메뉴 건너뛰기




Volumn 50, Issue 1-3, 2006, Pages 93-108

Recommended method for chromosome exploitation: RMCE-based cassette-exchange systems in animal cell biotechnology

Author keywords

Cassette exchange; Flexing; Floxing; Flrting; Froxing; RMCE; Site specific recombinase; Tissue engineering

Indexed keywords

ANIMAL CELL; BIOTECHNOLOGY; CELL LINE; CHROMOSOME ANALYSIS; EUKARYOTIC CELL; GENE LOCUS; GENE SILENCING; MOUSE; NONHUMAN; RECOMBINASE MEDIATED CASSETTE EXCHANGE; REVIEW; TISSUE ENGINEERING;

EID: 33747360766     PISSN: 09209069     EISSN: 15730778     Source Type: Journal    
DOI: 10.1007/s10616-006-6550-0     Document Type: Review
Times cited : (31)

References (52)
  • 1
    • 0036606856 scopus 로고    scopus 로고
    • Enhanced efficiency through nuclear localization signal fusion on phage C31-integrase: Activity comparison with Cre and FLPe recombinase in mammalian cells
    • Andreas S., Schwenk F., Küter-Luks B., Faust N. and Kühn R. 2002. Enhanced efficiency through nuclear localization signal fusion on phage C31-integrase: activity comparison with Cre and FLPe recombinase in mammalian cells. Nucleic Acids Res. 30: 2299-2306.
    • (2002) Nucleic Acids Res. , vol.30 , pp. 2299-2306
    • Andreas, S.1    Schwenk, F.2    Küter-Luks, B.3    Faust, N.4    Kühn, R.5
  • 2
    • 0040186086 scopus 로고    scopus 로고
    • Transcriptional properties of genomic transgene integration sites marked by electroporation or retroviral infection
    • Baer A., Schübeler D. and Bode J. 2000. Transcriptional properties of genomic transgene integration sites marked by electroporation or retroviral infection. Biochemistry 39: 7041-7049.
    • (2000) Biochemistry , vol.39 , pp. 7041-7049
    • Baer, A.1    Schübeler, D.2    Bode, J.3
  • 3
    • 0035476708 scopus 로고    scopus 로고
    • Coping with kinetic and thermodynamic barriers: RMCE, an efficient strategy for the targeted integration of transgenes
    • Baer A. and Bode J. 2001. Coping with kinetic and thermodynamic barriers: RMCE, an efficient strategy for the targeted integration of transgenes. Curr. Opin. Biotech. 12: 473-480.
    • (2001) Curr. Opin. Biotech. , vol.12 , pp. 473-480
    • Baer, A.1    Bode, J.2
  • 5
    • 0027301662 scopus 로고
    • A hit-and-run system for introducing mutations into the Ig H chain locus of hybridoma cells by homologous recombination
    • Bautista D. and Shulman M.J. 1993. A hit-and-run system for introducing mutations into the Ig H chain locus of hybridoma cells by homologous recombination. J. Immunol. 151: 1950-1958.
    • (1993) J. Immunol. , vol.151 , pp. 1950-1958
    • Bautista, D.1    Shulman, M.J.2
  • 6
    • 0037337299 scopus 로고    scopus 로고
    • Site-specific cassette exchange and germline transmission with mouse ES cells expressing phiC31 integrase
    • Belteki G., Gertsenstein M., Ow D.W. and Nagy A. 2003. Site-specific cassette exchange and germline transmission with mouse ES cells expressing phiC31 integrase. Nat. Biotechnol. 21: 321-324.
    • (2003) Nat. Biotechnol. , vol.21 , pp. 321-324
    • Belteki, G.1    Gertsenstein, M.2    Ow, D.W.3    Nagy, A.4
  • 7
    • 0000908807 scopus 로고    scopus 로고
    • Transcription-promoting genomic sites in mammalia: Their elucidation and architectural principles
    • Bode J., Bartsch J., Boulikas T., Iber M., Mielke C., Schübeler D., Seibler J. and Benham C. 1998. Transcription-promoting genomic sites in mammalia: their elucidation and architectural principles. Gene Ther. Mol. Biol. 1: 551-880.http://www.gtmb.org/volume1/29_Bode.htm.
    • (1998) Gene Ther. Mol. Biol. , vol.1 , pp. 551-880
    • Bode, J.1    Bartsch, J.2    Boulikas, T.3    Iber, M.4    Mielke, C.5    Schübeler, D.6    Seibler, J.7    Benham, C.8
  • 8
    • 0033790710 scopus 로고    scopus 로고
    • The transgeneticist's toolbox - Novel methods for the targeted modification of eukaryotic genomes
    • Bode J., Schlake T., Iber M., Schübeler D., Seibler J., Snezhkov E. and Nikolaev L. 2000. The transgeneticist's toolbox - novel methods for the targeted modification of eukaryotic genomes. Biol. Chem. 381: 801-813.
    • (2000) Biol. Chem. , vol.381 , pp. 801-813
    • Bode, J.1    Schlake, T.2    Iber, M.3    Schübeler, D.4    Seibler, J.5    Snezhkov, E.6    Nikolaev, L.7
  • 9
    • 33747364729 scopus 로고    scopus 로고
    • Architecture and utilization of highly-expressed genomic sites in New Comprehensive Biochemistry
    • Makrides S. and Bernardi G. (eds), (volume ed.), Elsevier, Amsterdam
    • Bode J., Goetze S., Ernst E., Huesemann Y., Baer A., Seibler J. and Mielke C. 2003. Architecture and utilization of highly-expressed genomic sites in New Comprehensive Biochemistry Vol 38. In: Makrides S. and Bernardi G. (eds), (volume ed.), Gene Transfer and Expression in Mammalian Cells. Elsevier, Amsterdam.
    • (2003) Gene Transfer and Expression in Mammalian Cells , vol.38
    • Bode, J.1    Goetze, S.2    Ernst, E.3    Huesemann, Y.4    Baer, A.5    Seibler, J.6    Mielke, C.7
  • 10
    • 33747342664 scopus 로고    scopus 로고
    • Correlations between scaffold/matrix attachment region (S/MAR) binding activity and DNA duplex destabilization energy
    • in press
    • Bode J., Winkelmann S., Götze S., Spiker S., Tsutsui K., Bi C. and Benham C. 2005. Correlations between scaffold/matrix attachment region (S/MAR) binding activity and DNA duplex destabilization energy. J. Mol. Biol. in press.
    • (2005) J. Mol. Biol.
    • Bode, J.1    Winkelmann, S.2    Götze, S.3    Spiker, S.4    Tsutsui, K.5    Bi, C.6    Benham, C.7
  • 11
    • 0030736079 scopus 로고    scopus 로고
    • Transcriptional behavior of LCR enhancer elements integrated at the same chromosomal locus by recombinase-mediated cassette exchange
    • Bouhassira E., Westerman K. and Leboulch P. 1997. Transcriptional behavior of LCR enhancer elements integrated at the same chromosomal locus by recombinase-mediated cassette exchange. Blood 90: 3332-3344.
    • (1997) Blood , vol.90 , pp. 3332-3344
    • Bouhassira, E.1    Westerman, K.2    Leboulch, P.3
  • 12
    • 0346503889 scopus 로고    scopus 로고
    • Talking about a revolution: The impact of site-specific recombinases on genetic analyses in mice
    • Branda C.S. and Dymecki S.M. 2004. Talking about a revolution: the impact of site-specific recombinases on genetic analyses in mice. Develop. Cell 6: 7-28.
    • (2004) Develop. Cell , vol.6 , pp. 7-28
    • Branda, C.S.1    Dymecki, S.M.2
  • 13
    • 0029860719 scopus 로고    scopus 로고
    • Different thermostabilities of FLP and Cre recombinases: Implications for applied site specific recombination
    • Buchholz F., Ringrose L., Angrand P., Rossi F. and Stewart A. 1996. Different thermostabilities of FLP and Cre recombinases: implications for applied site specific recombination. Nucl. Acids Res. 24: 4256-4262.
    • (1996) Nucl. Acids Res. , vol.24 , pp. 4256-4262
    • Buchholz, F.1    Ringrose, L.2    Angrand, P.3    Rossi, F.4    Stewart, A.5
  • 14
    • 0031874849 scopus 로고    scopus 로고
    • Improved properties of Flp recombinase evolved by cycling mutagenesis
    • Buchholz F., Angrand P.-O. and Stewart A.F. 1998. Improved properties of Flp recombinase evolved by cycling mutagenesis. Nat. Biotechnol. 16: 657-662.
    • (1998) Nat. Biotechnol. , vol.16 , pp. 657-662
    • Buchholz, F.1    Angrand, P.-O.2    Stewart, A.F.3
  • 17
    • 33747353545 scopus 로고    scopus 로고
    • The use of recombinase cassette exchange in retroviral vector producer cell lines: Predictability and efficiency in transgene replacement
    • Submitted
    • Coroadinha A.S., Schucht R., Gama-Norton L., Wirth D., Hauser H. and Carrondo M.J.T. 2005. The use of recombinase cassette exchange in retroviral vector producer cell lines: predictability and efficiency in transgene replacement. J. Biotechnol., Submitted.
    • (2005) J. Biotechnol.
    • Coroadinha, A.S.1    Schucht, R.2    Gama-Norton, L.3    Wirth, D.4    Hauser, H.5    Carrondo, M.J.T.6
  • 18
    • 0026756197 scopus 로고
    • Genomic targeting with a positive-selection lox integration vector allows highly reproducible gene expression in mammalian cells
    • Fukushige S. and Sauer B. 1992. Genomic targeting with a positive-selection lox integration vector allows highly reproducible gene expression in mammalian cells. Proc. Natl. Acad. Sci. 89: 7905-7909.
    • (1992) Proc. Natl. Acad. Sci. , vol.89 , pp. 7905-7909
    • Fukushige, S.1    Sauer, B.2
  • 20
    • 0037794034 scopus 로고    scopus 로고
    • Functional characterization of transgene integration patterns by Halo-FISH: Electroporation versus retroviral infection
    • Goetze S., Huesemann Y., Baer A. and Bode J. 2003. Functional characterization of transgene integration patterns by Halo-FISH: electroporation versus retroviral infection. Biochemistry 42: 7035-7043.
    • (2003) Biochemistry , vol.42 , pp. 7035-7043
    • Goetze, S.1    Huesemann, Y.2    Baer, A.3    Bode, J.4
  • 22
    • 0032848329 scopus 로고    scopus 로고
    • Genetic engineering of recombinant glycoproteins and the glycosylation pathway in mammalian host cells
    • Grabenhorst E., Schlenke P., Pohl S., Nimtz M. and Conradt H.S. 1999. Genetic engineering of recombinant glycoproteins and the glycosylation pathway in mammalian host cells. Glycoconjugate J. 16: 81-97.
    • (1999) Glycoconjugate J. , vol.16 , pp. 81-97
    • Grabenhorst, E.1    Schlenke, P.2    Pohl, S.3    Nimtz, M.4    Conradt, H.S.5
  • 23
    • 0034705105 scopus 로고    scopus 로고
    • A phage integrase directs efficient site-specific integration in human cells
    • USA
    • Groth A.C., Olivares E.C., Thyagarajan B. and Calos M.P. 2000. A phage integrase directs efficient site-specific integration in human cells. Proc. Natl. Acad. Sci. USA 97: 5995-6000.
    • (2000) Proc. Natl. Acad. Sci. , vol.97 , pp. 5995-6000
    • Groth, A.C.1    Olivares, E.C.2    Thyagarajan, B.3    Calos, M.P.4
  • 24
    • 0033180218 scopus 로고    scopus 로고
    • Site specific recombination in mammalian cells expressing the Int recombinase of bacteriophage HK022
    • Kolot M., Silberstein N. and Yagil E. 1999. Site specific recombination in mammalian cells expressing the Int recombinase of bacteriophage HK022. Mol. Biol. Rep. 26: 207-213.
    • (1999) Mol. Biol. Rep. , vol.26 , pp. 207-213
    • Kolot, M.1    Silberstein, N.2    Yagil, E.3
  • 25
    • 7544242666 scopus 로고    scopus 로고
    • The dynamic response of upstream DNA to transcription-generated torsional stress
    • Kouzine K., Liu L., Sanford S., Chung H.J. and Levens D. 2004. The dynamic response of upstream DNA to transcription-generated torsional stress. Nature Struct. Mol. Biol. 11: 1092-1100.
    • (2004) Nature Struct. Mol. Biol. , vol.11 , pp. 1092-1100
    • Kouzine, K.1    Liu, L.2    Sanford, S.3    Chung, H.J.4    Levens, D.5
  • 26
    • 0345044372 scopus 로고    scopus 로고
    • Stable and efficient cassette exchange under non-selectable conditions by combined use of two site-specific recombinases
    • Lauth M., Spreafico F., Dethleffsen K. and Meyer M. 2002. Stable and efficient cassette exchange under non-selectable conditions by combined use of two site-specific recombinases. Nucl. Acids Res. 30: e115.
    • (2002) Nucl. Acids Res. , vol.30
    • Lauth, M.1    Spreafico, F.2    Dethleffsen, K.3    Meyer, M.4
  • 27
    • 0037151780 scopus 로고    scopus 로고
    • The promiscuity of heterospecific lox sites increases dramatically in the presence of palindromic DNA
    • Mlynarova L., Libantova J., Vrba L. and Nap J.P. 2002. The promiscuity of heterospecific lox sites increases dramatically in the presence of palindromic DNA. Gene 296: 129-137.
    • (2002) Gene , vol.296 , pp. 129-137
    • Mlynarova, L.1    Libantova, J.2    Vrba, L.3    Nap, J.P.4
  • 29
    • 0031841944 scopus 로고    scopus 로고
    • High efficiency site-specific modification of the chromosomal immunoglobulin locus by gene targeting
    • Ng P. and Baker M.D. 1998. High efficiency site-specific modification of the chromosomal immunoglobulin locus by gene targeting. J. Immunol. Meth. 214: 81-96.
    • (1998) J. Immunol. Meth. , vol.214 , pp. 81-96
    • Ng, P.1    Baker, M.D.2
  • 30
    • 0025847620 scopus 로고
    • Recombinase-mediated gene activation and site-specific integration in mammalian cells
    • O'Gorman S., Fox D.T. and Wahl G.M. 1991. Recombinase-mediated gene activation and site-specific integration in mammalian cells. Science 251: 1351-1355.
    • (1991) Science , vol.251 , pp. 1351-1355
    • O'Gorman, S.1    Fox, D.T.2    Wahl, G.M.3
  • 31
    • 0037007121 scopus 로고    scopus 로고
    • Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: A tool for efficient genetic engineering of mammalian genomes
    • USA
    • Peitz M., Pfannkuche K., Rajewsky K. and Edenhofer F. 2002. Ability of the hydrophobic FGF and basic TAT peptides to promote cellular uptake of recombinant Cre recombinase: a tool for efficient genetic engineering of mammalian genomes. Proc. Natl. Acad. Sci. USA 99: 4489-4494.
    • (2002) Proc. Natl. Acad. Sci. , vol.99 , pp. 4489-4494
    • Peitz, M.1    Pfannkuche, K.2    Rajewsky, K.3    Edenhofer, F.4
  • 32
    • 30644470236 scopus 로고    scopus 로고
    • Mutant Lrp1 knock-in mice generated by RMCE reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development
    • Roebroek A.J.M., Reekmans S., Lauwers A., Feyaerts N., Smeijers L. and Hartmann D. 2006. Mutant Lrp1 knock-in mice generated by RMCE reveal differential importance of the NPXY motifs in the intracellular domain of LRP1 for normal fetal development. Mol. Cell Biol. 26: 605-616
    • (2006) Mol. Cell Biol. , vol.26 , pp. 605-616
    • Roebroek, A.J.M.1    Reekmans, S.2    Lauwers, A.3    Feyaerts, N.4    Smeijers, L.5    Hartmann, D.6
  • 33
    • 19644363037 scopus 로고    scopus 로고
    • Increased maintenance and persistence of transgenes by excision of expression cassettes from plasmid sequences in vivo
    • Riu E., Grimm D., Huang Z., Mark A. and Kay M.A. 2005. Increased maintenance and persistence of transgenes by excision of expression cassettes from plasmid sequences in vivo. Hum. Gene. Ther. 16: 558-570.
    • (2005) Hum. Gene. Ther. , vol.16 , pp. 558-570
    • Riu, E.1    Grimm, D.2    Huang, Z.3    Mark, A.4    Kay, M.A.5
  • 34
    • 0028109636 scopus 로고
    • Use of mutated FLP recognition target (FRT) sites for the exchange of expression cassettes at defined chromosomal loci
    • Schlake T. and Bode J. 1994. Use of mutated FLP recognition target (FRT) sites for the exchange of expression cassettes at defined chromosomal loci. Biochemistry 33: 12746-12751.
    • (1994) Biochemistry , vol.33 , pp. 12746-12751
    • Schlake, T.1    Bode, J.2
  • 35
    • 0034610394 scopus 로고    scopus 로고
    • Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids
    • USA
    • Schmidt E.E., Taylor D.S., Prigge J.R., Arnett S. and Capecchi M.R. 2000. Illegitimate Cre-dependent chromosome rearrangements in transgenic mouse spermatids. Proc. Natl. Acad. Sci. USA 97: 13702-13707.
    • (2000) Proc. Natl. Acad. Sci. , vol.97 , pp. 13702-13707
    • Schmidt, E.E.1    Taylor, D.S.2    Prigge, J.R.3    Arnett, S.4    Capecchi, M.R.5
  • 37
    • 33747370669 scopus 로고    scopus 로고
    • A new generation of retroviral producer cells: Predictable and stable virus production by Flp mediated site-specific integration of retroviral vectors
    • Submitted
    • Schucht R., Coroadinha A.S., Zanta-Boussif M.A., Carrondo M., Hauser H. and Wirth D. 2005. A new generation of retroviral producer cells: predictable and stable virus production by Flp mediated site-specific integration of retroviral vectors. Mol. Thera., Submitted.
    • (2005) Mol. Thera.
    • Schucht, R.1    Coroadinha, A.S.2    Zanta-Boussif, M.A.3    Carrondo, M.4    Hauser, H.5    Wirth, D.6
  • 38
    • 0039226809 scopus 로고    scopus 로고
    • Retargeting of retroviral integration sites for the predictable expression of transgenes and the analysis of cis-acting sequences
    • Schübeler D. and Bode J. 1998. Retargeting of retroviral integration sites for the predictable expression of transgenes and the analysis of cis-acting sequences. Biochemistry 37: 11907-11914.
    • (1998) Biochemistry , vol.37 , pp. 11907-11914
    • Schübeler, D.1    Bode, J.2
  • 39
    • 0344333424 scopus 로고    scopus 로고
    • DNA cassette exchange mediated by FLP recombinase: An efficient strategy for the repeated modification of tagged loci by marker-free constructs
    • Seibler J., Schübeler D., Fiering S., Groudine M. and Bode J. 1998. DNA cassette exchange mediated by FLP recombinase: an efficient strategy for the repeated modification of tagged loci by marker-free constructs. Biochemistry 37: 6229-6234.
    • (1998) Biochemistry , vol.37 , pp. 6229-6234
    • Seibler, J.1    Schübeler, D.2    Fiering, S.3    Groudine, M.4    Bode, J.5
  • 42
    • 0032518164 scopus 로고    scopus 로고
    • Efficient production of Cre-mediated site-directed recombinants through the utilization of the puromycin resistance gene, pac: A transient gene-integration marker for ES cells
    • Taniguchi M., Sanbo M., Watanabe S., Naruse I., Mishina M. and Yagi T. 1998. Efficient production of Cre-mediated site-directed recombinants through the utilization of the puromycin resistance gene, pac: a transient gene-integration marker for ES cells. Nucl. Acids Res. 26: 679-680.
    • (1998) Nucl. Acids Res. , vol.26 , pp. 679-680
    • Taniguchi, M.1    Sanbo, M.2    Watanabe, S.3    Naruse, I.4    Mishina, M.5    Yagi, T.6
  • 43
    • 0032510752 scopus 로고    scopus 로고
    • In vitro site-specific integration of bacteriophage DNA catalyzed by a recombinase of the resolvase/invertase family
    • USA
    • Thorpe H.M. and Smith M.C.M. 1998. In vitro site-specific integration of bacteriophage DNA catalyzed by a recombinase of the resolvase/invertase family. Proc. Natl. Acad. Sci. USA 95: 5505-5510.
    • (1998) Proc. Natl. Acad. Sci. , vol.95 , pp. 5505-5510
    • Thorpe, H.M.1    Smith, M.C.M.2
  • 44
    • 0035008830 scopus 로고    scopus 로고
    • Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase
    • Thyagarajan B., Olivares E.C., Hollis R.P., Ginsburg D.S. and Calos M.P. 2001. Site-specific genomic integration in mammalian cells mediated by phage phiC31 integrase. Mol. Cell Biol. 21: 3926-3934.
    • (2001) Mol. Cell Biol. , vol.21 , pp. 3926-3934
    • Thyagarajan, B.1    Olivares, E.C.2    Hollis, R.P.3    Ginsburg, D.S.4    Calos, M.P.5
  • 45
    • 0024027282 scopus 로고
    • The functional significance of DNA sequence structure in a site-specific genetic recombination reaction
    • Umlauf S.W. and Cox M.M. 1988. The functional significance of DNA sequence structure in a site-specific genetic recombination reaction. EMBO J. 7: 1845-1852.
    • (1988) EMBO J. , vol.7 , pp. 1845-1852
    • Umlauf, S.W.1    Cox, M.M.2
  • 46
    • 2942527253 scopus 로고    scopus 로고
    • Stable and strictly controlled expression of LTR-flanked autoregulated expression cassettes upon adenoviral transfer
    • Unsinger J., Lindenmaier W., May T., Hauser H. and Wirth D. 2004. Stable and strictly controlled expression of LTR-flanked autoregulated expression cassettes upon adenoviral transfer. Biochem. Biophys. Res. Commun. 319: 879-887.
    • (2004) Biochem. Biophys. Res. Commun. , vol.319 , pp. 879-887
    • Unsinger, J.1    Lindenmaier, W.2    May, T.3    Hauser, H.4    Wirth, D.5
  • 47
    • 0023931957 scopus 로고
    • Amplified expression constructs for human tissue-type plasminogen activator in Chinese hamster ovary cells: Instability in the absence of selective pressure
    • Weidle U.H., Buckel P. and Wienberg J. 1988. Amplified expression constructs for human tissue-type plasminogen activator in Chinese hamster ovary cells: instability in the absence of selective pressure. Gene 66: 193-203.
    • (1988) Gene , vol.66 , pp. 193-203
    • Weidle, U.H.1    Buckel, P.2    Wienberg, J.3
  • 49
    • 0024236101 scopus 로고
    • Isolation of overproducing recombinant mammalian cell lines by a fast and simple selection procedure
    • Wirth M., Bode J., Zettelmeissl G. and Hauser H. 1988. Isolation of overproducing recombinant mammalian cell lines by a fast and simple selection procedure. Gene 73: 419-426.
    • (1988) Gene , vol.73 , pp. 419-426
    • Wirth, M.1    Bode, J.2    Zettelmeissl, G.3    Hauser, H.4
  • 50
    • 4644332204 scopus 로고    scopus 로고
    • Flp-mediated integration of expression cassettes into FRT-tagged chromosomal loci in mammalian cells
    • Wirth D. and Hauser H. 2004. Flp-mediated integration of expression cassettes into FRT-tagged chromosomal loci in mammalian cells. Methods Mol. Biol. 267: 467-476.
    • (2004) Methods Mol. Biol. , vol.267 , pp. 467-476
    • Wirth, D.1    Hauser, H.2
  • 51
    • 27644546742 scopus 로고    scopus 로고
    • Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange
    • doi:10.1093/nar/gni145
    • Wong E.T., Kolman J.L., Li Y.C., Mesner L.D., Hillen W., Berens C. and Wahl G.M. 2005. Reproducible doxycycline-inducible transgene expression at specific loci generated by Cre-recombinase mediated cassette exchange. Nucl. Acids Res. 33(17): e147, doi:10.1093/nar/gni145.
    • (2005) Nucl. Acids Res. , vol.33 , Issue.17
    • Wong, E.T.1    Kolman, J.L.2    Li, Y.C.3    Mesner, L.D.4    Hillen, W.5    Berens, C.6    Wahl, G.M.7
  • 52
    • 20744458620 scopus 로고    scopus 로고
    • Gene transfer and gene amplification in mammalian cells in "New Comprehensive Biochemistry 38"
    • Bernardi G. (ed.), Chapter 7. S. Makrides, Volume Ed. Elsevier, Amsterdam
    • Wurm F.M. and Jordan M. 2003. Gene transfer and gene amplification in mammalian cells in "New Comprehensive Biochemistry 38". In: Bernardi G. (ed.), A Gene Transfer and Expression in Mammalian Cells, Chapter 7. S. Makrides, Volume Ed. Elsevier, Amsterdam, 307-335.
    • (2003) A Gene Transfer and Expression in Mammalian Cells , pp. 307-335
    • Wurm, F.M.1    Jordan, M.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.