A novel class of positive allosteric modulators of AMPA receptors: Design, synthesis, and structure-activity relationships of 3-biphenyl-4-yl-4-cyano-5-ethyl-1-methyl-1H-pyrrole-2-carboxylic acid, LY2059346

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 19, 2006, Pages 5203-5206

  Zarrinmayeh, Hamideh ^a   Tromiczak, Eric ^a   Zimmerman, Dennis M ^a   Rankl, Nancy ^a,b   Ho, Ken H ^a   Dominguez, Esteban ^b   Castaño, Ana ^b   Escribano, Ana ^b   Fernandez, Carmen ^b   Jimenez, Alma ^b   Hornback, William J ^a   Nisenbaum, Eric S ^a  

^a ELI LILLY AND COMPANY   (United States)

^b ELI LILLY AND COMPANY   (Spain)

Author keywords

AMPA receptors; Positive allosteric modulators

Indexed keywords

3 BIPHENYL 4 YL 4 CYANO 5 ETHYL 1 METHYL 1H PYRROLE 2 CARBOXYLIC ACID; AMPA RECEPTOR; AMPA RECEPTOR AGONIST; CARBOXYLIC ACID DERIVATIVE; LY 2059346; UNCLASSIFIED DRUG;

ALLOSTERISM; ARTICLE; CELL STRAIN HEK293; CONTROLLED STUDY; DRUG DESIGN; DRUG POTENCY; DRUG SYNTHESIS; HUMAN; HUMAN CELL; STRUCTURE ACTIVITY RELATION; SUBSTITUTION REACTION;

ALLOSTERIC REGULATION; CARBOXYLIC ACIDS; CELL LINE; DRUG DESIGN; EXCITATORY AMINO ACIDS; GLUTAMIC ACID; HUMANS; PYRROLES; RECEPTORS, AMPA; STRUCTURE-ACTIVITY RELATIONSHIP; TRANSFECTION;

EID: 33747364015     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.07.012     Document Type: Article

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