An animal model of extrapyramidal side effects induced by antipsychotic drugs: Relationship with D2 dopamine receptor occupancy

Progress in Neuro-Psychopharmacology and Biological Psychiatry

Volumn 25, Issue 3, 2001, Pages 573-590

  Crocker, Ann D ^a   Hemsley, Kim M ^a  

^a FLINDERS UNIVERSITY   (Australia)

Author keywords

Antipsychotic drugs; Catalepsy; Dopamine D2 receptors; EMG; Extrapyramidal side effects; Fluphenazine; Haloperidol; Muscle rigidity; Receptor occupancy; Striatum; Substantia nigra; Thioridazine

Indexed keywords

DOPAMINE 2 RECEPTOR; FLUPHENAZINE; HALOPERIDOL; THIORIDAZINE;

ANIMAL BEHAVIOR; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CATALEPSY; CONTROLLED STUDY; DRUG INDUCED DISEASE; DRUG RECEPTOR BINDING; ELECTROMYOGRAPHY; EXTRAPYRAMIDAL SYMPTOM; HINDLIMB; MALE; MUSCLE RIGIDITY; NONHUMAN; RAT; RECEPTOR OCCUPANCY;

ANIMALS; ANTIPSYCHOTIC AGENTS; CATALEPSY; CORPUS STRIATUM; DISEASE MODELS, ANIMAL; DOSE-RESPONSE RELATIONSHIP, DRUG; ELECTROMYOGRAPHY; HALOPERIDOL; MALE; MUSCLE RIGIDITY; MUSCLE, SKELETAL; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, DOPAMINE D2; SUBSTANTIA NIGRA; THIORIDAZINE;

EID: 0035029302     PISSN: 02785846     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0278-5846(00)00176-7     Document Type: Article

References (38)

1. Extrapyramidal syndromes in non-human primates: Typical and atypical neuroleptics
2. Motor and mental aspects of acute extrapyramidal syndromes
3. Classical and atypical antipsychotic drugs: New insights
4. Modification of the behavioural effects of haloperidol and of dopamine receptor regulation by altered thyroid status
5. A new view of the role of dopamine receptors in the regulation of muscle tone
6. The regulation of motor control: An evaluation of the role of dopamine receptors in the substantia nigra
7. An animal model of extrapyramidal side effects induced by antipsychotic drugs: Relationship with dopamine receptor occupancy
8. Quantitative electromyographic changes following modification of central dopaminergic transmission
9. Dopamine receptors in the substantia nigra are involved in the regulation of muscle tone
10. Distinct sites of functional interaction between dopamine, acetylcholine and γ-aminobutyrate within the neostriatum: An electromyographic study in rats
11. Confirmation of D2-dopamine receptor occupancy by PET
12. PET analysis indicates atypical central dopamine receptor occupany in clozapine-treated patients
13. Positron emission tomographic analysis of central D1 and D2 dopamine receptor occupancy in patients treated with classical neuroleptics and clozapine. Relation to extrapyramidal side effects
14. Neuroleptic-sensitive binding sites in the nigrostriatal system: Evidence for differential distribution of sigma sites in the substantia nigra pars compacta of the cat
15. The effects of an irreversible dopamine receptor antagonist, N-ethoxycarbonyl-2-ethoxy-1,2-dihydroquinoline (EEDQ), on the regulation of muscle tone in the rat: The role of the substantia nigra
16. Raclopride and chlorpromazine, but not clozapine, increase muscle rigidity in the rat: Relationship with D2 dopamine receptor occupancy
17. Repeated testing of rats markedly enhances the duration of effects induced by haloperidol on treadmill locomotion, catalepsy, and a conditioned avoidance response
18. Catalepsy as a rodent model for detecting antipsychotic drugs with extrapyramidal side effect liability
19. Preclinical findings with antipsychotic agents: What makes them atypical?
20. Microcomputer video image analysis
21. Neuroleptic binding to sigma receptors: Possible involvement in neuroleptic-induced acute dystonia
22. Clozapine for the treatment-resistant schizophrenic. A double-blind comparison versus chlorpromazine
23. Drug effects on active immobility responses: What they tell us about neurotransmitter systems and functions
24. Interaction of antipsychotic drugs with neurotransmitter receptor sites in vitro and in vivo in relation to pharmacological and clinical effects: Role of 5HT2 receptors
25. New drugs for the treatment of schizophrenia
26. Comparative anticholinergic properties of thioridazine, mesoridazine and sulforidazine
27. Time-course of D2-dopamine receptor occupancy examined by PET after single oral doses of haloperidol
28. Positron emission tomography studies on D2 dopamine receptor occupancy and plasma antipsychotic levels in man
29. Muscle rigidity induced by fluphenazine in rats is antagonised by L-dopa, an antiparkinsonian drug
30. New and old antipsychotics versus clozapine in a monkey model: Adverse effects and antiamphetamine effects
31. Possible role of opiate receptors and des-tyrosine1-gamma endorphin in schizophrenia
32. D2 dopamine receptor occupancy differs between patients with and without extrapyramidal side effects
33. Occupancy of central neurotransmitter receptors by risperidone, clozapine and haloperidol, measured ex vivo by quantitative autoradiography
34. Antischizophrenic drugs and brain cholinergic receptors
35. Time course of dopamine D2 and serotonin 5HT2 receptor occupancy rates by haloperidol and clozapine in vivo
36. Atypicality of several antipsychotics on the basis of in vivo dopamine-D2 and serotonin-5HT2 receptor occupancy
37. Sigma receptors: Biology and function