Initial empirical antibiotic therapy for neutropenic fever: Analysis of the causes of death

Supportive Care in Cancer

Volumn 4, Issue 3, 1996, Pages 207-212

  Rossi, Camelia ^a   Klastersky, Jean ^a  

^a JULES BORDET INSTITUTE   (Belgium)

Author keywords

Antibiotic therapy; Cause of death; Febrile neutropenia

Indexed keywords

ANTIINFECTIVE AGENT;

AGRANULOCYTOSIS; ARTICLE; BACTERIAL INFECTION; BELGIUM; CAUSE OF DEATH; COMPARATIVE STUDY; FEVER; HUMAN; LEUKEMIA; LEUKOCYTE COUNT; LYMPHOMA; MORTALITY; MYCOSIS; NEOPLASM; NEUTROPENIA; RETROSPECTIVE STUDY;

AGRANULOCYTOSIS; ANTI-BACTERIAL AGENTS; BACTERIAL INFECTIONS; BELGIUM; CAUSE OF DEATH; FEVER; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; LEUKEMIA; LEUKOCYTE COUNT; LYMPHOMA; MYCOSES; NEOPLASMS; NEUTROPENIA; RETROSPECTIVE STUDIES;

EID: 0030148066     PISSN: 09414355     EISSN: None     Source Type: Journal    
DOI: 10.1007/BF01682342     Document Type: Article

References (11)

1. Elting LS, Bodey GP, Keefe BH (1992) Septicemia and shock syndrome due to viridans streptococci: a case-control study of predisposing factors. Clin Infect Dis 14:1201-1207
2. EORTC International Antimicrobial Therapy Cooperative Group (1987) Ceftazidime combined with a short or long course of amikacin for empirical therapy of gram-negative bacteremia in cancer patients with granulocytopenia. N Engl J Med 317:1692-1698
3. EORTC International Antimicrobial Therapy Cooperative Group (1991) Vancomycin added to empirical combination antibiotic therapy for fever in granulocytopenic cancer patients. J Infect Dis 163:951-958
4. EORTC International Antimicrobial Therapy Cooperative Group (1993) Efficacy and toxicity of single daily doses of amikacin and ceftriaxone versus multiple daily doses of amikacin and ceftazidime for infection in patients with cancer and granulocytopenia. Ann Intern Med 119:584-593
5. International Antimicrobial Therapy Co-operative Group of the EORTC (1993) Piperacillin/tazobactam plus amikacin (PT+A) versus ceftazidime plus amikacin (C+A) as empirical therapy for fever in patients with granulocytopenia: a prospective, randomized, multicenter study (efficacy, safety and tolerance) (abstract). Proc Int Conference Antimicrob Agents Chemother 17:22
6. Klastersky J, Zinner SH, Calandra H. et al (1988) Empiric antimicrobial therapy for febrile granulocytopenic cancer patients: lessons from four EORTC trials. Eur J Cancer Clin Oncol 24 [Suppl 1]:35-45
7. Meunier F, Zinner SH, Gava H, et al (1991) Prospective randomized evaluation of ciprofloxacin versus piperacillin plus amikacin for empiric antibiotic therapy of febrile granulocytopenic cancer patients with lymphomas and solid tumors. Antimicrob Agents Chemother 35:873-878
8. O'Donnell MR, Schmidt GM, Tegtmeier BR, et al (1994) Prediction of systemic fungal infection in allogeneic marrow recipients: impact of amphotericin prophylaxis in high-risk patients. J Clin Oncol 12:827-834
9. Schimpff S, Satterlee W, Young WM, et al (1971) Empirical therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia. N Engl J Med 284:1061-1065
10. Sculier JP, Weerts D, Klastersky J (1984) Causes of death in febrile granulocytopenic cancer patients receiving empiric antibiotic therapy. Eur J Cancer Clin Oncol 20:55-60
11. Sickles EA, Greene WH, Wiernik PH (1975) Clinical presentation of infection in granulocytopenic patients. Arch Intern Med 135:715-719