIV-1-infected patients: A review of pharmacolkinetics and clinical experience. Antivir Ther (2001) 6(4)-201-229.
    • (2001) Antivir Ther , vol.6 , Issue.4 , pp. 201-229
    • van Heeswijk, R.P.1    Veldkamp, A.2    Mulder, J.W.3    Meenhorst, P.L.4    Lange, J.M.5    Beijnen, J.H.6    Hoetelmans, R.M.7
  • 73
    • 0141814730 scopus 로고    scopus 로고
    • The entry of entry inhibitors: A fusion of science and medicine
    • Moore JP, Doms RW: The entry of entry inhibitors: A fusion of science and medicine. Proc Natl Acad Sci USA (2003) 100(19):10598-10602.
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.19 , pp. 10598-10602
    • Moore, J.P.1    Doms, R.W.2
  • 79
    • 32444443937 scopus 로고    scopus 로고
    • TNX-355 in combination with optimized background regimen (OBR) exhibits greater antiviral activity then OBR alone in HIV-treatment experienced patients
    • Abs
    • Norris D, Morales J, Gathe J, Godofsky E, Garcia F, Hardwicke R, Jackson J, Lewis S, Paradiso L: TNX-355 in combination with optimized background regimen (OBR) exhibits greater antiviral activity then OBR alone in HIV-treatment experienced patients. ICAAC (2005) 45:Abs LB2-26.
    • (2005) ICAAC , vol.45
    • Norris, D.1    Morales, J.2    Gathe, J.3    Godofsky, E.4    Garcia, F.5    Hardwicke, R.6    Jackson, J.7    Lewis, S.8    Paradiso, L.9
  • 84
    • 4544371685 scopus 로고    scopus 로고
    • Multiple dose study to investigate the safety of UK-427,857 (100 mg or 300 mg) bid for 28 days in healthy males and females
    • Abs
    • Russell D, Bakhtyari A, Jazrawi RP, Whitlock L, Ridgway C, Michale M, Abel S: Multiple dose study to investigate the safety of UK-427,857 (100 mg or 300 mg) bid for 28 days in healthy males and females. ICAAC (2003) 43:Abs H-874.
    • (2003) ICAAC , vol.43
    • Russell, D.1    Bakhtyari, A.2    Jazrawi, R.P.3    Whitlock, L.4    Ridgway, C.5    Michale, M.6    Abel, S.7
  • 85
    • 33746161275 scopus 로고    scopus 로고
    • Special presentation on aplaviroc-related hepatotoxicky
    • Dublin, Ireland, UK
    • Steel H: Special presentation on aplaviroc-related hepatotoxicky. Tenth European AIDS Conference, Dublin, Ireland, UK (2005).
    • (2005) Tenth European AIDS Conference
    • Steel, H.1
  • 86
    • 33747622711 scopus 로고    scopus 로고
    • Liver toxicity case seen with CCR5 antagonist maraviroc
    • Reston, VA, USA
    • Liver toxicity case seen with CCR5 antagonist maraviroc. Clinical Care Options, Reston, VA, USA (2005). http://www.cliniclcareoptions.com/HIV/Conference%2OCoverage/ Dublin%202005/News/news_dublin2005_5.aspx
    • (2005) Clinical Care Options
  • 92
    • 33749233727 scopus 로고    scopus 로고
    • Needle-free Fuzeon in works
    • Needle-free Fuzeon in works. AIDS Patient Care STDS (2005) 19(9):614-616.
    • (2005) AIDS Patient Care STDS , vol.19 , Issue.9 , pp. 614-616
  • 96
    • 33749519278 scopus 로고    scopus 로고
    • Safety and antiviral activity of PA-457, the first-in-class maturation inhibitor, in a 10-day monotherapy study in HIV-1 infected patients
    • Abs
    • Beatty G, Lalezari J, Eron JJ Jr. Safety and antiviral activity of PA-457, the first-in-class maturation inhibitor, in a 10-day monotherapy study in HIV-1 infected patients. ICAAC (2005) 45:Abs H-416d.
    • (2005) ICAAC , vol.45
    • Beatty, G.1    Lalezari, J.2    Eron Jr., J.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.