Unraveling the symmetry ambiguity in a hexamer: Calculation of the R6 human insulin structure

Journal of Biomolecular NMR

Volumn 16, Issue 2, 2000, Pages 93-108

  O'Donoghue, Seán I ^a   Chang, Xiaoqing ^b   Abseher, Roger ^a   Nilges, Michael ^a   Led, Jens J ^b  

^a EUROPEAN MOLECULAR BIOLOGY LABORATORY   (Germany)

^b UNIVERSITY OF COPENHAGEN   (Denmark)

Author keywords

Ambiguous distance restraints; Insulin hexamer; Principal component analysis; Solution structure; Symmetric oligomers

Indexed keywords

INSULIN; MONOMER; OLIGOMER; PHENOL; VEROTOXIN;

ARTICLE; CALCULATION; CHEMICAL STRUCTURE; CRYSTAL STRUCTURE; CRYSTALLOGRAPHY; NUCLEAR MAGNETIC RESONANCE; NUCLEAR OVERHAUSER EFFECT; PRINCIPAL COMPONENT ANALYSIS; PRIORITY JOURNAL;

BINDING SITES; DIMERIZATION; HUMANS; INSULIN; MODELS, MOLECULAR; MODELS, THEORETICAL; MOTION; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR; PHENOL; PROTEIN BINDING; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; SOLUBILITY; THERMODYNAMICS;

TRIXIS;

EID: 0034057133     PISSN: 09252738     EISSN: None     Source Type: Journal    
DOI: 10.1023/A:1008323819099     Document Type: Article

References (32)

1. Abseher, R., Horstink, L., Hilbers, C.W. and Nilges, M. (1998) Proteins, 31, 370-382.
2. Amadei, A., Linssen, A.B.M. and Berendsen, H.J.C. (1993) Proteins, 17, 412-425.
3. Arrowsmith, C.H., Pachter, R., Altman, R.B., Iyer, S.B. and Jardetzky, O. (1991) Biochemistry, 29, 6332-6341.
4. Baker, E.N., Blundell, T.L., Cutfield, J.F., Cutfield, S.M., Dodson, E.J., Dodson, G.G., Hodgkin, D.M.C., Hubbard, R.E., Isaacs, N.W., Reynolds, C.D., Sakabe, K., Sakabe, N. and Vijayan, N.M. (1988) Phil. Trans. R. Soc. Ser. B, 319, 369-456.
5. Blundell, T.L., Dodson, G.G., Hodgkin, D.M.C. and Mercola, D.A. (1972) Adv. Protein Chem., 26, 279-402.
6. Brader, M.L., Kaarsholm, N.C., Lee, R.W.-K. and Dunn, M.K. (1991) Biochemistry, 30, 6636-6645.
7. Brünger, A. (1992) X-PLOR Version 3.1. A System for X-ray Crystallography and NMR, Yale University Press, New Haven, CT.
8. Chang, X., Jørgensen, A.M.M., Bardrum, P. and Led, J.J. (1997) Biochemistry, 36, 9409-9422.
9. Chothia, C., Lesk, A.M., Dodson, G.G. and Hodgkin, D.C. (1983) Nature, 302, 500-505.
10. DeLano, W.L. and Brünger, A.T. (1994) Proteins, 20, 105-123.
11. Derewenda, U., Derewenda, Z., Dodson, E.J., Dodson, G.G., Reynolds, C.D., Smith, G.D., Sparks, C. and Swenson, D. (1989) Nature, 338, 594-596.
12. Hua, Q.X. and Weiss, M.A. (1991) Biochemistry, 30, 5505-5515.
13. Jacoby, E., Hua, Q.X., Stern, A.S., Frank, B.H. and Weiss, M.A. (1996) J. Mol. Biol., 258, 136-157.
14. Jørgensen, A.M.M., Kristensen, S.M., Led, J.J. and Balschmidt, P. (1992) J. Mol. Biol., 227, 1146-1163.
15. Jørgensen, A.M.M., Olsen, H.B., Balschmidt, P. and Led, J.J. (1996) J. Mol. Biol., 257, 684-699.
16. Kaarsholm, N.C., Ko, H.-C. and Dunn, M.F. (1989) Biochemistry, 28, 4427-4435.
17. Kraulis, P.J. (1991) J. Appl. Crystallogr., 24, 946-950.
18. Laskowski, R.A., Rullmann, J.A.C., MacArthur, M.W., Kaptein, R. and Thornton, J.M. (1996) J. Biomol. NMR, 8, 477-485.
19. Lee, W., Harvey, T.S., Yin, Y., Yau, P., Litchfield, D. and Arrowsmith, C.H., Nat. Struct. Biol., 1, 877-890.
20. Linge, J.P. and Nilges, M. (1998) J. Biamol. NMR, 13, 51-59.
21. Nilges, M. (1993) Proteins, 17, 297-309.
22. Nilges, M. (1995) J. Mol. Biol., 245, 645-660.
23. Nilges, M. and O'Donoghue, S.I. (1998) Prog. NMR Spectrosc., 32, 107-139.
24. Nilges, M., Clore, G.M. and Gronenborn, A.M. (1988) FEBS Lett., 229, 317-324.
25. Nilges, M., Gronenborn, A.M., Brünger, A.T. and Clore, G.M. (1988) Protein Eng., 2, 27-38.
26. Nilges, M., Macias, M.J., O'Donoghue, S.I. and Oschkinat, H. (1997) J. Mol. Biol., 269, 408-422.
27. O'Donoghue, S.I. (1998) Protocols for symmetric oligomers. http://www.EMBL-Heidelberg.DE/nmr/nilges/NMRProtocols/ SymmetricOligomers.html.
28. O'Donoghue, S.I. and Nilges, M. (1999) In Biological Magnetic Resonance Vol. 17: Structure Computation and Dynamics in Protein NMR (Krishna, N.R. and Berliner, J., Eds), Plenum Press, New York, NY, pp. 131-161.
29. O'Donoghue, S.I., Junius, F.K. and King, G.F. (1993) Protein Eng., 6, 557-564.
30. O'Donoghue, S.I., King, G.F. and Nilges, M. (1996) J. Biomol. NMR, 8, 193-206.
31. Schlitter, J., Engels, M., Krüger, P., Jacoby, E. and Wollmer, A. (1993) Mol. Simul., 10, 291-308.
32. Wollmer, A., Rannefeld, B., Johansen, B.R., Hejnaes, K.R., Balschmidt, P. and Johansen, F.B. (1987) Biol. Chem., 368, 903-911.