Rational Dissection of Binding Surfaces for Mimicking of Discontinuous Antigenic Sites

Chemistry and Biology

Volumn 13, Issue 8, 2006, Pages 815-823

  Villén, Judit ^a   Rodríguez Mias, Ricard A ^b   Núñez, José I ^c,d   Giralt, Ernest ^b   Sobrino, Francisco ^c,d   Andreu, David ^a  

^a UNIVERSITAT POMPEU FABRA   (Spain)

^b UNIVERSITY OF BARCELONA   (Spain)

^c CENTRO DE BIOLOGÍA MOLECULAR SEVERO OCHOA   (Spain)

^d Instituto Nacional de Investigación y Tecnología Agraria y Alimentaria   (Spain)

Author keywords

CHEMBIO

Indexed keywords

ANTIBODY; CYCLOPEPTIDE; EPITOPE; MEMBRANE ANTIGEN;

ANIMAL; ANTIGEN ANTIBODY COMPLEX; ANTIGEN ANTIBODY REACTION; ARTICLE; BINDING SITE; CHEMICAL STRUCTURE; CHEMISTRY; DISEASE MODEL; ENZYME LINKED IMMUNOSORBENT ASSAY; GUINEA PIG; IMMUNOLOGY; METHODOLOGY; MOLECULAR MIMICRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROTEIN CONFORMATION; SENSITIVITY AND SPECIFICITY; SYNTHESIS;

ANIMALS; ANTIBODIES; ANTIGEN-ANTIBODY COMPLEX; ANTIGEN-ANTIBODY REACTIONS; ANTIGENS, SURFACE; BINDING SITES; DISEASE MODELS, ANIMAL; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; GUINEA PIGS; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; MOLECULAR MIMICRY; PEPTIDES, CYCLIC; PROTEIN CONFORMATION; SENSITIVITY AND SPECIFICITY;

CAVIA; CAVIA PORCELLUS; FOOT-AND-MOUTH DISEASE VIRUS; MIRIDAE;

EID: 33747375662     PISSN: 10745521     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chembiol.2006.06.001     Document Type: Article

References (27)

1. Figeys D. Novel approaches to map protein interactions. Curr. Opin. Biotechnol. 14 (2003) 119-125
2. Fletcher S., and Hamilton A.D. Protein surface recognition and proteomimetics: mimics of protein surface structure and function. Curr. Opin. Chem. Biol. 9 (2005) 632-638
3. Chakrabarti P., and Janin J. Dissecting protein-protein recognition sites. Proteins 47 (2002) 334-343
4. Purcell A.W., Zeng W., Mifsud N.A., Ely L.K., Macdonald W.A., and Jackson D.C. Dissecting the role of peptides in the immune response: theory, practice and the application to vaccine design. J. Pept. Sci. 9 (2003) 255-281
5. Howie S.E., Cotton G.J., Heslop I., Martin N.J., Harrison D.J., and Ramage R. Synthetic peptides representing discontinuous CD4 binding epitopes of HIV-1 gp120 that induce T cell apoptosis and block cell death induced by gp120. FASEB J. 12 (1998) 991-998
6. Reineke U., Sabat R., Misselwitz R., Welfle H., Volk H.D., and Schneider-Mergener J. A synthetic mimic of a discontinuous binding site on interleukin-10. Nat. Biotechnol. 17 (1999) 271-275
7. Eichler J. Rational and random strategies for the mimicry of discontinuous protein binding sites. Protein Pept. Lett. 11 (2004) 281-290
8. Borràs E., Giralt E., and Andreu D. A rationally designed synthetic peptide mimic of a discontinuous viral antigenic site elicits neutralizing antibodies. J. Am. Chem. Soc. 121 (1999) 11932-11933
9. Mateu M.G., Escarmís C., and Domingo E. Mutational analysis of discontinuous epitopes of foot-and-mouth disease virus using an unprocessed capsid protomer precursor. Virus Res. 53 (1998) 27-37
10. Villén J., Borràs E., Schaaper W.M., Meloen R.H., Dávila M., Domingo E., Giralt E., and Andreu D. Functional mimicry of a discontinuous antigenic site by a designed synthetic peptide. ChemBioChem 3 (2002) 175-182
11. Doel T.R. FMD vaccines. Virus Res. 91 (2003) 81-99
12. Lea S., Hernández J., Blakemore W., Brocchi E., Curry S., Domingo E., Fry E., Abu-Ghazaleh R., King A., and Newman J. The structure and antigenicity of a type C foot-and-mouth disease virus. Structure 2 (1994) 123-139
13. Valero M.L., Camarero J.A., Haack T., Mateu M.G., Domingo E., Giralt E., and Andreu D. Native-like cyclic peptide models of a viral antigenic site: finding a balance between rigidity and flexibility. J. Mol. Recognit. 13 (2000) 5-13
14. Trabi M., and Craik D.J. Circular proteins-no end in sight. Trends Biochem. Sci. 27 (2002) 132-138
15. Núñez J.I., Baranowski E., Molina N., Ruíz-Jarabo C.M., Sanchez C., Domingo E., and Sobrino F. A single amino acid substitution in nonstructural protein 3A can mediate adaptation of foot-and-mouth disease virus to the guinea pig. J. Virol. 75 (2001) 3977-3983
16. Oliveira E., Jimenez-Clavero M.A., Nunez J.I., Sobrino F., and Andreu D. Analysis of the immune response against mixotope peptide libraries from a main antigenic site of foot-and-mouth disease virus. Vaccine 23 (2005) 2647-2657
17. Pellecchia M., Sem D.S., and Wuthrich K. NMR in drug discovery. Nat. Rev. Drug Discov. 1 (2002) 211-219
18. Salvatella X., and Giralt E. NMR-based methods and strategies for drug discovery. Chem. Soc. Rev. 32 (2003) 365-372
19. Pellecchia M. Solution nuclear magnetic resonance spectroscopy techniques for probing intermolecular interactions. Chem. Biol. 12 (2005) 961-971
20. Benie A.J., Moser R., Bauml E., Blaas D., and Peters T. Virus-ligand interactions: identification and characterization of ligand binding by NMR spectroscopy. J. Am. Chem. Soc. 125 (2003) 14-15
21. Johnson M.A., Rotondo A., and Pinto B.M. NMR studies of the antibody-bound conformation of a carbohydrate-mimetic peptide. Biochemistry 41 (2002) 2149-2157
22. Mayer M., and Meyer B. Characterization of ligand binding by saturation transfer difference NMR spectroscopy. Angew. Chem. Int. Ed. Engl. 38 (1999) 1784-1788
23. Mayer M., and Meyer B. Group epitope mapping by saturation transfer difference NMR to identify segments of a ligand in direct contact with a protein receptor. J. Am. Chem. Soc. 123 (2001) 6108-6117
24. Wutrich K. NMR of Proteins and Nucleic Acids (1986), Wiley, New York
25. Villén J., Oliveira E., Núñez J.I., Molina N., Sobrino F., and Andreu D. Towards a multi-site synthetic vaccine to foot-and-mouth disease: addition of discontinuous site peptide mimic increases the neutralization response in immunized animals. Vaccine 22 (2004) 3523-3529
26. Sobrino F., Sáiz M., Jiménez-Clavero M.A., Núñez J.I., and Rosas M.F. Foot-and-mouth disease virus: a long known virus, but a current threat. Vet. Res. 32 (2001) 1-30
27. Sobrino F., Dávila M., Ortín J., and Domingo E. Multiple genetic variants arise in the course of replication of foot-and-mouth disease virus in cell culture. Virology 128 (1983) 310-318