Separate functional features of proinsulin C-peptide

Cellular and Molecular Life Sciences

Volumn 62, Issue 15, 2005, Pages 1772-1778

  Henriksson, M ^a   Nordling, E ^a,d   Melles, E ^a   Shafqat, J ^a   Stahlberg M ^a   Ekberg, K ^b   Persson, B ^a,e   Bergman, T ^a   Wahren, J ^b   Johansson, J ^a,c   Jornvall H ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

^b KAROLINSKA UNIVERSITY HOSPITAL   (Sweden)

^c SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

^d BIOVITRUM AB   (Sweden)

^e LINKÖPING UNIVERSITY   (Sweden)

Author keywords

C peptide; Diabetes mellitus; Mitogen activated protein kinase (MAPK); Peptide secondary structure; Tripartite functional segment

Indexed keywords

C PEPTIDE; GLUTAMIC ACID; MITOGEN ACTIVATED PROTEIN KINASE; PENTAPEPTIDE;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ARTICLE; CELL STRAIN 3T3; CONTROLLED STUDY; ENZYME PHOSPHORYLATION; MOUSE; NONHUMAN; PROTEIN EXPRESSION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; METABOLISM; MOLECULAR GENETICS; NUCLEOTIDE SEQUENCE; PHOSPHORYLATION; PROTEIN SECONDARY STRUCTURE; SEQUENCE ALIGNMENT;

MAMMALIA;

AMINO ACID SEQUENCE; ANIMALS; C-PEPTIDE; CONSERVED SEQUENCE; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GLUTAMIC ACID; MICE; MOLECULAR SEQUENCE DATA; PHOSPHORYLATION; PROTEIN STRUCTURE, SECONDARY; SEQUENCE ALIGNMENT; SWISS 3T3 CELLS;

EID: 23844482127     PISSN: 1420682X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00018-005-5180-6     Document Type: Article

References (26)

1. Dodson G. and Steiner D.F. (1998) The role of assembly in insulin's biosynthesis. Curr. Opinion Struct. Biol. 8: 189-194
2. Steiner D. F. (1984) The biosynthesis of insulin: generic, evolutionary and pathophysiologic aspects. In: The Harvey Lectures, series 78, pp. 191-198, Gotshlich E. C. (ed.), Academic Press, New York
3. Johansson B., Sjöberg S. and Wahren J. (1992) The influence of human C-peptide on renal function and glucose utilization in type 1 (insulin-dependent) diabetic patients. Diabetologia 35: 121-128
4. Johansson B.-L., Borg K., Fernqvist-Forbes E., Kernell A., Odergren T. and Wahren J. (2000) Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with type I diabetes. Diabet. Med. 17: 181-189
5. Sima A. A., Zhang W., Sugimoto K., Henry D., Wahren J. and Grunberger G. (2001) C-peptide prevents and improves chronic type 1 diabetic polyneuropathy in the BB/Wor rat. Diabetologia 44: 889-897
6. Samnegård B., Jacobson S., Jaremko G., Johansson B.-L. and Sjöquist M. (2001) Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney Int. 60: 1258-1265
7. Ekberg K., Brismar T., Johansson B.-L., Jonsson B., Lindström P. and Wahren J. (2003) Amelioration of sensory nerve dysfunction by C-peptide in patients with type 1 diabetes. Diabetes 52: 536-541
8. Johansson J., Ekberg K., Shafqat J., Henriksson M., Chibalin A., Wahren J. et al. (2002) Molecular effects of proinsulin C-peptide. Biochem. Biophys. Res. Commun. 295: 1035-1040
9. Wahren J., Ekberg K., Shafqat J., Johansson J., Johansson B.-L. and Jörnvall H. (2004) Biological effects of C-peptide and Proinsulin. In: International Textbook of Diabetes Mellitus and Proinsulin 3rd edn, pp. 165-181, DeFronzo R. A., Ferrannini E., Keen H., Zimmet P. (eds), Wiley, Chichester
10. Kitamura T., Kimura K., Jung B. D., Makondo K., Okamoto S., Canas X. et al. (2001) Proinsulin C-peptide rapidly stimulates mitogen-activated protein kinases in Swiss 3T3 fibroblasts: requirement of protein kinase C, phosphoinositide 3-kinase and pertussis toxin-sensitive G-protein. Biochem. J. 355: 123-129
11. Kitamura T., Kimura K., Jung B. D., Makondo K., Sakane N., Yoshida T. et al. (2002) Proinsulin C-peptide activates cAMP response element-binding proteins through the p38 mitogen-activated protein kinase pathway in mouse lung capillary endothelial cells. Biochem. J. 366: 737-744
12. Zhong Z. H., Davidescu A., Ehrén, I., Ekberg K., Jörnvall H., Wahren J. et al. (2005) C-peptide stimulates ERK1/2 and JNK MAP-kinases via activation of PKC in human renal tubular cells. Diabetologia 48: 187-197
13. +-ATPase via activation of ERK1/2 MAP kinases in human renal tubular cells. Cell. Mol. Life Sci., 61: 2782-2790
14. Ido Y., Vindigni A., Chang K., Stramm L., Chance R., Heath W. et al. (1997) Prevention of vascular and neural dysfunction in diabetic rats by C-peptide. Science 277: 563-566
15. Grunberger G., Qiang X., Li Z., Mathews S. T., Sbrissa D., Shisheva A. et al. (2001) Molecular basis for the insuli-nomimetic effects of C-peptide. Diabetologia 44: 1247-1257
16. Rigler R., Pramanik A., Jonasson P., Kratz G., Jansson O.T., Nygren P.-Å. et al. (1999) Specific binding of proinsulin C-peptide to human cell membranes. Proc. Natl. Acad. Sci. USA 96: 13318-13323
17. +-ATPase activity of renal tubular segments. Diabetologia 41: 287-291
18. Li Z.G., Qiang X., Sima A. A. and Grunberger G. (2001) C-peptide attenuates protein tyrosine phosphatase activity and enhances glycogen synthesis in L6 myoblasts. Biochem. Biophys. Res. Commun. 280: 615-619
19. Henriksson M., Shafqat J., Liepinsh E., Tally M., Wahren J., Jörnvall H. et al. (2000) Unordered structure of proinsulin C-peptide in aqueous solution and in the presence of lipid vesicles. Cell. Mol. Life Sci., 57: 337-342
20. 2+ increases in human renal tubular cells. Cell. Mol. Life Sci. 59: 1185-1189
21. Sato Y., Oshida Y., Han Y-Q., Li L., Ekberg K., Jörnvall H. et al. (2004) C-peptide fragments stimulate glucose utilization in diabetic rats. Cell. Mol. Life Sci. 61: 727-732
22. Pramanik A., Ekberg K., Zhong Z., Shafqat J., Henriksson M., Jansson O. et al. (2001) C-peptide binding to human cell membranes: importance of Glu27. Biochem. Biophys. Res. Commun. 284: 94-98
23. Bourguignon J. P., Alvarez Gonzalez M. L., Gerard A. and Franchimont P. (1994) Gonadotropin releasing hormone inhibitory autofeedback by subproducts antagonist at N-methyl-D-aspartate receptors: a model of autocrine regulation of peptide secretion. Endocrinology 134: 1589-1592
24. Thompson J. D., Higgins D. G. and Gibson T. J. (1994) CLUSTAL W: improving the sensitivity of progressive multiple sequence alignment through sequence weighting, position-specific gap penalties and weight matrix choice. Nucleic Acids Res. 22: 4673-4680
25. Melles E., Jörnvall H., Tryggvason S., Ekberg K., Tryggvason K., Wahren J. and Bergman T. (2004) Degradation of proinsulin C-peptide in kidney and placenta extracts by a specific endoprotease activity. Cell. Mol. Life Sci. 61: 2979-2982
26. Pictet R. L., Rutter W. J., Cordell B., Tischer E., Goodman H. M. and Bell G.I. (1980) Nucleotide sequence of a cDNA clone encoding human preproinsulin. Nature 284: 26-32