Patients who take uneven doses of acenocoumarol exhibit significant fluctuating levels of anticoagulation

Blood Coagulation and Fibrinolysis

Volumn 17, Issue 6, 2006, Pages 509-512

  Marco, Fernando ^a   Gutiérrez, Juan I Rodríguez ^a   Orkolaga, Koro ^a   Márquez, José A ^a   Ojínaga, M José ^a   De Zárate, Itziar Ortiz ^a   De Heredia, José M Beltrán ^a  

^a HOSPITAL DE BASURTO   (Spain)

Author keywords

Acenocoumarol; Anticoagulation; International Normalized Ratio; Stability; Uneven doses

Indexed keywords

ACENOCOUMAROL; ANTICOAGULANT AGENT;

ADULT; AGED; ANTICOAGULATION; ARTICLE; CLINICAL ARTICLE; CLINICAL PRACTICE; CONTROLLED STUDY; DOSE RESPONSE; DRUG ACTIVITY; DRUG DOSE REGIMEN; FEMALE; HUMAN; INTERNATIONAL NORMALIZED RATIO; MALE; PRIORITY JOURNAL; PROSPECTIVE STUDY; SPAIN;

ACENOCOUMAROL; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; COHORT STUDIES; DRUG MONITORING; FEMALE; HEMOSTASIS; HUMANS; INTERNATIONAL NORMALIZED RATIO; MALE; MIDDLE AGED; PROSPECTIVE STUDIES;

EID: 33747180157     PISSN: 09575235     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.mbc.0000240928.26296.68     Document Type: Article

References (17)

1. The seventh ACCP Conference on antithrombotic and thrombolytic therapy: evidence-based guidelines. Chest 2004; 126 (Suppl):163S-696S.
2. Recommendations of the Italian Federation of Anticoagulation Clinics (FCSA). A guide to oral anticoagulant treatment. Haematologica 2003; 88(Suppl 2):1-52.
3. Rojas JC, Aguilar B, Rodriguez-Maldonado E, Collados MT. Pharmacogenetics of oral anticoagulants. Blood Coagul Fibrinolysis 2005; 16:389-398.
4. Khan T, Wynne H, Wood P, Torrance A, Hankey C, Avery P, et al. Dietary vitamin K influences intra-individual variability in anticoagulant response to warfarin. Br J Haematol 2004; 124:348-354.
5. Wells PS, Holbrook AM, Crowther NR, Hirsh J. Interaction of warfarin with drugs and food. Ann Intern Med 1994; 121:676-683.
6. Fihn SD, McDonell M, Martin D, Henikoff J, Vermes D, Kent D, White RH. Risk factors for complications of chronic anticoagulation. A multicenter study. Warfarin Optimised Outpatient Follow-up Study Group. Ann Intern Med 1993; 118:511-520.
7. Casais P, Sánchez Luceros A, Meschengieser S, Bermejo E, Lazzari MA. INR variability in anticoagulation with acenocoumarol: is it useful for identifying patients at risk of bleeding and thrombosis? Haematologica 1999; 84:753-754.
8. Thijssen HH, Hamulyak K, Willigers H. 4-Hydroxycoumarin oral anticoagulants: pharmacokinetics response relationship. Thromb Haemost 1988; 60:35-38.
9. Pattacini C, Manotti C, Pini M, Quintavalla R, Dettori AG. A comparative study on the quality of oral anticoagulant therapy (warfarin versus acenocoumarol). Thromb Haemost 1994; 71:188-191.
10. Amian A, Rodríguez JN, Muñiz R, Dieguez JC, Moreno MV, Quesada JA, et al. Comparative study of the stability of oral anticoagulant treatments (warfarin vs acenocoumarol). Sangre (Barcelona) 1996; 41:9-11.
11. Barcellona D, Vannini ML, Fenu L, Balestrieri C, Marongiu F. Warfarin or acenocoumarol: which is better in the management of oral anticoagulants? Thromb Haemost 1998; 80:899-902.
12. Gadisseur AP, van der Meer FJ, Adriaansen HJ, Fihn SD, Rosendaal FR. Therapeutic quality control of oral anticoagulant therapy comparing the short-acting acenocoumarol and the long-acting phenprocoumon. Br J Haematol 2002; 117:940-946.
13. Laporte S, Quenet S, Buchmüller-Cordier A, Reynaud J, Tardy-Poncet B, Thirion C, et al. Compliance and stability of INR of two oral anticoagulants with different half-lives: a randomised trial. Thromb Haemost 2003; 89:458-467.
14. Ageno W, Crowther M, Steidl L, Ultori C, Mera V, Dentali F, et al. Low dose oral vitamin K to reverse acenocoumarol-induced coagulopathy: a randomized controlled trial. Thromb Haemost 2002; 88:48-51.
15. Poli D, Antonucci E, Lombardi A, Gensini GF, Abbate R, Prisco D. Safety and effectiveness of low-dose, oral vitamin K1 administration in asymptomatic out-patients on warfarin or acenocoumarol with excessive anticoagulation. Haematologica 2003; 88:237-238.
16. Mismetti P, Reynaud J, Laporte-Simitsidis S, Thijssen H, Tardy-Poncet B, Tardy B, et al. Pharmacokinetic and pharmacodynamic variations of acenocoumarol orally administrated either once or twice daily in patients with deep venous thrombosis. Fundam Clin Pharmacol 1998; 12:631-635.
17. Rosendaal FR, Cannegieter SC, van der Meer FJM, Briët E. A method to determine the optimal intensity of oral anticoagulant therapy. Thromb Haemost 1993; 69:236-239.