Catalytic domain of AfsKav modulates both secondary metabolism and morphologic differentiation in Streptomyces avermitilis ATCC 31272

Current Microbiology

Volumn 53, Issue 3, 2006, Pages 204-208

  Rajkarnikar, A ^a   Kwon, H J ^a   Ryu, Y W ^b   Suh, J W ^a  

^a Myong Ji University   (South Korea)

^b Ajou University   (South Korea)

Author keywords

[No Author keywords available]

Indexed keywords

AVERMECTIN; BACTERIAL PROTEIN; PROTEIN AFSKAV; PROTEIN SERINE THREONINE KINASE; UNCLASSIFIED DRUG;

AFSKAV GENE; ARTICLE; BACTERIAL GENE; BACTERIAL METABOLISM; ENZYME ACTIVE SITE; EUKARYOTE; MELANOGENESIS; MORPHOLOGY; MUTANT; NONHUMAN; NUCLEOTIDE SEQUENCE; PHENOTYPE; PRIORITY JOURNAL; SPOROGENESIS; STREPTOMYCES; STREPTOMYCES AVERMITILIS;

BACTERIAL PROTEINS; CATALYTIC DOMAIN; GENETIC COMPLEMENTATION TEST; IVERMECTIN; MELANINS; MUTATION; PROTEIN-SERINE-THREONINE KINASES; SPORES, BACTERIAL; STREPTOMYCES;

EUKARYOTA; STREPTOMYCES AVERMITILIS;

EID: 33747617782     PISSN: 03438651     EISSN: 14320991     Source Type: Journal    
DOI: 10.1007/s00284-006-0062-1     Document Type: Article

References (24)

1. Bentley SD, Charter KF, Cerdeno-Tarraga AM, Challis GL, Thomson NR, James KD, et al. (2002) Complete genome sequence of the model actinomycete Streptomyces coelicolor A3(2). Nature 417:141-147
2. Bibb MJ (1996) The regulation of antibiotic production in Streptomyces coelicolor A3(2). Microbiology 142:1335-1344
3. Chater KF (1993) Genetics of differentiation in Streptomyces. Annu Rev Microbiol 47:685-713
4. Cole ST, Brosch R, Parkhill J, Garnier T, Churcher C, Harris D, et al. (1998) Deciphering the biology of Mycobarterium tuberculosis from the complete genomic sequence. Nature 393:537-544
5. Davis HG, Green RH (1986) Avermectins and milbemycins. Nat Prod Rep 3:87-121
6. Denis F, Brezinnski R (1991) An improved aminoglycoside resistance gene cassette for use in gram-negative bacteria and Streptomyces. FEMS Microbiol Lett 81:261-264
7. Durán R, Villarino A, Bellinzoni M, Wehenkel A, Fernandez P, Boitel B, et al. (2005) Conserved autophosphorylation pattern in activation loops and juxtamembrane regions of Mycobacterium tuberculosis Ser/Thr protein kinases. Biochem Biophys Res Commun 333:858-867
8. Flett F, Mersinias V, Smith CP (1997) High efficiency intergeneric conjugal transfer of plasmid DNA from Escherichia coli to methyl DNA-restricting streptomycetes. FEMS Microbiol Lett 155:223-229
9. Hwang YS, Kim Es, Biro S, Choi CY (2003) Cloning and analysis of a DNA fragment stimulating avermectin production in various Streptomyces avermitilis strains. Appl Environ Microbiol 69:1263-1269
10. Kenelly PJ (2002) Protein kinases and protein phosphatases in prokarytes: A genome perspective. FEMS Micorbiol Lett 206:1-8
11. Kieser T, Bibb MJ, Chater KF, Hopwood DA (2000) Practical Streptomyces genetics. Norwich Research Park, UK: John Innes Centre
12. Mandec E, Stensballe A, Kjellström S, Cladière L, Obuchowski M, Jensen ON, et al. (2003) Mass spectrometry and site-directed mutagenesis identify several autophosphorylated residues required for the activity of PrkC, a Ser/Thr kinase from Bacillus subtilis. J Mol Biol 330:459-472
13. Matsumoto A, Hong SK, Ishizuka H, Horinouchi S, Beppu T (1994) Phosphorylation of the AfsR protein involved in secondary metabolism in Streptomyces species by a eukaryotic-type protein kinase. Gene 146:47-57
14. Omura S, Ikeda H, Ishikawa J, Hanamoto A, Shinose M, Takahashi M, et al. (2001) Genome sequence of an industrial microorganism Streptomyces avermitilis: Deciphering the ability of producing secondary metabolites. Proc Natl Acad Sci USA 98:12215-12220
15. Petrickova K, Petricek M (2003) Eukaryotic-type protein kinases in Streptomyces coelicolor: Variation on a common theme. Microbiology 149:1609-1621
16. Sambrook J, Fritsch EF, Maniatis T (1989) Molecular cloning: A laboratory manual. New York, NY: Cold Spring Harbor Laboratory Press
17. Sawai R, Suzuki A, Takano Y, Lee PC, Horinouchi S (2004) Phosphorylation of AfsR by multiple serine/threonine kinases in Streptomyces coelicolor A3(2). Gene 334:53-61
18. Ueda K, Umeyama T, Beppu T, Horinouchi S (1996) The aerial mycelium-defective phenotype of Streptomyces griseus resulting from A-factor deficiency is suppressed by a Ser/Thr kinase of S. coelicolor A3(2). Gene 169:91-95
19. Umeyama T, Lee PC, Ueda K, Hourinochi S (1999) An Afsk/AfsR system involved in the response of aerial mycelium formation to glucose in Streptomyces griseus. Microbiology 145:2281-2292
20. Umeyama T, Lee PC, Hourinochi S (2002) Protein serine/threonine kinases in signal transduction for secondary metabolism and morphogenesis in Streptomyces. Appl Microbiol Biotechnol 59:419-425
21. Umeyama T, Hourinochi S (2001) Autophosphorylation of a bacterial serine/threonine kinase, AfsK, is inhibited by KbpA, an AfsK-binding protein. J Bacteriol 183:5506-5512
22. Wohlert SE, Lomovskaya N, Kulowski K, Fonstein L, Occi JL, Gewain KM, et al. (2001) Insights about the biosynthesis of the avermectin deoxysugar L-oleandrose through heterologous expression of Streptomyces avermitilis deoxysugar genes in Streptomyces lividans. Chem Biol 8:681-700
23. Yong JH, Byeon WH (2005) Alternative production of avermectin components in Streptomyces avermitilis by gene replacement. J Microbiol 43:277-284
24. Zhang CC (1996) Bacterial signaling involving eukaryotic-type protein kinases. Mol Microbiol 20:9-15