Proinsulin C-peptide elicits disaggregation of insulin resulting in enhanced physiological insulin effects

Cellular and Molecular Life Sciences

Volumn 63, Issue 15, 2006, Pages 1805-1811

  Shafqat, J ^a   Melles, E ^a   Sigmundsson, K ^a,c   Johansson, B L ^a   Ekberg, K ^a   Alvelius, G ^a   Henriksson, M ^a   Johansson, J ^b   Wahren, J ^a   Jornvall H ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^c NOVO NORDISK A S   (Denmark)

Author keywords

Diabetes type 1; Electrospray ionization mass spectrometry; Insulin disaggregation; Insulin effect; Insulin hexamer decrease; Proinsulin C peptide; Surface plasmon resonance

Indexed keywords

C PEPTIDE; HEMOGLOBIN A1C; HUMAN INSULIN; NEUTRAL INSULIN;

ADULT; ARTICLE; CLINICAL ARTICLE; DISEASE DURATION; DISSOCIATION CONSTANT; DRUG EFFECT; ELECTROSPRAY MASS SPECTROMETRY; EXOCYTOSIS; FEMALE; GLUCOSE BLOOD LEVEL; GLUCOSE METABOLISM; GLUCOSE UTILIZATION; HUMAN; HUMAN TISSUE; INSULIN BINDING; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; MALE; PANCREAS ISLET BETA CELL; PROTEIN PROTEIN INTERACTION; SECRETORY GRANULE; SURFACE PLASMON RESONANCE;

ADULT; C-PEPTIDE; DIABETES MELLITUS, TYPE 1; FEMALE; GLUCOSE; HUMANS; HYPOGLYCEMIC AGENTS; INSULIN; MALE; MIDDLE AGED; PROTEIN BINDING; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; SURFACE PLASMON RESONANCE;

EID: 33747169126     PISSN: 1420682X     EISSN: 15691632     Source Type: Journal    
DOI: 10.1007/s00018-006-6204-6     Document Type: Article

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