MT1-MMP hemopexin domain exchange with MT4-MMP blocks enzyme maturation and trafficking to the plasma membrane in MCF7 cells

Biochemical Journal

Volumn 398, Issue 1, 2006, Pages 15-22

  Atkinson, Susan J ^a   Roghi, Christian ^a   Murphy, Gillian ^a  

^a UNIVERSITY OF CAMBRIDGE   (United Kingdom)

Author keywords

Gelatin degradation; Hemopexin domain; MMP 2 activation; MT1 MMP; MT4 MMP; Propeptide

Indexed keywords

ACTIVATION ANALYSIS; CELL MEMBRANES; DEGRADATION; ENZYME KINETICS; ENZYMES; OLIGOMERS; PLASMAS;

GELATIN DEGRADATION; HEMOPEXIN DOMAIN; MMP-2 ACTIVATION; MT1-MMP; MT4-MMP; PROPEPTIDE;

CELLS;

GELATIN; GELATINASE A; HEMOPEXIN; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASE 17;

ANTIBODY SPECIFICITY; ARTICLE; BIOTINYLATION; CANCER CELL CULTURE; CELL ASSAY; CELL MEMBRANE; CELL SURFACE; CHIMERA; CONTROLLED STUDY; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INHIBITION; HUMAN; HUMAN CELL; IMMUNOFLUORESCENCE TEST; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; PROTEIN EXPRESSION; WILD TYPE;

AMINO ACID SEQUENCE; ANIMALS; BIOTINYLATION; CELL MEMBRANE; ENZYME ACTIVATION; ENZYME PRECURSORS; GELATIN; HEMOPEXIN; HUMANS; MATRIX METALLOPROTEINASE 14; MATRIX METALLOPROTEINASES; MATRIX METALLOPROTEINASES, MEMBRANE-ASSOCIATED; MEMBRANE PROTEINS; MICE; MOLECULAR SEQUENCE DATA; PROTEIN PROCESSING, POST-TRANSLATIONAL; PROTEIN TRANSPORT; RECOMBINANT FUSION PROTEINS; TUMOR CELLS, CULTURED;

CHIMAERIFORMES;

EID: 33747176841     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20060243     Document Type: Article

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