Perturbing integrin function inhibits microtubule growth from centrosomes, spindle assembly, and cytokinesis

Journal of Cell Biology

Volumn 174, Issue 4, 2006, Pages 491-497

  Reverte, Carlos G ^a   Benware, Angela ^a   Jones, Christopher W ^a   LaFlamme, Susan E ^a  

^a ALBANY MEDICAL COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

INTEGRIN; MUTANT PROTEIN; PROTEIN ANTIBODY;

ANIMAL CELL; ARTICLE; CENTROSOME; CONTROLLED STUDY; CYTOKINESIS; CYTOPLASM; INTERPHASE; MICROTUBULE ASSEMBLY; MITOSIS; MITOSIS SPINDLE; NONHUMAN; POINT MUTATION; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN FUNCTION; SPINDLE CELL;

ANIMALS; ANTIBODIES; ANTIGENS, CD29; CELL CYCLE; CENTROSOME; CHO CELLS; CRICETINAE; CYCLIN D1; CYTOKINESIS; INTERPHASE; MICROFILAMENTS; MICROTUBULES; MITOSIS; MITOTIC SPINDLE APPARATUS; POINT MUTATION; PROTEIN STRUCTURE, TERTIARY; SIGNAL TRANSDUCTION;

MAMMALIA;

EID: 33747179877     PISSN: 00219525     EISSN: 00219525     Source Type: Journal    
DOI: 10.1083/jcb.200603069     Document Type: Article

References (23)

1. Assoian, R.K., and M.A. Schwartz. 2001. Coordinate signaling by integrins and receptor tyrosine kinases in the regulation of G1 phase cell-cycle progression. Curr. Opin. Genet. Dev. 11:48-53.
2. Aszodi, A., E.B. Hunziker, C. Brakebusch, and R. Fässler. 2003. Beta1 integrins regulate chondrocyte rotation, G1 progression, and cytokinesis. Genes Dev. 17:2465-2479.
3. Ben-Ze'ev, A., and A. Raz. 1981. Multinucleation and inhibition of cytokinesis in suspended cells: reversal upon reattachment to a substrate. Cell. 26:107-115.
4. Bodeau, A.L., A.L. Berrier, A.M. Mastrangelo, R. Martinez, and S.E. LaFlamme. 2001. A functional comparison of mutations in integrin beta cytoplasmic domains: effects on the regulation of tryosine phosphorylation, cell spreading, cell attachment and beta1 integrin conformation. J. Cell Sci. 114:2795-2807.
5. Doxsey, S. 2001. Re-evaluating centrosome function. Nat. Rev. Mol. Cell Biol. 2:688-698.
6. Fässler, R., M. Pfaff, J. Murphy, A.A. Noegel, S. Johansson, R. Timpl, and R. Albrecht. 1995. Lack of β1 integrin gene in embryonic stem cells affects morphology, adhesion, and migration but not integration into the inner cell mass of blastocysts. J. Cell Biol. 128:979-988.
7. Frelinger, A.L., III, X.P. Du, E.F. Plow, and M.H. Ginsberg. 1991. Monoclonal antibodies to ligand-occupied conformers of integrin alpha IIb beta 3 (glycoprotein IIb-IIIa) alter receptor affinity, specificity, and function. J. Biol. Chem. 266:17106-17111.
8. Fry, A.M., P. Meraldi, and E.A. Nigg. 1998. A centrosomal function for the human Nek2 protein kinase, a member of the NIMA family of cell cycle regulators. EMBO J. 17:470-481.
9. Gadde, S., and R. Heald. 2004. Mechanisms and molecules of the mitotic spindle. Curr. Biol. 14:R797-R805.
10. Geiger, B., A. Bershadsky, R. Pankov, and K.M. Yamada. 2001. Transmembrane crosstalk between the extracellular matrix-cytoskeleton crosstalk. Nat. Rev. Mol. Cell Biol. 2:793-805.
11. Glotzer, M. 2001. Animal cell cytokinesis. Annu. Rev. Cell Dev. Biol. 17:351-386.
12. Hynes, R.O. 2002. Integrins: bidirectional, allosteric signaling machines. Cell. 110:673-687.
13. Kline-Smith, S.L., and C.E. Walczak. 2004. Mitotic spindle assembly and chromosome segregation: refocusing on microtubule dynamics. Mol. Cell. 15:317-327.
14. Maddox, A.S., and K. Burridge. 2003. RhoA is required for cortical retraction and rigidity during mitotic cell rounding. J. Cell Biol. 160:255-265.
15. Maiato, H., C.L. Rieder, and A. Khodjakov. 2004. Kinetochore-driven formation of kinetochore fibers contributes to spindle assembly during animal mitosis. J. Cell Biol. 167:831-840.
16. Masumoto, A., and M.E. Hemler. 1993. Multiple activation states of VLA-4. Mechanistic differences between adhesion to CS1/fibronectin and to vascular cell adhesion molecule-1. J. Biol. Chem. 268:228-234.
17. Orly, J., and G. Sato. 1979. Fibronectin mediates cytokinesis and growth of rat follicular cells in serum-free medium. Cell. 17:295-305.
18. O'Toole, T.E., Y. Katagiri, R.J. Faull, K. Peter, R. Tamura, V. Quaranta, J.C. Loftus, S.J. Shattil, and M.H. Ginsberg. 1994. Integrin cytoplasmic domains mediate inside-out signal transduction. J. Cell Biol. 124:1047-1059.
19. O'Toole, T.E., J. Ylanne, and B.M. Culley. 1995. Regulation of integrin affinity states through an NPXY motif in the beta subunit cytoplasmic domain. J. Biol. Chem. 270:8553-8558.
20. Tadokoro, S., S.J. Shattil, K. Eto, V. Tai, R.C. Liddington, J.M. de Pereda, M.H. Ginsberg, and D.A. Calderwood. 2003. Talin binding to integrin beta tails: a final common step in integrin activation. Science. 302:103-106.
21. Vandre, D.D., P. Kronebusch, and G.G. Borisy. 1984. The interphase-motisis transition: microtubule rearrangements in cultured cells and sea urchin eggs. In Molecular Biology of the Cytoskeleton. G.G. Borisy, D.W. Cleveland, and D.B. Murphy, editors. Cold Spring Harbor Laboratory Press, Cold Spring Harbor, NY. 3-16.
22. Winklbauer, R. 1986. Cell proliferation in the ectoderm of the Xenopus embryo: development of substratum requirements for cytokinesis. Dev. Biol. 118:70-81.
23. Ylanne, J., Y. Chen, T.E. O'Toole, J.C. Loftus, Y. Takada, and M.H. Ginsberg. 1993. Distinct functions of integrin α and β subunit cytoplasmic domains in cell spreading and formation of focal adhesions. J. Cell Biol. 122:223-233.