α-Tocopherol modulates phosphatidylserine externalization in erythrocytes: Relevance in phospholipid transfer protein-deficient mice

Arteriosclerosis, Thrombosis, and Vascular Biology

Volumn 26, Issue 9, 2006, Pages 2160-2167

  Klein, Alexis ^a   Deckert, Valérie ^a   Schneider, Martina ^a   Dutrillaux, Fabienne ^b   Hammann, Arlette ^a   Athias, Anne ^a   Le Guern, Naig ^a   De Barros, Jean Paul Pais ^a   Desrumaux, Catherine ^a   Masson, David ^a   Jiang, Xian Cheng ^c   Lagrost, Laurent ^a,d  

^a UNIVERSITÉ DE BOURGOGNE   (France)

^b DIJON UNIVERSITY HOSPITAL   (France)

^c SUNY DOWNSTATE MEDICAL CENTER   (United States)

^d INSERM   (France)

Author keywords

Antioxidants; Lipoproteins; Mice; Phospholipid transfer protein; Tocopherol

Indexed keywords

ALPHA TOCOPHEROL; APOLIPOPROTEIN B; D DIMER; FLUORESCEIN ISOTHIOCYANATE; GAMMA TOCOPHEROL; HIGH DENSITY LIPOPROTEIN; INTERMEDIATE DENSITY LIPOPROTEIN; LIPOCORTIN 5; LOW DENSITY LIPOPROTEIN; PHOSPHATIDYLETHANOLAMINE; PHOSPHATIDYLSERINE; PHOSPHOLIPID TRANSFER PROTEIN; SPHINGOMYELIN; VERY LOW DENSITY LIPOPROTEIN;

ANIMAL CELL; APOPTOSIS; ARTICLE; BLOOD CLOTTING TIME; CELL LABELING; CONTROLLED STUDY; ENZYME ACTIVITY; ERYTHROCYTE; GAS CHROMATOGRAPHY; HETEROZYGOTE; HOMOZYGOTE; IN VITRO STUDY; IN VIVO STUDY; LIPID COMPOSITION; MASS SPECTROMETRY; MOUSE; NONHUMAN; OXIDATION; PHOSPHOLIPID TRANSFER; PRIORITY JOURNAL; STATISTICAL ANALYSIS; WILD TYPE;

ALPHA-TOCOPHEROL; ANIMALS; BIOLOGICAL MARKERS; BLOOD COAGULATION; CELL SEPARATION; ERYTHROCYTE MEMBRANE; ERYTHROCYTES; FIBRIN FIBRINOGEN DEGRADATION PRODUCTS; HOMOZYGOTE; MICE; MICE, KNOCKOUT; OXIDATION-REDUCTION; PHENOTYPE; PHOSPHATIDYLSERINES; PHOSPHOLIPID TRANSFER PROTEINS; WHOLE BLOOD COAGULATION TIME;

EID: 33747424376     PISSN: 10795642     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.ATV.0000235699.98024.11     Document Type: Article

References (32)

1. Rothman JE, Lenard J. Membrane asymmetry. Science. 1977;195:743-753.
2. Vermes I, Haanen C, Steffens-Nakken H, Reutelingsperger C. A novel assay for apoptosis. Flow cytometric detection of phosphatidylserine expression on early apoptotic cells using fluorescein labelled Annexin V. J Immunol Methods. 1995;184:39-51.
3. Lentz BR. Exposure of platelet membrane phosphatidylserine regulates blood coagulation. Prog Lipid Res. 2003;42:423-438.
4. Mallat Z, Hugel B, Ohan J, Leseche G, Freyssinet JM, Tedgui A. Shed membrane microparticles with procoagulant potential in human atherosclerotic plaques: a role for apoptosis in plaque thrombogenicity. Circulation. 1999;99:348-353.
5. Zwaal RF, Comfurius P, Bevers EM. Surface exposure of phosphatidylserine in pathological cells. Cell Mol Life Sci. 2005;62:971-988.
6. Kawakami S, Kaibara M, Kawamoto Y, Yamanaka K. Rheological approach to the analysis of blood coagulation in endothelial cell-coated tubes: activation of the intrinsic reaction on the erythrocyte surface. Biorheology. 1995;32:521-536.
7. Chiu D, Lubin B, Roelofsen B, van Deenen LL. Sickled erythrocytes accelerate clotting in vitro: an effect of abnormal membrane lipid asymmetry. Blood. 1981;58:398-401.
8. Jain SK. In vivo externalization of phosphatidylserine and phosphatidylethanolamine in the membrane bilayer and hypercoagulability by the lipid peroxidation of erythrocytes in rats. J Clin Invest. 1985;76:281-286.
9. Jain SK, Palmer M, Chen Y. Effect of vitamin E and N-acetylcysteine on phosphatidylserine externalization and induction of coagulation by high-glucose-treated human erythrocytes. Metabolism. 1999;48:957-959.
10. Wilson MJ, Richter-Lowney K, Daleke DL. Hyperglycemia induces a loss of phospholipid asymmetry in human erythrocytes. Biochemistry. 1993;32:11302-11310.
11. Tall A. Plasma lipid transfer proteins. Annu Rev Biochem. 1995;64:235-257.
12. Jiang XC, Tall AR, Qin S, Lin M, Schneider M, Lalanne F, Deckert V, Desrumaux C, Athias A, Witztum JL, Lagrost L. Phospholipid transfer protein deficiency protects circulating lipoproteins from oxidation due to the enhanced accumulation of vitamin E. J Biol Chem. 2002;277:31850-31856.
13. Jiang XC, Li Z, Liu R, Yang XP, Pan M, Lagrost L, Fisher EA, Williams KJ. Phospholipid transfer protein deficiency impairs apolipoprotein-B secretion from hepatocytes by stimulating a proteolytic pathway through a relative deficiency of vitamin E and an increase in intracellular oxidants. J Biol Chem. 2005;280:18336-18340.
14. Jiang XC, Bruce C, Mar J, Lin M, Ji Y, Francone OL, Tall AR. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels. J Clin Invest. 1999;103:907-914.
15. Becart I, Chevalier C, Biesse JP. Quantitative analysis of phospholipids by HPLC with a light scattering evaporating detector - application to raw materials for cosmetic use. J High Resolut Chromatogr. 1990;13:126-129.
16. Deckert V, Persegol L, Viens L, Lizard G, Athias A, Lallemant C, Gambert P, Lagrost L. Inhibitors of arterial relaxation among components of human oxidized low-density lipoproteins. Cholesterol derivatives oxidized in position 7 are potent inhibitors of endothelium-dependent relaxation. Circulation. 1997;95:723-731.
17. Zwaal RF, Comfurius P, van Deenen LL. Membrane asymmetry and blood coagulation. Nature. 1977;268:358-360.
18. Masson D, Drouineaud V, Moiroux P, Gautier T, Dautin G, Schneider M, Fruchart-Najib J, Jauhiainen M, Ehnholm C, Sagot P, Gambert P, Jimenez C, Lagrost L. Human seminal plasma displays significant phospholipid transfer activity due to the presence of active phospholipid transfer protein. Mol Hum Reprod. 2003;9:457-464.
19. Qin S, Kawano K, Bruce C, Lin M, Bisgaier C, Tall AR, Jiang X. Phospholipid transfer protein gene knock-out mice have low high density lipoprotein levels, due to hypercatabolism, and accumulate apoA-IV-rich lamellar lipoproteins. J Lipid Res. 2000;41:269-276.
20. Schorer AE. Discordant effects on eicosanoids and fibrin degradation products in two murine models of antiphospholipid antibody. Thromb Res. 1997;85:295-304.
21. Kostner GM, Oettl K, Jauhiainen M, Ehnholm C, Esterbauer H, Dieplinger H. Human plasma phospholipid transfer protein accelerates exchange/transfer of alpha-tocopherol between lipoproteins and cells. Biochem J. 1995;305(pt 2):659-667.
22. de Jong K, Geldwerth D, Kuypers FA. Oxidative damage does not alter membrane phospholipid asymmetry in human erythrocytes. Biochemistry. 1997;36:6768-6776.
23. Tasinato A, Boscoboinik D, Bartoli GM, Maroni P, Azzi A. D-alpha-tocopherol inhibition of vascular smooth muscle cell proliferation occurs at physiological concentrations, correlates with protein kinase C inhibition, and is independent of its antioxidant properties. Proc Natl Acad Sci U S A. 1995;92:12190-12194.
24. Wang F, Wang T, Lai J, Li M, Zou C. Vitamin E inhibits hemolysis induced by hemin as a membrane stabilizer. Biochem Pharmacol. 2006;71:799-805.
25. de Franceschi L, Turrini F, Honczarenko M, Ayi K, Rivera A, Fleming MD, Law T, Mannu F, Kuypers FA, Bast A, van der Vijgh WJ, Brugnara C. In vivo reduction of erythrocyte oxidant stress in a murine model of beta-thalassemia. Haematologica. 2004;89:1287-1298.
26. Phillips G, Tangney CC. Relationship of plasma alpha tocopherol to index of clinical severity in individuals with sickle cell anemia. Am J Hematol. 1992;41:227-231.
27. Wali RK, Jaffe S, Kumar D, Kalra VK. Alterations in organization of phospholipids in erythrocytes as factor in adherence to endothelial cells in diabetes mellitus. Diabetes. 1988;37:104-111.
28. Schroit AJ, Madsen JW, Tanaka Y. In vivo recognition and clearance of red blood cells containing phosphatidylserine in their plasma membranes. J Biol Chem. 1985;260:5131-5138.
29. Franck PF, Bevers EM, Lubin BH, Comfurius P, Chiu DT, Op den Kamp JA, Zwaal RF, van Deenen LL, Roelofsen B. Uncoupling of the membrane skeleton from the lipid bilayer. The cause of accelerated phospholipid flip-flop leading to an enhanced procoagulant activity of sickled cells. J Clin Invest. 1985;75:183-190.
30. Casciola-Rosen L, Rosen A, Petri M, Schlissel M. Surface blebs on apoptotic cells are sites of enhanced procoagulant activity: implications for coagulation events and antigenic spread in systemic lupus erythematosus. Proc Natl Acad Sci U S A. 1996;93:1624-1629.
31. Schlitt A, Bickel C, Thumma P, Blankenberg S, Rupprecht HJ, Meyer J, Jiang XC. High plasma phospholipid transfer protein levels as a risk factor for coronary artery disease. Arterioscler Thromb Vasc Biol. 2003;23:1857-1862.
32. Desrumaux C, Athias A, Bessede G, Verges B, Farnier M, Persegol L, Gambert P, Lagrost L. Mass concentration of plasma phospholipid transfer protein in normolipidemic, type IIa hyperlipidemic, type IIb hyperlipidemic, and non-insulin-dependent diabetic subjects as measured by a specific ELISA. Arterioscler Thromb Vasc Biol. 1999;19:266-275.